LLPS-Art-2342
MSI1

▼ OVERVIEW

Status: Unreviewed
Protein Name: Histone-binding protein MSI1; CAF-1 p48 homolog; Chromatin assembly factor 1 subunit MSI1; CAF-1 subunit MSI1; Protein MULTICOPY SUPPRESSOR OF IRA 1; AtMSI1; Protein medicis; WD-40 repeat-containing protein MSI1
Gene Name: MSI1, At5g58230, MCK7.10
Ensembl Gene: AT5G58230
Ensembl Protein: AT5G58230.1
Organism: Arabidopsis thaliana
Taxa ID: 3702
LLPS Type: Others


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
PcG bodyPredicted from orthologs(View)

▼ FUNCTION

Core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the chromatin assembly factor 1 (CAF-1) complex, which is required for chromatin assembly following DNA replication and DNA repair, and the fertilization independent seed (FIS) complex, a polycomb group protein complex which is required to maintain the transcriptionally repressive state of homeotic genes throughout development. Required for several aspects of plant development including normal leaf expansion, correct development of flowers, normal endosperm development, repression of parthenogenetic seed development and repression of floral homeotic genes in leaf tissue. Also required for the recruitment of chromosomal DNA into heterochromatic chromocenters. Also involved in regulation of imprinted genes. Acts together with RBR1 to repress the expression of MET1 during female gametogenesis. This in turn activates expression of the imprinted genes FIS2 and FWA.

▼ SEQUENCE

Protein Sequence (FASTA)
1     MGKDEEEMRG  EIEERLINEE  YKIWKKNTPF  LYDLVITHAL  EWPSLTVEWL  PDREEPSGKD  60
61    YSVQKMILGT  HTSESEPNYL  MLAQVQLPLD  DTESEARQYD  DDRSEFGGFG  CATGKVQIIQ  120
121   QINHDGEVNR  ARYMPQNPFI  IATKTVNAEV  YVFDYSKHPS  KPPLDGACNP  DLKLRGHSSE  180
181   GYGLSWSKFK  QGHLLSGSDD  AQICLWDINA  TPKNKSLDAQ  QIFKAHEGVV  EDVAWHLRHE  240
241   YLFGSVGDDQ  YLLIWDLRSP  SASKPVQSVV  AHSMEVNCLA  FNPFNEWVVA  TGSTDKTVKL  300
301   FDLRKLSTAL  HTFDSHKEEV  FQVGWNPKNE  TILASCCLGR  RLMVWDLSRI  DEEQTVEDAE  360
361   DGPPELLFIH  GGHTSKISDF  SWNPCEDWVI  SSVAEDNILQ  IWQMAENIYH  DEDDAPGEEP  420
421   SKAS  424
Nucleotide CDS Sequence (FASTA)
1     ATGGGGAAAG  ACGAAGAGGA  AATGCGAGGT  GAGATCGAGG  AGCGACTAAT  CAATGAAGAG  60
61    TACAAGATCT  GGAAGAAGAA  CACTCCTTTC  CTCTACGATC  TCGTTATTAC  TCACGCTCTC  120
121   GAGTGGCCTT  CACTTACTGT  TGAATGGCTT  CCTGACCGTG  AAGAACCTTC  CGGTAAAGAC  180
181   TACTCCGTTC  AGAAGATGAT  TCTCGGTACC  CATACCTCCG  AGAGCGAGCC  CAATTACTTG  240
241   ATGCTAGCCC  AAGTTCAGCT  TCCTCTTGAC  GATACCGAGA  GTGAAGCTCG  TCAGTACGAT  300
301   GATGACCGCT  CTGAATTTGG  TGGCTTTGGC  TGTGCAACTG  GAAAGGTACA  AATTATCCAG  360
361   CAGATAAATC  ATGATGGTGA  GGTTAATCGA  GCTCGCTATA  TGCCTCAAAA  CCCTTTCATA  420
421   ATTGCTACCA  AGACAGTTAA  TGCGGAGGTC  TATGTTTTCG  ATTACAGTAA  GCATCCATCT  480
481   AAGCCTCCTC  TTGATGGGGC  TTGTAATCCT  GATTTAAAGC  TTAGAGGTCA  CAGCTCTGAG  540
541   GGATATGGTC  TCTCTTGGAG  TAAGTTCAAG  CAGGGTCATT  TGCTTAGTGG  CTCTGATGAT  600
601   GCTCAGATCT  GCTTGTGGGA  TATTAACGCT  ACTCCTAAAA  ACAAATCTCT  GGACGCTCAG  660
661   CAGATTTTTA  AGGCTCATGA  AGGGGTTGTG  GAAGATGTTG  CATGGCATCT  GAGACATGAG  720
721   TACCTGTTTG  GATCAGTTGG  AGATGACCAA  TACCTTCTCA  TATGGGATCT  GCGTTCTCCA  780
781   TCTGCCAGTA  AACCAGTACA  GTCTGTGGTT  GCTCATTCGA  TGGAGGTTAA  CTGCTTAGCC  840
841   TTCAATCCAT  TTAATGAGTG  GGTTGTGGCA  ACAGGATCAA  CTGACAAGAC  TGTTAAATTA  900
901   TTCGATCTAC  GGAAGCTAAG  CACCGCTCTT  CACACATTTG  ATAGCCACAA  AGAGGAGGTT  960
961   TTTCAAGTTG  GTTGGAACCC  AAAGAACGAG  ACTATTTTAG  CTTCATGTTG  CCTTGGTAGA  1020
1021  AGACTTATGG  TTTGGGACCT  TAGCAGGATC  GATGAGGAAC  AGACAGTGGA  GGACGCAGAA  1080
1081  GACGGCCCAC  CTGAGCTGCT  GTTTATTCAC  GGTGGTCACA  CTAGCAAAAT  TTCAGATTTC  1140
1141  TCGTGGAACC  CTTGTGAAGA  TTGGGTTATT  TCCAGTGTTG  CTGAGGACAA  CATACTCCAA  1200
1201  ATATGGCAAA  TGGCTGAAAA  CATCTATCAT  GATGAGGATG  ACGCTCCAGG  GGAAGAACCA  1260
1261  TCAAAAGCTT  CTTAG  1275

