LLPS-Art-0075
PTP1
▼ OVERVIEW
| Status: | Reviewed |
| Protein Name: | Protein-tyrosine-phosphatase PTP1; Protein tyrosine phosphatase 1; AtPTP1 |
| Gene Name: | PTP1, At1g71860, F14O23.24 |
| Ensembl Gene: | AT1G71860 |
| Ensembl Protein: | AT1G71860.3 |
| Organism: | Arabidopsis thaliana |
| Taxa ID: | 3702 |
| LLPS Type: | Others |
▼ Classification
Condensates:
| Condensate | Description | Tissue/Cell | PMIDs |
|---|---|---|---|
| Nucleolus | "...We identified 1602 proteins in the nucleolar and 2544 proteins in the nuclear fraction with an overlap of 1429 proteins." | Arabidopsis thaliana cells | 26980300 |
▼ FUNCTION
| Protein-tyrosine-phosphatase that dephosphorylates and probably inhibits MPK6 in non-oxidative stress conditions. In association with MKP1, represses salicylic acid (SA) and camalexin biosynthesis, thus modulating defense response. May also repress MPK3. Dephosphorylates and inactivates MPK4 in vitro. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | AT1G71860.3 | AT1G71860.3 |
| Ensembl | AT1G71860.1 | AT1G71860.1 |
| Ensembl | AT1G71860.2 | AT1G71860.2 |
| UniProt | O82656, PTP1_ARATH, O65190 | |
| GeneBank | AC012654, AY070403, AY117240, AF055635, AJ006309, CP002684 | AAL49899.1, CAA06978.1, AEE35243.1, AAF43239.1, AAM51315.1, AEE35242.1, AAC68859.1 |
| RefSeq | NM_001036189.1, NM_105844.4 | NP_001031266.1, NP_177331.1 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MATGKTSSAA NLFTGSTRFD LSSADSPPSK LSLSSDQLNH CHQALGVFRG KIQNPDSIAH 60 61 EFTGLQANRM WPSELLLNST VAMNSVNVEK NRYSDVVPFD KNRIVLNPCK DSSAKGYVNA 120 121 SLIKTSESES ISQFIATQGP LPHTMEDFWE MVIQQHCPII VMLTRLVDNN RTVKCGDYFQ 180 181 DEDGPREFGN ISLTTKWIKT TDTSLMLRNL EVNYKETEDQ PMSVLHIQYP EWPDHGVPKD 240 241 TVAVREILKR LYQVPPSLGP IIVHCSAGIG RTGTYCAIHN TIQRILAGDM SALDLAKTVA 300 301 LFRKQRIGMV QTMDQYFFCY NAIVDELEDL TAGTNAGTSS 340 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGGCGACCG GTAAAACCTC TTCCGCCGCG AATCTTTTCA CTGGCTCGAC GCGTTTTGAT 60 61 TTATCATCCG CTGATTCGCC TCCTTCAAAA CTCTCTCTCT CCTCCGATCA GCTCAACCAC 120 121 TGCCACCAAG CTCTCGGCGT TTTCCGGGGA AAGATCCAAA ATCCTGACTC GATCGCTCAT 180 181 GAGTTTACCG GTTTACAGGC TAATAGGATG TGGCCATCGG AGCTGCTGCT AAACAGTACA 240 241 GTGGCTATGA ACAGTGTCAA TGTTGAGAAA AACAGATACA GTGATGTTGT TCCATTTGAC 300 301 AAGAACAGGA TTGTTCTGAA TCCATGTAAA GACTCATCTG CAAAAGGATA TGTGAATGCA 360 361 AGCTTAATTA AGACGTCGGA GTCTGAGAGT ATTTCTCAGT TCATAGCTAC GCAAGGTCCT 420 421 TTACCACACA CGATGGAGGA CTTCTGGGAG ATGGTTATTC AGCAGCATTG CCCAATCATA 480 481 GTGATGCTCA CTCGATTGGT TGATAATAAT