• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Aon-1522
RNASEH1

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: Ribonuclease H1
Gene Name: RNASEH1
Ensembl Gene: ENSANAG00000024055.1
Ensembl Protein: ENSANAP00000012238.1
Organism: Aotus nancymaae
Taxa ID: 37293
LLPS Type: Client


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
Stress granulePredicted from orthologs(View)

▼ FUNCTION

Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.

▼ CROSS REFERENCE

▼ SEQUENCE

Protein Sequence (FASTA)
1     MSRLLFLAHR  VALAAVRCRS  ASRGFGMFYA  VRRGRKTGVF  LTWNECKAQV  DRFPAARFKK  60
61    FATEDEAWAF  VRKSASRETS  EGQENQHGQE  SQTKASKRLR  EPLDGDGDEG  TEPYAKHLKP  120
121   SVEPAPPVSR  DMFSYMGDSV  VVYTDGCCSS  NGRRRPRAGI  GVYWGPGHPL  NVGIRLPGRQ  180
181   TNQRAEIHAA  CKAIEQAKAQ  NINKLVLYTD  SMFTINGITN  WVQGWKKNGW  KTSTGKEVIN  240
241   KEDFVALERL  TQGMDIQWMH  IPGHSGFTGN  EEADRLAREG  AKQSED  286
Nucleotide CDS Sequence (FASTA)
1     ATGAGCCGGC  TTCTGTTTCT  GGCCCACAGA  GTCGCCTTGG  CCGCCGTGCG  CTGTCGCTCC  60
61    GCCTCTCGCG  GGTTCGGGAT  GTTCTATGCC  GTGAGGAGGG  GCCGCAAGAC  CGGGGTCTTT  120
121   CTGACCTGGA  ATGAGTGCAA  GGCTCAGGTG  GACCGGTTTC  CTGCTGCCAG  ATTTAAGAAG  180
181   TTTGCCACAG  AGGATGAGGC  CTGGGCCTTT  GTCAGGAAAT  CTGCAAGCCG  AGAAACTTCA  240
241   GAAGGGCAGG  AAAATCAACA  TGGACAAGAA  TCACAGACGA  AAGCCAGCAA  GCGACTCCGT  300
301   GAACCACTGG  ATGGAGATGG  AGATGAAGGC  ACAGAGCCGT  ATGCAAAGCA  CTTGAAGCCC  360
361   AGTGTGGAGC  CGGCGCCTCC  AGTTAGCAGA  GACATGTTTT  CCTACATGGG  AGACTCGGTT  420
421   GTCGTCTACA  CGGATGGCTG  CTGCTCCAGT  AATGGGCGGA  GGAGACCACG  AGCAGGAATC  480
481   GGCGTTTACT  GGGGGCCGGG  CCATCCTTTA  AATGTAGGCA  TTAGACTTCC  TGGGCGGCAG  540
541   ACAAACCAAA  GAGCAGAAAT  TCATGCAGCC  TGCAAAGCCA  TTGAACAAGC  AAAGGCTCAA  600
601   AACATCAATA  AATTGGTTCT  GTATACGGAC  AGTATGTTTA  CTATAAATGG  TATAACTAAC  660
661   TGGGTTCAAG  GTTGGAAGAA  AAATGGGTGG  AAGACAAGTA  CAGGGAAAGA  GGTGATCAAC  720
721   AAAGAGGACT  TTGTGGCACT  GGAGAGGCTC  ACCCAGGGCA  TGGACATCCA  GTGGATGCAC  780
781   ATTCCTGGTC  ATTCGGGATT  TACGGGCAAT  GAAGAAGCTG  ATAGATTAGC  CAGAGAAGGA  840
841   GCTAAACAAT  CGGAAGACTG  A  861

▼ KEYWORD

ID
Family
Complete proteome
Endonuclease
Hydrolase
Magnesium
Metal-binding
Nuclease
Reference proteome
Signal

