• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Asfu-0832
pfs2

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: Polyadenylation factor subunit 2
Gene Name: pfs2, AFUA_2G08390
Ensembl Gene: AFUA_2G08390
Ensembl Protein: EAL93135
Organism: Aspergillus fumigatus
Taxa ID: 330879
LLPS Type: Others


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
Nuclear speckle, P-bodyPredicted from orthologs(View)

▼ FUNCTION

Required for 3'-end cleavage and polyadenylation of pre-mRNAs. Also involved in chromosome segregation where it has a role in chromosome attachment to the mitotic spindle (By similarity).

▼ CROSS REFERENCE

DatabaseNucleotide IDProtein ID
EnsemblEAL93135EAL93135
UniProtQ4X1Y0, PFS2_ASPFU
GeneBankAAHF01000001EAL93135.1
RefSeqXM_750080.1XP_755173.1

▼ SEQUENCE

Protein Sequence (FASTA)
1     MLPPLARIHS  PADTIPVRHL  HQSIGKSKKP  ITVVRWTPEG  RRLLTGGHTG  EFMLWNGTAF  60
61    NFETVMDVRG  QKGDIKYWRP  NFNNVETIDD  AHHDAVRDLA  WSPSDTKFLS  ASDDTTLKIF  120
121   DFTARTADTV  LTGHNWDVKS  CDWHPTKGLL  VSGSKDHQVK  FWDPRTARCL  TTLHSHKNTV  180
181   TTTRFSRVNS  NLLATSSRDQ  TARVFDLRMM  RDICILRGHE  KPISSLTWHP  IHSSLISTGS  240
241   EDGSLYHYLL  DEPNLPSGQV  PTIAPYDSPD  PANTPAQVIY  PAHRIQYAHS  ATIWSLDWHP  300
301   LGHILASGSK  DNFTRFWSRA  RPGETSYMKD  RFHIGEEAAE  AQGTWSRGFG  RRQMREEEEQ  360
361   EAQDEAESLV  DQKNTTAQSL  PGIQIAPPGL  GSLQTGSGSL  LPGIGAPQPA  PQAGMSASMP  420
421   QMDPGRLAAI  LSQQNPSQPQ  NFPSATGIPG  FPMPPAMSGT  PPLNIDLAEL  QKQLLSQGIS  480
481   PQNFASLAAS  LGSAGLPGLQ  SSTPDNTYRR  510
Nucleotide CDS Sequence (FASTA)
1     ATGCTTCCGC  CGTTGGCGCG  AATCCATTCT  CCTGCAGATA  CGATACCCGT  ACGACACCTA  60
61    CACCAATCGA  TCGGTAAATC  GAAGAAACCT  ATCACAGTTG  TGAGATGGAC  GCCAGAAGGG  120
121   AGACGGTTGT  TGACCGGAGG  ACATACTGGC  GAATTTATGC  TGTGGAATGG  AACGGCTTTC  180
181   AACTTTGAGA  CAGTCATGGA  CGTGCGTGGA  CAAAAGGGCG  ACATCAAATA  CTGGCGACCT  240
241   AACTTCAACA  ATGTGGAGAC  GATCGATGAT  GCACATCACG  ATGCCGTACG  AGACCTAGCA  300
301   TGGTCACCGA  GCGACACAAA  ATTTTTGTCC  GCGTCTGATG  ATACGACCCT  AAAGATCTTC  360
361   GACTTCACCG  CACGAACTGC  CGACACCGTT  CTTACAGGTC  ATAACTGGGA  CGTCAAATCG  420
421   TGCGATTGGC  ACCCGACAAA  AGGTCTTCTG  GTGTCGGGGT  CGAAAGACCA  CCAGGTCAAG  480
481   TTTTGGGATC  CTCGCACCGC  TAGGTGCTTG  ACGACCCTTC  ACAGCCATAA  GAATACCGTC  540
541   ACGACTACCC  GATTCTCGCG  AGTAAACAGC  AACCTTCTCG  CTACGTCATC  GCGTGATCAG  600
601   ACTGCGAGAG  TATTTGATCT  ACGTATGATG  CGAGATATCT  GTATTCTCCG  GGGGCATGAG  660
661   AAGCCTATCT  CATCTCTTAC  ATGGCATCCT  ATTCACAGTT  CCCTCATTTC  CACAGGGAGC  720
721   GAGGATGGGT  CATTATACCA  TTATTTACTT  GATGAACCCA  ACCTTCCATC  AGGACAAGTT  780
781   CCTACAATTG  CCCCGTACGA  CAGTCCTGAT  CCTGCGAATA  CCCCAGCACA  GGTCATCTAC  840
841   CCCGCCCATC  GGATCCAATA  TGCCCACAGT  GCCACTATCT  GGTCACTCGA  CTGGCATCCT  900
901   CTGGGTCATA  TCTTGGCGTC  GGGCTCGAAA  GACAATTTCA  CACGCTTCTG  GTCTCGAGCA  960
961   AGACCAGGTG  AGACTAGTTA  CATGAAAGAC  AGATTTCATA  TCGGCGAGGA  GGCTGCAGAA  1020
1021  GCCCAAGGAA  CATGGAGTCG  TGGGTTTGGA  AGGCGACAGA  TGCGTGAAGA  GGAAGAGCAA  1080
1081  GAGGCACAAG  ACGAGGCTGA  AAGCTTGGTT  GACCAGAAGA  ATACTACCGC  CCAATCTCTT  1140
1141  CCCGGCATCC  AGATTGCTCC  CCCCGGTCTT  GGTTCTCTGC  AAACAGGATC  TGGCTCATTG  1200
1201  TTACCAGGCA  TTGGTGCTCC  ACAACCTGCA  CCGCAAGCTG  GGATGTCTGC  ATCCATGCCT  1260
1261  CAAATGGACC  CTGGCCGCTT  GGCAGCGATT  CTGTCTCAAC  AAAACCCCTC  TCAGCCACAA  1320
1321  AATTTTCCTT  CGGCCACAGG  CATTCCTGGA  TTCCCCATGC  CCCCTGCTAT  GTCAGGTACT  1380
1381  CCGCCATTGA  ACATCGACCT  TGCGGAGCTA  CAAAAGCAGC  TCCTTTCCCA  GGGCATTTCT  1440
1441  CCTCAAAATT  TCGCCTCTTT  GGCTGCATCT  CTAGGTTCTG  CGGGTCTTCC  TGGTCTGCAA  1500
1501  AGCAGCACGC  CCGATAACAC  GTATCGAAGA  TGA  1533

