LLPS-Art-2595
GTF2H2

▼ OVERVIEW

Status: Unreviewed
Protein Name: General transcription factor IIH subunit 2
Gene Name: GTF2H2, P44, At1g05055, T7A14.8
Ensembl Gene: AT1G05055
Ensembl Protein: AT1G05055.1
Organism: Arabidopsis thaliana
Taxa ID: 3702
LLPS Type: Others


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
NucleolusPredicted from orthologs(View)

▼ FUNCTION

Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription (By similarity). Can restore UV resistance in the NER-deficient ssl1-1 yeast mutant (PubMed:16623910).

▼ CROSS REFERENCE

▼ SEQUENCE

Protein Sequence (FASTA)
1     MSNQRKRSND  EREEEDDEDA  EGIGEWERAY  VDDRSWEELQ  EDESGLLRPI  DNSAIYHAQY  60
61    RRRLRMLSAA  AAGTRIQKGL  IRYLYIVIDF  SRAAAEMDFR  PSRMAIMAKH  VEAFIREFFD  120
121   QNPLSQIGLV  SIKNGVAHTL  TDLGGSPETH  IKALMGKLEA  LGDSSLQNAL  ELVHEHLNQV  180
181   PSYGHREVLI  LYSALCTCDP  GDIMETIQKC  KKSKLRCSVI  GLSAEMFICK  HLCQETGGLY  240
241   SVAVDEVHLK  DLLLEHAPPP  PAIAEFAIAN  LIKMGFPQRA  AEGSMAICSC  HKEVKIGAGY  300
301   MCPRCKARVC  DLPTECTICG  LTLVSSPHLA  RSYHHLFPIA  PFDEVPALSS  LNDNRRKLGK  360
361   SCFGCQQSLI  GAGNKPVPCV  TCRKCKHYFC  LDCDIYIHES  LHNCPGCESI  HRPKSVSLME  420
421   E  421
Nucleotide CDS Sequence (FASTA)
1     ATGAGTAATC  AAAGAAAGAG  ATCAAACGAT  GAAAGAGAAG  AAGAGGACGA  CGAAGATGCG  60
61    GAAGGTATCG  GCGAGTGGGA  GAGAGCTTAT  GTTGACGACC  GATCCTGGGA  GGAGTTGCAA  120
121   GAGGATGAGT  CTGGACTTTT  ACGGCCAATT  GATAACAGTG  CCATTTACCA  TGCTCAGTAT  180
181   CGCCGCCGTC  TTCGTATGCT  CTCCGCCGCT  GCTGCTGGTA  CTCGTATCCA  AAAGGGACTT  240
241   ATTCGATATC  TCTACATCGT  CATTGACTTC  TCTCGGGCAG  CTGCGGAAAT  GGATTTCAGA  300
301   CCAAGCCGGA  TGGCTATAAT  GGCCAAACAT  GTCGAAGCTT  TCATTAGAGA  GTTCTTTGAC  360
361   CAGAATCCTC  TGAGTCAAAT  TGGGTTGGTC  TCTATAAAAA  ATGGAGTTGC  GCATACATTA  420
421   ACAGATCTTG  GTGGTAGTCC  TGAGACTCAC  ATCAAAGCGT  TGATGGGGAA  GTTGGAAGCT  480
481   TTGGGTGACT  CCTCTTTGCA  GAACGCTCTG  GAACTTGTAC  ATGAGCATCT  CAACCAGGTT  540
541   CCATCTTATG  GTCACCGCGA  GGTTCTGATA  TTGTACTCAG  CTTTATGCAC  ATGTGATCCA  600
601   GGCGATATCA  TGGAGACCAT  TCAAAAATGC  AAGAAATCCA  AATTAAGATG  TTCTGTAATT  660
661   GGGCTCTCTG  CAGAAATGTT  CATATGTAAA  CACCTCTGCC  AGGAAACTGG  CGGATTGTAT  720
721   TCAGTTGCAG  TGGACGAGGT  GCATCTAAAG  GATCTTCTGC  TTGAACATGC  GCCTCCACCT  780
781   CCGGCAATAG  CAGAATTTGC  AATTGCAAAT  TTGATCAAGA  TGGGTTTCCC  ACAAAGAGCT  840
841   GCTGAGGGTT  CAATGGCGAT  TTGTTCGTGT  CATAAGGAAG  TTAAGATTGG  AGCTGGTTAC  900
901   ATGTGCCCAA  GATGCAAAGC  TCGGGTATGT  GACCTCCCTA  CGGAATGCAC  TATCTGCGGT  960
961   CTAACACTTG  TTTCTTCGCC  GCATTTGGCG  AGATCATACC  ATCATCTCTT  CCCGATTGCT  1020
1021  CCATTTGATG  AGGTGCCTGC  ACTTTCAAGT  CTGAATGATA  ATCGGAGAAA  ATTGGGAAAG  1080
1081  AGTTGTTTTG  GTTGCCAACA  GAGCCTAATT  GGTGCAGGGA  ATAAACCCGT  CCCATGCGTA  1140
1141  ACATGTCGTA  AATGCAAGCA  CTATTTCTGT  CTGGACTGTG  ACATATACAT  CCACGAGAGC  1200
1201  TTACACAACT  GTCCTGGCTG  TGAGAGCATT  CACCGTCCCA  AATCAGTTTC  TTTGATGGAA  1260
1261  GAATGA  1266

