LLPS-Art-2709
HOP2
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | Hsp70-Hsp90 organizing protein 2 |
| Gene Name: | HOP2, At1g62740, F23N19.10 |
| Ensembl Gene: | AT1G62740 |
| Ensembl Protein: | AT1G62740.1 |
| Organism: | Arabidopsis thaliana |
| Taxa ID: | 3702 |
| LLPS Type: | Client |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Nucleolus, Stress granule, Others | Predicted from orthologs | (View) |
▼ FUNCTION
| Mediates the association of the molecular chaperones HSP70 and HSP90. Mediates nuclear encoded chloroplast preproteins binding to HSP90 prior to chloroplastic sorting (By similarity). |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | AT1G62740.1 | AT1G62740.1 |
| UniProt | Q5XEP2, HSOP2_ARATH, Q84TJ2, Q9SI76 | |
| GeneBank | BT005735, BT020538, CP002684, AK228637, AC007190, BT015924 | AAF19538.1, AAW70384.1, BAF00546.1, AAU95460.1, AEE33999.1, AAO64147.1 |
| RefSeq | NM_104951.4 | NP_176461.1 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MADEAKAKGN AAFSSGDFNS AVNHFTDAIN LTPTNHVLFS NRSAAHASLN HYDEALSDAK 60 61 KTVELKPDWG KGYSRLGAAH LGLNQFDEAV EAYSKGLEID PSNEGLKSGL ADAKASASRS 120 121 RASAPNPFGD AFQGPEMWSK LTADPSTRGL LKQPDFVNMM KEIQRNPSNL NLYLQDQRVM 180 181 QALGVLLNIQ IRTQQAGDDM EIGEEEMAVP SRKEPEVEKK RKPEPEPEPE PEFGEEKQKK 240 241 LKAQKEKELG NAAYKKKDFE TAIQHYSTAM EIDDEDISYI TNRAAVHLEM GKYDECIKDC 300 301 DKAVERGREL RSDYKMVAKA LTRKGTALGK MAKVSKDYEP VIQTYQKALT EHRNPETLKR 360 361 LNEAERAKKE LEQQEYYDPN IGDEEREKGN DFFKEQKYPD AVRHYTEAIK RNPKDPRAYS 420 421 NRAACYTKLG AMPEGLKDAE KCIELDPTFL KGYSRKGAVQ FFMKEYDNAM ETYQKGLEHD 480 481 PNNQELLDGV KRCVQQINKA NRGDLTPEEL KERQAKGMQD PEIQNILTDP VMRQVLSDLQ 540 541 ENPAAAQKHM QNPMIMNKIQ KLISSGIVQM K 571 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGGCGGACG AAGCAAAAGC TAAAGGAAAC GCAGCTTTCT CCTCCGGTGA CTTCAATTCC 60 61 GCCGTTAATC ACTTCACCGA CGCAATCAAC CTAACACCAA CCAATCACGT TCTCTTCTCA 120 121 AACCGTTCCG CTGCTCACGC ATCGCTTAAT CACTACGACG AAGCTCTCTC AGACGCGAAG 180 181 AAGACTGTTG AACTTAAACC AGATTGGGGA AAAGGTTATA GCCGTCTCGG TGCTGCTCAC 240 241 TTAGGTCTAA ATCAGTTCGA TGAAGCCGTG GAGGCGTATT CGAAAGGGCT TGAGATTGAT 300 301 CCAAGTAACG AAGGTTTGAA ATCAGGTTTA GCTGATGCGA AAGCTTCTGC GTCTAGGTCA 360 361 CGCGCTTCCG CGCCCAATCC GTTTGGTGAT GCTTTTCAGG GACCGGAGAT GTGGTCGAAA 