DrLLPS - Data resource of LLPS

LLPS-Art-0901
SKP1A

▼ OVERVIEW


Status:	Reviewed
Protein Name:	SKP1-like protein 1A
Gene Name:	SKP1A, ASK1, SKP1, UIP1, At1g75950, T4O12.17
Ensembl Gene:	AT1G75950
Ensembl Protein:	AT1G75950.1
Organism:	Arabidopsis thaliana
Taxa ID:	3702
LLPS Type:	Others

PDB: 3OGM (A, B, Q) More

▼ PROPERTY

——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:

Condensate	Description	Tissue/Cell	PMIDs
Nucleolus	"...We identified 1602 proteins in the nucleolar and 2544 proteins in the nuclear fraction with an overlap of 1429 proteins."	Arabidopsis thaliana cells	26980300

▼ FUNCTION

Involved in ubiquitination and subsequent proteasomal degradation of target proteins. Together with CUL1, RBX1 and a F-box protein, it forms a SCF E3 ubiquitin ligase complex. The functional specificity of this complex depends on the type of F-box protein. In the SCF complex, it serves as an adapter that links the F-box protein to CUL1. SCF(UFO) is required for vegetative and floral organ development as well as for male gametogenesis. SCF(TIR1) is involved in auxin signaling pathway. SCF(COI1) regulates responses to jasmonates. SCF(EID1) and SCF(AFR) are implicated in phytochrome A light signaling. SCF(ADO1), SCF(ADO2), SCF(ADO3) are related to the circadian clock. SCF(ORE9) seems to be involved in senescence. SCF(EBF1/EBF2) may regulate ethylene signaling. Plays a role during embryogenesis and early postembryonic development, especially during cell elongation and division. Contributes to the correct chromosome segregation during tetrad formation.

▼ CROSS REFERENCE

Database	Nucleotide ID	Protein ID
Ensembl	AT1G75950.1	AT1G75950.1
UniProt		Q39255, SKP1A_ARATH, P92992
GeneBank	U97020, AF059294, AC007396, U70034, U60981, CP002684, AY113971, AY080884	AAB38862.1, AAB17535.1, AAL87354.1, AAM45019.1, AAC14444.1, AEE35780.1, AAF26761.1, AAC63109.1
RefSeq	NM_106245.5	NP_565123.1

▼ SEQUENCE

Protein Sequence (FASTA)
1 MSAKKIVLKS SDGESFEVEE AVALESQTIA HMVEDDCVDN GVPLPNVTSK ILAKVIEYCK 60 61 RHVEAAASKA EAVEGAATSD DDLKAWDADF MKIDQATLFE LILAANYLNI KNLLDLTCQT 120 121 VADMIKGKTP EEIRTTFNIK NDFTPEEEEE VRRENQWAFE 160
Nucleotide CDS Sequence (FASTA)
1 ATGTCTGCGA AGAAGATTGT GTTGAAGAGT TCCGATGGTG AATCTTTCGA GGTTGAGGAG 60 61 GCGGTGGCTC TCGAGTCACA AACCATAGCG CATATGGTTG AAGACGACTG CGTCGACAAC 120 121 GGAGTCCCTC TTCCTAACGT CACGAGCAAG ATCCTCGCCA AGGTGATCGA GTATTGCAAG 180 181 AGGCACGTCG AGGCTGCTGC CTCTAAGGCC GAGGCCGTCG AGGGTGCTGC TACCTCCGAT 240 241 GACGATCTTA AGGCCTGGGA CGCTGATTTT ATGAAGATCG ATCAAGCTAC TCTCTTTGAA 300 301 CTCATTCTGG CTGCTAATTA CCTGAATATC AAGAACTTGC TTGATCTAAC ATGTCAGACA 360 361 GTTGCGGATA TGATCAAAGG AAAGACTCCA GAAGAGATCC GCACAACGTT CAACATTAAG 420 421 AACGACTTCA CACCAGAGGA AGAGGAAGAG GTTCGCAGAG AGAACCAATG GGCTTTTGAA 480 481 TGA 483

