LLPS-Asc-0547
ACLA_006280
Integrated Annotations
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | Telomerase reverse transcriptase; Telomerase catalytic subunit |
| Gene Name: | ACLA_006280 |
| Ensembl Gene: | ACLA_006280 |
| Ensembl Protein: | EAW11871 |
| Organism: | Aspergillus clavatus |
| Taxa ID: | 344612 |
| LLPS Type: | LLPS regulator |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Cajal body, Nucleolus, Stress granule, Others | Predicted from orthologs | (View) |
▼ FUNCTION
| Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | EAW11871 | EAW11871 |
| UniProt | A1CDE4, A1CDE4_ASPCL | |
| GeneBank | DS027051 | EAW11871.1 |
| RefSeq | XM_001273296.1 | XP_001273297.1 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MGKKRKRPSK DSGAGEDLAQ KRLAGGPNGV RSHHATDAYE GSGHSHPVIS LYYHRVVTLR 60 61 QYLLQQIPVS SKSRRRRITS VQGATSTEKQ KNRGVRGYHA QGLADILDTT LVGVLKESSP 120 121 TVTQERLRDF ASYSQSQSQG RSEVPSTDVG PPCAQSEIVD FVISALFNRH AFSYQKPQHL 180 181 LTHGFQRAGG PDVKLASSIP GLARRYPNKN VQCLKQAPWT DVLGLLGGNG EEIMLRLLFD 240 241 CGIFMAIDHR KGIYYQISGL PLSSLEPIQN QSPLEVPNAN SKPSLAAGSN VARKNRSSDQ 300 301 GIAHKPNSVV FFRRRMLYAK PILNSRGEVH FGLSALHVLN RYPRSDSLSQ TVHILKYIFP 360 361 RQFGLHNVFT SVTDSRETVL PFKDYFSRET EIEEIEEKRR KQRRRIGPEF TNHYQDQKEF 420 421 IDIPKRLRGK ACELVQQLQN RNRRCPYTEL LNYYCPPVDT GPWKLGPTDS QTSHPSGTAI 480 481 SESLVTQRRG PQGSFAHASP LSHLQETPSV ATFKAEATVS KILKPKLCLI DYATPCSSVS 540 541 AFCRAALRKL VPPRFYGTGC HQRSNQDIVF RHVDRFVRMR RFESLSLHEV CKGIKITCMP 600 601 WLGHPANQQD EGSSQPKMSL SDLRKRTELL HEFIYYIFES ILVPLIRSNF YVTESQSHRN 660 661 RLFYFRHDVW RQLTQQPLAE FKTSLFEEMK RGVAERRLSS RSLGYSSLRL LPKTTGVRPI 720 721 LNLRRRMLKP GWAGKAPFLG PSINSTIAPV FNVLNYEKRR NPDSLGAALS FVGEIHTRLK 780 781 GFKERLTQKH AGHPRPHLYF VKVDIQSCFD TIPQENLVPL VESLVSEEGY YVAKHVEVRP 840 841 SDEFSSMWPL HESQQSKALR KYVGRAAPVT NSQDLTEAIA EGGISHRRNT VFVDTVAHKE 900 901 YSGDYLLDLL DEHIRYNLVR VGKKYFRQRN GIPQGSILSG VLCNLFYARM ERECLGFLQS 960 961 DESVLLRLID DFLLVTTDSS LAMRFLQVML KGQPEYGITV NPAKSLVNFA AAVDGVQIPR 1020 1021 LVDSALFPYC GSLINTATLE IYRDPERVVE GGDSAAATLA SSLTVESARA PGRSLHRKML 1080 1081 SAFKLQMHPM YLDTQHNSLS AVLSNLYASF VTAAMKMYQY MKALPRRAHP TAEVMARVIR 1140 1141 DLMYLAHRMV GARRELHTAR GPGSPSLCLV QGAQVQYLAT AAFRFVLGRK QTKYAGVLRW 1200 1201 LEQVWKAARP PSSAKAMRLA QVVRQGNASF AGWRF 1235 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Chromosome, telomeric region | |
Cellular Component | Nucleus | |
Molecular Function | DNA binding | |
Molecular Function | Metal ion binding | |