420 421 TTGACGGCGG ATCCTTCTAC TAGAGGGTTA TTGAAACAGC CTGATTTTGT TAATATGATG 480 481 AAGGAGATTC AGAGGAACCC TAGTAATCTT AATCTTTATT TGCAAGATCA GAGAGTTATG 540 541 CAAGCTCTTG GAGTTTTGTT GAATATTCAA ATCAGGACTC AACAGGCTGG TGATGATATG 600 601 GAGATTGGTG AGGAAGAGAT GGCTGTGCCT TCTAGGAAGG AGCCTGAGGT AGAGAAGAAA 660 661 CGAAAACCTG AGCCTGAGCC TGAGCCTGAG CCGGAGTTTG GAGAAGAGAA GCAGAAGAAG 720 721 CTTAAAGCTC AGAAGGAGAA AGAGTTGGGG AATGCTGCGT ATAAGAAGAA GGACTTCGAA 780 781 ACTGCAATCC AGCATTACTC TACAGCTATG GAGATTGATG ATGAAGATAT CTCTTATATC 840 841 ACTAATCGTG CTGCTGTTCA TCTAGAGATG GGAAAGTATG ATGAGTGTAT CAAGGATTGT 900 901 GATAAGGCTG TTGAAAGGGG TAGAGAGCTT AGGTCTGATT ACAAGATGGT GGCTAAAGCT 960 961 TTGACTAGGA AAGGAACTGC TTTAGGGAAG ATGGCTAAAG TCTCGAAAGA CTATGAACCT 1020 1021 GTGATTCAGA CTTACCAGAA AGCTCTTACG GAGCATCGTA ACCCTGAAAC ATTGAAGAGA 1080 1081 CTGAATGAGG CAGAGAGAGC AAAGAAAGAG TTGGAGCAGC AAGAGTACTA TGATCCTAAT 1140 1141 ATCGGTGATG AGGAGCGTGA GAAAGGTAAT GACTTTTTTA AGGAGCAAAA GTATCCTGAT 1200 1201 GCTGTGAGAC ATTACACTGA AGCGATCAAG AGGAATCCAA AAGACCCGAG AGCATATAGC 1260 1261 AACCGGGCTG CATGTTACAC TAAACTGGGG GCAATGCCCG AAGGATTAAA AGATGCAGAG 1320 1321 AAATGTATCG AGCTCGATCC AACATTCTTA AAGGGATACA GTAGAAAAGG TGCAGTCCAG 1380 1381 TTCTTCATGA AGGAGTATGA CAATGCAATG GAAACGTACC AGAAGGGTCT CGAACATGAT 1440 1441 CCTAATAACC AGGAACTTCT TGATGGTGTT AAAAGATGTG TACAACAGAT AAACAAGGCA 1500 1501 AACCGTGGCG ACCTTACTCC TGAGGAATTG AAAGAAAGAC AGGCTAAGGG AATGCAAGAC 1560 1561 CCAGAAATTC AGAACATTCT CACAGATCCT GTAATGAGAC AGGTACTGTC TGATCTCCAG 1620 1621 GAGAATCCAG CAGCAGCACA AAAGCACATG CAGAACCCAA TGATCATGAA CAAAATCCAA 1680 1681 AAGCTTATCA GCTCAGGAAT CGTCCAGATG AAATAA 1716 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Cytosol | |
Cellular Component | Nucleus | |
Cellular Component | Plasma membrane | |
Molecular Function | Hsp90 protein binding | |
Molecular Function | Preprotein binding | |
Biological Process | Chaperone-mediated protein complex assembly | |
Biological Process | Response to cadmium ion |
▼ ANNOTATION
| Disorder | ||||
| IUPred2A | ||||
| Physicochemical | ||||
| Compute pI/Mw | AAindex | |||
| Function | ||||
| PIRSF | ||||
| Localization | ||||
| COMPARTMENTS | ||||
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Bro-2466 | Brassica oleracea | 85.46 | 0.0 | 977 |
