LLPS-Art-1090
COP1

▼ OVERVIEW

Status: Reviewed
Protein Name: E3 ubiquitin-protein ligase COP1; Constitutive photomorphogenesis protein 1; RING-type E3 ubiquitin transferase COP1
Gene Name: COP1, At2g32950, T21L14.11
Ensembl Gene: AT2G32950
Ensembl Protein: AT2G32950.1
Organism: Arabidopsis thaliana
Taxa ID: 3702
LLPS Type: Others
PDB: 5IGO (A, U) More


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateDescriptionTissue/CellPMIDs
Nuclear speckle
"...CSU2 directly interacts with COP1 via their coiled-coil domains and is recruited by COP1 into nuclear speckles in living plant cells."
N/A26714275
Nuclear speckle
"...CFP-CSU1 produced a uniform fluorescence when it was expressed alone, and its localization in the nuclear speckles was detected only when coexpressed with YFP-COP1, suggesting that CSU1 is recruited into the nuclear speckles by COP1 in the dark."
N/A24838976

▼ FUNCTION

E3 ubiquitin-protein ligase that acts as a repressor of photomorphogenesis and as an activator of etiolation in darkness. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Represses photomorphogenesis in darkness by mediating ubiquitination and subsequent proteasomal degradation of light-induced transcription factors such as HY5, HYH and LAF1. Down-regulates MYB21, probably via ubiquitination process. Light stimuli abrogate the repression of photomorphogenesis, possibly due to its localization to the cytoplasm. Could play a role in switching between skotomorphogenetic and photomorphogenetic pathways. Mediates the ubiquitination-dependent degradation of HY5 in the darkness during seedling development (e.g. hypocotyl growth) (PubMed:26474641). Represses CIP7 in darkness (PubMed:9668129).

