LLPS-Art-1890
MSI5
▼ OVERVIEW
| Status: | Reviewed |
| Protein Name: | WD-40 repeat-containing protein MSI5 |
| Gene Name: | MSI5, At4g29730, T16L4.240 |
| Ensembl Gene: | AT4G29730 |
| Ensembl Protein: | AT4G29730.3 |
| Organism: | Arabidopsis thaliana |
| Taxa ID: | 3702 |
| LLPS Type: | Client |
▼ Classification
Condensates:
| Condensate | Description | Tissue/Cell | PMIDs |
|---|---|---|---|
| Nucleolus | "...We identified 1602 proteins in the nucleolar and 2544 proteins in the nuclear fraction with an overlap of 1429 proteins." | Arabidopsis thaliana cells | 26980300 |
▼ FUNCTION
| Core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | AT4G29730.3 | AT4G29730.3 |
| Ensembl | AT4G29730.1 | AT4G29730.1 |
| Ensembl | AT4G29730.2 | AT4G29730.2 |
| UniProt | Q9SU78, MSI5_ARATH, Q6NQ53 | |
| GeneBank | AL079344, CP002687, BT010610, AL161575, AK176425 | AAQ89632.1, BAD44188.1, CAB79731.1, CAB45333.1, AEE85666.1 |
| RefSeq | NM_119118.3 | NP_194702.2 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MESEAAATVQ ATRPRRAPRT PVTAILTDKR RRKPKSNNES QLPFLLQQSQ KATVDDTYSQ 60 61 WKTLLPILYD SFVNHTLVWP SLSCRWGPQL EQAGSKTQRL YLSEQTNGSV PNTLVIANCE 120 121 TVNRQLNEKA HSPFVKKYKT IIHPGEVNRI RELPQNSKIV ATHTDSPDIL IWNTETQPDR 180 181 YAVLGAPDSR PDLLLIGHQD DAEFALAMCP TEPFVLSGGK DKSVILWNIQ DHITMAGSDS 240 241 KSPGSSFKQT GEGSDKTGGP SVGPRGIYNG HKDTVEDVAF CPSSAQEFCS VGDDSCLMLW 300 301 DARTGTSPAM KVEKAHDADL HCVDWNPHDN NLILTGSADN TVRVFDRRNL TSNGVGSPVY 360 361 KFEGHRAAVL CVQWSPDKSS VFGSSAEDGL LNIWDCDRVG KKSERATKTP DGLFFQHAGH 420 421 RDKVVDFHWS LLNPWTIVSV SDNCESIGGG GTLQIWRMSD LIYRPEDEVL TELEKFKSHV 480 481 FTCTSKS 487 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGGAAAGCG AAGCAGCAGC GACTGTTCAA GCCACCAGGC CGAGAAGAGC ACCTAGGACT 60 61 CCGGTGACAG CCATTTTGAC GGATAAGAGA AGACGGAAAC CTAAGAGCAA CAACGAGTCT 120 121 CAGTTACCAT TTTTGCTACA GCAGAGTCAA AAGGCCACCG TTGACGACAC TTACTCTCAG 180 181 TGGAAGACTC TTCTTCCCAT TCTCTATGAT TCGTTTGTTA ATCATACCCT CGTCTGGCCC 240 241 TCTCTCTCTT GCAGATGGGG GCCACAGCTT GAGCAAGCAG GTTCTAAGAC TCAACGTCTC 300 301 TATCTCTCGG AACAAACGAA TGGCAGTGTG CCTAATACTT TGGTCATAGC CAATTGCGAA 360 361 ACTGTTAATA GGCAGCTTAA TGAAAAGGCA CACTCTCCAT TTGTGAAGAA GTACAAGACC 420 421 ATCATCCACC CTGGAGAGGT CAACAGAATT AGGGAACTCC CTCAAAATAG CAAGATTGTA 480 481 GCTACTCACA CCGACAGTCC TGATATTCTC ATTTGGAACA CTGAGACTCA ACCAGACCGG 540 541 TATGCTGTGC TTGGAGCTCC AGATTCTCGT CCAGATTTGT TACTAATTGG GCACCAGGAT 600 601 GATGCTGAAT TTGCTCTTGC AATGTGCCCA ACCGAACCTT TTGTTCTCTC TGGAGGCAAG 660 661 GACAAGTCCG TTATTTTGTG GAATATCCAA GACCATATCA CAATGGCTGG TTCGGATTCC 720 721 AAATCCCCTG GATCCAGCTT CAAGCAGACT GGTGAAGGTA GTGATAAAAC TGGTGGTCCT 780 781 TCTGTTGGCC CTCGAGGCAT ATATAATGGC CACAAAGATA CTGTTGAAGA CGTGGCATTC 