DrLLPS - Data resource of LLPS

LLPS-Art-2051
MTM1

▼ OVERVIEW


Status:	Unreviewed
Protein Name:	Mitochondrial carrier protein MTM1; Manganese tracking factor for mitochondrial SOD2
Gene Name:	MTM1, At4g27940, T13J8.50
Ensembl Gene:	AT4G27940
Ensembl Protein:	AT4G27940.1
Organism:	Arabidopsis thaliana
Taxa ID:	3702
LLPS Type:	Regulator

▼ PROPERTY

——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:

Condensate	Evidence	Orthologs
Stress granule	Predicted from orthologs	(View)

Organism	DrLLPS ID	UniProt ID	LLPS type	Condensate	Identity	E-value	Score
Saccharomyces cerevisiae	LLPS-Sac-0333	P53320	Regulator	Stress granule	31.64	1e-41	156

▼ FUNCTION

Involved in the mitochondrial activation of MSD1 by specifically facilitating insertion of the essential manganese cofactor. Has the ability to activate iron regulon in an iron-dependent manner.

▼ CROSS REFERENCE

Database	Nucleotide ID	Protein ID
Ensembl	AT4G27940.1	AT4G27940.1
UniProt		Q944H5, MTM1_ARATH, Q9SUE4
GeneBank	AY125549, AL035524, AY085360, AF428433, AL161572, CP002687	AEE85411.1, CAB36763.1, CAB79596.1, AAM62590.1, AAM78059.1, AAL16202.1
RefSeq	NM_118932.5	NP_567790.1

▼ SEQUENCE

Protein Sequence (FASTA)
1 MVEAERAENS WIASETSPSS SPVVIESSDF SITDGMRDVS GFGIASRPQL DKGLSENNIG 60 61 FTERVFSAAG AAVLSAVTLN PLDVVKTRLQ AQAAGMSYSH PLSNSIGRMA FFGPNMMFAD 120 121 LRCSPSCARA GVEGTVSICP PDCFQYKGTF DVFTKIIRQE GLGRLWRGTN AGLALAVPMV 180 181 GIYLPFYDMF RNRLEELSRE KAPAMTFCVP TVAGSLARSL ACTVCYPIDL ARTRMQAFKE 240 241 AKAGVKPPGV FKTLVGVFSE VRTANNLESS LHNYRGLWRG LGAQLARDVP FSAICWSTLE 300 301 PIKKRLLGVA GNDTNLVGVF GATFSAGFIA GSIAAAATCP LDVARTRRQI EKDPGRALMM 360 361 TTRQTLIEVW RDGGMRGLFM GMGPRVARAG PSVGIVVSFY EVVKYVLHRH ASS 413
Nucleotide CDS Sequence (FASTA)
1 ATGGTTGAGG CAGAGCGCGC GGAGAATAGT TGGATTGCTT CGGAAACGTC TCCGTCGTCG 60 61 TCTCCGGTGG TAATAGAAAG CAGTGATTTT TCGATAACTG ATGGAATGAG AGATGTGAGC 120 121 GGATTTGGTA TAGCTTCTCG ACCTCAGTTG GACAAGGGTT TGTCGGAAAA CAATATAGGG 180 181 TTCACGGAAA GAGTTTTCTC TGCCGCCGGA GCTGCGGTTT TGTCCGCCGT TACTCTAAAT 240 241 CCTCTTGACG TTGTCAAGAC TCGATTGCAA GCTCAAGCCG CCGGAATGTC GTACTCTCAC 300 301 CCACTCAGTA ACTCCATTGG ACGCATGGCA TTTTTTGGCC CAAACATGAT GTTTGCAGAC 360 361 TTGAGATGTT CTCCTTCATG TGCACGCGCT GGTGTTGAAG GTACTGTTTC TATTTGCCCA 420 421 CCGGATTGTT TCCAGTACAA AGGAACATTT GATGTCTTCA CCAAGATCAT ACGACAGGAG 480 481 GGTCTGGGAC GCCTTTGGAG AGGGACTAAT GCTGGTCTTG CCCTAGCTGT GCCCATGGTT 540 541 GGGATATATC TCCCATTCTA TGATATGTTC CGCAACCGGT TGGAAGAATT ATCTCGGGAG 600 601 AAAGCTCCTG CTATGACATT TTGTGTGCCT ACTGTGGCAG GGTCTTTAGC GCGGTCCTTA 660 661 GCTTGTACAG TCTGCTATCC TATTGATCTT GCAAGAACGC GTATGCAGGC ATTCAAAGAA 720 721 GCAAAAGCCG GTGTGAAGCC TCCGGGAGTT TTTAAAACTC TAGTTGGTGT TTTCTCTGAA 780 781 GTCAGGACAG CAAATAACCT TGAAAGTAGC TTGCACAACT ATCGTGGTCT CTGGAGAGGC 840 841 TTGGGTGCAC AGCTTGCCCG TGATGTTCCA TTCTCAGCAA TCTGCTGGTC GACCCTCGAG 900 901 CCAATAAAAA AGAGGCTCCT TGGAGTTGCG GGCAATGATA CAAATCTTGT TGGTGTTTTC 960 961 GGTGCAACCT TTTCTGCTGG ATTTATAGCT GGAAGTATCG CTGCTGCTGC TACTTGTCCT 1020 1021 CTTGACGTTG CAAGAACAAG AAGACAGATA GAGAAGGACC CTGGTAGGGC ATTGATGATG 1080 1081 ACGACACGAC AGACACTAAT AGAGGTTTGG AGGGATGGAG GGATGAGAGG ACTGTTCATG 1140 1141 GGAATGGGTC CACGAGTGGC ACGTGCAGGA CCATCGGTAG GGATAGTGGT TTCCTTCTAC 1200 1201 GAAGTGGTCA AGTATGTTCT GCATCGCCAT GCTTCATCAT GA 1242