| LLPS-Brn-0195 | Brassica napus | 84.06 | 0.0 | 962 |
| LLPS-Brr-0812 | Brassica rapa | 83.36 | 0.0 | 956 |
| LLPS-Lep-2215 | Leersia perrieri | 82.3 | 0.0 | 580 |
| LLPS-Orp-0753 | Oryza punctata | 81.37 | 0.0 | 578 |
| LLPS-Orbr-1139 | Oryza brachyantha | 81.06 | 0.0 | 573 |
| LLPS-Mua-2277 | Musa acuminata | 80.75 | 0.0 | 572 |
| LLPS-Zem-0927 | Zea mays | 80.12 | 0.0 | 573 |
| LLPS-Vir-0401 | Vigna radiata | 79.93 | 2e-169 | 496 |
| LLPS-Prp-1972 | Prunus persica | 74.69 | 0.0 | 867 |
| LLPS-Arl-0995 | Arabidopsis lyrata | 74.55 | 3e-48 | 170 |
| LLPS-Gor-1160 | Gossypium raimondii | 74.53 | 0.0 | 862 |
| LLPS-Coc-0076 | Corchorus capsularis | 74.14 | 0.0 | 865 |
| LLPS-Orb-0269 | Oryza barthii | 73.98 | 8e-172 | 506 |
| LLPS-Nia-1200 | Nicotiana attenuata | 73.96 | 0.0 | 859 |
| LLPS-Mae-0625 | Manihot esculenta | 73.39 | 0.0 | 861 |
| LLPS-Sol-1146 | Solanum lycopersicum | 73.23 | 0.0 | 858 |
| LLPS-Pot-0341 | Populus trichocarpa | 72.81 | 0.0 | 843 |
| LLPS-Sot-1517 | Solanum tuberosum | 72.37 | 0.0 | 848 |
| LLPS-Hea-0738 | Helianthus annuus | 72.2 | 0.0 | 834 |
| LLPS-Met-2356 | Medicago truncatula | 72.04 | 0.0 | 848 |
| LLPS-Dac-1084 | Daucus carota | 71.45 | 0.0 | 816 |
| LLPS-Glm-2639 | Glycine max | 71.11 | 0.0 | 845 |
| LLPS-Orr-0052 | Oryza rufipogon | 70.24 | 0.0 | 808 |
| LLPS-Org-1182 | Oryza glaberrima | 70.24 | 0.0 | 808 |
| LLPS-Ors-1553 | Oryza sativa | 70.24 | 0.0 | 808 |
| LLPS-Thc-1595 | Theobroma cacao | 70.08 | 0.0 | 838 |
| LLPS-Tru-0980 | Triticum urartu | 69.97 | 2e-161 | 479 |
| LLPS-Orgl-0698 | Oryza glumaepatula | 69.79 | 0.0 | 796 |
| LLPS-Ori-2280 | Oryza indica | 69.79 | 0.0 | 796 |
| LLPS-Orni-0199 | Oryza nivara | 69.74 | 0.0 | 796 |
| LLPS-Orm-0536 | Oryza meridionalis | 69.62 | 0.0 | 797 |
| LLPS-Cus-0950 | Cucumis sativus | 69.48 | 0.0 | 828 |
| LLPS-Tra-0917 | Triticum aestivum | 69.26 | 0.0 | 800 |
| LLPS-Phv-1768 | Phaseolus vulgaris | 69.01 | 0.0 | 833 |
| LLPS-Amt-0902 | Amborella trichopoda | 68.57 | 0.0 | 803 |
| LLPS-Via-1837 | Vigna angularis | 68.56 | 0.0 | 824 |
| LLPS-Sob-2054 | Sorghum bicolor | 68.28 | 0.0 | 803 |
| LLPS-Sei-0442 | Setaria italica | 68.28 | 0.0 | 801 |
| LLPS-Brd-0572 | Brachypodium distachyon | 68.1 | 0.0 | 804 |
