LLPS-Art-0222
DDL

▼ OVERVIEW

Status: Reviewed
Protein Name: FHA domain-containing protein DDL; Protein DAWDLE
Gene Name: DDL, At3g20550, K10D20.9
Ensembl Gene: AT3G20550
Ensembl Protein: AT3G20550.1
Organism: Arabidopsis thaliana
Taxa ID: 3702
LLPS Type: Others
PDB: 3VPY (A) More


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateDescriptionTissue/CellPMIDs
Nucleolus
"...We identified 1602 proteins in the nucleolar and 2544 proteins in the nuclear fraction with an overlap of 1429 proteins."
Arabidopsis thaliana cells26980300

▼ FUNCTION

Involved in the microRNA (miRNA) and short interfering RNA (siRNA) biogenesis. May facilitate DCL1 to access or recognize primary miRNAs. Binds RNA non-specifically.

▼ CROSS REFERENCE

▼ SEQUENCE

Protein Sequence (FASTA)
1     MAPSSRSPSP  RTKRLRRARG  EKEIGRSRER  EDDGREREKR  NSRERDRDIG  RDRDRERKGE  60
61    GERDREVGDK  RRRSGREDTE  KRRRTRTDDE  RYSRGRHERS  TSPSDRSHRS  SRRSPERAIA  120
121   SRHDEGSNAR  GGSEEPNVEE  DSVARMRAVE  EALAAKKKEE  PSFELSGKLA  EETNRYRGIT  180
181   LLFNEPPEAR  KPSERWRLYV  FKDGEPLNEP  LCLHRQSCYL  FGRERRIADI  PTDHPSCSKQ  240
241   HAVIQYREME  KEKPDGMMGK  QVKPYIMDLG  STNKTYINES  PIEPQRYYEL  FEKDTIKFGN  300
301   SSREYVLLHE  NSAE  314
Nucleotide CDS Sequence (FASTA)
1     ATGGCTCCTA  GTTCTAGGTC  TCCTTCACCA  CGTACGAAGA  GACTGAGAAG  AGCTCGAGGA  60
61    GAGAAGGAAA  TTGGGAGAAG  TAGAGAGAGA  GAAGATGATG  GTAGAGAAAG  GGAGAAGAGA  120
121   AACAGTAGGG  AAAGGGATAG  AGATATAGGA  AGAGATAGGG  ATAGGGAGAG  AAAAGGAGAA  180
181   GGAGAAAGAG  ATAGGGAAGT  TGGGGATAAG  AGAAGACGAT  CAGGGAGAGA  GGATACTGAA  240
241   AAAAGGAGAA  GGACAAGAAC  AGATGATGAG  AGATACTCTA  GAGGAAGACA  TGAGAGGTCT  300
301   ACTTCACCGT  CAGATAGGAG  TCACAGGAGT  AGTAGGCGTT  CACCTGAAAG  AGCTATTGCC  360
361   TCAAGGCATG  ATGAGGGGTC  TAATGCAAGA  GGGGGCAGCG  AGGAGCCAAA  TGTCGAGGAA  420
421   GATTCAGTCG  CGAGAATGAG  AGCAGTTGAA  GAGGCTCTGG  CAGCGAAGAA  AAAGGAAGAA  480
481   CCATCATTTG  AGCTATCAGG  GAAACTTGCT  GAAGAAACTA  ACAGATACAG  AGGTATCACA  540
541   CTCCTCTTCA  ATGAGCCCCC  AGAGGCTAGA  AAACCCAGCG  AACGATGGAG  ACTGTATGTT  600
601   TTTAAGGATG  GTGAACCACT  GAATGAGCCA  CTCTGCCTTC  ACCGCCAAAG  CTGCTACCTC  660
661   TTTGGACGTG  AAAGAAGGAT  TGCCGACATT  CCTACGGATC  ACCCATCTTG  CAGCAAGCAG  720
721   CATGCTGTCA  TTCAGTACCG  GGAAATGGAA  AAGGAGAAAC  CAGATGGTAT  GATGGGGAAG  780
781   CAAGTGAAGC  CTTACATAAT  GGATCTTGGT  AGTACCAACA  AAACTTATAT  CAATGAAAGT  840
841   CCCATTGAGC  CACAAAGATA  TTATGAGCTT  TTTGAGAAAG  ACACCATAAA  GTTTGGCAAC  900
901   AGCAGCCGAG  AGTACGTACT  GTTGCACGAG  AATTCTGCCG  AGTGA  945

