LLPS-Art-1527
SHM4

▼ OVERVIEW

Status: Reviewed
Protein Name: Serine hydroxymethyltransferase 4
Gene Name: SHM4, SHMT4, At4g13930, dl3005c, FCAALL.160
Ensembl Gene: AT4G13930
Ensembl Protein: AT4G13930.1
Organism: Arabidopsis thaliana
Taxa ID: 3702
LLPS Type: Others


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateDescriptionTissue/CellPMIDs
Nucleolus
"...Comparative analysis revealed that 562 proteins were consistently identified in both experimental data sets."
3 weeks-old Arabidopsis thaliana plants29104584
Nucleolus
"...We identified 1602 proteins in the nucleolar and 2544 proteins in the nuclear fraction with an overlap of 1429 proteins."
Arabidopsis thaliana cells26980300

▼ FUNCTION

Catalyzes the interconversion of serine and glycine.

▼ SEQUENCE

Protein Sequence (FASTA)
1     MEPVSSWGNT  SLVSVDPEIH  DLIEKEKRRQ  CRGIELIASE  NFTSFAVIEA  LGSALTNKYS  60
61    EGIPGNRYYG  GNEFIDEIEN  LCRSRALEAF  HCDPAAWGVN  VQPYSGSPAN  FAAYTALLQP  120
121   HDRIMGLDLP  SGGHLTHGYY  TSGGKKISAT  SIYFESLPYK  VNFTTGYIDY  DKLEEKALDF  180
181   RPKLLICGGS  AYPRDWDYAR  FRAIADKVGA  LLLCDMAHIS  GLVAAQEAAN  PFEYCDVVTT  240
241   TTHKSLRGPR  AGMIFYRKGP  KPPKKGQPEG  AVYDFEDKIN  FAVFPALQGG  PHNHQIGALA  300
301   VALKQANTPG  FKVYAKQVKA  NAVALGNYLM  SKGYQIVTNG  TENHLVLWDL  RPLGLTGNKV  360
361   EKLCDLCSIT  LNKNAVFGDS  SALAPGGVRI  GAPAMTSRGL  VEKDFEQIGE  FLSRAVTLTL  420
421   DIQKTYGKLL  KDFNKGLVNN  KDLDQLKADV  EKFSASYEMP  GFLMSEMKYK  D  471
Nucleotide CDS Sequence (FASTA)
1     ATGGAACCAG  TCTCTTCATG  GGGTAACACC  TCTCTCGTCT  CCGTAGATCC  AGAGATCCAC  60
61    GACCTAATCG  AGAAGGAGAA  ACGTCGGCAA  TGTCGAGGAA  TCGAACTTAT  CGCTTCCGAG  120
121   AATTTCACTT  CCTTCGCCGT  CATCGAAGCT  CTCGGAAGTG  CCTTAACCAA  CAAATACTCC  180
