LLPS-Art-3128
UBQ9
▼ OVERVIEW
| Status: | Reviewed |
| Protein Name: | Polyubiquitin 9 |
| Gene Name: | UBQ9, At5g37640, K12B20.90 |
| Ensembl Gene: | AT5G37640 |
| Ensembl Protein: | AT5G37640.1 |
| Organism: | Arabidopsis thaliana |
| Taxa ID: | 3702 |
| LLPS Type: | Others |
▼ Classification
Condensates:
| Condensate | Description | Tissue/Cell | PMIDs |
|---|---|---|---|
| Nucleolus | "...Here, we describe the first proteomic analysis of plant nucleoli, in which we have identified 217 proteins." | Protoplasts | 15496452 |
▼ FUNCTION
| Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in lysosomal degradation; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, and DNA-damage responses. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling (By similarity). |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | AT5G37640.1 | AT5G37640.1 |
| UniProt | Q9FHQ6, UBQ9_ARATH | |
| GeneBank | CP002688, AB018107 | AED94213.1, BAB08310.1 |
| RefSeq | NM_123123.1 | NP_568552.1 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MSMQIHAKTL TEKTITIDVV SSDTINNVKA KIQDIEGIPL DQQRLIFSGK LLDDGRTLAD 60 61 YSIQKDSILH LALRLRGGMQ IFVKTLTGKT ITLEVESSDT IDNVKAKIQD KEGVPPDQQR 120 121 LIFAGKQLDD GRTLADYNIQ KESTLHLVLR LRGGMQIFVR TLTRKTIALE VESSDTTDNV 180 181 KAKIQDKEGI PPDQQRLIFA GKQLEDGRTL ADYNIQKEST LHLVLRLCGG MQIFVNTLTG 240 241 KTITLEVESS DTIDNVKAKI QDKERIQPDQ QRLIFAGEQL EDGYYTLADY NIQKESTLHL 300 301 VLRLRGGECF GFIFLFLLCF NS 322 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGTCGATGC AAATTCACGC AAAGACTCTC ACAGAAAAGA CCATAACCAT TGACGTTGTA 60 61 AGCTCCGACA CCATCAATAA TGTCAAAGCA AAGATCCAGG ACATAGAAGG GATTCCTCTA 120 121 GACCAGCAAA GACTCATCTT TTCCGGTAAA CTGCTAGATG ATGGCCGTAC TTTGGCCGAT 180 181 TACAGTATCC AAAAAGATTC AATACTCCAC TTAGCTCTCA GGTTGAGAGG TGGTATGCAG 240 241 ATATTTGTCA AGACGCTTAC CGGTAAAACC ATTACCCTTG AAGTTGAGAG TTCAGACACT 300 301 ATTGACAATG TTAAAGCTAA GATCCAAGAC AAGGAAGGAG TCCCTCCGGA TCAACAGAGA 360 361 CTAATCTTTG CTGGTAAACA GCTTGACGAT GGTCGCACTC TTGCAGATTA CAACATCCAG 420 421 AAAGAATCAA CTCTCCACTT GGTTCTCAGG TTGAGAGGTG GTATGCAGAT TTTTGTCAGG 480 481 ACACTTACCC GAAAAACCAT AGCTTTGGAA GTTGAGAGCT CTGACACAAC CGATAATGTG 540 541 AAGGCCAAGA TACAAGACAA AGAAGGGATC CCACCAGACC AACAGAGACT TATCTTTGCA 600 601 GGCAAACAAC TCGAAGATGG TCGGACGCTT GCTGATTACA ACATCCAGAA GGAGTCAACA 660 661 CTTCATCTCG TGCTGCGTCT TTGTGGTGGG ATGCAGATAT TTGTCAACAC TTTGACGGGA 720 721 AAGACCATCA CACTTGAAGT GGAGAGCTCT GATACGATTG ACAATGTGAA GGCCAAGATT 780 781 CAGGACAAAG AAAGGATCCA ACCGGACCAA CAGAGGCTAA TCTTTGCAGG CGAGCAGCTT 840 841 GAAGATGGTT ATTACACTTT AGCGGATTAC AATATCCAGA AAGAGTCAAC TCTTCACCTT 900 901 GTTCTCCGTC TCCGCGGTGG AGAGTGCTTT GGTTTTATTT TTCTTTTCTT GTTATGTTTT 960 961 AACTCTTGA 969 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Cell wall | |
