LLPS-Art-0757
CLF

▼ OVERVIEW


Status: Reviewed
Protein Name: Histone-lysine N-methyltransferase CLF; Polycomb group protein CURLY LEAF; Protein INCURVATA 1; Protein SET DOMAIN GROUP 1; Protein photoperiod insensitive flowering
Gene Name: CLF, ICU1, PIF1, PIF2, SDG1, SET1, At2g23380, F26B6.3
Ensembl Gene: AT2G23380
Ensembl Protein: AT2G23380.1
Organism: Arabidopsis thaliana
Taxa ID: 3702
LLPS Type: Client


▼ PROPERTY



——— Disorder propensity (calculated by IUPred2A)

▼ Classification


Condensates:
CondensateDescriptionTissue/CellPMIDs
Nuclear speckle
"...However, when PWO1-mCherry was coexpressed with GFP-CLF, one-third of nuclei showed speckle formation for GFP-CLF, which largely overlap with the PWO1 speckles."
N/A29330200
ChromatinPredicted from orthologsN/A(View)

▼ FUNCTION


Polycomb group (PcG) protein. Catalytic subunit of some PcG multiprotein complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target genes. Required to regulate floral development by repressing the AGAMOUS homeotic gene in leaves, influorescence stems and flowers. Regulates the antero-posterior organization of the endosperm, as well as the division and elongation rates of leaf cells. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development.