Molecular Function | Telomerase RNA reverse transcriptase activity |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Nef-0439 | Neosartorya fischeri | 72.15 | 0.0 | 1704 |
| LLPS-Asfu-0442 | Aspergillus fumigatus | 70.71 | 0.0 | 1711 |
| LLPS-Aso-0881 | Aspergillus oryzae | 66.9 | 0.0 | 954 |
| LLPS-Asf-0422 | Aspergillus flavus | 66.9 | 0.0 | 954 |
| LLPS-Asni-0935 | Aspergillus niger | 60.25 | 0.0 | 849 |
| LLPS-Ast-0697 | Aspergillus terreus | 57.58 | 0.0 | 1322 |
| LLPS-Asn-0638 | Aspergillus nidulans | 51.83 | 0.0 | 1085 |
| LLPS-Phn-1132 | Phaeosphaeria nodorum | 42.43 | 4e-56 | 214 |
| LLPS-Tum-0868 | Tuber melanosporum | 41.12 | 0.0 | 632 |
| LLPS-Pyt-1019 | Pyrenophora teres | 40.1 | 0.0 | 716 |
| LLPS-Cog-0333 | Colletotrichum gloeosporioides | 39.58 | 1e-105 | 350 |
| LLPS-Coo-0151 | Colletotrichum orbiculare | 39.24 | 0.0 | 608 |
| LLPS-Cogr-0602 | Colletotrichum graminicola | 39.07 | 0.0 | 679 |
| LLPS-Beb-0040 | Beauveria bassiana | 38.78 | 0.0 | 706 |
| LLPS-Lem-0686 | Leptosphaeria maculans | 37.55 | 0.0 | 697 |
| LLPS-Nec-0549 | Neurospora crassa | 36.86 | 0.0 | 691 |
| LLPS-Blg-0604 | Blumeria graminis | 35.98 | 0.0 | 582 |
| LLPS-Scs-0883 | Sclerotinia sclerotiorum | 34.2 | 4e-69 | 254 |
| LLPS-Chr-1537 | Chlamydomonas reinhardtii | 34.17 | 2e-19 | 99.8 |
| LLPS-Mal-1532 | Mandrillus leucophaeus | 32.39 | 6e-37 | 149 |
| LLPS-Crn-0804 | Cryptococcus neoformans | 31.87 | 3e-84 | 303 |
| LLPS-Spr-0867 | Sporisorium reilianum | 31.52 | 3e-114 | 394 |
| LLPS-Pat-3644 | Pan troglodytes | 31.45 | 2e-35 | 144 |
| LLPS-Aim-1603 | Ailuropoda melanoleuca | 31.4 | 6e-72 | 266 |
| LLPS-Put-0304 | Puccinia triticina | 31.3 | 1e-59 | 226 |
| LLPS-Caf-0678 | Canis familiaris | 30.98 | 1e-71 | 265 |
| LLPS-Fec-3498 | Felis catus | 30.94 | 4e-64 | 242 |
| LLPS-Mea-0408 | Mesocricetus auratus | 30.35 | 3e-56 | 218 |
| LLPS-Otg-0275 | Otolemur garnettii | 30.28 | 3e-65 | 246 |
| LLPS-Loa-2580 | Loxodonta africana | 30.25 | 5e-72 | 266 |
| LLPS-Ict-2161 | Ictidomys tridecemlineatus | 29.94 | 2e-70 | 260 |
| LLPS-Poa-0840 | Pongo abelii | 29.83 | 3e-58 | 222 |
| LLPS-Eqc-0521 | Equus caballus | 29.83 | 6e-70 | 261 |
| LLPS-Ora-1929 | Ornithorhynchus anatinus | 29.82 | 2e-64 | 243 |
| LLPS-Scj-0031 | Schizosaccharomyces japonicus | 29.78 | 3e-74 | 269 |
| LLPS-Fud-0200 | Fukomys damarensis | 29.76 | 1e-72 | 265 |
| LLPS-Cas-0593 | Carlito syrichta | 29.45 | 7e-65 | 244 |
| LLPS-Abg-0896 | Absidia glauca | 29.43 | 4e-55 | 213 |
| LLPS-Gaa-2184 | Gasterosteus aculeatus | 29.43 | 4e-57 | 220 |
| LLPS-Mup-1674 | Mustela putorius furo | 29.39 | 7e-67 | 250 |
| LLPS-Ova-0427 | Ovis aries | 29.3 | 4e-22 | 107 |