Cellular Component | Cytoplasm | |
Cellular Component | Nucleolus | |
Cellular Component | Nucleus | |
Cellular Component | Vacuolar membrane | |
Molecular Function | Protein tag | |
Molecular Function | Ubiquitin protein ligase binding | |
Biological Process | Modification-dependent protein catabolic process | |
Biological Process | Protein ubiquitination | |
Biological Process | Response to cytokinin | |
Biological Process | Ubiquitin-dependent protein catabolic process |
▼ ANNOTATION
| Disorder | ||||
| IUPred2A | ||||
| PTM | ||||
| EPSD | ||||
| Physicochemical | ||||
| Compute pI/Mw | AAindex | |||
| Function | ||||
| PIRSF | ||||
| Localization | ||||
| COMPARTMENTS | ||||
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Orni-1025 | Oryza nivara | 97.44 | 1e-44 | 157 |
| LLPS-Mua-0837 | Musa acuminata | 96.1 | 7e-45 | 155 |
| LLPS-Hea-0839 | Helianthus annuus | 96.1 | 1e-44 | 155 |
| LLPS-Brn-1724 | Brassica napus | 96.1 | 9e-45 | 155 |
| LLPS-Glm-0276 | Glycine max | 96.1 | 9e-45 | 155 |
| LLPS-Sol-2129 | Solanum lycopersicum | 96.1 | 7e-45 | 155 |
| LLPS-Met-0393 | Medicago truncatula | 96.1 | 1e-44 | 155 |
| LLPS-Sot-0567 | Solanum tuberosum | 96.1 | 7e-45 | 155 |
| LLPS-Via-0511 | Vigna angularis | 96.1 | 9e-45 | 155 |
| LLPS-Phv-1584 | Phaseolus vulgaris | 96.1 | 9e-45 | 155 |
| LLPS-Mae-0265 | Manihot esculenta | 96.1 | 9e-45 | 155 |
| LLPS-Nia-1661 | Nicotiana attenuata | 96.1 | 9e-45 | 155 |
| LLPS-Pot-1311 | Populus trichocarpa | 96.1 | 7e-45 | 155 |
| LLPS-Viv-1974 | Vitis vinifera | 96.1 | 9e-45 | 155 |
| LLPS-Gor-1960 | Gossypium raimondii | 96.1 | 9e-45 | 155 |
| LLPS-Bro-1621 | Brassica oleracea | 96.1 | 9e-45 | 155 |
| LLPS-Put-1311 | Puccinia triticina | 96.1 | 3e-45 | 157 |
| LLPS-Prp-0833 | Prunus persica | 96.1 | 1e-44 | 155 |
| LLPS-Brr-1587 | Brassica rapa | 94.77 | 1e-97 | 292 |
| LLPS-Usm-1547 | Ustilago maydis | 92.86 | 1e-95 | 290 |
| LLPS-Orb-0684 | Oryza barthii | 92.21 | 1e-40 | 144 |
| LLPS-Ori-1814 | Oryza indica | 92.21 | 1e-40 | 144 |
| LLPS-Sei-0111 | Setaria italica | 92.21 | 1e-40 | 144 |
| LLPS-Tra-1122 | Triticum aestivum | 92.21 | 1e-40 | 144 |