840 841 TGTCCATCTA GTGCACAAGA ATTCTGCAGT GTTGGTGACG ATTCTTGCCT TATGCTATGG 900 901 GACGCAAGAA CTGGCACTAG TCCTGCCATG AAGGTTGAGA AGGCACATGA TGCTGATCTT 960 961 CACTGTGTCG ATTGGAATCC TCATGACAAT AATCTGATCC TGACTGGGTC AGCAGATAAC 1020 1021 ACTGTCCGTG TGTTTGACCG CCGAAACCTT ACCTCAAATG GAGTTGGTTC ACCTGTTTAC 1080 1081 AAATTTGAAG GCCACAGAGC TGCTGTTCTT TGTGTTCAGT GGTCTCCTGA TAAATCATCT 1140 1141 GTTTTTGGGA GTTCTGCAGA AGATGGTCTC TTGAACATAT GGGATTGTGA TAGGGTTGGC 1200 1201 AAGAAGTCTG AGCGTGCAAC CAAAACTCCT GATGGGCTTT TCTTCCAGCA TGCTGGTCAC 1260 1261 AGGTTCTCAA GACTTAATTC TAATTCACTT GCTTGCCTTT CCCTTTTACT CTCTTCAGTG 1320 1321 GAATCTATAA TTTCCTCGTG TATATCTTCT TAG 1353 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Cul4-RING E3 ubiquitin ligase complex | |
Cellular Component | Nucleus | |
Biological Process | Chromatin organization | |
Biological Process | Negative regulation of gene expression |
▼ ANNOTATION
| Disorder | ||||
| IUPred2A | ||||
| PTM | ||||
| EPSD | ||||
| Physicochemical | ||||
| Compute pI/Mw | AAindex | |||
| Function | ||||
| iEKPD | ||||
| Localization | ||||
| COMPARTMENTS | ||||
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Arl-2762 | Arabidopsis lyrata | 91.13 | 0.0 | 885 |
| LLPS-Bro-1667 | Brassica oleracea | 81.55 | 0.0 | 749 |
| LLPS-Glm-2944 | Glycine max | 77.75 | 0.0 | 738 |
| LLPS-Mae-0018 | Manihot esculenta | 77.46 | 0.0 | 738 |
| LLPS-Brn-1475 | Brassica napus | 77.45 | 0.0 | 769 |
| LLPS-Brr-1879 | Brassica rapa | 77.45 | 0.0 | 763 |
| LLPS-Gor-0359 | Gossypium raimondii | 77.41 | 0.0 | 729 |
| LLPS-Met-2094 | Medicago truncatula | 76.61 | 0.0 | 728 |
| LLPS-Thc-0638 | Theobroma cacao | 76.43 | 0.0 | 729 |
| LLPS-Pot-1259 | Populus trichocarpa | 76.03 | 0.0 | 726 |
| LLPS-Phv-2386 | Phaseolus vulgaris | 75.56 | 0.0 | 713 |
| LLPS-Mua-0866 | Musa acuminata | 74.88 | 0.0 | 617 |
| LLPS-Via-1921 | Vigna angularis | 74.5 | 0.0 | 697 |
| LLPS-Coc-0017 | Corchorus capsularis | 74.2 | 0.0 | 670 |
| LLPS-Prp-0478 | Prunus persica | 73.89 | 0.0 | 718 |
| LLPS-Cus-0305 | Cucumis sativus | 72.82 | 0.0 | 727 |
| LLPS-Sol-2290 | Solanum lycopersicum | 72.63 | 0.0 | 677 |
| LLPS-Viv-1380 | Vitis vinifera | 72.62 | 0.0 | 677 |
| LLPS-Sot-1041 | Solanum tuberosum | 72.19 | 6e-175 | 503 |
| LLPS-Nia-0892 | Nicotiana attenuata | 72.12 | 0.0 | 684 |
| LLPS-Amt-1768 | Amborella trichopoda | 71.55 | 0.0 | 681 |
| LLPS-Sei-0104 | Setaria italica | 71.43 | 0.0 | 673 |
| LLPS-Hov-1175 | Hordeum vulgare | 71.33 | 0.0 | 676 |
| LLPS-Sob-1724 | Sorghum bicolor | 70.31 | 0.0 | 664 |
| LLPS-Brd-2321 | Brachypodium distachyon | 70.29 | 0.0 | 650 |
| LLPS-Hea-1596 | Helianthus annuus | 69.64 | 0.0 | 653 |
| LLPS-Ori-2152 | Oryza indica | 69.52 | 0.0 | 657 |