181   GAAGGTATTC  CTGGTAATCG  TTATTACGGA  GGTAACGAAT  TCATCGATGA  GATCGAGAAT  240
241   CTTTGCCGTT  CAAGAGCTCT  CGAAGCTTTC  CATTGTGATC  CAGCAGCGTG  GGGCGTTAAT  300
301   GTTCAGCCGT  ATTCTGGATC  TCCGGCAAAT  TTCGCTGCTT  ACACGGCTTT  GCTTCAGCCT  360
361   CACGATCGTA  TCATGGGGCT  TGATTTGCCT  TCAGGTGGTC  ATTTGACTCA  TGGTTACTAT  420
421   ACATCTGGTG  GTAAGAAGAT  CTCTGCGACT  TCGATCTACT  TTGAGAGTCT  TCCGTATAAG  480
481   GTGAATTTCA  CCACTGGTTA  CATTGATTAC  GATAAGCTTG  AAGAGAAGGC  GTTGGATTTC  540
541   AGGCCTAAGT  TGCTTATCTG  TGGTGGTAGT  GCGTATCCTA  GGGATTGGGA  TTACGCTAGA  600
601   TTTAGAGCTA  TTGCTGATAA  GGTTGGAGCT  CTTTTGCTTT  GTGACATGGC  TCACATCAGT  660
661   GGTCTCGTTG  CTGCTCAGGA  AGCTGCAAAC  CCATTTGAGT  ACTGTGACGT  TGTGACAACC  720
721   ACAACCCACA  AGAGTTTGAG  GGGTCCAAGG  GCTGGTATGA  TTTTCTACAG  GAAGGGTCCA  780
781   AAACCACCAA  AGAAGGGTCA  ACCCGAGGGT  GCAGTCTATG  ATTTTGAGGA  CAAAATCAAC  840
841   TTTGCTGTAT  TCCCTGCGCT  TCAAGGTGGT  CCTCACAATC  ACCAGATTGG  TGCTCTAGCT  900
901   GTTGCGTTGA  AGCAGGCTAA  TACTCCTGGG  TTCAAGGTCT  ACGCAAAACA  AGTGAAAGCC  960
961   AATGCTGTTG  CCCTTGGAAA  CTACCTAATG  AGCAAGGGTT  ACCAGATTGT  GACCAATGGA  1020
1021  ACTGAGAACC  ACCTTGTTCT  CTGGGATCTT  CGCCCTCTTG  GATTGACCGG  AAACAAGGTT  1080
1081  GAGAAGCTCT  GCGATCTGTG  CAGCATTACA  TTGAACAAGA  ACGCAGTATT  TGGAGACAGT  1140
1141  AGTGCTCTTG  CTCCTGGAGG  TGTAAGAATC  GGTGCACCCG  CGATGACATC  GAGAGGATTG  1200
1201  GTGGAGAAGG  ACTTTGAGCA  GATAGGAGAA  TTCCTGAGCC  GTGCAGTGAC  ACTGACGTTG  1260
1261  GACATCCAAA  AGACATACGG  TAAGTTGTTG  AAGGACTTCA  ACAAGGGTTT  GGTGAACAAC  1320
1321  AAAGATCTCG  ATCAGCTCAA  GGCTGATGTC  GAGAAGTTCT  CGGCGTCTTA  TGAGATGCCT  1380
1381  GGATTCCTCA  TGTCTGAGAT  GAAGTACAAG  GATTAG  1416