▼ KEYWORD

ID	Family
KW-0002	3D-structure
KW-0927	Auxin signaling pathway
KW-0159	Chromosome partition
KW-0181	Complete proteome
KW-0963	Cytoplasm
KW-0206	Cytoskeleton
KW-0217	Developmental protein
KW-0936	Ethylene signaling pathway
KW-0945	Host-virus interaction
KW-0539	Nucleus
KW-1185	Reference proteome
KW-0833	Ubl conjugation pathway

▼ GENE ONTOLOGY

ID	Classification	Description
GO:0005829	Cellular Component	Cytosol
GO:0005634	Cellular Component	Nucleus
GO:0009524	Cellular Component	Phragmoplast
GO:0005886	Cellular Component	Plasma membrane
GO:0005819	Cellular Component	Spindle
GO:0009734	Biological Process	Auxin-activated signaling pathway
GO:0007059	Biological Process	Chromosome segregation
GO:0009873	Biological Process	Ethylene-activated signaling pathway
GO:0000226	Biological Process	Microtubule cytoskeleton organization
GO:0007275	Biological Process	Multicellular organism development
GO:0045910	Biological Process	Negative regulation of DNA recombination
GO:0016567	Biological Process	Protein ubiquitination
GO:0046686	Biological Process	Response to cadmium ion
GO:0006511	Biological Process	Ubiquitin-dependent protein catabolic process
GO:0016032	Biological Process	Viral process

