DrLLPS - Data resource of LLPS

LLPS-Aon-a100
PANX2

Integrated Annotations

▼ OVERVIEW


Status:	Unreviewed
Protein Name:	Pannexin
Gene Name:	PANX2, PANX
Ensembl Gene:	ENSANAG00000032907.1
Ensembl Protein:	ENSANAP00000030297.1
Organism:	Aotus nancymaae
Taxa ID:	37293
LLPS Type:	Others

▼ PROPERTY

——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:

Condensate	Evidence	Orthologs
Postsynaptic density	Predicted from orthologs	(View)

Organism	DrLLPS ID	UniProt ID	LLPS type	Condensate	Identity	E-value	Score
Mus musculus	LLPS-Mum-a102	Q6IMP4	Client	Postsynaptic density	90.87	0.0	1187

▼ FUNCTION

Structural component of the gap junctions and the hemichannels.

▼ CROSS REFERENCE

Database	Nucleotide ID	Protein ID
Ensembl	ENSANAT00000048333.1	ENSANAP00000030297.1
Ensembl	ENSANAT00000048335.1	ENSANAP00000030299.1
UniProt		A0A2K5EAP5, A0A2K5EAP5_AOTNA
RefSeq	XM_012434407.1	XP_012289830.1

▼ SEQUENCE

Protein Sequence (FASTA)
1 MHHLLEQSAD MATALLAGEK LRELILPGAQ DDKAGALAAL LLQLKLELPF DRVVTIGTVL 60 61 VPILLVTLVF TKNFAEEPIY CYTPHNFTRD QALYARGYCW TELRDALPGV DSSLWPSLFE 120 121 HKFLPYALLA FAAIMYVPAL GWEFLASTRL TSELNFLLQE IDNCYHRAAE GRAPKIEKQI 180 181 QSKGPGITER EKREIIENAE KEKSPEQNLF EKYLERRGRS NFLAKLYLAR HVLILLLSAV 240 241 PISYLCTYYA TQKQNEFTCA LGAAPDGPAG AGSTVRVSCK LPSVQLQRII AGVDIVLLCV 300 301 MNLIILVNLI HLFIFRKSNF IFDKLHKVGI KTRRQWRRSQ FCDINILAMF CNENRDHIKS 360 361 LNRLDFITNE SDLMYDNVVR QLLAALAQSN HDATPTVRDS GVQTVDPSAN PAEPDGAAEP 420 421 PVVKRPRKKM KWIPTSNPLP QPFKEPLAIM RVENSKAEKP KPARRKTATD TLIAPLLDAG 480 481 ARAAHHYKGG GGDPGPAPAP APPPAPDKKH ARHFSLDVQP YILGTKKAKP EAVPAALPAS 540 541 RSQEGGFLSQ DDDCGLGLAV VPAKDAALPE KEILFPSEPA RAGLPSGAPF HVRSPPAAPA 600 601 VAPLSPASLG KAEPLTILSR NATHPLLHIN TLYEAREEDE GGPRLPQDVG DLIAIPAPQQ 660 661 ILIATFDEPR TVVSTVEF 678

Protein Sequence (FASTA)

1     MHHLLEQSAD  MATALLAGEK  LRELILPGAQ  DDKAGALAAL  LLQLKLELPF  DRVVTIGTVL  60
61    VPILLVTLVF  TKNFAEEPIY  CYTPHNFTRD  QALYARGYCW  TELRDALPGV  DSSLWPSLFE  120
121   HKFLPYALLA  FAAIMYVPAL  GWEFLASTRL  TSELNFLLQE  IDNCYHRAAE  GRAPKIEKQI  180
181   QSKGPGITER  EKREIIENAE  KEKSPEQNLF  EKYLERRGRS  NFLAKLYLAR  HVLILLLSAV  240
241   PISYLCTYYA  TQKQNEFTCA  LGAAPDGPAG  AGSTVRVSCK  LPSVQLQRII  AGVDIVLLCV  300
301   MNLIILVNLI  HLFIFRKSNF  IFDKLHKVGI  KTRRQWRRSQ  FCDINILAMF  CNENRDHIKS  360
361   LNRLDFITNE  SDLMYDNVVR  QLLAALAQSN  HDATPTVRDS  GVQTVDPSAN  PAEPDGAAEP  420
421   PVVKRPRKKM  KWIPTSNPLP  QPFKEPLAIM  RVENSKAEKP  KPARRKTATD  TLIAPLLDAG  480
481   ARAAHHYKGG  GGDPGPAPAP  APPPAPDKKH  ARHFSLDVQP  YILGTKKAKP  EAVPAALPAS  540
541   RSQEGGFLSQ  DDDCGLGLAV  VPAKDAALPE  KEILFPSEPA  RAGLPSGAPF  HVRSPPAAPA  600
601   VAPLSPASLG  KAEPLTILSR  NATHPLLHIN  TLYEAREEDE  GGPRLPQDVG  DLIAIPAPQQ  660
661   ILIATFDEPR  TVVSTVEF  678

▼ KEYWORD

ID	Family
KW-0965	Cell junction
KW-0181	Complete proteome
KW-0303	Gap junction
KW-0325	Glycoprotein
KW-0407	Ion channel
KW-0406	Ion transport
KW-0472	Membrane
KW-1185	Reference proteome
KW-0812	Transmembrane
KW-1133	Transmembrane helix
KW-0813	Transport

▼ GENE ONTOLOGY

ID	Classification	Description
GO:0005737	Cellular Component	Cytoplasm
GO:0005921	Cellular Component	Gap junction
GO:0016021	Cellular Component	Integral component of membrane
GO:0005886	Cellular Component	Plasma membrane
GO:0015267	Molecular Function	Channel activity
GO:0006812	Biological Process	Cation transport
GO:0050716	Biological Process	Positive regulation of interleukin-1 secretion
GO:0002931	Biological Process	Response to ischemia

▼ ORTHOLOGY

DrLLPS ID	Organism	Identity	E-value	Score
LLPS-Hos-a099	Homo sapiens	0.0	1326	undefined
LLPS-Mum-a102	Mus musculus	0.0	1187	undefined

LLPS-Aon-a100PANX2

Protein Sequence

Nucleotide Sequence

LLPS-Aon-a100
PANX2