| LLPS-Brd-0863 | Brachypodium distachyon | 92.21 | 1e-40 | 144 |
| LLPS-Orgl-1745 | Oryza glumaepatula | 92.21 | 1e-40 | 144 |
| LLPS-Sob-0716 | Sorghum bicolor | 92.21 | 1e-40 | 144 |
| LLPS-Orbr-1466 | Oryza brachyantha | 92.21 | 1e-40 | 144 |
| LLPS-Org-0556 | Oryza glaberrima | 92.21 | 1e-40 | 144 |
| LLPS-Zem-0048 | Zea mays | 92.21 | 1e-40 | 144 |
| LLPS-Tru-0947 | Triticum urartu | 92.21 | 1e-40 | 144 |
| LLPS-Orm-1223 | Oryza meridionalis | 92.21 | 1e-40 | 144 |
| LLPS-Orr-0056 | Oryza rufipogon | 92.21 | 1e-40 | 144 |
| LLPS-Fuo-1309 | Fusarium oxysporum | 92.07 | 2e-144 | 414 |
| LLPS-Mal-4560 | Mandrillus leucophaeus | 91.67 | 5e-105 | 311 |
| LLPS-Paa-3014 | Papio anubis | 91.67 | 5e-105 | 311 |
| LLPS-Coo-1209 | Colletotrichum orbiculare | 91.63 | 6e-144 | 412 |
| LLPS-Zyt-1131 | Zymoseptoria tritici | 91.63 | 6e-144 | 412 |
| LLPS-Pyt-0652 | Pyrenophora teres | 91.63 | 6e-144 | 412 |
| LLPS-Cog-0210 | Colletotrichum gloeosporioides | 91.63 | 6e-144 | 412 |
| LLPS-Phn-1557 | Phaeosphaeria nodorum | 91.63 | 1e-143 | 412 |
| LLPS-Ved-0270 | Verticillium dahliae | 91.63 | 6e-144 | 412 |
| LLPS-Dos-0093 | Dothistroma septosporum | 91.63 | 6e-144 | 412 |
| LLPS-Pytr-1592 | Pyrenophora triticirepentis | 91.63 | 6e-144 | 412 |
| LLPS-Cas-3350 | Carlito syrichta | 91.45 | 5e-94 | 283 |
| LLPS-Ten-3003 | Tetraodon nigroviridis | 91.45 | 4e-94 | 283 |
| LLPS-Myl-3697 | Myotis lucifugus | 91.36 | 7e-101 | 301 |
| LLPS-Scf-0937 | Scleropages formosus | 90.98 | 2e-72 | 228 |
| LLPS-Chs-2237 | Chlorocebus sabaeus | 90.85 | 6e-94 | 283 |
| LLPS-Dio-0430 | Dipodomys ordii | 90.85 | 4e-94 | 283 |
| LLPS-Otg-4396 | Otolemur garnettii | 90.85 | 6e-94 | 283 |
| LLPS-Pap-1953 | Pan paniscus | 90.85 | 4e-94 | 283 |
| LLPS-Cap-0753 | Cavia porcellus | 90.85 | 4e-94 | 283 |
| LLPS-Pof-0104 | Poecilia formosa | 90.51 | 1e-82 | 253 |
| LLPS-Thc-1980 | Theobroma cacao | 90.43 | 0.0 | 535 |
| LLPS-Mel-0619 | Melampsora laricipopulina | 90.43 | 0.0 | 535 |
| LLPS-Vir-0513 | Vigna radiata | 90.43 | 0.0 | 535 |
| LLPS-Cus-1909 | Cucumis sativus | 90.43 | 0.0 | 535 |
| LLPS-Pug-0459 | Puccinia graminis | 90.43 | 0.0 | 535 |
| LLPS-Osl-0187 | Ostreococcus lucimarinus | 90.43 | 0.0 | 535 |
| LLPS-Fud-0415 | Fukomys damarensis | 90.31 | 3e-141 | 406 |
| LLPS-Gog-1715 | Gorilla gorilla | 90.31 | 3e-140 | 407 |
| LLPS-Sus-2337 | Sus scrofa | 90.31 | 4e-141 | 405 |
| LLPS-Aim-0387 | Ailuropoda melanoleuca | 90.31 | 4e-141 | 405 |