▼ SEQUENCE

Protein Sequence (FASTA)
1     MEEISTDPVV  PAVKPDPRTS  SVGEGANRHE  NDDGGSGGSE  IGAPDLDKDL  LCPICMQIIK  60
61    DAFLTACGHS  FCYMCIITHL  RNKSDCPCCS  QHLTNNQLYP  NFLLDKLLKK  TSARHVSKTA  120
121   SPLDQFREAL  QRGCDVSIKE  VDNLLTLLAE  RKRKMEQEEA  ERNMQILLDF  LHCLRKQKVD  180
181   ELNEVQTDLQ  YIKEDINAVE  RHRIDLYRAR  DRYSVKLRML  GDDPSTRNAW  PHEKNQIGFN  240
241   SNSLSIRGGN  FVGNYQNKKV  EGKAQGSSHG  LPKKDALSGS  DSQSLNQSTV  SMARKKRIHA  300
301   QFNDLQECYL  QKRRQLADQP  NSKQENDKSV  VRREGYSNGL  ADFQSVLTTF  TRYSRLRVIA  360
361   EIRHGDIFHS  ANIVSSIEFD  RDDELFATAG  VSRCIKVFDF  SSVVNEPADM  QCPIVEMSTR  420
421   SKLSCLSWNK  HEKNHIASSD  YEGIVTVWDV  TTRQSLMEYE  EHEKRAWSVD  FSRTEPSMLV  480
481   SGSDDCKVKV  WCTRQEASVI  NIDMKANICC  VKYNPGSSNY  IAVGSADHHI  HYYDLRNISQ  540
541   PLHVFSGHKK  AVSYVKFLSN  NELASASTDS  TLRLWDVKDN  LPVRTFRGHT  NEKNFVGLTV  600
601   NSEYLACGSE  TNEVYVYHKE  ITRPVTSHRF  GSPDMDDAEE  EAGSYFISAV  CWKSDSPTML  660
661   TANSQGTIKV  LVLAA  675
Nucleotide CDS Sequence (FASTA)
1     ATGTGTCAAA  AACTGCATCG  CCCTTGGATC  AGTTTCGGGA  AGCACTACAA  AGGACAGGGT  60
61    TGTGATGTGT  CAATTAAGGA  GGTTGATAAT  CTTCTGACAC  TTCTTGCGGA  AAGGAAGAGA  120
121   AAAATGGAAC  AGGAAGAAGC  TGAGAGGAAC  ATGCAGATAC  TTTTGGACTT  TTTGCATTGT  180
181   CTAAGGAAGC  AAAAAGTTGA  TGAACTAAAT  GAGGTGCAAA  CTGATCTCCA  GTATATTAAA  240
241   GAAGATATAA  ATGCCGTTGA  GAGACATAGA  ATAGATTTAT  ACCGAGCTAG  GGACAGATAT  300
301   TCTGTAAAGT  TGCGGATGCT  CGGAGATGAT  CCAAGCACAA  GAAATGCATG  GCCACATGAG  360
361   AAGAACCAGA  TTGGTTTCAA  CTCCAATTCT  CTCAGCATAA  GAGGAGGAAA  TTTTGTAGGC  420
421   AATTATCAAA  ACAAAAAGGT  AGAGGGGAAG  GCACAAGGAA  GCTCTCATGG  GCTACCAAAG  480
481   AAGGATGCGC  TGAGTGGGTC  AGATTCGCAA  AGTTTGAATC  AGTCAACTGT  CTCAATGGCT  540
541   AGAAAGAAAC  GGATTCATGC  TCAGTTCAAT  GATTTACAAG  AATGTTACCT  CCAAAAGCGG  600
601   CGTCAGTTGG  CAGACCAACC  AAATAGTAAA  CAAGAAAATG  ATAAGAGTGT  AGTACGGAGG  660
661   GAAGGCTATA  GCAACGGCCT  TGCAGATTTT  CAATCTGTGT  TGACTACCTT  CACTCGCTAC  720
721   AGTCGTCTAA  GAGTTATAGC  AGAAATCCGG  CATGGGGATA  TATTTCATTC  AGCCAACATT  780
781   GTATCAAGCA  TAGAGTTTGA  TCGTGATGAT  GAGCTGTTTG  CCACTGCTGG  TGTTTCTAGA  840
841   TGTATAAAGG  TTTTTGACTT  CTCTTCGGTT  GTAAATGAAC  CAGCAGATAT  GCAGTGTCCG  900
901   ATTGTGGAGA  TGTCAACTCG  GTCTAAACTT  AGTTGCTTGA  GTTGGAATAA  GCATGAAAAA  960
961   AATCACATAG  CAAGCAGTGA  TTATGAAGGA  ATAGTAACAG  TGTGGGATGT  AACTACTAGG  1020
1021  CAGAGTCTTA  TGGAGTATGA  AGAGCACGAA  AAACGTGCCT  GGAGTGTTGA  CTTTTCACGA  1080
1081  ACAGAACCAT  CAATGCTTGT  ATCTGGTAGT  GACGACTGCA  AGGTTAAAGT  TTGGTGCACG  1140
1141  AGGCAGGAAG  CAAGTGTGAT  TAATATTGAT  ATGAAAGCAA  ACATATGTTG  TGTCAAGTAC  1200
1201  AATCCTGGCT  CAAGCAACTA  CATTGCGGTC  GGATCAGCTG  ATCATCACAT  CCATTATTAC  1260
1261  GATCTAAGAA  ACATAAGCCA  ACCACTTCAT  GTCTTCAGTG  GACACAAGAA  AGCAGTTTCC  1320
1321  TATGTTAAAT  TTTTGTCCAA  CAACGAGCTC  GCTTCTGCGT  CCACAGATAG  CACACTACGC  1380
1381  TTATGGGATG  TCAAAGACAA  CTTGCCAGTT  CGAACATTCA  GAGGACATAC  TAACGAGAAG  1440
1441  AACTTTGTGG  GTCTCACAGT  GAACAGCGAG  TATCTCGCCT  GTGGAAGCGA  GACAAACGAA  1500
1501  GTATATGTAT  ATCACAAGGA  AATCACGAGA  CCCGTGACAT  CGCACAGATT  TGGATCGCCA  1560
1561  GACATGGACG  ATGCAGAGGA  AGAGGCAGGT  TCCTACTTTA  TTAGTGCGGT  TTGCTGGAAG  1620
1621  AGTGATAGTC  CCACGATGTT  GACTGCGAAT  AGTCAAGGAA  CCATCAAAGT  TCTGGTACTC  1680
1681  GCTGCGTGA  1689

▼ KEYWORD

ID
Family
3D-structure
Coiled coil
Complete proteome
Cytoplasm
Metal-binding
Nucleus
Phytochrome signaling pathway
Reference proteome
Repeat
Transferase
Ubl conjugation
Ubl conjugation pathway
WD repeat
Zinc
Zinc-finger

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Cul4-RING E3 ubiquitin ligase complex
Cellular Component
Cytoplasm
Cellular Component
Nuclear body
Cellular Component
Nuclear ubiquitin ligase complex
Cellular Component
Nucleus
Molecular Function
Identical protein binding
Molecular Function
Metal ion binding
Molecular Function
Ubiquitin protein ligase activity
Molecular Function
Ubiquitin-protein transferase activity
Biological Process
Anthocyanin-containing compound metabolic process
Biological Process
DNA repair
Biological Process
Entrainment of circadian clock
Biological Process
Photomorphogenesis
Biological Process
Photoperiodism, flowering
Biological Process
Red, far-red light phototransduction
Biological Process
Regulation of stomatal movement
Biological Process
Shade avoidance
Biological Process
Skotomorphogenesis