| LLPS-Hov-1754 | Hordeum vulgare | 67.71 | 0.0 | 781 |
| LLPS-Viv-2501 | Vitis vinifera | 66.44 | 3e-117 | 357 |
| LLPS-Php-1991 | Physcomitrella patens | 62.71 | 0.0 | 733 |
| LLPS-Drm-1844 | Drosophila melanogaster | 54.21 | 9e-26 | 114 |
| LLPS-Osl-0591 | Ostreococcus lucimarinus | 51.39 | 0.0 | 570 |
| LLPS-Chr-0305 | Chlamydomonas reinhardtii | 50.51 | 0.0 | 538 |
| LLPS-Orn-2989 | Oreochromis niloticus | 49.07 | 5e-101 | 323 |
| LLPS-Scf-1931 | Scleropages formosus | 48.76 | 6e-98 | 315 |
| LLPS-Bot-2229 | Bos taurus | 48.76 | 2e-96 | 314 |
| LLPS-Aon-1305 | Aotus nancymaae | 48.76 | 2e-97 | 315 |
| LLPS-Sah-2868 | Sarcophilus harrisii | 48.76 | 2e-97 | 315 |
| LLPS-Caj-2188 | Callithrix jacchus | 48.76 | 2e-97 | 315 |
| LLPS-Poa-3994 | Pongo abelii | 48.45 | 4e-97 | 313 |
| LLPS-Cap-1865 | Cavia porcellus | 48.45 | 5e-97 | 313 |
| LLPS-Hos-1535 | Homo sapiens | 48.45 | 2e-96 | 313 |
| LLPS-Pap-3589 | Pan paniscus | 48.45 | 2e-96 | 312 |
| LLPS-Pat-0819 | Pan troglodytes | 48.45 | 2e-96 | 313 |
| LLPS-Otg-0141 | Otolemur garnettii | 48.45 | 2e-97 | 314 |
| LLPS-Dio-3673 | Dipodomys ordii | 48.45 | 1e-96 | 312 |
| LLPS-Ova-2995 | Ovis aries | 48.45 | 2e-96 | 313 |
| LLPS-Mup-3331 | Mustela putorius furo | 48.45 | 4e-97 | 313 |
| LLPS-Mea-2018 | Mesocricetus auratus | 48.45 | 2e-97 | 313 |
| LLPS-Orl-1792 | Oryzias latipes | 48.45 | 7e-100 | 320 |
| LLPS-Sus-0417 | Sus scrofa | 48.45 | 4e-97 | 313 |
| LLPS-Gog-0251 | Gorilla gorilla | 48.45 | 4e-96 | 312 |
| LLPS-Gas-0325 | Galdieria sulphuraria | 48.42 | 7e-48 | 181 |
| LLPS-Crn-1105 | Cryptococcus neoformans | 48.31 | 4e-97 | 314 |
| LLPS-Mam-2302 | Macaca mulatta | 48.14 | 2e-96 | 311 |
| LLPS-Nol-1029 | Nomascus leucogenys | 48.14 | 1e-94 | 308 |
| LLPS-Urm-1330 | Ursus maritimus | 48.14 | 9e-97 | 312 |
| LLPS-Rhb-1641 | Rhinopithecus bieti | 48.14 | 4e-96 | 311 |
| LLPS-Mal-0279 | Mandrillus leucophaeus | 48.14 | 1e-96 | 311 |
| LLPS-Paa-2432 | Papio anubis | 48.14 | 4e-96 | 311 |
| LLPS-Aim-3280 | Ailuropoda melanoleuca | 48.14 | 9e-97 | 312 |
| LLPS-Mum-4047 | Mus musculus | 48.14 | 7e-97 | 312 |
| LLPS-Maf-2730 | Macaca fascicularis | 48.14 | 4e-95 | 311 |
| LLPS-Cea-0850 | Cercocebus atys | 48.14 | 2e-96 | 311 |
| LLPS-Fud-3547 | Fukomys damarensis | 48.14 | 4e-96 | 310 |