▼ KEYWORD

ID
Family
Complete proteome
DNA damage
DNA repair
Metal-binding
Nucleus
Reference proteome
Transcription
Transcription regulation
Zinc
Zinc-finger

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Transcription factor TFIIH core complex
Cellular Component
Transcription factor TFIIH holo complex
Molecular Function
Zinc ion binding
Biological Process
Nucleotide-excision repair
Biological Process
Regulation of transcription by RNA polymerase II
Biological Process
Transcription, DNA-templated

▼ KEGG


▼ ANNOTATION

Disorder
IUPred2A
Interaction
HINTMenthaPINA
Physicochemical
Compute pI/MwAAindex
Function
CGDB
Localization
COMPARTMENTS

▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Arl-1109Arabidopsis lyrata99.290.0 765
LLPS-Brn-0941Brassica napus92.650.0 728
LLPS-Brr-1414Brassica rapa92.650.0 728
LLPS-Bro-0653Brassica oleracea92.180.0 724
LLPS-Coc-0032Corchorus capsularis81.690.0 545
LLPS-Pot-0193Populus trichocarpa80.680.0 604
LLPS-Thc-1044Theobroma cacao79.90.0 607
LLPS-Hea-0219Helianthus annuus79.740.0 599
LLPS-Mae-0286Manihot esculenta79.110.0 578
LLPS-Gor-1091Gossypium raimondii79.110.0 594
LLPS-Prp-1610Prunus persica78.810.0 588
LLPS-Viv-1353Vitis vinifera78.680.0 611
LLPS-Cus-0895Cucumis sativus77.890.0 597
LLPS-Tru-0907Triticum urartu76.265e-134 395
LLPS-Dac-1771Daucus carota76.240.0 527
LLPS-Phv-0406Phaseolus vulgaris75.90.0 576
LLPS-Glm-1086Glycine max75.640.0 580
LLPS-Met-0466Medicago truncatula75.570.0 589
LLPS-Vir-0857Vigna radiata75.380.0 577
LLPS-Sol-1020Solanum lycopersicum75.380.0 575
LLPS-Via-0869Vigna angularis75.130.0 576
LLPS-Sot-0118Solanum tuberosum75.112e-111 334
LLPS-Orni-1503Oryza nivara74.571e-170 494
LLPS-Sob-0826Sorghum bicolor74.410.0 542
LLPS-Orgl-1172Oryza glumaepatula74.211e-170 498
LLPS-Orb-0381Oryza barthii74.211e-171 497
LLPS-Orr-0448Oryza rufipogon74.215e-171 496
LLPS-Tra-1942Triticum aestivum74.150.0 540
LLPS-Orp-1242Oryza punctata74.030.0 545
LLPS-Orm-0388Oryza meridionalis73.932e-169 495
LLPS-Sei-0405Setaria italica73.890.0 541
LLPS-Hov-0049Hordeum vulgare73.890.0 543
LLPS-Brd-2305Brachypodium distachyon73.890.0 546
LLPS-Zem-1059Zea mays73.630.0 537
LLPS-Org-0842Oryza glaberrima73.510.0 542
LLPS-Nia-0334Nicotiana attenuata73.330.0 575
LLPS-Orbr-1060Oryza brachyantha73.250.0 547
LLPS-Ors-1304Oryza sativa73.250.0 542
LLPS-Lep-0064Leersia perrieri72.730.0 549
LLPS-Mua-0972Musa acuminata72.430.0 560
LLPS-Ori-1134Oryza indica71.673e-136 407
LLPS-Amt-1396Amborella trichopoda70.488e-154 446
LLPS-Php-0380Physcomitrella patens63.455e-173 498
LLPS-Sem-0016Selaginella moellendorffii59.641e-165 478