| LLPS-Ova-4410 | Ovis aries | 90.31 | 4e-141 | 405 |
| LLPS-Tut-2128 | Tursiops truncatus | 90.31 | 4e-141 | 405 |
| LLPS-Orc-2857 | Oryctolagus cuniculus | 90.31 | 4e-141 | 405 |
| LLPS-Hos-4070 | Homo sapiens | 90.31 | 4e-141 | 405 |
| LLPS-Scm-3964 | Scophthalmus maximus | 90.31 | 1e-140 | 407 |
| LLPS-Fec-2059 | Felis catus | 90.31 | 4e-141 | 405 |
| LLPS-Mod-4347 | Monodelphis domestica | 90.31 | 4e-141 | 405 |
| LLPS-Nol-1056 | Nomascus leucogenys | 90.31 | 3e-140 | 407 |
| LLPS-Tag-2285 | Taeniopygia guttata | 90.31 | 2e-140 | 406 |
| LLPS-Gaga-1028 | Gallus gallus | 90.31 | 2e-141 | 406 |
| LLPS-Xet-2382 | Xenopus tropicalis | 90.31 | 4e-141 | 405 |
| LLPS-Mam-2861 | Macaca mulatta | 90.31 | 4e-141 | 405 |
| LLPS-Poa-3289 | Pongo abelii | 90.31 | 4e-141 | 405 |
| LLPS-Hov-1242 | Hordeum vulgare | 90.13 | 0.0 | 534 |
| LLPS-Ors-1439 | Oryza sativa | 90.13 | 0.0 | 536 |
| LLPS-Caj-0025 | Callithrix jacchus | 90.12 | 1e-105 | 315 |
| LLPS-Arl-1305 | Arabidopsis lyrata | 90.1 | 0.0 | 533 |
| LLPS-Maf-1290 | Macaca fascicularis | 90.05 | 8e-125 | 363 |
| LLPS-Pat-1391 | Pan troglodytes | 90.05 | 6e-125 | 364 |
| LLPS-Sah-0420 | Sarcophilus harrisii | 89.87 | 2e-140 | 404 |
| LLPS-Caf-3409 | Canis familiaris | 89.87 | 2e-140 | 404 |
| LLPS-Asm-0441 | Astyanax mexicanus | 89.86 | 5e-125 | 371 |
| LLPS-Lem-0875 | Leptosphaeria maculans | 89.74 | 3e-142 | 414 |
| LLPS-Chr-1443 | Chlamydomonas reinhardtii | 89.44 | 0.0 | 531 |
| LLPS-Meg-1150 | Meleagris gallopavo | 89.44 | 1e-97 | 292 |
| LLPS-Php-1281 | Physcomitrella patens | 89.11 | 0.0 | 527 |
| LLPS-Scs-0100 | Sclerotinia sclerotiorum | 89.11 | 0.0 | 529 |
| LLPS-Sem-0932 | Selaginella moellendorffii | 89.11 | 0.0 | 528 |
| LLPS-Crn-1189 | Cryptococcus neoformans | 89.11 | 0.0 | 530 |
| LLPS-Gas-0243 | Galdieria sulphuraria | 88.99 | 6e-140 | 402 |
| LLPS-Aon-3949 | Aotus nancymaae | 88.46 | 5e-75 | 233 |
| LLPS-Fuv-0637 | Fusarium verticillioides | 88.12 | 0.0 | 526 |
| LLPS-Fus-0571 | Fusarium solani | 88.12 | 0.0 | 526 |
| LLPS-Anp-2775 | Anas platyrhynchos | 88.0 | 7e-170 | 480 |
| LLPS-Map-0650 | Magnaporthe poae | 87.79 | 0.0 | 525 |
| LLPS-Asg-0162 | Ashbya gossypii | 87.79 | 0.0 | 526 |
| LLPS-Mao-0839 | Magnaporthe oryzae | 87.79 | 0.0 | 525 |
| LLPS-Asni-1199 | Aspergillus niger | 87.79 | 0.0 | 522 |
| LLPS-Asn-0550 | Aspergillus nidulans | 87.79 | 0.0 | 523 |
| LLPS-Yal-0440 | Yarrowia lipolytica | 87.79 | 0.0 | 525 |
| LLPS-Gag-1113 | Gaeumannomyces graminis | 87.79 | 0.0 | 525 |