| LLPS-Scj-0797 | Schizosaccharomyces japonicus | 47.98 | 2e-49 | 185 |
| LLPS-Caf-1630 | Canis familiaris | 47.83 | 5e-96 | 310 |
| LLPS-Loa-0739 | Loxodonta africana | 47.83 | 3e-96 | 310 |
| LLPS-Ran-2763 | Rattus norvegicus | 47.83 | 1e-96 | 311 |
| LLPS-Ict-1452 | Ictidomys tridecemlineatus | 47.53 | 2e-92 | 301 |
| LLPS-Orc-2007 | Oryctolagus cuniculus | 47.52 | 3e-95 | 308 |
| LLPS-Gaga-1162 | Gallus gallus | 46.89 | 4e-93 | 302 |
| LLPS-Ere-0018 | Erinaceus europaeus | 46.89 | 4e-96 | 306 |
| LLPS-Tar-0641 | Takifugu rubripes | 46.58 | 2e-94 | 306 |
| LLPS-Gaa-0544 | Gasterosteus aculeatus | 46.58 | 6e-96 | 310 |
| LLPS-Eqc-1822 | Equus caballus | 45.96 | 5e-88 | 290 |
| LLPS-Scm-1310 | Scophthalmus maximus | 45.96 | 1e-93 | 307 |
| LLPS-Pug-0885 | Puccinia graminis | 45.87 | 2e-23 | 105 |
| LLPS-Anc-1528 | Anolis carolinensis | 45.53 | 2e-156 | 466 |
| LLPS-Abg-0695 | Absidia glauca | 45.22 | 3e-97 | 307 |
| LLPS-Scp-0499 | Schizosaccharomyces pombe | 44.9 | 1e-40 | 159 |
| LLPS-Xet-1572 | Xenopus tropicalis | 44.74 | 5e-149 | 447 |
| LLPS-Pes-0473 | Pelodiscus sinensis | 44.74 | 1e-152 | 456 |
| LLPS-Ora-0583 | Ornithorhynchus anatinus | 44.21 | 1e-42 | 159 |
| LLPS-Asm-0903 | Astyanax mexicanus | 43.99 | 4e-147 | 442 |
| LLPS-Fec-3302 | Felis catus | 43.86 | 2e-145 | 441 |
| LLPS-Lac-3113 | Latimeria chalumnae | 43.73 | 6e-118 | 368 |
| LLPS-Ten-0055 | Tetraodon nigroviridis | 43.64 | 4e-152 | 455 |
| LLPS-Icp-0092 | Ictalurus punctatus | 43.64 | 6e-145 | 437 |
| LLPS-Cae-0629 | Caenorhabditis elegans | 43.48 | 3e-90 | 288 |
| LLPS-Dar-1407 | Danio rerio | 43.46 | 1e-145 | 439 |
| LLPS-Chs-1727 | Chlorocebus sabaeus | 43.31 | 2e-139 | 424 |
| LLPS-Miv-0735 | Microbotryum violaceum | 43.3 | 2e-76 | 252 |
| LLPS-Anp-0647 | Anas platyrhynchos | 43.24 | 3e-20 | 91.7 |
| LLPS-Myl-1974 | Myotis lucifugus | 42.98 | 1e-146 | 443 |
| LLPS-Man-4376 | Macaca nemestrina | 42.63 | 8e-40 | 157 |
| LLPS-Cas-0663 | Carlito syrichta | 42.55 | 6e-38 | 151 |
| LLPS-Xim-1213 | Xiphophorus maculatus | 42.11 | 3e-142 | 431 |
| LLPS-Pof-1296 | Poecilia formosa | 41.93 | 2e-142 | 431 |
| LLPS-Fuo-0640 | Fusarium oxysporum | 41.75 | 4e-125 | 387 |
| LLPS-Sac-0442 | Saccharomyces cerevisiae | 41.72 | 6e-75 | 256 |