| LLPS-Paa-1496 | Papio anubis | 29.28 | 2e-71 | 265 |
| LLPS-Mam-1026 | Macaca mulatta | 29.23 | 5e-73 | 269 |
| LLPS-Rhb-1416 | Rhinopithecus bieti | 29.23 | 6e-73 | 269 |
| LLPS-Cap-0712 | Cavia porcellus | 29.17 | 4e-65 | 244 |
| LLPS-Maf-3391 | Macaca fascicularis | 29.1 | 5e-73 | 269 |
| LLPS-Chs-0860 | Chlorocebus sabaeus | 29.1 | 5e-73 | 269 |
| LLPS-Man-1177 | Macaca nemestrina | 29.1 | 5e-73 | 269 |
| LLPS-Bot-1784 | Bos taurus | 29.03 | 3e-72 | 266 |
| LLPS-Gog-3650 | Gorilla gorilla | 28.97 | 2e-72 | 267 |
| LLPS-Mum-2471 | Mus musculus | 28.91 | 5e-61 | 233 |
| LLPS-Dar-0907 | Danio rerio | 28.85 | 2e-61 | 234 |
| LLPS-Hos-1828 | Homo sapiens | 28.85 | 4e-72 | 266 |
| LLPS-Orn-1531 | Oreochromis niloticus | 28.81 | 1e-56 | 219 |
| LLPS-Scf-1927 | Scleropages formosus | 28.79 | 1e-56 | 218 |
| LLPS-Ran-0885 | Rattus norvegicus | 28.77 | 1e-64 | 243 |
| LLPS-Sus-0329 | Sus scrofa | 28.75 | 1e-63 | 241 |
| LLPS-Caj-1161 | Callithrix jacchus | 28.71 | 1e-30 | 135 |
| LLPS-Yal-0147 | Yarrowia lipolytica | 28.68 | 7e-45 | 181 |
| LLPS-Pap-0306 | Pan paniscus | 28.59 | 5e-72 | 265 |
| LLPS-Nol-2504 | Nomascus leucogenys | 28.57 | 7e-67 | 249 |
| LLPS-Usm-0497 | Ustilago maydis | 28.53 | 2e-103 | 363 |
| LLPS-Mod-1291 | Monodelphis domestica | 28.35 | 6e-64 | 242 |
| LLPS-Aon-0289 | Aotus nancymaae | 28.17 | 7e-68 | 253 |
| LLPS-Myl-0850 | Myotis lucifugus | 28.16 | 2e-64 | 243 |
| LLPS-Asm-0980 | Astyanax mexicanus | 28.08 | 3e-47 | 189 |
| LLPS-Osl-0820 | Ostreococcus lucimarinus | 28.03 | 1e-59 | 227 |
| LLPS-Ten-0954 | Tetraodon nigroviridis | 27.96 | 6e-57 | 219 |
| LLPS-Orni-1354 | Oryza nivara | 27.88 | 5e-25 | 117 |
| LLPS-Orm-1608 | Oryza meridionalis | 27.88 | 5e-25 | 117 |
| LLPS-Orl-1299 | Oryzias latipes | 27.74 | 5e-58 | 223 |
| LLPS-Cea-1935 | Cercocebus atys | 27.65 | 2e-55 | 215 |
| LLPS-Gor-0303 | Gossypium raimondii | 27.56 | 1e-65 | 247 |
| LLPS-Coc-0404 | Corchorus capsularis | 27.5 | 2e-49 | 195 |
| LLPS-Mae-0539 | Manihot esculenta | 27.5 | 6e-48 | 191 |
| LLPS-Thc-0763 | Theobroma cacao | 27.48 | 3e-58 | 224 |
| LLPS-Tar-0447 | Takifugu rubripes | 27.45 | 9e-58 | 222 |
| LLPS-Xim-0434 | Xiphophorus maculatus | 27.41 | 1e-54 | 212 |
| LLPS-Dac-0739 | Daucus carota | 27.37 | 1e-57 | 223 |
| LLPS-Fia-0423 | Ficedula albicollis | 27.27 | 9e-57 | 219 |
| LLPS-Cii-0348 | Ciona intestinalis | 27.24 | 4e-35 | 149 |
| LLPS-Vir-1400 | Vigna radiata | 27.22 | 3e-11 | 72.0 |
| LLPS-Tag-2299 | Taeniopygia guttata | 27.21 | 4e-58 | 224 |
| LLPS-Pof-1665 | Poecilia formosa | 27.13 | 1e-54 | 212 |