▼ KEYWORD

ID
Family
3D-structure
Complete proteome
Nucleus
Phosphoprotein
Reference proteome
RNA-binding
RNA-mediated gene silencing

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Chloroplast
Cellular Component
Cytosol
Cellular Component
Nucleus
Molecular Function
MRNA binding
Molecular Function
RNA binding
Biological Process
Cell population proliferation
Biological Process
Production of miRNAs involved in gene silencing by miRNA
Biological Process
Regulation of developmental growth

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Arl-0350Arabidopsis lyrata97.769e-133 387
LLPS-Bro-0999Brassica oleracea86.87e-111 332
LLPS-Brr-0455Brassica rapa86.83e-111 332
LLPS-Brn-2889Brassica napus86.86e-111 332
LLPS-Org-1216Oryza glaberrima82.566e-46 157
LLPS-Mua-2080Musa acuminata79.433e-92 286
LLPS-Vir-0979Vigna radiata78.533e-84 261
LLPS-Sot-1902Solanum tuberosum78.532e-93 288
LLPS-Sol-0333Solanum lycopersicum77.976e-92 290
LLPS-Phv-1895Phaseolus vulgaris77.91e-94 292
LLPS-Met-1741Medicago truncatula77.892e-98 300
LLPS-Php-1269Physcomitrella patens77.781e-83 263
LLPS-Pot-1008Populus trichocarpa76.293e-96 297
LLPS-Glm-0145Glycine max75.92e-95 295
LLPS-Orbr-1228Oryza brachyantha75.866e-86 273
LLPS-Hea-0081Helianthus annuus75.792e-94 292
LLPS-Hov-1742Hordeum vulgare75.291e-83 268
LLPS-Orp-0347Oryza punctata75.281e-84 272
LLPS-Orgl-0406Oryza glumaepatula75.282e-88 273
LLPS-Orni-0424Oryza nivara75.284e-84 275
LLPS-Cus-1364Cucumis sativus75.263e-97 298
LLPS-Nia-2239Nicotiana attenuata75.138e-94 295
LLPS-Lep-0527Leersia perrieri74.713e-85 271
LLPS-Dac-2183Daucus carota74.712e-79 256
LLPS-Viv-2327Vitis vinifera74.486e-98 301
LLPS-Mae-1358Manihot esculenta73.61e-87 267
LLPS-Amt-0550Amborella trichopoda72.962e-87 284
LLPS-Coc-1909Corchorus capsularis72.865e-88 275
LLPS-Via-1975Vigna angularis72.869e-95 292
LLPS-Sei-0210Setaria italica72.042e-86 276
LLPS-Prp-0688Prunus persica71.436e-90 282
LLPS-Sob-0903Sorghum bicolor71.052e-88 281
LLPS-Ors-1326Oryza sativa70.836e-87 275
LLPS-Orb-1563Oryza barthii70.837e-87 276
LLPS-Tra-1779Triticum aestivum70.313e-84 270
LLPS-Thc-1728Theobroma cacao70.01e-58 201
LLPS-Orr-1181Oryza rufipogon69.663e-76 249
LLPS-Gor-1429Gossypium raimondii69.415e-59 200
LLPS-Brd-0960Brachypodium distachyon69.315e-83 265
LLPS-Icp-0201Ictalurus punctatus66.893e-64 213
LLPS-Anc-3644Anolis carolinensis66.451e-64 213
LLPS-Dar-1643Danio rerio66.457e-63 210
LLPS-Leo-2124Lepisosteus oculatus66.457e-65 215
LLPS-Myl-1033Myotis lucifugus66.013e-63 211