▼ CROSS REFERENCE


▼ SEQUENCE


Protein Sequence (FASTA)
1     MASEASPSSS  ATRSEPPKDS  PAEERGPASK  EVSEVIESLK  KKLAADRCIS  IKKRIDENKK  60
61    NLFAITQSFM  RSSMERGGSC  KDGSDLLVKR  QRDSPGMKSG  IDESNNNRYV  EDGPASSGMV  120
121   QGSSVPVKIS  LRPIKMPDIK  RLSPYTTWVF  LDRNQRMTED  QSVVGRRRIY  YDQTGGEALI  180
181   CSDSEEEAID  DEEEKRDFLE  PEDYIIRMTL  EQLGLSDSVL  AELASFLSRS  TSEIKARHGV  240
241   LMKEKEVSES  GDNQAESSLL  NKDMEGALDS  FDNLFCRRCL  VFDCRLHGCS  QDLIFPAEKP  300
301   APWCPPVDEN  LTCGANCYKT  LLKSGRFPGY  GTIEGKTGTS  SDGAGTKTTP  TKFSSKLNGR  360
361   KPKTFPSESA  SSNEKCALET  SDSENGLQQD  TNSDKVSSSP  KVKGSGRRVG  RKRNKNRVAE  420
421   RVPRKTQKRQ  KKTEASDSDS  IASGSCSPSD  AKHKDNEDAT  SSSQKHVKSG  NSGKSRKNGT  480
481   PAEVSNNSVK  DDVPVCQSNE  VASELDAPGS  DESLRKEEFM  GETVSRGRLA  TNKLWRPLEK  540
541   SLFDKGVEIF  GMNSCLIARN  LLSGFKSCWE  VFQYMTCSEN  KASFFGGDGL  NPDGSSKFDI  600
601   NGNMVNNQVR  RRSRFLRRRG  KVRRLKYTWK  SAAYHSIRKR  ITEKKDQPCR  QFNPCNCKIA  660
661   CGKECPCLLN  GTCCEKYCGC  PKSCKNRFRG  CHCAKSQCRS  RQCPCFAADR  ECDPDVCRNC  720
721   WVIGGDGSLG  VPSQRGDNYE  CRNMKLLLKQ  QQRVLLGISD  VSGWGAFLKN  SVSKHEYLGE  780
781   YTGELISHKE  ADKRGKIYDR  ENCSFLFNLN  DQFVLDAYRK  GDKLKFANHS  PEPNCYAKVI  840
841   MVAGDHRVGI  FAKERILAGE  ELFYDYRYEP  DRAPAWAKKP  EAPGSKKDEN  VTPSVGRPKK  900
901   LA  902
Nucleotide CDS Sequence (FASTA)
1     ATGAACACCG  ACCATCTTAT  ACAGGCAAGA  CATGGAGTGC  TTATGAAGGA  AAAAGAAGTA  60
61    TCCGAGAGTG  GCGATAATCA  AGCAGAGAGC  TCCCTTCTCA  ACAAAGATAT  GGAAGGAGCA  120
121   TTAGATTCTT  TCGATAACCT  GTTCTGCCGT  AGATGCCTTG  TATTTGATTG  CCGGCTTCAT  180
181   GGGTGTTCAC  AGGATCTCAT  TTTTCCGGCT  GAGAAACCAG  CTCCATGGTG  TCCTCCTGTA  240
241   GATGAAAATT  TAACCTGTGG  TGCAAACTGC  TATAAAACGC  TTCTCAAGTC  TGGAAGATTT  300
301   CCGGGATATG  GCACCATTGA  AGGTAAAACT  GGCACTTCAT  CAGATGGTGC  AGGTACTAAA  360
361   ACCACACCCA  CGAAGTTCTC  CAGCAAACTT  AATGGGAGAA  AACCAAAGAC  CTTCCCAAGT  420
421   GAAAGTGCAT  CGTCTAATGA  AAAGTGCGCA  CTAGAAACAA  GTGACTCAGA  GAATGGACTA  480
481   CAGCAGGATA  CCAATTCCGA  TAAAGTTTCA  TCATCGCCAA  AGGTGAAAGG  TAGTGGGAGA  540