▼ KEYWORD

ID
Family
Chromatin regulator
Complete proteome
Developmental protein
Differentiation
DNA replication
Flowering
Nucleus
Reference proteome
Repeat
Repressor
Transcription
Transcription regulation
WD repeat

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Chloroplast
Cellular Component
Chromatin silencing complex
Cellular Component
Cul4-RING E3 ubiquitin ligase complex
Cellular Component
Nucleus
Biological Process
Cell population proliferation
Biological Process
DNA replication
Biological Process
Embryo development ending in seed dormancy
Biological Process
Flower development
Biological Process
Heterochromatin assembly
Biological Process
Heterochromatin organization
Biological Process
Leaf development
Biological Process
Multicellular organism development
Biological Process
Pollen development
Biological Process
Positive regulation of cell cycle
Biological Process
Regulation of flower development
Biological Process
Regulation of gene expression by genetic imprinting
Biological Process
Regulation of genetic imprinting
Biological Process
Seed coat development
Biological Process
Seed development
Biological Process
Trichome differentiation

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Arl-2185Arabidopsis lyrata98.830.0 850
LLPS-Brn-3400Brassica napus95.270.0 832
LLPS-Bro-0505Brassica oleracea94.160.0 824
LLPS-Prp-0102Prunus persica92.420.0 800
LLPS-Viv-0810Vitis vinifera92.220.0 804
LLPS-Mae-1600Manihot esculenta92.220.0 805
LLPS-Thc-0722Theobroma cacao91.980.0 803
LLPS-Coc-0671Corchorus capsularis91.730.0 800
LLPS-Gor-1627Gossypium raimondii91.510.0 802
LLPS-Cus-1906Cucumis sativus91.510.0 796
LLPS-Nia-0313Nicotiana attenuata91.490.0 800
LLPS-Sot-0289Solanum tuberosum91.490.0 801
LLPS-Sol-0386Solanum lycopersicum91.020.0 798
LLPS-Glm-1747Glycine max90.330.0 785
LLPS-Pot-1785Populus trichocarpa90.090.0 790
LLPS-Phv-0326Phaseolus vulgaris90.090.0 785
LLPS-Via-1361Vigna angularis89.860.0 784
LLPS-Met-0556Medicago truncatula89.180.0 763
LLPS-Mua-1102Musa acuminata88.440.0 771
LLPS-Hea-2300Helianthus annuus87.940.0 777
LLPS-Brd-1839Brachypodium distachyon87.560.0 766
LLPS-Orr-1236Oryza rufipogon87.290.0 761
LLPS-Orm-0556Oryza meridionalis87.290.0 765
LLPS-Org-0181Oryza glaberrima87.290.0 761
LLPS-Ors-0362Oryza sativa87.290.0 761
LLPS-Lep-1451Leersia perrieri87.290.0 763
LLPS-Sei-0651Setaria italica87.10.0 756
LLPS-Orbr-0442Oryza brachyantha87.070.0 757