LLPS-Rhb-1519Rhinopithecus bieti52.172e-30 124
LLPS-Abg-0971Absidia glauca46.53e-91 294
LLPS-Chr-0847Chlamydomonas reinhardtii46.371e-107 332
LLPS-Osl-1002Ostreococcus lucimarinus44.624e-98 306
LLPS-Cas-1719Carlito syrichta42.249e-96 300
LLPS-Eqc-0761Equus caballus42.216e-96 300
LLPS-Gag-0993Gaeumannomyces graminis42.112e-68 233
LLPS-Dar-0253Danio rerio42.094e-96 300
LLPS-Pof-0259Poecilia formosa42.049e-56 191
LLPS-Orl-2546Oryzias latipes42.015e-91 287
LLPS-Aon-0254Aotus nancymaae41.983e-96 301
LLPS-Sus-2904Sus scrofa41.982e-95 300
LLPS-Ict-2278Ictidomys tridecemlineatus41.982e-95 299
LLPS-Caf-0191Canis familiaris41.986e-96 300
LLPS-Anc-1022Anolis carolinensis41.91e-79 258
LLPS-Sac-1123Saccharomyces cerevisiae41.751e-91 291
LLPS-Orn-0240Oreochromis niloticus41.752e-92 291
LLPS-Paa-2074Papio anubis41.739e-95 297
LLPS-Maf-0215Macaca fascicularis41.739e-95 297
LLPS-Chs-2603Chlorocebus sabaeus41.736e-95 297
LLPS-Mam-0524Macaca mulatta41.739e-95 297
LLPS-Poa-2965Pongo abelii41.739e-95 297
LLPS-Man-1575Macaca nemestrina41.739e-95 297
LLPS-Hos-1448Homo sapiens41.731e-94 297
LLPS-Fec-0294Felis catus41.736e-95 297
LLPS-Ten-3210Tetraodon nigroviridis41.672e-85 273
LLPS-Asm-0527Astyanax mexicanus41.549e-93 292
LLPS-Aim-1659Ailuropoda melanoleuca41.51e-94 296
LLPS-Beb-1102Beauveria bassiana41.492e-87 281
LLPS-Lac-2493Latimeria chalumnae41.493e-91 288
LLPS-Caj-2408Callithrix jacchus41.489e-95 297
LLPS-Nol-0527Nomascus leucogenys41.482e-93 294
LLPS-Trv-1153Trichoderma virens41.483e-84 270
LLPS-Pat-3663Pan troglodytes41.481e-94 296
LLPS-Pap-1841Pan paniscus41.481e-94 296
LLPS-Mod-0921Monodelphis domestica41.483e-92 291
LLPS-Ran-0209Rattus norvegicus41.284e-94 295
LLPS-Asg-1031Ashbya gossypii41.278e-89 284
LLPS-Urm-1012Ursus maritimus41.257e-95 297
LLPS-Gaga-1775Gallus gallus41.244e-92 290
LLPS-Ova-1358Ovis aries41.226e-94 295
LLPS-Fud-0896Fukomys damarensis41.225e-95 298
LLPS-Sah-0766Sarcophilus harrisii41.221e-89 284
LLPS-Cap-1806Cavia porcellus41.221e-94 297
LLPS-Pes-1343Pelodiscus sinensis41.224e-93 293
LLPS-Loa-1085Loxodonta africana41.213e-95 298
LLPS-Dos-0563Dothistroma septosporum41.164e-92 292
LLPS-Yal-0772Yarrowia lipolytica41.126e-86 277
LLPS-Mum-0798Mus musculus41.011e-92 291
LLPS-Xim-1845Xiphophorus maculatus40.984e-90 285
LLPS-Gaa-1992Gasterosteus aculeatus40.913e-86 275
LLPS-Bot-0103Bos taurus40.871e-90 287
LLPS-Scm-1413Scophthalmus maximus40.875e-88 280
LLPS-Ora-1020Ornithorhynchus anatinus40.755e-91 287
LLPS-Miv-1083Microbotryum violaceum40.751e-91 293
LLPS-Tag-1305Taeniopygia guttata40.72e-91 288
LLPS-Fia-2107Ficedula albicollis40.73e-91 288