541   CGAGTAGGTC  GTAAGAGGAA  CAAAAACCGA  GTTGCTGAGC  GAGTTCCTCG  TAAGACTCAG  600
601   AAGAGGCAGA  AGAAGACAGA  AGCCTCGGAT  AGTGATTCCA  TCGCCAGTGG  AAGTTGTTCA  660
661   CCCAGCGATG  CAAAACATAA  AGATAATGAA  GATGCTACTT  CCTCTTCTCA  GAAGCATGTA  720
721   AAATCTGGGA  ACTCCGGGAA  GTCAAGGAAG  AATGGCACTC  CTGCCGAAGT  CTCCAATAAT  780
781   TCTGTGAAGG  ATGACGTTCC  TGTTTGCCAG  TCAAATGAGG  TTGCGTCAGA  GCTTGATGCG  840
841   CCGGGTAGTG  ATGAAAGTCT  AAGGAAAGAA  GAGTTTATGG  GTGAAACTGT  ATCTCGAGGA  900
901   AGATTGGCTA  CAAATAAGTT  GTGGAGACCA  CTTGAGAAAA  GCCTTTTTGA  TAAAGGTGTT  960
961   GAGATTTTTG  GAATGAATAG  CTGCTTGATT  GCTAGAAATC  TTTTGAGTGG  TTTCAAATCA  1020
1021  TGTTGGGAGG  TCTTCCAATA  CATGACGTGC  TCGGAAAATA  AAGCTTCCTT  CTTTGGAGGT  1080
1081  GATGGATTGA  ATCCTGATGG  CTCTTCCAAG  TTCGATATCA  ATGGAAATAT  GGTTAATAAC  1140
1141  CAAGTGAGGA  GAAGGTCAAG  ATTTCTACGT  AGGAGAGGCA  AAGTGCGGCG  CTTGAAGTAT  1200
1201  ACCTGGAAGT  CTGCTGCATA  TCATTCAATT  AGGAAAAGAA  TTACTGAGAA  GAAAGACCAG  1260
1261  CCCTGCCGTC  AGTTTAATCC  ATGTAACTGC  AAAATTGCTT  GTGGGAAGGA  ATGTCCTTGT  1320
1321  TTGCTAAACG  GGACTTGCTG  CGAGAAGTAC  TGCGGTTGCC  CAAAGAGCTG  CAAGAATAGG  1380
1381  TTTAGAGGTT  GTCATTGTGC  CAAAAGTCAG  TGTCGAAGCC  GCCAGTGTCC  ATGCTTTGCT  1440
1441  GCAGATCGGG  AATGTGACCC  AGATGTTTGT  AGAAACTGCT  GGGTCATTGG  TGGGGATGGT  1500
1501  TCGCTTGGGG  TCCCAAGCCA  AAGAGGCGAT  AATTATGAGT  GCAGGAATAT  GAAATTGCTC  1560
1561  CTGAAACAAC  AACAAAGGGT  TTTACTTGGA  ATATCTGATG  TTTCTGGTTG  GGGAGCTTTC  1620
1621  TTAAAGAACA  GTGTAAGTAA  GCATGAATAC  CTTGGGGAAT  ACACAGGAGA  GCTGATCTCA  1680
1681  CATAAAGAGG  CAGATAAACG  CGGGAAGATA  TACGATCGCG  AGAACTGCTC  TTTTCTCTTC  1740
1741  AATCTAAACG  ATCAGTTTGT  GCTAGATGCT  TACAGGAAAG  GAGATAAACT  GAAATTCGCC  1800
1801  AACCATTCTC  CTGAACCTAA  CTGTTACGCA  AAGGTCATCA  TGGTTGCTGG  AGATCACAGG  1860
1861  GTGGGGATCT  TCGCAAAAGA  GAGGATACTG  GCTGGAGAAG  AACTATTTTA  CGATTACCGG  1920
1921  TATGAGCCAG  ATCGAGCTCC  AGCTTGGGCC  AAAAAACCTG  AAGCTCCTGG  TTCTAAGAAA  1980
1981  GACGAAAATG  TTACACCTTC  TGTTGGTAGA  CCCAAGAAGC  TTGCTTAG  2028