| LLPS-Ors-2220 | Oryza sativa | 69.52 | 0.0 | 657 |
| LLPS-Orbr-1808 | Oryza brachyantha | 69.5 | 0.0 | 654 |
| LLPS-Tra-1913 | Triticum aestivum | 68.67 | 0.0 | 664 |
| LLPS-Org-0812 | Oryza glaberrima | 68.6 | 0.0 | 654 |
| LLPS-Dac-2450 | Daucus carota | 67.71 | 0.0 | 628 |
| LLPS-Tru-0358 | Triticum urartu | 67.58 | 0.0 | 600 |
| LLPS-Orni-0107 | Oryza nivara | 66.01 | 0.0 | 610 |
| LLPS-Orb-1421 | Oryza barthii | 65.05 | 0.0 | 594 |
| LLPS-Orr-1921 | Oryza rufipogon | 64.66 | 0.0 | 600 |
| LLPS-Lep-1798 | Leersia perrieri | 63.11 | 0.0 | 587 |
| LLPS-Zem-2019 | Zea mays | 62.35 | 0.0 | 606 |
| LLPS-Vir-2208 | Vigna radiata | 62.17 | 6e-178 | 512 |
| LLPS-Orgl-2314 | Oryza glumaepatula | 61.1 | 0.0 | 541 |
| LLPS-Orp-2233 | Oryza punctata | 60.76 | 0.0 | 556 |
| LLPS-Php-0284 | Physcomitrella patens | 59.87 | 0.0 | 551 |
| LLPS-Chr-0834 | Chlamydomonas reinhardtii | 48.0 | 2e-13 | 76.6 |
| LLPS-Osl-1382 | Ostreococcus lucimarinus | 36.7 | 4e-92 | 295 |
| LLPS-Paa-1712 | Papio anubis | 34.94 | 6e-50 | 181 |
| LLPS-Chc-0535 | Chondrus crispus | 34.61 | 3e-66 | 227 |
| LLPS-Ten-2988 | Tetraodon nigroviridis | 33.1 | 3e-62 | 215 |
| LLPS-Caj-3279 | Callithrix jacchus | 32.88 | 3e-60 | 210 |
| LLPS-Fud-0922 | Fukomys damarensis | 32.88 | 3e-60 | 210 |
| LLPS-Gog-4070 | Gorilla gorilla | 32.88 | 3e-60 | 210 |
| LLPS-Aon-0002 | Aotus nancymaae | 32.88 | 3e-60 | 210 |
| LLPS-Sus-1736 | Sus scrofa | 32.88 | 3e-60 | 210 |
| LLPS-Mum-0176 | Mus musculus | 32.88 | 3e-60 | 210 |
| LLPS-Myl-0828 | Myotis lucifugus | 32.88 | 3e-60 | 210 |
| LLPS-Ova-0736 | Ovis aries | 32.88 | 3e-60 | 210 |
| LLPS-Mup-3003 | Mustela putorius furo | 32.88 | 2e-60 | 210 |
| LLPS-Ran-1030 | Rattus norvegicus | 32.88 | 3e-60 | 210 |
| LLPS-Bot-1428 | Bos taurus | 32.88 | 3e-60 | 210 |
| LLPS-Dio-0602 | Dipodomys ordii | 32.88 | 3e-60 | 210 |
| LLPS-Loa-2335 | Loxodonta africana | 32.88 | 3e-60 | 210 |
| LLPS-Man-0911 | Macaca nemestrina | 32.88 | 3e-60 | 210 |
| LLPS-Lac-0155 | Latimeria chalumnae | 32.88 | 1e-60 | 211 |
| LLPS-Fec-2909 | Felis catus | 32.88 | 3e-60 | 210 |
| LLPS-Pap-1887 | Pan paniscus | 32.88 | 3e-60 | 210 |
| LLPS-Pat-0863 | Pan troglodytes | 32.88 | 3e-60 | 210 |
| LLPS-Hos-2258 | Homo sapiens | 32.88 | 3e-60 | 210 |
| LLPS-Meg-1845 | Meleagris gallopavo | 32.88 | 2e-60 | 210 |
| LLPS-Ict-2287 | Ictidomys tridecemlineatus | 32.88 | 3e-60 | 210 |
| LLPS-Anc-2521 | Anolis carolinensis | 32.88 | 4e-60 | 210 |
| LLPS-Cas-0463 | Carlito syrichta | 32.88 | 3e-60 | 210 |
| LLPS-Gaga-1897 | Gallus gallus | 32.88 | 3e-60 | 210 |
| LLPS-Mam-2420 | Macaca mulatta | 32.88 | 2e-60 | 210 |
| LLPS-Cap-1144 | Cavia porcellus | 32.88 | 3e-60 | 210 |