▼ KEYWORD

ID	Family
KW-0181	Complete proteome
KW-0472	Membrane
KW-0496	Mitochondrion
KW-0999	Mitochondrion inner membrane
KW-1185	Reference proteome
KW-0677	Repeat
KW-0812	Transmembrane
KW-1133	Transmembrane helix
KW-0813	Transport

▼ GENE ONTOLOGY

ID	Classification	Description
GO:0016021	Cellular Component	Integral component of membrane
GO:0005743	Cellular Component	Mitochondrial inner membrane
GO:0005739	Cellular Component	Mitochondrion
GO:0016530	Molecular Function	Metallochaperone activity
GO:0022857	Molecular Function	Transmembrane transporter activity
GO:0005215	Molecular Function	Transporter activity
GO:0006828	Biological Process	Manganese ion transport
GO:1901562	Biological Process	Response to paraquat

▼ KEGG

ath:AT4G27940

▼ ANNOTATION

Disorder
IUPred2A

Domain
SMART	Pfam	InterPro	LCR-eXXXplorer	CDD
PROSITE	Gene3D

Interaction
HINT	Mentha	PINA	iRefIndex

Physicochemical
Compute pI/Mw	AAindex

Function
CGDB

Localization
COMPARTMENTS

▼ ORTHOLOGY

DrLLPS ID	Organism	Identity	E-value	Score
LLPS-Arl-2025	Arabidopsis lyrata	95.44	0.0	742
LLPS-Brr-0514	Brassica rapa	80.05	0.0	639
LLPS-Brn-0550	Brassica napus	79.81	0.0	635
LLPS-Bro-2536	Brassica oleracea	78.28	0.0	633
LLPS-Gor-0324	Gossypium raimondii	74.79	0.0	540
LLPS-Hea-1908	Helianthus annuus	74.52	0.0	536
LLPS-Pot-0852	Populus trichocarpa	73.89	0.0	520
LLPS-Cus-0702	Cucumis sativus	73.22	0.0	526
LLPS-Viv-2163	Vitis vinifera	73.05	0.0	538
LLPS-Sol-0047	Solanum lycopersicum	72.98	1e-180	517
LLPS-Sot-1350	Solanum tuberosum	72.7	0.0	518
LLPS-Dac-0121	Daucus carota	72.14	0.0	540
LLPS-Mae-2594	Manihot esculenta	71.66	0.0	520
LLPS-Met-0649	Medicago truncatula	71.15	3e-177	507
LLPS-Mua-1956	Musa acuminata	68.78	1e-163	475
LLPS-Glm-2465	Glycine max	68.42	2e-177	508
LLPS-Amt-2134	Amborella trichopoda	68.12	2e-168	488
LLPS-Orbr-2173	Oryza brachyantha	65.81	2e-159	461
LLPS-Prp-0203	Prunus persica	65.64	1e-151	442
LLPS-Nia-2471	Nicotiana attenuata	64.58	9e-156	453
LLPS-Ors-0338	Oryza sativa	64.25	9e-158	459
LLPS-Sob-0540	Sorghum bicolor	64.25	8e-158	458
LLPS-Orr-1309	Oryza rufipogon	64.25	9e-158	459
LLPS-Org-0620	Oryza glaberrima	64.25	9e-158	459
LLPS-Orb-0950	Oryza barthii	64.25	9e-158	459
LLPS-Ori-0650	Oryza indica	64.25	1e-157	458