| LLPS-Asc-0676 | Aspergillus clavatus | 87.79 | 0.0 | 525 |
| LLPS-Scj-0579 | Schizosaccharomyces japonicus | 87.79 | 0.0 | 525 |
| LLPS-Asf-0852 | Aspergillus flavus | 87.79 | 0.0 | 525 |
| LLPS-Nec-1078 | Neurospora crassa | 87.79 | 0.0 | 520 |
| LLPS-Sac-1147 | Saccharomyces cerevisiae | 87.79 | 0.0 | 526 |
| LLPS-Tum-0788 | Tuber melanosporum | 87.79 | 0.0 | 526 |
| LLPS-Aso-1072 | Aspergillus oryzae | 87.79 | 0.0 | 525 |
| LLPS-Kop-0178 | Komagataella pastoris | 87.79 | 0.0 | 525 |
| LLPS-Scp-1245 | Schizosaccharomyces pombe | 87.79 | 0.0 | 525 |
| LLPS-Nef-0940 | Neosartorya fischeri | 87.79 | 0.0 | 525 |
| LLPS-Trr-1137 | Trichoderma reesei | 87.79 | 0.0 | 525 |
| LLPS-Ast-0805 | Aspergillus terreus | 87.79 | 0.0 | 525 |
| LLPS-Beb-0348 | Beauveria bassiana | 87.79 | 0.0 | 525 |
| LLPS-Cogr-0011 | Colletotrichum graminicola | 87.79 | 0.0 | 525 |
| LLPS-Trv-0170 | Trichoderma virens | 87.79 | 0.0 | 525 |
| LLPS-Asfu-0292 | Aspergillus fumigatus | 87.5 | 2e-135 | 394 |
| LLPS-Cis-1279 | Ciona savignyi | 87.27 | 6e-159 | 469 |
| LLPS-Cae-0469 | Caenorhabditis elegans | 86.8 | 5e-178 | 521 |
| LLPS-Orl-1176 | Oryzias latipes | 86.8 | 1e-177 | 519 |
| LLPS-Mum-2027 | Mus musculus | 86.8 | 0.0 | 518 |
| LLPS-Ora-0733 | Ornithorhynchus anatinus | 86.8 | 0.0 | 518 |
| LLPS-Ran-2588 | Rattus norvegicus | 86.8 | 1e-177 | 520 |
| LLPS-Gaa-2323 | Gasterosteus aculeatus | 86.8 | 5e-180 | 519 |
| LLPS-Bot-0083 | Bos taurus | 86.8 | 0.0 | 517 |
| LLPS-Drm-0480 | Drosophila melanogaster | 86.8 | 1e-177 | 518 |
| LLPS-Xim-3660 | Xiphophorus maculatus | 86.8 | 7e-177 | 518 |
| LLPS-Fia-3042 | Ficedula albicollis | 86.8 | 0.0 | 518 |
| LLPS-Loa-4202 | Loxodonta africana | 86.8 | 0.0 | 517 |
| LLPS-Dar-0195 | Danio rerio | 86.8 | 8e-180 | 518 |
| LLPS-Urm-3420 | Ursus maritimus | 86.8 | 0.0 | 519 |
| LLPS-Anc-0844 | Anolis carolinensis | 86.8 | 0.0 | 518 |
| LLPS-Eqc-0938 | Equus caballus | 86.8 | 0.0 | 517 |
| LLPS-Cii-1954 | Ciona intestinalis | 86.47 | 0.0 | 521 |
| LLPS-Abg-0310 | Absidia glauca | 86.47 | 0.0 | 516 |
| LLPS-Mup-3025 | Mustela putorius furo | 79.07 | 2e-132 | 385 |
| LLPS-Rhb-3510 | Rhinopithecus bieti | 78.52 | 1e-70 | 223 |
| LLPS-Scc-0374 | Schizosaccharomyces cryophilus | 76.47 | 7e-72 | 225 |
| LLPS-Coc-0913 | Corchorus capsularis | 76.32 | 3e-75 | 235 |
| LLPS-Man-1472 | Macaca nemestrina | 75.5 | 8e-64 | 205 |
| LLPS-Cea-1914 | Cercocebus atys | 74.83 | 2e-64 | 207 |