LLPS-Ict-3382Ictidomys tridecemlineatus65.791e-63 213
LLPS-Nol-3247Nomascus leucogenys65.795e-63 211
LLPS-Gaga-2499Gallus gallus65.792e-63 211
LLPS-Cas-3086Carlito syrichta65.792e-63 212
LLPS-Eqc-3203Equus caballus65.793e-63 211
LLPS-Cap-2727Cavia porcellus65.792e-63 212
LLPS-Poa-2540Pongo abelii65.794e-63 211
LLPS-Orn-3134Oreochromis niloticus65.797e-64 212
LLPS-Rhb-0490Rhinopithecus bieti65.794e-63 211
LLPS-Otg-0628Otolemur garnettii65.792e-63 212
LLPS-Loa-2745Loxodonta africana65.793e-63 211
LLPS-Pat-0521Pan troglodytes65.793e-63 211
LLPS-Pap-2275Pan paniscus65.793e-63 211
LLPS-Meg-0367Meleagris gallopavo65.795e-64 211
LLPS-Hos-3095Homo sapiens65.792e-63 212
LLPS-Mup-0955Mustela putorius furo65.791e-63 213
LLPS-Ova-2862Ovis aries65.799e-64 213
LLPS-Ran-2959Rattus norvegicus65.797e-64 213
LLPS-Bot-2654Bos taurus65.794e-63 212
LLPS-Scf-1595Scleropages formosus65.791e-63 212
LLPS-Dio-1033Dipodomys ordii65.796e-64 212
LLPS-Tut-0757Tursiops truncatus65.792e-63 212
LLPS-Caj-4402Callithrix jacchus65.791e-63 212
LLPS-Asm-0305Astyanax mexicanus65.796e-64 212
LLPS-Fud-3335Fukomys damarensis65.792e-63 212
LLPS-Gog-2729Gorilla gorilla65.793e-63 211
LLPS-Aon-0311Aotus nancymaae65.793e-63 211
LLPS-Chs-0161Chlorocebus sabaeus65.794e-63 211
LLPS-Mea-3334Mesocricetus auratus65.797e-64 213
LLPS-Mum-2463Mus musculus65.792e-63 212
LLPS-Tag-0887Taeniopygia guttata65.131e-62 208
LLPS-Mam-3679Macaca mulatta65.132e-62 209
LLPS-Caf-0656Canis familiaris65.135e-63 211
LLPS-Fia-2108Ficedula albicollis65.135e-62 207
LLPS-Orc-2481Oryctolagus cuniculus65.136e-63 211
LLPS-Anp-1442Anas platyrhynchos65.131e-63 209
LLPS-Man-0660Macaca nemestrina65.132e-62 209
LLPS-Fec-0194Felis catus65.136e-63 211
LLPS-Pof-2494Poecilia formosa65.131e-63 211
LLPS-Aim-1117Ailuropoda melanoleuca65.136e-63 211
LLPS-Mal-1546Mandrillus leucophaeus65.131e-62 210
LLPS-Paa-1531Papio anubis65.131e-62 210
LLPS-Ere-0417Erinaceus europaeus65.132e-63 209
LLPS-Tar-2298Takifugu rubripes65.132e-62 208
LLPS-Cea-3172Cercocebus atys65.131e-62 209
LLPS-Sah-3304Sarcophilus harrisii65.131e-63 210
LLPS-Maf-2961Macaca fascicularis65.132e-62 209
LLPS-Ten-1692Tetraodon nigroviridis64.473e-62 207
LLPS-Lac-1333Latimeria chalumnae64.473e-62 208
LLPS-Mod-2565Monodelphis domestica64.471e-61 208
LLPS-Gaa-1111Gasterosteus aculeatus64.471e-59 201
LLPS-Orl-1772Oryzias latipes64.472e-63 211
LLPS-Xim-2353Xiphophorus maculatus63.829e-63 206
LLPS-Sem-1089Selaginella moellendorffii62.141e-53 178
LLPS-Cii-2145Ciona intestinalis61.827e-1675.5
LLPS-Pes-2710Pelodiscus sinensis61.543e-55 188