▼ KEYWORD

ID
Family
Chromosome partition
Complete proteome
mRNA processing
Nucleus
Reference proteome
Repeat
WD repeat

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
MRNA cleavage and polyadenylation specificity factor complex
Biological Process
Chromosome segregation
Biological Process
MRNA polyadenylation

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Nef-0118Neosartorya fischeri94.00.0 864
LLPS-Asni-0842Aspergillus niger88.436e-167 483
LLPS-Asc-0559Aspergillus clavatus85.40.0 807
LLPS-Aso-0371Aspergillus oryzae83.170.0 788
LLPS-Asf-0214Aspergillus flavus82.970.0 786
LLPS-Ast-0290Aspergillus terreus80.890.0 799
LLPS-Asn-0316Aspergillus nidulans76.450.0 719
LLPS-Nec-1540Neurospora crassa65.326e-171 506
LLPS-Beb-0444Beauveria bassiana65.032e-170 502
LLPS-Blg-0770Blumeria graminis64.89e-169 498
LLPS-Fuv-0210Fusarium verticillioides64.481e-168 498
LLPS-Coo-1005Colletotrichum orbiculare64.295e-170 502
LLPS-Fuo-1186Fusarium oxysporum64.217e-168 496
LLPS-Fus-0153Fusarium solani63.935e-168 496
LLPS-Cogr-1104Colletotrichum graminicola63.523e-171 503
LLPS-Gag-0756Gaeumannomyces graminis61.482e-166 490
LLPS-Pytr-0842Pyrenophora triticirepentis60.978e-164 485
LLPS-Pyt-0611Pyrenophora teres60.972e-163 486
LLPS-Mao-0478Magnaporthe oryzae60.732e-163 485
LLPS-Lem-0668Leptosphaeria maculans60.718e-163 483
LLPS-Trr-0170Trichoderma reesei60.76e-162 481
LLPS-Ved-0643Verticillium dahliae60.62e-162 479
LLPS-Trv-1381Trichoderma virens60.27e-160 475
LLPS-Phn-0624Phaeosphaeria nodorum58.064e-155 462
LLPS-Zyt-1201Zymoseptoria tritici57.776e-147 442
LLPS-Map-0187Magnaporthe poae57.215e-81 265
LLPS-Dos-0756Dothistroma septosporum54.723e-141 427
LLPS-Tum-0188Tuber melanosporum54.151e-129 397
LLPS-Scp-1532Schizosaccharomyces pombe48.351e-112 350
LLPS-Scj-1467Schizosaccharomyces japonicus48.353e-109 341
LLPS-Php-2533Physcomitrella patens43.98e-91 298
LLPS-Kop-0460Komagataella pastoris43.89e-102 320
LLPS-Pug-0407Puccinia graminis43.535e-97 315
LLPS-Put-1009Puccinia triticina43.59e-88 290
LLPS-Abg-0925Absidia glauca42.826e-89 293
LLPS-Miv-1413Microbotryum violaceum42.272e-93 303
LLPS-Usm-1167Ustilago maydis42.153e-82 274
LLPS-Spr-0864Sporisorium reilianum42.123e-83 277
LLPS-Xet-1103Xenopus tropicalis41.572e-84 291
LLPS-Icp-2196Ictalurus punctatus41.577e-85 289
LLPS-Lac-0694Latimeria chalumnae41.298e-85 290
LLPS-Leo-0858Lepisosteus oculatus41.291e-84 290
LLPS-Asm-1572Astyanax mexicanus41.296e-85 289