| LLPS-Leo-0693 | Lepisosteus oculatus | 27.11 | 7e-58 | 222 |
| LLPS-Anp-1238 | Anas platyrhynchos | 26.91 | 7e-50 | 197 |
| LLPS-Anc-2051 | Anolis carolinensis | 26.87 | 3e-60 | 231 |
| LLPS-Icp-2480 | Ictalurus punctatus | 26.83 | 7e-52 | 203 |
| LLPS-Pot-0408 | Populus trichocarpa | 26.79 | 1e-54 | 213 |
| LLPS-Gaga-0398 | Gallus gallus | 26.74 | 1e-61 | 236 |
| LLPS-Sei-0694 | Setaria italica | 26.61 | 2e-13 | 79.0 |
| LLPS-Gas-0562 | Galdieria sulphuraria | 26.19 | 4e-42 | 170 |
| LLPS-Scm-1356 | Scophthalmus maximus | 26.06 | 2e-60 | 230 |
| LLPS-Hea-1669 | Helianthus annuus | 26.05 | 5e-53 | 207 |
| LLPS-Viv-0684 | Vitis vinifera | 26.01 | 7e-52 | 202 |
| LLPS-Pes-2537 | Pelodiscus sinensis | 25.83 | 1e-55 | 216 |
| LLPS-Sah-0325 | Sarcophilus harrisii | 25.64 | 7e-65 | 244 |
| LLPS-Scp-0252 | Schizosaccharomyces pombe | 25.44 | 8e-76 | 276 |
| LLPS-Phv-0624 | Phaseolus vulgaris | 25.41 | 3e-51 | 202 |
| LLPS-Glm-1208 | Glycine max | 25.35 | 1e-52 | 206 |
| LLPS-Scc-1448 | Schizosaccharomyces cryophilus | 25.09 | 2e-70 | 260 |
| LLPS-Orbr-0894 | Oryza brachyantha | 25.04 | 6e-51 | 201 |
| LLPS-Amt-0461 | Amborella trichopoda | 25.0 | 3e-24 | 114 |
| LLPS-Lac-0087 | Latimeria chalumnae | 24.94 | 9e-23 | 109 |
| LLPS-Prp-0343 | Prunus persica | 24.8 | 9e-49 | 194 |
| LLPS-Org-0414 | Oryza glaberrima | 24.75 | 1e-50 | 200 |
| LLPS-Sol-1303 | Solanum lycopersicum | 24.65 | 2e-46 | 186 |
| LLPS-Bro-0366 | Brassica oleracea | 24.55 | 2e-25 | 119 |
| LLPS-Tra-2121 | Triticum aestivum | 24.46 | 8e-46 | 184 |
| LLPS-Via-0897 | Vigna angularis | 24.35 | 2e-43 | 173 |
| LLPS-Orgl-0609 | Oryza glumaepatula | 24.31 | 1e-50 | 200 |
| LLPS-Hov-0070 | Hordeum vulgare | 24.21 | 7e-47 | 188 |
| LLPS-Brr-1373 | Brassica rapa | 24.05 | 3e-35 | 150 |
| LLPS-Xet-0306 | Xenopus tropicalis | 23.93 | 6e-45 | 181 |
| LLPS-Zem-1020 | Zea mays | 23.92 | 5e-49 | 195 |
| LLPS-Tru-0216 | Triticum urartu | 23.85 | 3e-32 | 139 |
| LLPS-Orp-0919 | Oryza punctata | 23.68 | 4e-45 | 182 |
| LLPS-Php-0242 | Physcomitrella patens | 23.66 | 3e-47 | 189 |
| LLPS-Cus-0893 | Cucumis sativus | 23.63 | 6e-28 | 126 |
| LLPS-Brd-0903 | Brachypodium distachyon | 23.51 | 7e-44 | 178 |
| LLPS-Sac-1061 | Saccharomyces cerevisiae | 23.43 | 4e-17 | 91.3 |
| LLPS-Art-0723 | Arabidopsis thaliana | 23.23 | 2e-31 | 138 |
| LLPS-Sob-1114 | Sorghum bicolor | 23.2 | 3e-46 | 186 |
| LLPS-Ori-0856 | Oryza indica | 22.86 | 3e-15 | 83.6 |
| LLPS-Kop-0493 | Komagataella pastoris | 22.61 | 1e-17 | 92.8 |
| LLPS-Asg-0125 | Ashbya gossypii | 20.35 | 5e-16 | 87.8 |