LLPS-Sus-3477Sus scrofa60.86e-65 216
LLPS-Pug-0853Puccinia graminis60.02e-28 115
LLPS-Xet-0009Xenopus tropicalis59.683e-46 163
LLPS-Cae-0894Caenorhabditis elegans59.311e-54 186
LLPS-Cis-0460Ciona savignyi58.973e-54 188
LLPS-Zem-0735Zea mays58.623e-77 253
LLPS-Drm-0608Drosophila melanogaster57.799e-56 192
LLPS-Miv-0783Microbotryum violaceum55.332e-48 171
LLPS-Scm-1182Scophthalmus maximus55.031e-60 204
LLPS-Crn-1561Cryptococcus neoformans54.977e-52 178
LLPS-Put-0713Puccinia triticina54.611e-45 164
LLPS-Asfu-0203Aspergillus fumigatus53.97e-41 150
LLPS-Nef-0048Neosartorya fischeri53.91e-41 152
LLPS-Asn-0307Aspergillus nidulans53.254e-42 154
LLPS-Abg-1290Absidia glauca52.981e-47 166
LLPS-Chr-0584Chlamydomonas reinhardtii52.761e-48 174
LLPS-Mel-1531Melampsora laricipopulina52.632e-26 106
LLPS-Asc-1634Aspergillus clavatus51.951e-41 152
LLPS-Usm-0632Ustilago maydis51.638e-45 162
LLPS-Gas-0220Galdieria sulphuraria50.664e-41 150
LLPS-Ast-0335Aspergillus terreus49.358e-38 142
LLPS-Spr-0345Sporisorium reilianum49.023e-44 160
LLPS-Osl-1222Ostreococcus lucimarinus48.392e-39 142
LLPS-Zyt-0551Zymoseptoria tritici48.033e-39 146
LLPS-Nec-0417Neurospora crassa48.01e-34 134
LLPS-Beb-1643Beauveria bassiana47.737e-33 129
LLPS-Lem-0258Leptosphaeria maculans47.444e-36 139
LLPS-Asni-1448Aspergillus niger47.42e-35 136
LLPS-Fuo-1452Fusarium oxysporum47.379e-35 135
LLPS-Tum-1123Tuber melanosporum47.339e-38 141
LLPS-Mao-0937Magnaporthe oryzae47.16e-37 140
LLPS-Fuv-1375Fusarium verticillioides47.023e-34 133
LLPS-Pyt-1501Pyrenophora teres46.796e-34 134
LLPS-Asf-1044Aspergillus flavus46.451e-35 137
LLPS-Pytr-1598Pyrenophora triticirepentis46.11e-31 127
LLPS-Aso-1292Aspergillus oryzae45.815e-35 135
LLPS-Gag-1262Gaeumannomyces graminis45.811e-35 137
LLPS-Cogr-1375Colletotrichum graminicola45.451e-34 134
LLPS-Fus-1563Fusarium solani45.455e-35 134
LLPS-Map-0952Magnaporthe poae45.249e-1576.6
LLPS-Ved-1256Verticillium dahliae45.161e-33 130
LLPS-Coo-0805Colletotrichum orbiculare44.677e-33 133
LLPS-Trr-1510Trichoderma reesei44.528e-33 129
LLPS-Cog-0969Colletotrichum gloeosporioides44.526e-35 134
LLPS-Dos-0749Dothistroma septosporum44.083e-34 132
LLPS-Blg-1106Blumeria graminis44.04e-30 120
LLPS-Trv-0417Trichoderma virens43.872e-32 127
LLPS-Yal-0947Yarrowia lipolytica36.31e-2197.1
LLPS-Ori-2242Oryza indica33.611e-1272.4
LLPS-Urm-0014Ursus maritimus33.337e-1269.3
LLPS-Ora-0023Ornithorhynchus anatinus33.071e-1064.7
LLPS-Kop-0534Komagataella pastoris32.062e-1372.0
LLPS-Asg-0070Ashbya gossypii30.03e-1269.3