| LLPS-Caf-1813 | Canis familiaris | 32.88 | 3e-60 | 210 |
| LLPS-Poa-0779 | Pongo abelii | 32.88 | 3e-60 | 210 |
| LLPS-Ora-1086 | Ornithorhynchus anatinus | 32.81 | 9e-60 | 208 |
| LLPS-Pes-0453 | Pelodiscus sinensis | 32.78 | 2e-54 | 193 |
| LLPS-Urm-2131 | Ursus maritimus | 32.78 | 2e-54 | 193 |
| LLPS-Sah-3131 | Sarcophilus harrisii | 32.74 | 3e-59 | 207 |
| LLPS-Mod-2199 | Monodelphis domestica | 32.74 | 3e-59 | 207 |
| LLPS-Asm-3827 | Astyanax mexicanus | 32.73 | 1e-59 | 208 |
| LLPS-Xet-0400 | Xenopus tropicalis | 32.73 | 5e-60 | 209 |
| LLPS-Xim-0480 | Xiphophorus maculatus | 32.71 | 4e-59 | 206 |
| LLPS-Pof-0640 | Poecilia formosa | 32.67 | 2e-61 | 213 |
| LLPS-Mal-0444 | Mandrillus leucophaeus | 32.65 | 2e-60 | 210 |
| LLPS-Fia-0880 | Ficedula albicollis | 32.65 | 2e-60 | 210 |
| LLPS-Anp-1615 | Anas platyrhynchos | 32.65 | 2e-60 | 210 |
| LLPS-Tag-2010 | Taeniopygia guttata | 32.65 | 2e-60 | 210 |
| LLPS-Eqc-2346 | Equus caballus | 32.65 | 4e-60 | 210 |
| LLPS-Dar-1873 | Danio rerio | 32.59 | 3e-60 | 210 |
| LLPS-Cea-0684 | Cercocebus atys | 32.57 | 3e-58 | 204 |
| LLPS-Rhb-1514 | Rhinopithecus bieti | 32.56 | 6e-58 | 203 |
| LLPS-Aim-0133 | Ailuropoda melanoleuca | 32.52 | 1e-58 | 207 |
| LLPS-Leo-3064 | Lepisosteus oculatus | 32.5 | 9e-61 | 211 |
| LLPS-Orl-2077 | Oryzias latipes | 32.5 | 9e-60 | 208 |
| LLPS-Scf-1081 | Scleropages formosus | 32.5 | 1e-59 | 208 |
| LLPS-Orn-2905 | Oreochromis niloticus | 32.5 | 9e-60 | 208 |
| LLPS-Scm-3106 | Scophthalmus maximus | 32.5 | 1e-59 | 208 |
| LLPS-Nol-1753 | Nomascus leucogenys | 32.41 | 1e-57 | 202 |
| LLPS-Chs-2232 | Chlorocebus sabaeus | 32.29 | 5e-59 | 206 |
| LLPS-Mea-0236 | Mesocricetus auratus | 32.29 | 5e-59 | 206 |
| LLPS-Maf-3161 | Macaca fascicularis | 32.29 | 2e-58 | 206 |
| LLPS-Orc-0211 | Oryctolagus cuniculus | 32.29 | 4e-59 | 207 |
| LLPS-Gaa-1023 | Gasterosteus aculeatus | 32.27 | 5e-60 | 209 |
| LLPS-Cis-1455 | Ciona savignyi | 32.05 | 7e-61 | 211 |
| LLPS-Abg-0032 | Absidia glauca | 31.97 | 2e-59 | 207 |
| LLPS-Otg-0186 | Otolemur garnettii | 31.9 | 6e-57 | 201 |
| LLPS-Cae-0613 | Caenorhabditis elegans | 31.89 | 6e-58 | 203 |
| LLPS-Cym-0979 | Cyanidioschyzon merolae | 31.71 | 1e-57 | 204 |
| LLPS-Cii-0588 | Ciona intestinalis | 31.52 | 4e-60 | 209 |
| LLPS-Sem-1424 | Selaginella moellendorffii | 31.4 | 3e-58 | 204 |
| LLPS-Orm-0556 | Oryza meridionalis | 31.29 | 1e-54 | 201 |
| LLPS-Drm-0175 | Drosophila melanogaster | 31.14 | 1e-58 | 206 |
| LLPS-Gas-0952 | Galdieria sulphuraria | 30.48 | 5e-57 | 201 |
| LLPS-Crn-0856 | Cryptococcus neoformans | 29.05 | 5e-57 | 201 |
| LLPS-Miv-0072 | Microbotryum violaceum | 28.99 | 4e-53 | 190 |
| LLPS-Pug-1184 | Puccinia graminis | 27.75 | 6e-52 | 187 |