LLPS-Orni-1178	Oryza nivara	64.25	1e-157	458
LLPS-Orgl-1295	Oryza glumaepatula	64.25	9e-158	459
LLPS-Lep-2304	Leersia perrieri	64.25	6e-157	456
LLPS-Zem-2032	Zea mays	64.07	1e-156	456
LLPS-Orp-2336	Oryza punctata	63.97	3e-157	457
LLPS-Orm-0727	Oryza meridionalis	63.69	9e-156	454
LLPS-Sei-2042	Setaria italica	63.16	5e-103	313
LLPS-Coc-1349	Corchorus capsularis	63.09	2e-148	434
LLPS-Thc-2309	Theobroma cacao	61.88	3e-154	449
LLPS-Tra-2773	Triticum aestivum	58.89	1e-123	370
LLPS-Phv-2469	Phaseolus vulgaris	58.79	7e-132	391
LLPS-Brd-2410	Brachypodium distachyon	58.71	4e-123	368
LLPS-Hov-1566	Hordeum vulgare	58.33	1e-122	367
LLPS-Via-0644	Vigna angularis	57.92	7e-133	393
LLPS-Tru-0021	Triticum urartu	54.98	2e-85	270
LLPS-Sem-1524	Selaginella moellendorffii	54.55	1e-116	353
LLPS-Php-2445	Physcomitrella patens	54.49	4e-114	347
LLPS-Vir-2159	Vigna radiata	51.94	6e-111	338
LLPS-Osl-1462	Ostreococcus lucimarinus	34.71	3e-34	135
LLPS-Scm-3520	Scophthalmus maximus	34.17	4e-37	144
LLPS-Abg-0785	Absidia glauca	33.6	5e-33	137
LLPS-Leo-1650	Lepisosteus oculatus	33.33	4e-38	146
LLPS-Cis-0449	Ciona savignyi	33.2	4e-24	103
LLPS-Pof-0126	Poecilia formosa	33.15	1e-37	145
LLPS-Tum-0363	Tuber melanosporum	33.04	2e-14	76.6
LLPS-Xim-3152	Xiphophorus maculatus	32.97	1e-38	147
LLPS-Cap-2562	Cavia porcellus	32.95	1e-35	139
LLPS-Poa-0096	Pongo abelii	32.51	2e-36	142
LLPS-Spr-0988	Sporisorium reilianum	32.47	2e-24	108
LLPS-Fec-0642	Felis catus	32.43	8e-36	140
LLPS-Eqc-4079	Equus caballus	32.42	3e-36	141
LLPS-Cog-0533	Colletotrichum gloeosporioides	32.31	1e-17	85.9
LLPS-Crn-0843	Cryptococcus neoformans	32.24	1e-12	73.6
LLPS-Chc-0813	Chondrus crispus	32.17	3e-31	127
LLPS-Hos-4874	Homo sapiens	32.15	2e-35	139
LLPS-Myl-3389	Myotis lucifugus	32.15	1e-35	139
LLPS-Xet-0764	Xenopus tropicalis	32.12	4e-33	132
LLPS-Anc-0328	Anolis carolinensis	32.03	1e-34	137
LLPS-Loa-1126	Loxodonta africana	32.02	3e-31	126
LLPS-Mel-1367	Melampsora laricipopulina	31.99	7e-24	107
LLPS-Dar-4271	Danio rerio	31.94	7e-34	134
LLPS-Cas-3382	Carlito syrichta	31.92	2e-33	133
LLPS-Orc-0971	Oryctolagus cuniculus	31.88	2e-34	136
LLPS-Caf-2370	Canis familiaris	31.88	3e-32	129
LLPS-Pap-3893	Pan paniscus	31.79	2e-35	139
LLPS-Ere-0601	Erinaceus europaeus	31.74	2e-16	82.0