▼ KEGG

ath:AT1G75950

▼ ANNOTATION

Disorder
IUPred2A

Domain
SMART	Pfam	InterPro	LCR-eXXXplorer	CDD
Gene3D

PTM
EPSD	dbPTM	PTMcode

Interaction
HINT	Mentha	PINA	iRefIndex

Physicochemical
Compute pI/Mw	AAindex

Function
CGDB	PIRSF

Structure
PDB	MMDB

Localization
COMPARTMENTS	NLSdb

▼ ORTHOLOGY

DrLLPS ID	Organism	Identity	E-value	Score
LLPS-Brn-1683	Brassica napus	93.12	4e-89	264
LLPS-Brr-0783	Brassica rapa	93.12	5e-90	266
LLPS-Bro-1120	Brassica oleracea	93.12	5e-90	266
LLPS-Glm-2163	Glycine max	83.02	1e-80	243
LLPS-Prp-2540	Prunus persica	83.02	1e-80	242
LLPS-Mae-0302	Manihot esculenta	82.5	6e-82	246
LLPS-Thc-0282	Theobroma cacao	81.13	6e-80	241
LLPS-Vir-0415	Vigna radiata	81.13	2e-79	239
LLPS-Via-1742	Vigna angularis	81.13	2e-79	239
LLPS-Phv-0323	Phaseolus vulgaris	81.13	2e-79	239
LLPS-Gor-0839	Gossypium raimondii	81.13	2e-80	242
LLPS-Mua-1151	Musa acuminata	80.38	2e-80	242
LLPS-Nia-0036	Nicotiana attenuata	79.87	3e-77	234
LLPS-Lep-1355	Leersia perrieri	79.63	2e-66	207
LLPS-Orbr-1795	Oryza brachyantha	78.75	4e-69	213
LLPS-Sot-0039	Solanum tuberosum	78.71	1e-74	227
LLPS-Dac-1204	Daucus carota	78.62	9e-71	217
LLPS-Met-1004	Medicago truncatula	78.62	1e-77	234
LLPS-Pot-0772	Populus trichocarpa	78.62	3e-78	236
LLPS-Sol-0723	Solanum lycopersicum	77.99	8e-76	230
LLPS-Coc-1135	Corchorus capsularis	77.99	2e-75	229
LLPS-Amt-1090	Amborella trichopoda	76.43	3e-75	229
LLPS-Viv-0677	Vitis vinifera	76.1	1e-74	227
LLPS-Tru-1748	Triticum urartu	75.47	5e-73	223
LLPS-Orp-0487	Oryza punctata	75.3	2e-65	204
LLPS-Sob-2024	Sorghum bicolor	75.18	1e-60	191
LLPS-Tra-0154	Triticum aestivum	75.16	1e-72	222
LLPS-Arl-1522	Arabidopsis lyrata	74.85	1e-76	233
LLPS-Sem-0458	Selaginella moellendorffii	73.08	9e-67	207
LLPS-Php-0886	Physcomitrella patens	72.5	3e-69	214
LLPS-Brd-0400	Brachypodium distachyon	71.7	5e-68	210
LLPS-Hea-0033	Helianthus annuus	70.44	1e-69	214
LLPS-Cus-0264	Cucumis sativus	70.44	1e-69	214
LLPS-Orni-1842	Oryza nivara	69.7	4e-66	206
LLPS-Ori-1825	Oryza indica	69.7	4e-66	206
LLPS-Orgl-0709	Oryza glumaepatula	69.7	9e-66	205
LLPS-Ors-0776	Oryza sativa	69.7	4e-66	206
LLPS-Sei-0841	Setaria italica	69.51	8e-67	207
LLPS-Orm-0106	Oryza meridionalis	69.51	5e-66	206
LLPS-Orb-0830	Oryza barthii	69.09	3e-65	204
LLPS-Org-1757	Oryza glaberrima	69.09	1e-65	205
LLPS-Orr-0351	Oryza rufipogon	69.03	2e-60	191
LLPS-Chr-0774	Chlamydomonas reinhardtii	67.09	1e-59	189
LLPS-Osl-0178	Ostreococcus lucimarinus	65.19	1e-56	181
LLPS-Hov-0435	Hordeum vulgare	64.71	1e-67	210
LLPS-Rhb-0063	Rhinopithecus bieti	58.49	4e-48	160
LLPS-Zem-0564	Zea mays	58.08	5e-52	173
LLPS-Lac-1955	Latimeria chalumnae	57.05	3e-46	155
LLPS-Gog-1987	Gorilla gorilla	56.88	2e-47	157
LLPS-Fud-0419	Fukomys damarensis	56.88	4e-47	158
LLPS-Mum-0437	Mus musculus	56.88	2e-47	157