| LLPS-Cii-1403 | Ciona intestinalis | 41.68 | 2e-145 | 438 |
| LLPS-Cym-1064 | Cyanidioschyzon merolae | 41.61 | 2e-77 | 263 |
| LLPS-Fuv-0338 | Fusarium verticillioides | 41.58 | 3e-125 | 387 |
| LLPS-Trv-0468 | Trichoderma virens | 40.92 | 1e-122 | 380 |
| LLPS-Mao-1170 | Magnaporthe oryzae | 40.75 | 2e-125 | 388 |
| LLPS-Cis-1480 | Ciona savignyi | 40.72 | 2e-136 | 416 |
| LLPS-Yal-0982 | Yarrowia lipolytica | 40.38 | 9e-129 | 396 |
| LLPS-Blg-0470 | Blumeria graminis | 40.17 | 3e-124 | 384 |
| LLPS-Scs-0221 | Sclerotinia sclerotiorum | 39.83 | 9e-124 | 384 |
| LLPS-Cogr-0747 | Colletotrichum graminicola | 39.62 | 5e-119 | 371 |
| LLPS-Kop-0172 | Komagataella pastoris | 39.42 | 8e-124 | 383 |
| LLPS-Ved-0805 | Verticillium dahliae | 39.39 | 5e-124 | 384 |
| LLPS-Map-0421 | Magnaporthe poae | 39.36 | 3e-119 | 372 |
| LLPS-Phn-0503 | Phaeosphaeria nodorum | 39.29 | 9e-123 | 381 |
| LLPS-Nef-0814 | Neosartorya fischeri | 39.29 | 7e-125 | 386 |
| LLPS-Tum-1146 | Tuber melanosporum | 39.15 | 2e-129 | 398 |
| LLPS-Asfu-0266 | Aspergillus fumigatus | 39.01 | 9e-116 | 363 |
| LLPS-Chc-0893 | Chondrus crispus | 39.01 | 7e-92 | 296 |
| LLPS-Asg-0135 | Ashbya gossypii | 38.97 | 1e-123 | 383 |
| LLPS-Coo-1568 | Colletotrichum orbiculare | 38.8 | 1e-110 | 368 |
| LLPS-Beb-0791 | Beauveria bassiana | 38.67 | 2e-118 | 369 |
| LLPS-Pytr-0741 | Pyrenophora triticirepentis | 38.5 | 6e-126 | 389 |
| LLPS-Nec-1533 | Neurospora crassa | 38.38 | 1e-116 | 365 |
| LLPS-Asn-1094 | Aspergillus nidulans | 38.21 | 3e-120 | 374 |
| LLPS-Pyt-0269 | Pyrenophora teres | 38.16 | 1e-125 | 388 |
| LLPS-Lem-0273 | Leptosphaeria maculans | 37.77 | 1e-115 | 362 |
| LLPS-Gag-0241 | Gaeumannomyces graminis | 37.69 | 1e-115 | 363 |
| LLPS-Cog-1150 | Colletotrichum gloeosporioides | 37.65 | 2e-113 | 359 |
| LLPS-Asc-0856 | Aspergillus clavatus | 37.59 | 5e-119 | 371 |
| LLPS-Ast-0706 | Aspergillus terreus | 37.56 | 1e-123 | 383 |
| LLPS-Scc-0645 | Schizosaccharomyces cryophilus | 37.35 | 4e-119 | 372 |
| LLPS-Asni-0179 | Aspergillus niger | 37.24 | 7e-120 | 375 |
| LLPS-Aso-0934 | Aspergillus oryzae | 35.8 | 1e-117 | 367 |
| LLPS-Asf-0764 | Aspergillus flavus | 35.8 | 1e-117 | 367 |
| LLPS-Tag-2848 | Taeniopygia guttata | 34.94 | 5e-20 | 95.5 |