LLPS-Cae-0631Caenorhabditis elegans40.651e-75 247
LLPS-Kop-0775Komagataella pastoris40.61e-91 290
LLPS-Trr-1191Trichoderma reesei40.599e-85 274
LLPS-Cii-0279Ciona intestinalis40.418e-89 281
LLPS-Leo-0857Lepisosteus oculatus40.361e-90 286
LLPS-Fus-1313Fusarium solani40.258e-93 295
LLPS-Scf-0760Scleropages formosus40.211e-88 281
LLPS-Tar-0988Takifugu rubripes40.29e-88 279
LLPS-Otg-1110Otolemur garnettii40.21e-92 291
LLPS-Mal-0541Mandrillus leucophaeus39.959e-90 283
LLPS-Zyt-0602Zymoseptoria tritici39.951e-84 272
LLPS-Tum-0036Tuber melanosporum39.852e-90 288
LLPS-Fuo-0112Fusarium oxysporum39.572e-87 280
LLPS-Scj-1340Schizosaccharomyces japonicus39.533e-85 273
LLPS-Fuv-0205Fusarium verticillioides39.522e-55 194
LLPS-Pyt-0355Pyrenophora teres39.11e-67 229
LLPS-Orc-0237Oryctolagus cuniculus39.078e-65 217
LLPS-Cis-0943Ciona savignyi38.976e-86 274
LLPS-Put-0108Puccinia triticina38.972e-89 285
LLPS-Pytr-0569Pyrenophora triticirepentis38.921e-68 231
LLPS-Ved-1500Verticillium dahliae38.892e-86 278
LLPS-Coo-0261Colletotrichum orbiculare38.884e-83 270
LLPS-Myl-0674Myotis lucifugus38.862e-79 258
LLPS-Scp-1005Schizosaccharomyces pombe38.862e-87 279
LLPS-Nec-0012Neurospora crassa38.815e-87 279
LLPS-Ast-0463Aspergillus terreus38.796e-1886.3
LLPS-Chc-0753Chondrus crispus38.731e-79 258
LLPS-Pug-0438Puccinia graminis38.731e-87 281
LLPS-Icp-3645Ictalurus punctatus38.643e-79 256
LLPS-Drm-1163Drosophila melanogaster38.482e-88 282
LLPS-Nef-1406Neosartorya fischeri38.18e-1267.8
LLPS-Mel-0390Melampsora laricipopulina38.089e-92 291
LLPS-Mup-0060Mustela putorius furo38.05e-76 248
LLPS-Asf-1253Aspergillus flavus37.971e-1371.2
LLPS-Gas-0057Galdieria sulphuraria37.84e-85 272
LLPS-Scc-0824Schizosaccharomyces cryophilus37.731e-82 266
LLPS-Cog-0239Colletotrichum gloeosporioides37.354e-78 256
LLPS-Cea-1478Cercocebus atys37.176e-1987.4
LLPS-Mao-0260Magnaporthe oryzae37.12e-89 287
LLPS-Xet-0183Xenopus tropicalis37.061e-74 245
LLPS-Cogr-0555Colletotrichum graminicola37.049e-80 261
LLPS-Asni-0860Aspergillus niger37.033e-84 271
LLPS-Asc-1024Aspergillus clavatus37.033e-84 272
LLPS-Dio-0528Dipodomys ordii36.835e-74 242
LLPS-Aso-0865Aspergillus oryzae36.81e-86 278
LLPS-Blg-1057Blumeria graminis36.451e-80 263
LLPS-Asfu-1341Aspergillus fumigatus36.39e-84 270
LLPS-Crn-0327Cryptococcus neoformans36.232e-83 270
LLPS-Asn-0731Aspergillus nidulans36.025e-84 271
LLPS-Usm-0639Ustilago maydis35.559e-81 265
LLPS-Spr-0017Sporisorium reilianum35.489e-81 264
LLPS-Lem-0839Leptosphaeria maculans35.193e-72 244
LLPS-Cym-0115Cyanidioschyzon merolae32.654e-59 208
LLPS-Mea-2718Mesocricetus auratus32.341e-23 101