LLPS-Xim-2685Xiphophorus maculatus41.295e-86 290
LLPS-Mup-0977Mustela putorius furo41.262e-82 283
LLPS-Crn-1520Cryptococcus neoformans41.235e-82 276
LLPS-Phv-1707Phaseolus vulgaris41.182e-89 295
LLPS-Man-2020Macaca nemestrina41.012e-84 289
LLPS-Loa-0441Loxodonta africana41.012e-84 289
LLPS-Pat-2382Pan troglodytes41.012e-84 290
LLPS-Pap-0113Pan paniscus41.012e-84 289
LLPS-Viv-1366Vitis vinifera41.016e-88 293
LLPS-Urm-3266Ursus maritimus41.012e-84 289
LLPS-Hos-1371Homo sapiens41.012e-84 289
LLPS-Meg-1935Meleagris gallopavo41.012e-84 289
LLPS-Dar-2747Danio rerio41.014e-85 290
LLPS-Mod-2178Monodelphis domestica41.013e-84 289
LLPS-Fec-0819Felis catus41.012e-84 289
LLPS-Orc-0502Oryctolagus cuniculus41.012e-84 289
LLPS-Orn-0652Oreochromis niloticus41.011e-84 289
LLPS-Otg-0109Otolemur garnettii41.012e-84 289
LLPS-Pes-1959Pelodiscus sinensis41.013e-84 289
LLPS-Mam-2046Macaca mulatta41.012e-84 289
LLPS-Poa-1821Pongo abelii41.012e-84 290
LLPS-Caf-3279Canis familiaris41.013e-84 289
LLPS-Ten-1404Tetraodon nigroviridis41.014e-85 290
LLPS-Eqc-3656Equus caballus41.012e-84 289
LLPS-Cap-1075Cavia porcellus41.012e-84 289
LLPS-Ict-2046Ictidomys tridecemlineatus41.012e-84 289
LLPS-Anc-1898Anolis carolinensis41.013e-84 288
LLPS-Nol-4232Nomascus leucogenys41.012e-84 289
LLPS-Tag-3508Taeniopygia guttata41.014e-84 288
LLPS-Cas-3820Carlito syrichta41.012e-84 290
LLPS-Aon-2888Aotus nancymaae41.012e-84 289
LLPS-Sah-0221Sarcophilus harrisii41.013e-84 289
LLPS-Cea-2021Cercocebus atys41.012e-84 289
LLPS-Sus-3270Sus scrofa41.012e-84 289
LLPS-Mea-4009Mesocricetus auratus41.013e-84 289
LLPS-Maf-1897Macaca fascicularis41.012e-84 289
LLPS-Mum-1825Mus musculus41.011e-84 290
LLPS-Ora-1459Ornithorhynchus anatinus41.012e-84 289
LLPS-Fud-0154Fukomys damarensis41.011e-84 290
LLPS-Caj-1509Callithrix jacchus41.012e-84 289
LLPS-Gog-3555Gorilla gorilla41.012e-84 289
LLPS-Dio-3357Dipodomys ordii41.012e-84 290
LLPS-Bot-0577Bos taurus41.012e-84 289
LLPS-Paa-0487Papio anubis41.012e-84 289
LLPS-Mal-0710Mandrillus leucophaeus41.012e-84 290
LLPS-Aim-2597Ailuropoda melanoleuca41.014e-84 290
LLPS-Myl-0335Myotis lucifugus41.012e-84 290
LLPS-Ova-2604Ovis aries41.012e-84 289
LLPS-Ran-3295Rattus norvegicus41.013e-84 288
LLPS-Prp-2057Prunus persica40.972e-90 298
LLPS-Glm-1440Glycine max40.964e-89 294
LLPS-Hea-0832Helianthus annuus40.962e-89 294
LLPS-Pof-0801Poecilia formosa40.92e-83 284
LLPS-Via-0057Vigna angularis40.91e-89 296
LLPS-Anp-2705Anas platyrhynchos40.783e-82 283