▼ KEYWORD


ID
Family
Chromatin regulator
Complete proteome
Developmental protein
Differentiation
Flowering
Methyltransferase
Nucleus
Reference proteome
Repressor
S-adenosyl-L-methionine
Transcription
Transcription regulation
Transferase

▼ GENE ONTOLOGY


ID
Classification
Description
Cellular Component
Chromatin silencing complex
Cellular Component
Nucleus
Cellular Component
PcG protein complex
Molecular Function
DNA-binding transcription factor activity
Molecular Function
Histone-lysine N-methyltransferase activity
Molecular Function
Single-stranded RNA binding
Biological Process
Cell differentiation
Biological Process
Chromatin silencing
Biological Process
DNA mediated transformation
Biological Process
Flower development
Biological Process
Histone H3-K27 methylation
Biological Process
Histone methylation
Biological Process
Leaf morphogenesis
Biological Process
Negative regulation of molecular function, epigenetic
Biological Process
Regulation of gene expression by genetic imprinting
Biological Process
Regulation of long-day photoperiodism, flowering
Biological Process
Vegetative to reproductive phase transition of meristem

▼ KEGG



▼ ORTHOLOGY


DrLLPS IDOrganismIdentityE-valueScore
LLPS-Arl-1107Arabidopsis lyrata93.80.01519
LLPS-Tru-0667Triticum urartu88.133e-127 389
LLPS-Brn-0725Brassica napus87.090.01401
LLPS-Lep-1254Leersia perrieri87.082e-91 314
LLPS-Bro-0345Brassica oleracea87.010.01408
LLPS-Brr-1937Brassica rapa86.980.01405
LLPS-Vir-1590Vigna radiata74.442e-70 256
LLPS-Mua-2337Musa acuminata69.540.0 595
LLPS-Pot-1407Populus trichocarpa69.198e-155 484
LLPS-Coc-1312Corchorus capsularis69.118e-152 496
LLPS-Amt-1483Amborella trichopoda69.093e-162 503
LLPS-Thc-0303Theobroma cacao68.836e-158 493
LLPS-Gor-0687Gossypium raimondii68.831e-156 489
LLPS-Sob-0544Sorghum bicolor68.292e-154 484
LLPS-Phv-1076Phaseolus vulgaris68.114e-153 479
LLPS-Zem-0694Zea mays67.22e-121 397
LLPS-Sei-0589Setaria italica66.679e-156 488
LLPS-Prp-0362Prunus persica66.675e-150 473
LLPS-Mae-2572Manihot esculenta66.311e-103 348
LLPS-Ori-0001Oryza indica66.34e-152 471
LLPS-Ors-0213Oryza sativa66.32e-150 474
LLPS-Org-0080Oryza glaberrima66.128e-149 469
LLPS-Orbr-1896Oryza brachyantha65.695e-152 478
LLPS-Php-0896Physcomitrella patens64.977e-151 478
LLPS-Sem-1477Selaginella moellendorffii64.818e-156 486
LLPS-Brd-1607Brachypodium distachyon64.815e-145 455
LLPS-Ten-3681Tetraodon nigroviridis64.664e-43 171
LLPS-Dac-0789Daucus carota64.567e-154 480
LLPS-Viv-2272Vitis vinifera63.430.0 965
LLPS-Cus-2247Cucumis sativus63.050.0 999
LLPS-Glm-0157Glycine max62.250.0 963
LLPS-Met-2047Medicago truncatula61.672e-151 474
LLPS-Via-1478Vigna angularis60.450.0 939
LLPS-Sot-0472Solanum tuberosum60.134e-155 484
LLPS-Sol-1011Solanum lycopersicum59.471e-156 479
LLPS-Hea-2354Helianthus annuus59.440.0 875
LLPS-Nia-1733Nicotiana attenuata59.010.0 877
LLPS-Tra-1169Triticum aestivum55.852e-142 450
LLPS-Orb-1914Oryza barthii55.732e-109 364
LLPS-Orgl-0726Oryza glumaepatula55.731e-109 365
LLPS-Orr-0983Oryza rufipogon55.733e-109 365
LLPS-Orni-2230Oryza nivara55.623e-107 360
LLPS-Orp-1663Oryza punctata55.477e-110 365
LLPS-Hov-0080Hordeum vulgare55.417e-141 445
LLPS-Orm-0899Oryza meridionalis54.770.0 804
LLPS-Pes-1113Pelodiscus sinensis53.854e-65 238
LLPS-Icp-0400Ictalurus punctatus52.296e-67 244
LLPS-Asm-1161Astyanax mexicanus52.291e-66 243
LLPS-Scm-3782Scophthalmus maximus52.291e-66 243
LLPS-Lac-1131Latimeria chalumnae52.293e-67 244
LLPS-Anc-1754Anolis carolinensis52.292e-67 245
LLPS-Cas-0409Carlito syrichta52.293e-67 244
LLPS-Gaa-0015Gasterosteus aculeatus52.274e-65 238
LLPS-Tar-2354Takifugu rubripes51.265e-69 249
LLPS-Orl-1301Oryzias latipes50.847e-68 247
LLPS-Xim-2215Xiphophorus maculatus50.844e-68 247
LLPS-Pof-0500Poecilia formosa50.842e-68 248
