LLPS-Art-1403
UPP

▼ OVERVIEW

Status: Reviewed
Protein Name: Uracil phosphoribosyltransferase, chloroplastic
Gene Name: UPP, PYRR, At3g53900, F5K20.200
Ensembl Gene: AT3G53900
Ensembl Protein: AT3G53900.1
Organism: Arabidopsis thaliana
Taxa ID: 3702
LLPS Type: Client


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateDescriptionTissue/CellPMIDs
Nucleolus
"...We identified 1602 proteins in the nucleolar and 2544 proteins in the nuclear fraction with an overlap of 1429 proteins."
Arabidopsis thaliana cells26980300

▼ FUNCTION

Uracil phosphoribosyltransferase (UPRT) that catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate. Is probably the only functional UPRT, since the dual-domain proteins of the UKL family seem to lack this activity.

▼ SEQUENCE

Protein Sequence (FASTA)
1     MACSIGNAFR  CSSDTLRFAP  RQQCSSRLNP  NPSSFLSFNS  SPILAQNLGA  SSSSLSRRTI  60
61    RARTKMAASE  ASINGSNRML  VFVPPHPLIK  HWISVLRNEQ  TPCPVFRNAI  AELGRLLMYE  120
121   ASREWLPTVV  GEIMSPMGPA  SVEFIDPREP  IAVVPILRAG  LALAEHASSV  LPANKIYHLG  180
181   VSRDEKTLLP  SVYLNKLPDE  FPKNSRVFLV  DPVLATGGTI  MAAMDLLKER  GLSVQQIKVI  240
241   CAIAAPPALS  KLNEKFPGLH  VYAGIIDPEV  NEKGYIIPGL  GDAGDRSFGT  ETHWVK  296
Nucleotide CDS Sequence (FASTA)
1     ATGGCGTGCT  CAATTGGTAA  CGCTTTCAGG  TGTTCTTCTG  ATACGCTGCG  TTTTGCTCCC  60
61    CGACAACAAT  GCAGCAGCCG  CCTAAACCCT  AATCCTTCCT  CTTTCCTCTC  CTTTAATTCC  120
121   TCCCCAATTC  TCGCACAGAA  TTTGGGTGCT  TCTTCTTCGT  CACTTTCCCG  ACGGACTATA  180
181   CGAGCTAGAA  CAAAAATGGC  TGCGTCGGAG  GCTTCCATTA  ACGGGAGCAA  CAGGATGCTG  240
241   GTCTTTGTGC  CACCACATCC  TTTGATCAAA  CACTGGATCT  CTGTTCTGAG  AAATGAACAA  300
301   ACTCCTTGTC  CTGTTTTCAG  GAATGCAATA  GCTGAACTAG  GGAGATTACT  CATGTATGAA  360
361   GCATCACGAG  AGTGGCTGCC  AACTGTTGTG  GGTGAAATAA  TGTCTCCAAT  GGGTCCTGCT  420
421   TCTGTTGAAT  TCATTGATCC  TAGAGAGCCT  ATTGCGGTTG  TTCCGATATT  AAGAGCTGGT  480
481   CTTGCTCTTG  CGGAACACGC  ATCCTCAGTT  TTACCTGCTA  ATAAAATTTA  TCATTTAGGA  540
541   GTAAGTAGAG  ATGAGAAAAC  ACTTTTACCA  TCGGTGTATC  TTAACAAGTT  GCCTGATGAA  600
601   TTTCCCAAGA  ATTCAAGAGT  ATTTTTGGTC  GACCCAGTGC  TTGCCACAGG  TGGTACCATA  660
661   ATGGCGGCGA  TGGATCTATT  GAAGGAACGT  GGTTTGTCTG  TTCAGCAAAT  CAAAGTGATT  720
721   TGTGCGATTG  CTGCACCTCC  TGCACTATCG  AAGCTTAACG  AGAAATTCCC  CGGGCTTCAT  780
781   GTATATGCTG  GAATTATTGA  TCCTGAAGTC  AATGAAAAGG  GGTACATAAT  CCCTGGGCTT  840
841   GGAGACGCTG  GAGACCGCAG  TTTCGGGACA  GAAACACATT  GGGTGAAGTG  A  891

▼ KEYWORD

ID
Family
Acetylation
Allosteric enzyme
Alternative splicing
Chloroplast
Complete proteome
Glycosyltransferase
GTP-binding
Nucleotide-binding
Plastid
Reference proteome
Transferase
Transit peptide

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Chloroplast
Cellular Component
Chloroplast stroma
Cellular Component
Cytosol
Cellular Component
Plastid
Molecular Function
GTP binding
Molecular Function
Uracil phosphoribosyltransferase activity
Biological Process
Cellular response to phosphate starvation
Biological Process
Developmental process
Biological Process
Nucleoside metabolic process
Biological Process
UMP salvage
Biological Process
Uracil salvage