AGGACTGTTA AATGCGGGGA CTATTTTCAA 540 541 GACGAAGATG GACCTAGAGA ATTTGGCAAC ATATCTCTTA CAACAAAGTG GATAAAGACT 600 601 ACTGACACTT CATTGATGTT ACGGAATCTT GAGGTTAACT ACAAGGAGAC AGAGGATCAG 660 661 CCCATGTCCG TTTTGCATAT TCAGTATCCA GAATGGCCTG ATCATGGAGT TCCCAAGGAT 720 721 ACAGTGGCTG TCCGTGAAAT TCTAAAAAGA CTATATCAAG TACCACCTAG TCTCGGCCCA 780 781 ATCATTGTGC ACTGCAGGTA TAGGAAGAAC TGGAACATAC TGTGCGATAC ATAA 834 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Cytoplasm | |
Cellular Component | Nucleus | |
Cellular Component | Plasma membrane | |
Molecular Function | Kinase binding | |
Molecular Function | MAP kinase tyrosine phosphatase activity | |
Molecular Function | Protein tyrosine phosphatase activity | |
Biological Process | Defense response | |
Biological Process | Intracellular signal transduction | |
Biological Process | Negative regulation of defense response |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Arl-1534 | Arabidopsis lyrata | 92.98 | 0.0 | 639 |
| LLPS-Bro-2788 | Brassica oleracea | 83.17 | 0.0 | 530 |
| LLPS-Brr-1852 | Brassica rapa | 79.77 | 0.0 | 532 |
| LLPS-Brn-2629 | Brassica napus | 79.19 | 0.0 | 530 |
| LLPS-Mae-2443 | Manihot esculenta | 73.42 | 2e-170 | 485 |
| LLPS-Pot-2781 | Populus trichocarpa | 72.85 | 6e-171 | 486 |
| LLPS-Thc-2326 | Theobroma cacao | 72.22 | 5e-167 | 476 |
| LLPS-Viv-2141 | Vitis vinifera | 72.03 | 1e-156 | 449 |
| LLPS-Phv-1104 | Phaseolus vulgaris | 71.48 | 2e-148 | 429 |
| LLPS-Prp-0703 | Prunus persica | 71.48 | 2e-163 | 467 |
| LLPS-Coc-1948 | Corchorus capsularis | 71.24 | 7e-161 | 461 |
| LLPS-Gor-1984 | Gossypium raimondii | 70.59 | 4e-165 | 472 |
| LLPS-Met-1997 | Medicago truncatula | 69.46 | 1e-158 | 454 |
| LLPS-Vir-1173 | Vigna radiata | 69.46 | 2e-159 | 458 |
| LLPS-Glm-2372 | Glycine max | 69.13 | 2e-158 | 454 |
| LLPS-Via-0220 | Vigna angularis | 69.13 | 5e-159 | 456 |
| LLPS-Dac-0642 | Daucus carota | 68.17 | 7e-142 | 412 |
| LLPS-Sol-1553 | Solanum lycopersicum | 67.66 | 4e-152 | 440 |
| LLPS-Nia-1635 | Nicotiana attenuata | 66.45 | 2e-151 | 437 |
| LLPS-Hea-0362 | Helianthus annuus | 65.9 | 3e-143 | 417 |
| LLPS-Sot-1665 | Solanum tuberosum | 63.82 | 1e-62 | 204 |
| LLPS-Mua-0590 | Musa acuminata | 60.27 | 3e-132 | 387 |
| LLPS-Amt-0497 | Amborella trichopoda | 60.13 | 2e-134 | 394 |
| LLPS-Cus-1325 | Cucumis sativus | 59.89 | 7e-65 | 214 |
| LLPS-Orbr-2304 | Oryza brachyantha | 53.67 | 5e-82 | 258 |
| LLPS-Orp-2001 | Oryza punctata | 51.67 | 2e-69 | 224 |
| LLPS-Brd-1688 | Brachypodium distachyon | 49.83 | 2e-90 | 283 |