LLPS-Cii-1166Ciona intestinalis49.389e-66 228
LLPS-Cis-0736Ciona savignyi47.544e-63 232
LLPS-Cym-0161Cyanidioschyzon merolae44.964e-51 196
LLPS-Chr-0804Chlamydomonas reinhardtii43.041e-47 186
LLPS-Tum-0609Tuber melanosporum42.922e-49 180
LLPS-Anp-0482Anas platyrhynchos42.351e-69 249
LLPS-Meg-0684Meleagris gallopavo42.352e-69 250
LLPS-Orn-3027Oreochromis niloticus42.345e-1997.4
LLPS-Osl-0372Ostreococcus lucimarinus42.317e-58 218
LLPS-Tag-3405Taeniopygia guttata42.183e-69 245
LLPS-Mod-1190Monodelphis domestica42.066e-69 250
LLPS-Cap-0110Cavia porcellus42.014e-69 249
LLPS-Caj-4622Callithrix jacchus41.962e-67 245
LLPS-Fud-2527Fukomys damarensis41.766e-69 249
LLPS-Gog-1006Gorilla gorilla41.769e-69 249
LLPS-Aon-3712Aotus nancymaae41.761e-68 249
LLPS-Sah-1281Sarcophilus harrisii41.761e-68 249
LLPS-Cea-2768Cercocebus atys41.761e-68 248
LLPS-Chs-0350Chlorocebus sabaeus41.761e-68 248
LLPS-Mum-1863Mus musculus41.762e-68 248
LLPS-Maf-0930Macaca fascicularis41.761e-68 248
LLPS-Mea-0648Mesocricetus auratus41.765e-69 249
LLPS-Ova-0939Ovis aries41.767e-69 249
LLPS-Myl-0565Myotis lucifugus41.767e-69 249
LLPS-Aim-2555Ailuropoda melanoleuca41.761e-68 248
LLPS-Mup-2993Mustela putorius furo41.766e-69 249
LLPS-Mal-2806Mandrillus leucophaeus41.769e-69 249
LLPS-Paa-3769Papio anubis41.761e-68 248
LLPS-Ran-0390Rattus norvegicus41.761e-68 248
LLPS-Dio-1429Dipodomys ordii41.763e-69 248
LLPS-Rhb-2261Rhinopithecus bieti41.761e-68 248
LLPS-Orc-3160Oryctolagus cuniculus41.761e-68 249
LLPS-Fia-0470Ficedula albicollis41.761e-68 248
LLPS-Otg-0659Otolemur garnettii41.769e-69 249
LLPS-Loa-0470Loxodonta africana41.768e-69 249
LLPS-Man-0130Macaca nemestrina41.761e-68 249
LLPS-Fec-0072Felis catus41.761e-68 250
LLPS-Hos-4564Homo sapiens41.761e-68 248
LLPS-Pat-2846Pan troglodytes41.761e-68 248
LLPS-Ict-1765Ictidomys tridecemlineatus41.768e-69 249
LLPS-Eqc-0625Equus caballus41.768e-69 249
LLPS-Caf-2571Canis familiaris41.767e-69 249
LLPS-Poa-0846Pongo abelii41.767e-69 248
LLPS-Chc-1051Chondrus crispus41.542e-47 188
LLPS-Mam-4411Macaca mulatta41.521e-67 245
LLPS-Pap-2821Pan paniscus41.253e-67 244
LLPS-Xet-2618Xenopus tropicalis41.123e-67 244
LLPS-Dar-0311Danio rerio40.832e-66 243
LLPS-Leo-0653Lepisosteus oculatus40.532e-67 245
LLPS-Sus-1252Sus scrofa40.471e-67 245
LLPS-Urm-0824Ursus maritimus40.472e-67 245
LLPS-Ora-3308Ornithorhynchus anatinus40.181e-67 245
LLPS-Bot-0250Bos taurus40.187e-68 246
LLPS-Nol-2628Nomascus leucogenys40.189e-68 246
LLPS-Gaga-0403Gallus gallus40.187e-68 246
LLPS-Drm-0723Drosophila melanogaster39.648e-1997.1
LLPS-Cae-0527Caenorhabditis elegans38.711e-44 177
LLPS-Scf-2987Scleropages formosus38.522e-67 245
LLPS-Scs-0357Sclerotinia sclerotiorum37.444e-37 154
LLPS-Dos-1136Dothistroma septosporum37.385e-39 149
LLPS-Gas-1045Galdieria sulphuraria37.261e-29 130
LLPS-Pytr-1420Pyrenophora triticirepentis36.366e-35 148
LLPS-Pyt-0533Pyrenophora teres36.251e-34 147
LLPS-Zyt-0238Zymoseptoria tritici35.49e-37 144
LLPS-Phn-0143Phaeosphaeria nodorum34.985e-34 140
LLPS-Lem-0113Leptosphaeria maculans34.293e-31 136
LLPS-Ved-1417Verticillium dahliae33.475e-26 119
LLPS-Trv-0083Trichoderma virens33.474e-27 123
LLPS-Coo-0679Colletotrichum orbiculare32.923e-27 123
LLPS-Map-0924Magnaporthe poae32.652e-23 111
LLPS-Nec-1250Neurospora crassa32.566e-23 110
LLPS-Cogr-0456Colletotrichum graminicola32.513e-26 120
LLPS-Mao-0637Magnaporthe oryzae32.392e-23 111
LLPS-Gag-0532Gaeumannomyces graminis32.229e-23 109
LLPS-Cog-0306Colletotrichum gloeosporioides31.694e-25 116
LLPS-Fus-0631Fusarium solani31.547e-27 122
LLPS-Fuo-0422Fusarium oxysporum31.152e-25 117
LLPS-Pug-0708Puccinia graminis31.087e-2098.6
LLPS-Trr-0478Trichoderma reesei30.554e-25 116
LLPS-Beb-0824Beauveria bassiana30.512e-25 117
LLPS-Crn-0979Cryptococcus neoformans27.548e-2099.4