▼ GENE ONTOLOGY

ID
Classification
Description
Molecular Function
Magnesium ion binding
Molecular Function
Nucleic acid binding
Molecular Function
RNA-DNA hybrid ribonuclease activity

▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Caj-4824Callithrix jacchus94.830.0 573
LLPS-Pat-1999Pan troglodytes92.660.0 557
LLPS-Pap-1454Pan paniscus92.660.0 557
LLPS-Hos-1727Homo sapiens92.660.0 557
LLPS-Gog-2083Gorilla gorilla92.310.0 555
LLPS-Paa-4331Papio anubis91.960.0 555
LLPS-Maf-1900Macaca fascicularis91.610.0 552
LLPS-Cea-1638Cercocebus atys91.260.0 551
LLPS-Man-1856Macaca nemestrina91.260.0 550
LLPS-Rhb-3394Rhinopithecus bieti91.260.0 550
LLPS-Chs-4660Chlorocebus sabaeus90.560.0 548
LLPS-Poa-3910Pongo abelii87.366e-168 473
LLPS-Otg-1151Otolemur garnettii84.672e-177 498
LLPS-Mal-2347Mandrillus leucophaeus84.625e-177 497
LLPS-Aim-4063Ailuropoda melanoleuca84.033e-164 465
LLPS-Myl-3248Myotis lucifugus82.891e-34 126
LLPS-Orc-1131Oryctolagus cuniculus82.174e-172 485
LLPS-Cas-2759Carlito syrichta82.173e-174 490
LLPS-Mup-3787Mustela putorius furo81.956e-122 354
LLPS-Fec-0414Felis catus81.883e-174 490
LLPS-Mam-4241Macaca mulatta81.822e-169 478
LLPS-Eqc-3478Equus caballus81.542e-153 442
LLPS-Caf-2240Canis familiaris80.482e-168 476
LLPS-Cap-4244Cavia porcellus80.423e-167 473
LLPS-Ict-2468Ictidomys tridecemlineatus80.364e-164 464
LLPS-Loa-0981Loxodonta africana79.729e-167 471
LLPS-Mum-3806Mus musculus79.371e-165 468
LLPS-Nol-2981Nomascus leucogenys78.823e-159 451
LLPS-Urm-0476Ursus maritimus78.684e-108 323
LLPS-Dio-1152Dipodomys ordii78.327e-162 459
LLPS-Ran-3468Rattus norvegicus77.896e-156 444
LLPS-Sus-3929Sus scrofa77.824e-155 442
LLPS-Mea-3501Mesocricetus auratus76.844e-162 459
LLPS-Fud-1527Fukomys damarensis76.578e-156 445
LLPS-Bot-3005Bos taurus74.671e-161 459
LLPS-Mod-1369Monodelphis domestica73.661e-139 402
LLPS-Sah-3707Sarcophilus harrisii69.26e-137 395
LLPS-Ova-3401Ovis aries67.818e-130 377
LLPS-Anp-0641Anas platyrhynchos60.774e-101 303
LLPS-Gaga-3728Gallus gallus60.763e-115 340
LLPS-Pes-1376Pelodiscus sinensis60.451e-110 329
LLPS-Meg-3067Meleagris gallopavo60.413e-96 290
LLPS-Leo-1089Lepisosteus oculatus58.822e-103 310
LLPS-Icp-4190Ictalurus punctatus58.31e-102 308
LLPS-Tag-2794Taeniopygia guttata57.912e-108 323
LLPS-Fia-1329Ficedula albicollis57.684e-110 328
LLPS-Ten-2813Tetraodon nigroviridis57.143e-99 299
LLPS-Pof-2060Poecilia formosa57.093e-96 292
LLPS-Fuv-1474Fusarium verticillioides56.823e-0858.2
LLPS-Xet-1620Xenopus tropicalis56.182e-102 308