LLPS-Maf-0558	Macaca fascicularis	56.88	2e-47	157
LLPS-Orl-0389	Oryzias latipes	56.88	2e-47	157
LLPS-Sus-1715	Sus scrofa	56.88	2e-47	157
LLPS-Leo-0960	Lepisosteus oculatus	56.88	2e-47	157
LLPS-Aon-2463	Aotus nancymaae	56.88	2e-47	157
LLPS-Paa-0113	Papio anubis	56.88	2e-47	157
LLPS-Myl-1810	Myotis lucifugus	56.88	2e-47	157
LLPS-Aim-0434	Ailuropoda melanoleuca	56.88	2e-47	157
LLPS-Mup-2268	Mustela putorius furo	56.88	2e-47	157
LLPS-Xim-0018	Xiphophorus maculatus	56.88	2e-47	157
LLPS-Tut-0413	Tursiops truncatus	56.88	2e-47	157
LLPS-Tar-0950	Takifugu rubripes	56.88	4e-45	152
LLPS-Gaa-0031	Gasterosteus aculeatus	56.88	2e-47	157
LLPS-Dio-1137	Dipodomys ordii	56.88	2e-47	157
LLPS-Scf-2969	Scleropages formosus	56.88	2e-47	157
LLPS-Bot-3730	Bos taurus	56.88	2e-47	157
LLPS-Otg-1415	Otolemur garnettii	56.88	2e-47	157
LLPS-Pes-0111	Pelodiscus sinensis	56.88	2e-47	157
LLPS-Orc-0837	Oryctolagus cuniculus	56.88	2e-47	157
LLPS-Fia-1009	Ficedula albicollis	56.88	2e-47	157
LLPS-Orn-2134	Oreochromis niloticus	56.88	2e-47	157
LLPS-Meg-2443	Meleagris gallopavo	56.88	2e-47	157
LLPS-Hos-1265	Homo sapiens	56.88	2e-47	157
LLPS-Dar-0450	Danio rerio	56.88	2e-47	158
LLPS-Pap-0273	Pan paniscus	56.88	2e-47	157
LLPS-Urm-0793	Ursus maritimus	56.88	2e-47	157
LLPS-Pof-1608	Poecilia formosa	56.88	2e-47	157
LLPS-Pat-3134	Pan troglodytes	56.88	2e-47	157
LLPS-Mod-3055	Monodelphis domestica	56.88	2e-47	157
LLPS-Fec-0436	Felis catus	56.88	2e-47	157
LLPS-Man-0139	Macaca nemestrina	56.88	2e-47	158
LLPS-Loa-1311	Loxodonta africana	56.88	2e-47	157
LLPS-Anp-0462	Anas platyrhynchos	56.88	2e-47	157
LLPS-Cas-0508	Carlito syrichta	56.88	2e-47	157
LLPS-Xet-0391	Xenopus tropicalis	56.88	2e-47	157
LLPS-Gaga-1303	Gallus gallus	56.88	2e-47	157
LLPS-Nol-0939	Nomascus leucogenys	56.88	2e-47	157
LLPS-Anc-0747	Anolis carolinensis	56.88	2e-47	157
LLPS-Ict-0273	Ictidomys tridecemlineatus	56.88	2e-47	157
LLPS-Tag-1158	Taeniopygia guttata	56.88	2e-47	157
LLPS-Caf-2141	Canis familiaris	56.88	6e-47	156
LLPS-Ten-0576	Tetraodon nigroviridis	56.88	5e-45	152
LLPS-Poa-0614	Pongo abelii	56.88	2e-47	157
LLPS-Eqc-1185	Equus caballus	56.88	2e-47	157
LLPS-Cis-0570	Ciona savignyi	56.6	4e-48	159
LLPS-Asm-1206	Astyanax mexicanus	56.25	2e-45	152
LLPS-Chs-1903	Chlorocebus sabaeus	56.25	9e-47	156
LLPS-Scm-0383	Scophthalmus maximus	56.25	2e-44	152
LLPS-Gas-0195	Galdieria sulphuraria	55.77	2e-45	152
LLPS-Cea-1336	Cercocebus atys	55.76	8e-48	159
LLPS-Ran-0353	Rattus norvegicus	55.76	1e-47	159
LLPS-Mal-0652	Mandrillus leucophaeus	55.76	8e-48	159
LLPS-Mam-1355	Macaca mulatta	55.56	2e-44	150
LLPS-Cii-0336	Ciona intestinalis	55.35	2e-47	157
LLPS-Icp-0470	Ictalurus punctatus	54.78	3e-44	151
LLPS-Drm-1029	Drosophila melanogaster	54.09	6e-42	144
LLPS-Caj-0649	Callithrix jacchus	53.85	1e-40	140