▼ KEGG


▼ ANNOTATION

Disorder
IUPred2A
PTM
EPSD
Physicochemical
Compute pI/MwAAindex
Function
PIRSF
Localization
COMPARTMENTS
Expression
ArrayExpress

▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Arl-1834Arabidopsis lyrata95.610.0 544
LLPS-Brn-1212Brassica napus85.967e-170 480
LLPS-Brr-2089Brassica rapa85.916e-173 488
LLPS-Bro-2917Brassica oleracea84.544e-172 485
LLPS-Viv-2488Vitis vinifera80.933e-131 379
LLPS-Coc-2360Corchorus capsularis78.798e-133 389
LLPS-Sot-0186Solanum tuberosum78.294e-71 222
LLPS-Nia-0378Nicotiana attenuata78.035e-131 379
LLPS-Sol-2432Solanum lycopersicum77.585e-128 374
LLPS-Glm-1672Glycine max75.426e-130 381
LLPS-Phv-0778Phaseolus vulgaris73.752e-129 377
LLPS-Cus-2006Cucumis sativus73.369e-130 378
LLPS-Dac-2457Daucus carota72.816e-121 353
LLPS-Orbr-1945Oryza brachyantha72.642e-115 338
LLPS-Met-2284Medicago truncatula72.376e-124 363
LLPS-Sob-2362Sorghum bicolor71.862e-118 349
LLPS-Orm-0691Oryza meridionalis71.839e-115 338
LLPS-Mua-2082Musa acuminata71.621e-114 337
LLPS-Pot-1688Populus trichocarpa71.266e-130 379
LLPS-Orgl-1685Oryza glumaepatula71.232e-115 342
LLPS-Ors-1919Oryza sativa71.232e-115 342
LLPS-Brd-1829Brachypodium distachyon71.05e-117 346
LLPS-Zem-0934Zea mays71.02e-115 342
LLPS-Lep-1002Leersia perrieri70.781e-114 340
LLPS-Org-1165Oryza glaberrima70.783e-114 339
LLPS-Hov-1610Hordeum vulgare70.563e-116 344
LLPS-Sei-1584Setaria italica70.463e-120 353
LLPS-Tra-0588Triticum aestivum70.134e-116 343
LLPS-Orp-0361Oryza punctata70.134e-116 345
LLPS-Hea-2083Helianthus annuus70.124e-126 368
LLPS-Tru-0990Triticum urartu69.684e-92 283
LLPS-Amt-0165Amborella trichopoda68.331e-116 344
LLPS-Gor-1095Gossypium raimondii67.469e-133 385
LLPS-Prp-1634Prunus persica67.017e-131 380
LLPS-Via-2296Vigna angularis67.02e-40 145
LLPS-Thc-1829Theobroma cacao66.674e-133 389
LLPS-Mae-1011Manihot esculenta66.214e-130 379
LLPS-Sem-1026Selaginella moellendorffii65.719e-96 288
LLPS-Ori-2063Oryza indica63.62e-102 309
LLPS-Orb-2049Oryza barthii62.741e-91 276
LLPS-Orr-1111Oryza rufipogon61.644e-92 281
LLPS-Orni-2416Oryza nivara60.611e-92 282
LLPS-Php-2159Physcomitrella patens59.763e-94 288
LLPS-Osl-1217Ostreococcus lucimarinus57.554e-90 274
LLPS-Vir-0119Vigna radiata54.513e-78 244
LLPS-Chr-1577Chlamydomonas reinhardtii50.05e-69 222
LLPS-Fus-0930Fusarium solani41.322e-30 119
LLPS-Usm-0684Ustilago maydis38.976e-41 147
LLPS-Crn-0718Cryptococcus neoformans38.943e-42 150
LLPS-Spr-0956Sporisorium reilianum37.384e-39 142
LLPS-Asfu-1218Aspergillus fumigatus36.942e-30 120
LLPS-Pug-1351Puccinia graminis36.544e-38 140
LLPS-Asni-0848Aspergillus niger36.536e-30 118
LLPS-Nef-1281Neosartorya fischeri36.538e-30 118
LLPS-Asc-0456Aspergillus clavatus36.074e-31 122
LLPS-Mel-1313Melampsora laricipopulina35.862e-34 129
LLPS-Miv-0955Microbotryum violaceum35.819e-40 144
LLPS-Ast-0647Aspergillus terreus35.432e-28 114
LLPS-Asn-1609Aspergillus nidulans34.638e-31 121
LLPS-Aso-0683Aspergillus oryzae34.554e-28 113
LLPS-Asf-1289Aspergillus flavus34.554e-28 113
LLPS-Mao-1575Magnaporthe oryzae34.231e-30 120
LLPS-Fuo-0702Fusarium oxysporum32.735e-24 102
LLPS-Map-0985Magnaporthe poae32.146e-26 107
LLPS-Scj-0126Schizosaccharomyces japonicus32.064e-32 123
LLPS-Scp-0607Schizosaccharomyces pombe31.584e-31 121
LLPS-Scc-1264Schizosaccharomyces cryophilus30.811e-24 103