▼ KEYWORD

ID
Family
Acetylation
Complete proteome
Cytoplasm
One-carbon metabolism
Pyridoxal phosphate
Reference proteome
Transferase

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Cytosol
Cellular Component
Membrane
Cellular Component
Plasma membrane
Cellular Component
Plasmodesma
Molecular Function
Amino acid binding
Molecular Function
Cobalt ion binding
Molecular Function
Glycine hydroxymethyltransferase activity
Molecular Function
Pyridoxal phosphate binding
Molecular Function
Serine binding
Molecular Function
Zinc ion binding
Biological Process
Cellular response to tetrahydrofolate
Biological Process
Circadian rhythm
Biological Process
Folic acid metabolic process
Biological Process
Glycine biosynthetic process from serine
Biological Process
Glycine metabolic process
Biological Process
L-serine catabolic process
Biological Process
One-carbon metabolic process
Biological Process
Response to cadmium ion
Biological Process
Tetrahydrofolate interconversion
Biological Process
Tetrahydrofolate metabolic process

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Arl-2442Arabidopsis lyrata98.730.0 943
LLPS-Brn-3127Brassica napus93.420.0 898
LLPS-Bro-2310Brassica oleracea93.420.0 898
LLPS-Brr-0240Brassica rapa93.420.0 895
LLPS-Cus-1033Cucumis sativus91.510.0 880
LLPS-Gor-1873Gossypium raimondii90.680.0 873
LLPS-Prp-1712Prunus persica90.660.0 877
LLPS-Viv-1221Vitis vinifera90.660.0 879
LLPS-Via-2243Vigna angularis90.450.0 875
LLPS-Thc-0545Theobroma cacao90.450.0 879
LLPS-Pot-0564Populus trichocarpa90.230.0 874
LLPS-Met-1291Medicago truncatula90.020.0 867
LLPS-Coc-0456Corchorus capsularis90.020.0 877
LLPS-Sot-2249Solanum tuberosum89.380.0 864
LLPS-Sol-1601Solanum lycopersicum89.380.0 863
LLPS-Nia-1060Nicotiana attenuata89.170.0 853
LLPS-Mae-1446Manihot esculenta88.960.0 868
LLPS-Phv-2293Phaseolus vulgaris88.960.0 859
LLPS-Dac-0638Daucus carota88.320.0 855
LLPS-Amt-1026Amborella trichopoda87.690.0 841
LLPS-Hea-2582Helianthus annuus87.470.0 844
LLPS-Sei-1253Setaria italica87.260.0 847
LLPS-Sob-2031Sorghum bicolor86.20.0 829
LLPS-Zem-0967Zea mays85.990.0 835
LLPS-Brd-1738Brachypodium distachyon85.560.0 827
LLPS-Orbr-0202Oryza brachyantha85.560.0 827
LLPS-Orni-1644Oryza nivara85.380.0 815
LLPS-Lep-1272Leersia perrieri84.930.0 822
LLPS-Orgl-0927Oryza glumaepatula84.930.0 822
LLPS-Orb-0663Oryza barthii84.930.0 822
LLPS-Orr-2053Oryza rufipogon84.930.0 822
LLPS-Orm-0848Oryza meridionalis84.930.0 822
LLPS-Org-0279Oryza glaberrima84.930.0 822
LLPS-Orp-0483Oryza punctata84.930.0 822
LLPS-Ors-1529Oryza sativa84.930.0 822
LLPS-Tra-1518Triticum aestivum84.290.0 818
LLPS-Hov-1258Hordeum vulgare84.080.0 816
LLPS-Glm-1740Glycine max83.670.0 845
LLPS-Mua-0574Musa acuminata82.590.0 777
LLPS-Ori-2278Oryza indica81.950.0 804
LLPS-Sem-2340Selaginella moellendorffii81.240.0 785
LLPS-Php-0788Physcomitrella patens81.120.0 777
LLPS-Tru-0954Triticum urartu80.70.0 802
LLPS-Osl-0908Ostreococcus lucimarinus73.610.0 692
LLPS-Chc-0471Chondrus crispus69.150.0 632
LLPS-Chr-1718Chlamydomonas reinhardtii67.650.0 649
LLPS-Gas-0784Galdieria sulphuraria67.620.0 622
LLPS-Cym-0219Cyanidioschyzon merolae67.040.0 622