LLPS-Tra-0785Triticum aestivum87.070.0 763
LLPS-Zem-2139Zea mays86.620.0 756
LLPS-Amt-1073Amborella trichopoda86.560.0 768
LLPS-Dac-0657Daucus carota86.320.0 762
LLPS-Brr-1815Brassica rapa84.270.0 758
LLPS-Tru-0343Triticum urartu84.260.0 577
LLPS-Orp-0660Oryza punctata83.620.0 716
LLPS-Sob-0670Sorghum bicolor82.850.0 717
LLPS-Orni-0039Oryza nivara80.374e-52 190
LLPS-Sem-1321Selaginella moellendorffii76.630.0 668
LLPS-Orgl-1438Oryza glumaepatula75.780.0 650
LLPS-Orb-1997Oryza barthii75.780.0 652
LLPS-Php-1507Physcomitrella patens75.710.0 674
LLPS-Ori-1209Oryza indica72.880.0 611
LLPS-Chr-0279Chlamydomonas reinhardtii69.080.0 600
LLPS-Mod-2199Monodelphis domestica68.50.0 578
LLPS-Sah-3131Sarcophilus harrisii68.50.0 577
LLPS-Mam-2420Macaca mulatta68.250.0 577
LLPS-Cap-1144Cavia porcellus68.250.0 577
LLPS-Caf-1813Canis familiaris68.250.0 577
LLPS-Poa-0779Pongo abelii68.250.0 577
LLPS-Anc-2521Anolis carolinensis68.250.0 577
LLPS-Ict-2287Ictidomys tridecemlineatus68.250.0 577
LLPS-Cas-0463Carlito syrichta68.250.0 577
LLPS-Gaga-2422Gallus gallus68.250.0 573
LLPS-Loa-2335Loxodonta africana68.250.0 577
LLPS-Anp-1615Anas platyrhynchos68.250.0 577
LLPS-Man-0911Macaca nemestrina68.250.0 577
LLPS-Fec-2909Felis catus68.250.0 577
LLPS-Meg-1845Meleagris gallopavo68.250.0 578
LLPS-Hos-2258Homo sapiens68.250.0 577
LLPS-Pap-1887Pan paniscus68.250.0 577
LLPS-Pat-0863Pan troglodytes68.250.0 577
LLPS-Fia-0880Ficedula albicollis68.250.0 577
LLPS-Bot-1428Bos taurus68.250.0 577
LLPS-Dio-0602Dipodomys ordii68.250.0 577
LLPS-Myl-0828Myotis lucifugus68.250.0 577
LLPS-Ova-0736Ovis aries68.250.0 577
LLPS-Mal-0444Mandrillus leucophaeus68.250.0 577
LLPS-Ran-1030Rattus norvegicus68.250.0 577
LLPS-Sus-1736Sus scrofa68.250.0 577
LLPS-Aon-0002Aotus nancymaae68.250.0 577
LLPS-Ora-1023Ornithorhynchus anatinus68.250.0 575
LLPS-Mum-0176Mus musculus68.250.0 577
LLPS-Caj-3279Callithrix jacchus68.250.0 577
LLPS-Fud-0922Fukomys damarensis68.250.0 577
LLPS-Gog-4070Gorilla gorilla68.250.0 577
LLPS-Tag-2010Taeniopygia guttata68.00.0 576
LLPS-Osl-0636Ostreococcus lucimarinus67.940.0 571
LLPS-Rhb-1514Rhinopithecus bieti67.860.0 563
LLPS-Nol-1753Nomascus leucogenys67.770.0 561
LLPS-Cea-0684Cercocebus atys67.770.0 562
LLPS-Orn-2905Oreochromis niloticus67.750.0 570
LLPS-Xim-2449Xiphophorus maculatus67.750.0 570
LLPS-Aim-0361Ailuropoda melanoleuca67.750.0 564
LLPS-Mup-3003Mustela putorius furo67.750.0 573
LLPS-Leo-3064Lepisosteus oculatus67.750.0 573