▼ KEGG


▼ ANNOTATION

Disorder
IUPred2A
Physicochemical
Compute pI/MwAAindex
Structure
PDB
Localization
COMPARTMENTSNLSdb

▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Arl-1043Arabidopsis lyrata97.930.01392
LLPS-Brn-1494Brassica napus94.390.01335
LLPS-Bro-1761Brassica oleracea94.080.01334
LLPS-Brr-0481Brassica rapa93.210.01311
LLPS-Via-1333Vigna angularis85.170.0 575
LLPS-Gor-0503Gossypium raimondii80.990.01145
LLPS-Thc-2262Theobroma cacao79.390.01132
LLPS-Mae-0114Manihot esculenta78.610.01118
LLPS-Glm-1334Glycine max77.910.01100
LLPS-Viv-1544Vitis vinifera77.650.0 984
LLPS-Met-0074Medicago truncatula77.50.01095
LLPS-Prp-0849Prunus persica77.430.01082
LLPS-Pot-0626Populus trichocarpa77.40.01101
LLPS-Nia-0787Nicotiana attenuata77.170.01074
LLPS-Phv-1600Phaseolus vulgaris76.910.01087
LLPS-Sol-0665Solanum lycopersicum76.50.01073
LLPS-Coc-1192Corchorus capsularis75.660.0 959
LLPS-Vir-1146Vigna radiata75.320.01072
LLPS-Mua-1660Musa acuminata75.00.0 979
LLPS-Cus-2090Cucumis sativus74.740.01049
LLPS-Sob-1297Sorghum bicolor74.330.0 977
LLPS-Amt-0819Amborella trichopoda74.220.01031
LLPS-Orbr-2111Oryza brachyantha74.010.0 966
LLPS-Sot-1388Solanum tuberosum73.790.01023
LLPS-Sei-0134Setaria italica73.320.0 972
LLPS-Tra-1871Triticum aestivum73.170.0 972
LLPS-Orm-0680Oryza meridionalis72.940.0 894
LLPS-Tru-0459Triticum urartu72.920.0 952
LLPS-Orb-0774Oryza barthii72.770.0 946
LLPS-Lep-0290Leersia perrieri72.20.0 948
LLPS-Brd-1842Brachypodium distachyon72.130.0 951
LLPS-Dac-1637Daucus carota71.340.0 972
LLPS-Zem-1339Zea mays70.990.0 999
LLPS-Ors-1851Oryza sativa70.180.0 972
LLPS-Orr-0443Oryza rufipogon70.180.0 972
LLPS-Org-0441Oryza glaberrima70.180.0 972
LLPS-Orni-1152Oryza nivara70.180.0 972
LLPS-Orgl-1130Oryza glumaepatula70.180.0 972
LLPS-Orp-1742Oryza punctata70.120.0 971
LLPS-Ori-0711Oryza indica69.340.0 896
LLPS-Hea-0710Helianthus annuus68.820.0 972
LLPS-Php-2403Physcomitrella patens62.660.0 882
LLPS-Sem-0154Selaginella moellendorffii62.070.0 797
LLPS-Osl-0842Ostreococcus lucimarinus46.776e-86 279
LLPS-Scm-3074Scophthalmus maximus46.685e-112 358
LLPS-Sah-1424Sarcophilus harrisii46.323e-113 352
LLPS-Dio-2164Dipodomys ordii44.742e-118 368
LLPS-Chr-1214Chlamydomonas reinhardtii44.413e-82 288
LLPS-Caf-3442Canis familiaris40.123e-150 461
LLPS-Pes-1908Pelodiscus sinensis39.942e-146 446
LLPS-Ict-2460Ictidomys tridecemlineatus39.944e-150 457
LLPS-Mum-1107Mus musculus39.942e-149 459
LLPS-Fud-0055Fukomys damarensis39.942e-150 458
LLPS-Ran-0253Rattus norvegicus39.942e-149 458
LLPS-Mod-0847Monodelphis domestica39.885e-149 457
LLPS-Eqc-3263Equus caballus39.882e-149 458
LLPS-Aim-0365Ailuropoda melanoleuca39.881e-149 455
LLPS-Hos-3599Homo sapiens39.851e-149 459
LLPS-Pat-0812Pan troglodytes39.851e-149 459
LLPS-Man-0229Macaca nemestrina39.854e-150 460
LLPS-Poa-1140Pongo abelii39.851e-149 459
LLPS-Nol-3832Nomascus leucogenys39.858e-150 459
LLPS-Maf-1657Macaca fascicularis39.854e-150 460