LLPS-Sac-0333	Saccharomyces cerevisiae	31.64	6e-35	137
LLPS-Gog-3268	Gorilla gorilla	31.55	6e-32	129
LLPS-Mum-4174	Mus musculus	31.54	2e-35	139
LLPS-Tar-3992	Takifugu rubripes	31.52	2e-35	139
LLPS-Otg-1198	Otolemur garnettii	31.51	1e-37	145
LLPS-Mod-2569	Monodelphis domestica	31.49	5e-34	134
LLPS-Ten-1240	Tetraodon nigroviridis	31.45	1e-32	131
LLPS-Pes-1723	Pelodiscus sinensis	31.42	2e-27	115
LLPS-Pat-4642	Pan troglodytes	31.4	2e-31	127
LLPS-Ora-0980	Ornithorhynchus anatinus	31.4	4e-37	143
LLPS-Mup-0791	Mustela putorius furo	31.37	1e-34	136
LLPS-Miv-1459	Microbotryum violaceum	31.35	1e-28	121
LLPS-Zyt-0887	Zymoseptoria tritici	31.34	3e-28	119
LLPS-Urm-0508	Ursus maritimus	31.32	3e-35	138
LLPS-Fia-2415	Ficedula albicollis	31.27	4e-31	126
LLPS-Meg-1936	Meleagris gallopavo	31.22	4e-35	138
LLPS-Rhb-3939	Rhinopithecus bieti	31.13	6e-36	140
LLPS-Chs-4680	Chlorocebus sabaeus	31.13	2e-35	139
LLPS-Aon-2286	Aotus nancymaae	31.13	1e-36	142
LLPS-Bot-4066	Bos taurus	31.13	1e-35	139
LLPS-Aim-3845	Ailuropoda melanoleuca	31.13	6e-35	137
LLPS-Gas-1371	Galdieria sulphuraria	31.07	3e-25	108
LLPS-Asg-0487	Ashbya gossypii	31.06	3e-33	132
LLPS-Man-3623	Macaca nemestrina	31.04	3e-34	135
LLPS-Mam-1022	Macaca mulatta	31.04	1e-34	136
LLPS-Gaga-0710	Gallus gallus	31.04	1e-34	137
LLPS-Maf-2300	Macaca fascicularis	31.04	9e-35	136
LLPS-Cea-4071	Cercocebus atys	31.04	1e-34	136
LLPS-Caj-2849	Callithrix jacchus	31.04	8e-36	139
LLPS-Paa-3816	Papio anubis	31.04	9e-35	136
LLPS-Fud-3754	Fukomys damarensis	31.02	7e-35	137
LLPS-Orn-3347	Oreochromis niloticus	30.96	1e-33	134
LLPS-Sus-1364	Sus scrofa	30.96	3e-35	138
LLPS-Ova-2327	Ovis aries	30.94	2e-35	139
LLPS-Fuo-0606	Fusarium oxysporum	30.89	6e-32	130
LLPS-Cii-0944	Ciona intestinalis	30.88	9e-32	128
LLPS-Put-0488	Puccinia triticina	30.83	4e-33	133
LLPS-Sah-1773	Sarcophilus harrisii	30.81	1e-32	130
LLPS-Nol-3107	Nomascus leucogenys	30.77	4e-34	135
LLPS-Icp-3738	Ictalurus punctatus	30.71	5e-34	135
LLPS-Ran-1837	Rattus norvegicus	30.68	5e-37	143
LLPS-Mao-1270	Magnaporthe oryzae	30.64	2e-29	123
LLPS-Mal-0790	Mandrillus leucophaeus	30.62	5e-32	129
LLPS-Dio-3328	Dipodomys ordii	30.58	2e-34	136
LLPS-Gaa-1860	Gasterosteus aculeatus	30.56	1e-35	139
LLPS-Asfu-1023	Aspergillus fumigatus	30.52	4e-33	134