LLPS-Orl-2077Oryzias latipes67.750.0 570
LLPS-Asm-3827Astyanax mexicanus67.750.0 570
LLPS-Ten-0305Tetraodon nigroviridis67.660.0 570
LLPS-Pof-0195Poecilia formosa67.580.0 565
LLPS-Xet-0400Xenopus tropicalis67.570.0 575
LLPS-Lac-0155Latimeria chalumnae67.570.0 579
LLPS-Scm-3106Scophthalmus maximus67.50.0 568
LLPS-Dar-1130Danio rerio67.50.0 569
LLPS-Orc-0211Oryctolagus cuniculus67.50.0 570
LLPS-Scf-1081Scleropages formosus67.50.0 570
LLPS-Paa-1492Papio anubis67.50.0 570
LLPS-Chs-2232Chlorocebus sabaeus67.50.0 570
LLPS-Maf-3161Macaca fascicularis67.50.0 570
LLPS-Mea-0236Mesocricetus auratus67.50.0 570
LLPS-Eqc-2346Equus caballus67.320.0 577
LLPS-Gaa-1023Gasterosteus aculeatus66.910.0 570
LLPS-Urm-2131Ursus maritimus66.750.0 534
LLPS-Pes-0453Pelodiscus sinensis66.750.0 534
LLPS-Drm-0175Drosophila melanogaster66.50.0 568
LLPS-Icp-0478Ictalurus punctatus65.828e-168 485
LLPS-Cii-0588Ciona intestinalis65.70.0 572
LLPS-Otg-0186Otolemur garnettii64.760.0 532
LLPS-Tar-3087Takifugu rubripes64.743e-169 489
LLPS-Cis-1455Ciona savignyi64.730.0 566
LLPS-Cae-0613Caenorhabditis elegans60.851e-177 510
LLPS-Chc-0876Chondrus crispus58.296e-176 506
LLPS-Vir-0510Vigna radiata55.444e-149 438
LLPS-Miv-0072Microbotryum violaceum53.872e-159 463
LLPS-Gas-0952Galdieria sulphuraria53.872e-154 451
LLPS-Abg-0032Absidia glauca53.432e-151 443
LLPS-Spr-0217Sporisorium reilianum52.727e-158 460
LLPS-Usm-0587Ustilago maydis52.726e-161 468
LLPS-Mel-1314Melampsora laricipopulina52.164e-147 432
LLPS-Crn-0856Cryptococcus neoformans50.382e-148 436
LLPS-Tum-1425Tuber melanosporum50.372e-146 431
LLPS-Cym-0979Cyanidioschyzon merolae50.352e-148 438
LLPS-Pug-1184Puccinia graminis50.135e-147 432
LLPS-Ast-0204Aspergillus terreus49.033e-140 416
LLPS-Asc-1321Aspergillus clavatus48.794e-139 412
LLPS-Gag-0951Gaeumannomyces graminis48.792e-130 390
LLPS-Asfu-0589Aspergillus fumigatus48.552e-136 405
LLPS-Nef-0068Neosartorya fischeri48.551e-136 406
LLPS-Aso-0021Aspergillus oryzae48.551e-138 411
LLPS-Asf-0790Aspergillus flavus48.551e-138 411
LLPS-Asni-0215Aspergillus niger48.551e-137 409
LLPS-Scc-1447Schizosaccharomyces cryophilus48.513e-130 390
LLPS-Mao-0459Magnaporthe oryzae47.65e-132 394
LLPS-Fuv-1037Fusarium verticillioides47.336e-134 399
LLPS-Fuo-1087Fusarium oxysporum46.844e-133 397
LLPS-Trv-1126Trichoderma virens46.845e-132 394
LLPS-Trr-1390Trichoderma reesei46.831e-131 393
LLPS-Ved-0626Verticillium dahliae46.425e-131 392