LLPS-Gog-3252Gorilla gorilla39.851e-149 459
LLPS-Mal-1189Mandrillus leucophaeus39.854e-150 460
LLPS-Mea-0760Mesocricetus auratus39.812e-148 455
LLPS-Fia-1919Ficedula albicollis39.782e-148 452
LLPS-Loa-0782Loxodonta africana39.722e-148 455
LLPS-Orc-3470Oryctolagus cuniculus39.713e-144 441
LLPS-Pap-3943Pan paniscus39.694e-147 452
LLPS-Lac-0252Latimeria chalumnae39.698e-152 464
LLPS-Chs-0996Chlorocebus sabaeus39.691e-148 457
LLPS-Caj-0852Callithrix jacchus39.691e-148 456
LLPS-Icp-1846Ictalurus punctatus39.663e-154 469
LLPS-Rhb-1981Rhinopithecus bieti39.641e-141 438
LLPS-Fec-0912Felis catus39.636e-150 459
LLPS-Cap-0351Cavia porcellus39.636e-149 459
LLPS-Sus-3510Sus scrofa39.632e-149 458
LLPS-Tar-0594Takifugu rubripes39.67e-149 456
LLPS-Otg-3390Otolemur garnettii39.552e-142 440
LLPS-Ova-2250Ovis aries39.551e-143 441
LLPS-Dar-2365Danio rerio39.545e-152 464
LLPS-Ora-0676Ornithorhynchus anatinus39.522e-139 428
LLPS-Ten-1112Tetraodon nigroviridis39.482e-149 456
LLPS-Leo-3116Lepisosteus oculatus39.481e-145 448
LLPS-Orn-3211Oreochromis niloticus39.453e-149 457
LLPS-Tag-2454Taeniopygia guttata39.455e-148 451
LLPS-Paa-2556Papio anubis39.392e-143 443
LLPS-Asm-1697Astyanax mexicanus39.361e-151 463
LLPS-Mup-0501Mustela putorius furo39.351e-141 434
LLPS-Meg-1235Meleagris gallopavo39.299e-141 431
LLPS-Anp-2035Anas platyrhynchos39.293e-141 432
LLPS-Myl-1580Myotis lucifugus39.293e-139 427
LLPS-Aon-3557Aotus nancymaae39.265e-147 452
LLPS-Urm-2326Ursus maritimus39.232e-139 430
LLPS-Cii-1672Ciona intestinalis39.225e-146 447
LLPS-Gaa-1580Gasterosteus aculeatus39.25e-149 457
LLPS-Bot-1423Bos taurus39.161e-143 444
LLPS-Anc-2996Anolis carolinensis39.043e-147 454
LLPS-Pof-0548Poecilia formosa38.921e-146 450
LLPS-Xim-1982Xiphophorus maculatus38.868e-147 451
LLPS-Gaga-2604Gallus gallus38.621e-137 427
LLPS-Xet-2059Xenopus tropicalis38.511e-149 458
LLPS-Orl-1247Oryzias latipes38.271e-150 460
LLPS-Cea-3188Cercocebus atys37.941e-137 429
LLPS-Gas-0474Galdieria sulphuraria37.242e-120 377
LLPS-Chc-0584Chondrus crispus36.799e-111 357
LLPS-Abg-1840Absidia glauca35.947e-118 389
LLPS-Cym-0921Cyanidioschyzon merolae35.291e-102 339
LLPS-Pyt-0875Pyrenophora teres29.942e-1480.5
LLPS-Mam-4089Macaca mulatta28.574e-1480.1
LLPS-Cas-2604Carlito syrichta28.574e-1480.1
LLPS-Scf-3191Scleropages formosus28.574e-1583.2
LLPS-Asn-1010Aspergillus nidulans28.363e-1479.0
LLPS-Cis-1455Ciona savignyi27.651e-1480.5
LLPS-Fus-0445Fusarium solani27.613e-1583.2
LLPS-Trr-1107Trichoderma reesei27.481e-1479.7
LLPS-Cae-0613Caenorhabditis elegans26.925e-1582.0
LLPS-Cogr-0494Colletotrichum graminicola26.221e-1480.9
LLPS-Asc-1321Aspergillus clavatus26.142e-1479.7
LLPS-Nec-0266Neurospora crassa25.61e-1584.3
LLPS-Crn-0856Cryptococcus neoformans25.567e-1684.7
LLPS-Ved-0626Verticillium dahliae25.172e-1480.5
LLPS-Map-0981Magnaporthe poae24.853e-1478.6
LLPS-Drm-0662Drosophila melanogaster24.812e-1479.0
LLPS-Mao-1040Magnaporthe oryzae24.313e-1478.6