LLPS-Blg-1478	Blumeria graminis	30.41	4e-32	130
LLPS-Orl-2804	Oryzias latipes	30.38	1e-35	139
LLPS-Kop-0685	Komagataella pastoris	30.25	2e-31	128
LLPS-Scs-1105	Sclerotinia sclerotiorum	30.23	3e-33	134
LLPS-Usm-1014	Ustilago maydis	30.13	2e-24	109
LLPS-Asni-0161	Aspergillus niger	30.1	9e-32	129
LLPS-Fuv-1554	Fusarium verticillioides	30.09	2e-31	129
LLPS-Nef-1605	Neosartorya fischeri	30.02	2e-33	134
LLPS-Beb-1349	Beauveria bassiana	29.95	3e-28	119
LLPS-Mea-4078	Mesocricetus auratus	29.94	4e-32	129
LLPS-Ast-0212	Aspergillus terreus	29.93	2e-26	113
LLPS-Trv-1021	Trichoderma virens	29.82	2e-27	116
LLPS-Dos-0700	Dothistroma septosporum	29.82	6e-31	127
LLPS-Gag-1387	Gaeumannomyces graminis	29.81	1e-28	120
LLPS-Scf-4139	Scleropages formosus	29.79	1e-37	145
LLPS-Drm-0699	Drosophila melanogaster	29.71	3e-35	139
LLPS-Lac-1349	Latimeria chalumnae	29.66	8e-34	134
LLPS-Coo-0537	Colletotrichum orbiculare	29.51	8e-29	121
LLPS-Asn-1470	Aspergillus nidulans	29.5	1e-23	106
LLPS-Asc-0944	Aspergillus clavatus	29.48	1e-33	134
LLPS-Asm-2594	Astyanax mexicanus	29.43	7e-32	129
LLPS-Ict-1228	Ictidomys tridecemlineatus	29.4	1e-31	127
LLPS-Tut-2316	Tursiops truncatus	29.4	2e-34	135
LLPS-Pyt-1410	Pyrenophora teres	29.26	5e-27	115
LLPS-Ved-0523	Verticillium dahliae	29.23	2e-28	119
LLPS-Aso-1344	Aspergillus oryzae	29.12	2e-26	114
LLPS-Asf-0387	Aspergillus flavus	28.88	5e-26	112
LLPS-Map-0341	Magnaporthe poae	28.81	2e-29	122
LLPS-Cae-0492	Caenorhabditis elegans	28.74	2e-09	62.8
LLPS-Pug-1196	Puccinia graminis	28.57	2e-29	122
LLPS-Trr-0864	Trichoderma reesei	28.57	2e-27	116
LLPS-Lem-1418	Leptosphaeria maculans	28.47	1e-25	111
LLPS-Scp-1027	Schizosaccharomyces pombe	28.45	7e-23	102
LLPS-Cogr-1566	Colletotrichum graminicola	28.25	9e-20	94.4
LLPS-Scc-0615	Schizosaccharomyces cryophilus	27.95	5e-21	97.1
LLPS-Yal-0037	Yarrowia lipolytica	27.62	1e-27	117
LLPS-Tag-1507	Taeniopygia guttata	27.6	1e-31	128
LLPS-Scj-0481	Schizosaccharomyces japonicus	27.27	4e-22	100
LLPS-Nec-1343	Neurospora crassa	27.21	4e-28	119
LLPS-Phn-1154	Phaeosphaeria nodorum	26.81	4e-11	67.4
LLPS-Cym-0220	Cyanidioschyzon merolae	26.46	8e-17	86.3
LLPS-Pytr-0370	Pyrenophora triticirepentis	25.47	6e-09	61.2

LLPS-Art-2051MTM1

Protein Sequence

Nucleotide Sequence

LLPS-Art-2051
MTM1