LLPS-Yal-0014	Yarrowia lipolytica	53.8	7e-43	146
LLPS-Blg-0853	Blumeria graminis	53.5	2e-42	145
LLPS-Cap-1906	Cavia porcellus	53.46	1e-40	140
LLPS-Sac-0231	Saccharomyces cerevisiae	52.99	1e-31	118
LLPS-Chc-0293	Chondrus crispus	52.94	9e-41	140
LLPS-Cae-0282	Caenorhabditis elegans	52.8	2e-40	140
LLPS-Spr-0680	Sporisorium reilianum	52.6	3e-43	147
LLPS-Put-0027	Puccinia triticina	52.34	1e-33	125
LLPS-Tum-0378	Tuber melanosporum	52.26	9e-42	143
LLPS-Scc-1029	Schizosaccharomyces cryophilus	51.92	2e-39	137
LLPS-Beb-0963	Beauveria bassiana	51.57	1e-40	140
LLPS-Mel-0664	Melampsora laricipopulina	51.3	2e-41	142
LLPS-Scs-0438	Sclerotinia sclerotiorum	51.28	2e-40	140
LLPS-Asn-0789	Aspergillus nidulans	51.25	9e-42	143
LLPS-Abg-1210	Absidia glauca	50.96	7e-37	139
LLPS-Miv-0198	Microbotryum violaceum	50.94	8e-43	146
LLPS-Pug-0269	Puccinia graminis	50.65	1e-41	143
LLPS-Usm-0119	Ustilago maydis	50.65	3e-39	136
LLPS-Scj-0064	Schizosaccharomyces japonicus	50.64	3e-38	134
LLPS-Scp-1277	Schizosaccharomyces pombe	50.64	3e-39	137
LLPS-Nef-0616	Neosartorya fischeri	50.61	7e-40	138
LLPS-Asfu-0702	Aspergillus fumigatus	50.61	7e-40	138
LLPS-Crn-1270	Cryptococcus neoformans	50.6	1e-40	140
LLPS-Map-0015	Magnaporthe poae	50.31	5e-43	146
LLPS-Asc-0162	Aspergillus clavatus	50.3	3e-39	136
LLPS-Fuv-1060	Fusarium verticillioides	50.0	1e-41	143
LLPS-Cog-0335	Colletotrichum gloeosporioides	50.0	3e-40	139
LLPS-Fuo-0220	Fusarium oxysporum	50.0	9e-42	143
LLPS-Asf-0102	Aspergillus flavus	49.7	4e-41	142
LLPS-Aso-0618	Aspergillus oryzae	49.7	4e-41	142
LLPS-Gag-0499	Gaeumannomyces graminis	49.69	5e-43	147
LLPS-Mea-1887	Mesocricetus auratus	49.67	2e-35	126
LLPS-Fus-0309	Fusarium solani	49.07	1e-39	138
LLPS-Mao-0227	Magnaporthe oryzae	49.06	9e-43	146
LLPS-Cogr-0801	Colletotrichum graminicola	49.06	6e-39	136
LLPS-Lem-0099	Leptosphaeria maculans	49.03	2e-39	137
LLPS-Ast-0850	Aspergillus terreus	48.81	8e-40	138
LLPS-Nec-0710	Neurospora crassa	48.43	3e-41	142
LLPS-Dos-0272	Dothistroma septosporum	48.39	2e-37	132
LLPS-Coo-0177	Colletotrichum orbiculare	47.83	2e-37	132
LLPS-Pyt-0446	Pyrenophora teres	47.8	2e-39	137
LLPS-Pytr-0841	Pyrenophora triticirepentis	47.8	1e-39	138
LLPS-Zyt-0048	Zymoseptoria tritici	47.74	2e-36	129
LLPS-Phn-0746	Phaeosphaeria nodorum	47.44	2e-37	132
LLPS-Trv-0467	Trichoderma virens	46.91	2e-38	135
LLPS-Cym-0383	Cyanidioschyzon merolae	46.54	1e-39	138
LLPS-Trr-0210	Trichoderma reesei	46.3	1e-37	133
LLPS-Ved-0243	Verticillium dahliae	46.3	5e-39	136
LLPS-Ova-1505	Ovis aries	46.29	2e-40	140
LLPS-Ora-0282	Ornithorhynchus anatinus	44.23	1e-17	79.3
LLPS-Asg-0291	Ashbya gossypii	44.19	1e-33	123
LLPS-Kop-1052	Komagataella pastoris	42.86	3e-32	119

LLPS-Art-0901SKP1A

Protein Sequence

Nucleotide Sequence

LLPS-Art-0901
SKP1A