LLPS-Cae-0537Caenorhabditis elegans40.772e-83 281
LLPS-Asg-0017Ashbya gossypii40.747e-82 268
LLPS-Orl-2655Oryzias latipes40.735e-84 286
LLPS-Chs-1553Chlorocebus sabaeus40.737e-84 288
LLPS-Sem-1759Selaginella moellendorffii40.642e-92 295
LLPS-Gas-1341Galdieria sulphuraria40.562e-83 270
LLPS-Drm-0669Drosophila melanogaster40.451e-80 273
LLPS-Amt-0524Amborella trichopoda40.232e-85 284
LLPS-Yal-0839Yarrowia lipolytica40.225e-86 281
LLPS-Cus-1721Cucumis sativus40.224e-89 294
LLPS-Gaa-0694Gasterosteus aculeatus40.178e-82 281
LLPS-Met-1306Medicago truncatula40.171e-85 286
LLPS-Org-1143Oryza glaberrima40.146e-68 234
LLPS-Sac-1127Saccharomyces cerevisiae39.833e-77 256
LLPS-Ori-0395Oryza indica39.721e-86 288
LLPS-Mua-1131Musa acuminata39.722e-85 285
LLPS-Chc-0068Chondrus crispus39.663e-86 277
LLPS-Gor-0321Gossypium raimondii39.615e-84 281
LLPS-Dac-0458Daucus carota39.511e-52 188
LLPS-Hov-0315Hordeum vulgare39.446e-85 284
LLPS-Art-2827Arabidopsis thaliana39.355e-88 290
LLPS-Brd-0602Brachypodium distachyon39.358e-87 288
LLPS-Mae-0521Manihot esculenta39.347e-87 289
LLPS-Thc-0977Theobroma cacao39.342e-87 290
LLPS-Gaga-1895Gallus gallus39.325e-2095.1
LLPS-Tra-1469Triticum aestivum39.35e-86 286
LLPS-Sei-1814Setaria italica39.152e-84 282
LLPS-Pot-0088Populus trichocarpa39.061e-88 293
LLPS-Coc-1780Corchorus capsularis39.068e-86 290
LLPS-Brr-0795Brassica rapa38.771e-89 294
LLPS-Bro-0139Brassica oleracea38.778e-90 295
LLPS-Brn-1400Brassica napus38.772e-89 294
LLPS-Cis-1574Ciona savignyi38.487e-77 255
LLPS-Cii-0561Ciona intestinalis38.481e-74 256
LLPS-Sob-1809Sorghum bicolor38.44e-84 281
LLPS-Arl-0952Arabidopsis lyrata38.271e-88 292
LLPS-Sol-0356Solanum lycopersicum38.192e-86 288
LLPS-Osl-0859Ostreococcus lucimarinus37.391e-79 259
LLPS-Scm-2813Scophthalmus maximus37.128e-1991.7
LLPS-Rhb-2014Rhinopithecus bieti37.124e-1992.4
LLPS-Scf-0095Scleropages formosus37.128e-1991.7
LLPS-Tar-2694Takifugu rubripes37.129e-1992.0
LLPS-Orbr-1050Oryza brachyantha37.044e-87 287
LLPS-Zem-0719Zea mays37.043e-85 284
LLPS-Chr-0550Chlamydomonas reinhardtii36.781e-66 235
LLPS-Orp-1357Oryza punctata34.931e-66 234
LLPS-Orr-0446Oryza rufipogon34.931e-68 239
LLPS-Orb-2280Oryza barthii34.939e-69 239
LLPS-Orni-1210Oryza nivara34.931e-68 239
LLPS-Orgl-0216Oryza glumaepatula34.931e-68 239
LLPS-Orm-1404Oryza meridionalis34.651e-67 236
LLPS-Lep-0789Leersia perrieri32.593e-66 233
LLPS-Fia-1591Ficedula albicollis30.172e-0654.3
LLPS-Vir-0902Vigna radiata26.85e-43 167