| LLPS-Hov-1027 | Hordeum vulgare | 49.82 | 2e-79 | 250 |
| LLPS-Lep-1225 | Leersia perrieri | 49.78 | 2e-64 | 211 |
| LLPS-Orb-0637 | Oryza barthii | 48.25 | 1e-75 | 240 |
| LLPS-Sei-0204 | Setaria italica | 47.64 | 3e-81 | 259 |
| LLPS-Tra-1202 | Triticum aestivum | 47.47 | 6e-86 | 268 |
| LLPS-Sob-2019 | Sorghum bicolor | 47.14 | 2e-82 | 260 |
| LLPS-Orni-1120 | Oryza nivara | 46.96 | 5e-82 | 259 |
| LLPS-Ors-1580 | Oryza sativa | 46.96 | 9e-83 | 261 |
| LLPS-Orr-0660 | Oryza rufipogon | 46.96 | 9e-83 | 261 |
| LLPS-Zem-2332 | Zea mays | 46.64 | 4e-80 | 260 |
| LLPS-Ori-1929 | Oryza indica | 46.62 | 4e-81 | 256 |
| LLPS-Org-0819 | Oryza glaberrima | 46.62 | 2e-82 | 260 |
| LLPS-Tru-1993 | Triticum urartu | 43.47 | 9e-74 | 238 |
| LLPS-Php-1832 | Physcomitrella patens | 42.57 | 1e-80 | 257 |
| LLPS-Sem-2304 | Selaginella moellendorffii | 42.42 | 4e-76 | 243 |
| LLPS-Bot-1077 | Bos taurus | 41.43 | 1e-45 | 169 |
| LLPS-Caj-4405 | Callithrix jacchus | 41.27 | 8e-45 | 167 |
| LLPS-Paa-4620 | Papio anubis | 41.04 | 8e-44 | 164 |
| LLPS-Aon-2871 | Aotus nancymaae | 40.87 | 1e-43 | 163 |
| LLPS-Ova-2316 | Ovis aries | 40.87 | 4e-44 | 164 |
| LLPS-Orm-1144 | Oryza meridionalis | 40.83 | 8e-52 | 182 |
| LLPS-Gog-1180 | Gorilla gorilla | 40.64 | 2e-43 | 162 |
| LLPS-Rhb-4444 | Rhinopithecus bieti | 40.64 | 1e-43 | 163 |
| LLPS-Pap-1843 | Pan paniscus | 40.64 | 1e-43 | 164 |
| LLPS-Ict-3748 | Ictidomys tridecemlineatus | 40.64 | 7e-44 | 164 |
| LLPS-Aim-4027 | Ailuropoda melanoleuca | 40.48 | 5e-44 | 164 |
| LLPS-Mup-2494 | Mustela putorius furo | 40.48 | 1e-43 | 163 |
| LLPS-Otg-3199 | Otolemur garnettii | 40.48 | 3e-43 | 162 |
| LLPS-Eqc-3316 | Equus caballus | 40.48 | 7e-44 | 164 |
| LLPS-Mal-3875 | Mandrillus leucophaeus | 40.24 | 6e-43 | 161 |
| LLPS-Tar-1427 | Takifugu rubripes | 40.08 | 3e-42 | 160 |
| LLPS-Fec-3727 | Felis catus | 40.08 | 3e-43 | 162 |
| LLPS-Caf-4114 | Canis familiaris | 40.08 | 7e-44 | 164 |
| LLPS-Sus-1708 | Sus scrofa | 39.84 | 2e-43 | 163 |
| LLPS-Leo-2802 | Lepisosteus oculatus | 39.68 | 1e-44 | 167 |
| LLPS-Dio-4300 | Dipodomys ordii | 39.52 | 2e-42 | 160 |
| LLPS-Cap-0003 | Cavia porcellus | 39.44 | 1e-42 | 160 |
| LLPS-Myl-4133 | Myotis lucifugus | 39.29 | 6e-43 | 161 |
| LLPS-Xet-1386 | Xenopus tropicalis | 39.23 | 5e-45 | 168 |
| LLPS-Gaa-3814 | Gasterosteus aculeatus | 39.2 | 7e-40 | 156 |
| LLPS-Fud-1736 | Fukomys damarensis | 39.04 | 2e-43 | 163 |
| LLPS-Ten-0156 | Tetraodon nigroviridis | 38.78 | 2e-42 | 164 |