LLPS-Crn-0441Cryptococcus neoformans63.160.0 571
LLPS-Spr-1434Sporisorium reilianum62.440.0 584
LLPS-Usm-0618Ustilago maydis62.00.0 580
LLPS-Caf-0064Canis familiaris60.920.0 533
LLPS-Aon-2076Aotus nancymaae60.30.0 551
LLPS-Caj-4755Callithrix jacchus60.30.0 551
LLPS-Paa-0726Papio anubis59.961e-178 516
LLPS-Maf-4336Macaca fascicularis59.963e-178 516
LLPS-Mam-3670Macaca mulatta59.963e-178 516
LLPS-Mal-4235Mandrillus leucophaeus59.910.0 548
LLPS-Poa-3846Pongo abelii59.870.0 548
LLPS-Lac-1839Latimeria chalumnae59.830.0 564
LLPS-Man-4759Macaca nemestrina59.781e-177 514
LLPS-Ten-1134Tetraodon nigroviridis59.740.0 541
LLPS-Cea-1738Cercocebus atys59.732e-178 516
LLPS-Hos-0773Homo sapiens59.733e-177 513
LLPS-Pap-4685Pan paniscus59.734e-177 513
LLPS-Pat-0850Pan troglodytes59.734e-177 513
LLPS-Rhb-3293Rhinopithecus bieti59.732e-178 516
LLPS-Chs-2450Chlorocebus sabaeus59.690.0 546
LLPS-Abg-1181Absidia glauca59.660.0 573
LLPS-Myl-2997Myotis lucifugus59.660.0 550
LLPS-Scm-2054Scophthalmus maximus59.650.0 541
LLPS-Scf-2491Scleropages formosus59.520.0 546
LLPS-Otg-1848Otolemur garnettii59.514e-179 518
LLPS-Asm-1638Astyanax mexicanus59.440.0 545
LLPS-Gog-2559Gorilla gorilla59.440.0 546
LLPS-Loa-0219Loxodonta africana59.440.0 550
LLPS-Fec-3953Felis catus59.440.0 550
LLPS-Xim-1691Xiphophorus maculatus59.310.0 540
LLPS-Xet-3438Xenopus tropicalis59.310.0 547
LLPS-Ran-1760Rattus norvegicus59.32e-176 518
LLPS-Anc-3279Anolis carolinensis59.30.0 538
LLPS-Cas-2133Carlito syrichta59.295e-178 515
LLPS-Aim-3168Ailuropoda melanoleuca59.230.0 550
LLPS-Mum-3405Mus musculus59.230.0 550
LLPS-Mea-0700Mesocricetus auratus59.230.0 553
LLPS-Eqc-3485Equus caballus59.230.0 550
LLPS-Icp-0434Ictalurus punctatus59.220.0 543
LLPS-Tut-0673Tursiops truncatus59.160.0 535
LLPS-Orl-1966Oryzias latipes59.160.0 539
LLPS-Ict-3696Ictidomys tridecemlineatus59.082e-177 514
LLPS-Bot-2589Bos taurus59.010.0 548
LLPS-Fud-2617Fukomys damarensis59.010.0 548
LLPS-Cap-2472Cavia porcellus59.010.0 550
LLPS-Urm-1529Ursus maritimus59.010.0 549
LLPS-Gaa-1164Gasterosteus aculeatus59.00.0 538
LLPS-Leo-0252Lepisosteus oculatus59.00.0 545
LLPS-Fia-3442Ficedula albicollis58.990.0 542
LLPS-Mel-1496Melampsora laricipopulina58.970.0 557
LLPS-Vir-0976Vigna radiata58.960.0 543
LLPS-Cii-1692Ciona intestinalis58.960.0 551
LLPS-Miv-0601Microbotryum violaceum58.950.0 553
LLPS-Mod-0460Monodelphis domestica58.940.0 530
LLPS-Tag-2072Taeniopygia guttata58.850.0 539
LLPS-Pes-1713Pelodiscus sinensis58.820.0 540
LLPS-Mup-3762Mustela putorius furo58.80.0 546
LLPS-Sus-1953Sus scrofa58.720.0 528
LLPS-Pof-2570Poecilia formosa58.660.0 536
LLPS-Put-0470Puccinia triticina58.490.0 545
LLPS-Meg-0026Meleagris gallopavo58.420.0 526
LLPS-Orc-2179Oryctolagus cuniculus58.423e-176 511
LLPS-Dio-3021Dipodomys ordii58.370.0 543
LLPS-Cae-0855Caenorhabditis elegans58.310.0 525
LLPS-Orn-3549Oreochromis niloticus58.280.0 528
LLPS-Dar-0710Danio rerio58.210.0 542
LLPS-Ora-3550Ornithorhynchus anatinus57.840.0 525
LLPS-Cis-1282Ciona savignyi57.670.0 542
LLPS-Tar-2590Takifugu rubripes57.580.0 533
LLPS-Nol-1402Nomascus leucogenys57.245e-177 514
LLPS-Gaga-1352Gallus gallus56.997e-176 509