LLPS-Orn-3994Oreochromis niloticus55.62e-97 295
LLPS-Orl-0946Oryzias latipes55.063e-94 286
LLPS-Dar-2860Danio rerio54.892e-94 287
LLPS-Sac-1651Saccharomyces cerevisiae54.354e-0960.8
LLPS-Lac-3381Latimeria chalumnae54.27e-98 297
LLPS-Scf-3490Scleropages formosus53.822e-93 285
LLPS-Scm-0758Scophthalmus maximus53.584e-97 295
LLPS-Xim-4042Xiphophorus maculatus53.381e-92 283
LLPS-Php-0661Physcomitrella patens53.339e-0853.9
LLPS-Anc-2703Anolis carolinensis53.22e-104 314
LLPS-Tar-0487Takifugu rubripes53.192e-97 295
LLPS-Asm-2629Astyanax mexicanus52.512e-81 253
LLPS-Gaa-1568Gasterosteus aculeatus52.22e-96 293
LLPS-Cae-0998Caenorhabditis elegans42.352e-56 189
LLPS-Scj-0593Schizosaccharomyces japonicus40.541e-25 108
LLPS-Cis-0518Ciona savignyi37.782e-38 141
LLPS-Tum-1326Tuber melanosporum37.564e-23 101
LLPS-Cii-1167Ciona intestinalis37.292e-52 179
LLPS-Dos-1493Dothistroma septosporum37.148e-1266.6
LLPS-Crn-0710Cryptococcus neoformans36.63e-36 137
LLPS-Cogr-1227Colletotrichum graminicola36.114e-0651.6
LLPS-Chc-1168Chondrus crispus35.711e-42 155
LLPS-Fuo-1044Fusarium oxysporum35.661e-38 144
LLPS-Abg-0965Absidia glauca35.134e-39 145
LLPS-Pyt-0030Pyrenophora teres34.436e-0651.6
LLPS-Spr-1042Sporisorium reilianum34.258e-33 128
LLPS-Aso-1286Aspergillus oryzae33.331e-30 123
LLPS-Ast-0933Aspergillus terreus33.336e-31 124
LLPS-Usm-1449Ustilago maydis33.08e-33 128
LLPS-Asn-1358Aspergillus nidulans32.657e-30 121
LLPS-Drm-2128Drosophila melanogaster32.62e-37 140
LLPS-Trr-1128Trichoderma reesei32.574e-33 129
LLPS-Blg-1555Blumeria graminis32.481e-30 122
LLPS-Asni-1606Aspergillus niger32.273e-29 119
LLPS-Asf-1450Aspergillus flavus32.142e-29 120
LLPS-Beb-1298Beauveria bassiana32.135e-30 121
LLPS-Gas-0971Galdieria sulphuraria32.124e-24 103
LLPS-Yal-0908Yarrowia lipolytica32.082e-35 134
LLPS-Trv-1483Trichoderma virens32.067e-30 119
LLPS-Phn-1563Phaeosphaeria nodorum32.012e-2198.2
LLPS-Nec-1409Neurospora crassa31.83e-27 114
LLPS-Nef-1543Neosartorya fischeri31.721e-29 120
LLPS-Kop-1392Komagataella pastoris31.271e-33 129
LLPS-Fus-1053Fusarium solani31.113e-1372.4
LLPS-Asfu-1572Aspergillus fumigatus31.033e-30 122
LLPS-Scp-1398Schizosaccharomyces pombe30.943e-32 125
LLPS-Asc-1312Aspergillus clavatus30.894e-28 116
LLPS-Scc-1117Schizosaccharomyces cryophilus30.823e-32 125
LLPS-Coo-0962Colletotrichum orbiculare30.567e-32 126
LLPS-Lem-0811Leptosphaeria maculans30.17e-27 112
LLPS-Cog-0871Colletotrichum gloeosporioides29.923e-27 113
LLPS-Scs-0962Sclerotinia sclerotiorum29.651e-1168.6