| LLPS-Xim-1423 | Xiphophorus maculatus | 38.67 | 2e-42 | 160 |
| LLPS-Mea-0061 | Mesocricetus auratus | 38.66 | 2e-42 | 163 |
| LLPS-Pes-2856 | Pelodiscus sinensis | 38.66 | 1e-41 | 160 |
| LLPS-Anc-1881 | Anolis carolinensis | 38.62 | 1e-44 | 166 |
| LLPS-Orl-1920 | Oryzias latipes | 38.61 | 4e-43 | 162 |
| LLPS-Scm-2257 | Scophthalmus maximus | 38.58 | 4e-43 | 162 |
| LLPS-Lac-2403 | Latimeria chalumnae | 38.52 | 2e-44 | 165 |
| LLPS-Sah-3428 | Sarcophilus harrisii | 38.49 | 1e-44 | 166 |
| LLPS-Dar-0136 | Danio rerio | 38.24 | 2e-45 | 165 |
| LLPS-Cas-1698 | Carlito syrichta | 38.24 | 9e-42 | 161 |
| LLPS-Pof-2362 | Poecilia formosa | 38.22 | 8e-43 | 160 |
| LLPS-Scf-1153 | Scleropages formosus | 37.92 | 1e-43 | 163 |
| LLPS-Orn-1789 | Oreochromis niloticus | 37.79 | 4e-44 | 164 |
| LLPS-Anp-0112 | Anas platyrhynchos | 37.77 | 6e-43 | 161 |
| LLPS-Gaga-1591 | Gallus gallus | 37.77 | 8e-43 | 161 |
| LLPS-Ora-2715 | Ornithorhynchus anatinus | 37.59 | 2e-43 | 163 |
| LLPS-Chr-1574 | Chlamydomonas reinhardtii | 37.46 | 2e-59 | 202 |
| LLPS-Mod-2917 | Monodelphis domestica | 37.23 | 8e-44 | 161 |
| LLPS-Icp-3066 | Ictalurus punctatus | 37.18 | 2e-44 | 166 |
| LLPS-Meg-0553 | Meleagris gallopavo | 37.15 | 3e-42 | 154 |
| LLPS-Cii-1209 | Ciona intestinalis | 37.14 | 8e-42 | 158 |
| LLPS-Tag-2599 | Taeniopygia guttata | 37.14 | 3e-42 | 156 |
| LLPS-Asm-2665 | Astyanax mexicanus | 37.04 | 1e-43 | 167 |
| LLPS-Drm-1586 | Drosophila melanogaster | 36.68 | 6e-44 | 166 |
| LLPS-Fia-3727 | Ficedula albicollis | 36.68 | 2e-42 | 159 |
| LLPS-Mum-4442 | Mus musculus | 36.55 | 6e-44 | 162 |
| LLPS-Ran-0430 | Rattus norvegicus | 36.13 | 5e-44 | 162 |
| LLPS-Orc-2605 | Oryctolagus cuniculus | 35.34 | 5e-40 | 152 |
| LLPS-Nol-1024 | Nomascus leucogenys | 35.27 | 3e-44 | 163 |
| LLPS-Cea-0628 | Cercocebus atys | 35.16 | 1e-43 | 161 |
| LLPS-Pat-3518 | Pan troglodytes | 35.16 | 5e-44 | 163 |
| LLPS-Hos-4090 | Homo sapiens | 35.16 | 6e-44 | 162 |
| LLPS-Cae-1953 | Caenorhabditis elegans | 35.14 | 2e-41 | 155 |
| LLPS-Urm-2844 | Ursus maritimus | 34.96 | 9e-40 | 152 |
| LLPS-Loa-4053 | Loxodonta africana | 34.96 | 2e-39 | 151 |
| LLPS-Chs-1967 | Chlorocebus sabaeus | 34.8 | 2e-43 | 161 |
| LLPS-Maf-3192 | Macaca fascicularis | 34.8 | 2e-43 | 161 |
| LLPS-Man-3898 | Macaca nemestrina | 34.8 | 2e-43 | 161 |
| LLPS-Mam-4189 | Macaca mulatta | 34.8 | 2e-43 | 161 |
| LLPS-Poa-4467 | Pongo abelii | 34.17 | 3e-36 | 142 |
| LLPS-Tut-2072 | Tursiops truncatus | 32.29 | 7e-43 | 159 |