• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Aon-0633
KATNAL1

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: Multifunctional fusion protein
Gene Name: KATNAL1, KATNA1
Ensembl Gene: ENSANAG00000029176.1
Ensembl Protein: ENSANAP00000022881.1
Organism: Aotus nancymaae
Taxa ID: 37293
LLPS Type: Others


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
Centrosome/Spindle pole bodyPredicted from orthologs(View)

▼ FUNCTION

Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal processes by microtubule-dependent motor proteins. This transport is required for axonal growth.

▼ SEQUENCE

Protein Sequence (FASTA)
1     MNLAEICDNA  KKGREYALLG  NYDSSMVYYQ  GVIQQIQRHC  QSVRDPAIKG  KWQQVRQELL  60
61    EEYEQVKSIV  STLESFKIDK  PPDFPVSCQD  EPFRDPAVWP  PPVPAEHRAP  PQIRRANREV  120
121   RPLRKEMAGV  GARGPVGRAH  PISKSEKPST  SRDKDCRARG  RDDKGRKNMP  DGASDGEIQK  180
181   FDGAGYDKDL  VEALERDIVS  RNPSIHWDDI  ADLEEAKKLL  REAVVLPMWM  PDFFKGIRRP  240
241   WKGVLMVGPP  GTGKTMLAKA  VATECGTTFF  NVSSSTLTSK  YRGESEKLVR  LLFEMARFYA  300
301   PTTIFIDEID  SICSRRGTSD  EHEASRRVKS  ELLIQMDGVG  GALENDDPSK  MVMVLAATNF  360
361   PWDIDEALRR  RLEKRIYIPL  PTAKGRAELL  KINLREVELD  PDIQLEDIAE  KIEGYSGADI  420
421   TNVCRDASLM  AMRRRINGLS  PEEIRALSKE  ELQMPVTKGD  FELALKKIAK  SVSAADLEKY  480
481   EKWMVEFGSA  490
Nucleotide CDS Sequence (FASTA)
1     ATGAATTTAG  CTGAGATTTG  TGATAATGCA  AAGAAAGGAA  GAGAATATGC  CCTTCTTGGA  60
61    AATTATGACT  CATCAATGGT  GTATTACCAG  GGGGTGATAC  AACAGATTCA  GAGACATTGC  120
121   CAGTCAGTAA  GAGATCCAGC  TATCAAAGGC  AAATGGCAAC  AGGTTCGACA  GGAATTATTG  180
181   GAAGAATATG  AACAAGTTAA  AAGTATTGTC  AGCACTTTAG  AAAGTTTTAA  AATCGACAAG  240
241   CCTCCAGATT  TCCCTGTGTC  CTGTCAAGAT  GAACCATTTA  GAGATCCTGC  TGTGTGGCCA  300
301   CCCCCTGTTC  CTGCAGAACA  CAGAGCTCCA  CCTCAGATCA  GGCGTGCCAA  TCGAGAAGTA  360
361   AGACCTCTGA  GGAAAGAAAT  GGCAGGAGTA  GGAGCCCGGG  GACCTGTAGG  CCGAGCACAT  420
421   CCTATATCAA  AGAGTGAAAA  ACCTTCTACA  AGTAGGGACA  AGGATTGTAG  AGCAAGAGGG  480
481   AGAGATGACA  AGGGAAGGAA  GAATATGCCA  GATGGTGCAA  GTGATGGTGA  AATTCAAAAA  540
541   TTTGATGGTG  CTGGTTATGA  TAAGGATCTG  GTGGAAGCCC  TTGAGAGAGA  CATTGTATCC  600
601   AGGAATCCTA  GCATTCATTG  GGATGACATA  GCAGATCTGG  AAGAAGCTAA  GAAGCTGCTA  660
661   AGAGAAGCTG  TCGTTCTTCC  AATGTGGATG  CCCGACTTCT  TCAAAGGGAT  TAGAAGGCCA  720
721   TGGAAGGGTG  TACTAATGGT  TGGACCCCCA  GGCACTGGTA  AAACTATGCT  AGCTAAAGCT  780
781   GTTGCTACTG  AATGTGGTAC  AACATTCTTC  AACGTTTCCT  CTTCTACGCT  GACATCTAAA  840
841   TATAGAGGTG  AATCTGAGAA  GTTAGTTCGT  CTGTTGTTTG  AGATGGCTAG  ATTTTATGCG  900
901   CCTACCACGA  TCTTCATTGA  TGAGATAGAT  TCTATCTGCA  GTCGAAGAGG  AACCTCTGAT  960
961   GAACATGAGG  CAAGTCGCAG  GGTCAAGTCT  GAACTACTCA  TTCAGATGGA  TGGAGTTGGA  1020
1021  GGAGCTTTAG  AAAATGACGA  TCCTTCCAAA  ATGGTTATGG  TATTGGCCGC  TACTAACTTC  1080
1081  CCTTGGGACA  TTGATGAAGC  TTTGCGAAGA  AGGTTAGAAA  AAAGGATATA  TATACCTCTC  1140
1141  CCAACAGCAA  AAGGAAGAGC  CGAGCTTCTG  AAGATCAACC  TTCGAGAGGT  CGAATTAGAT  1200
1201  CCTGATATTC  AACTGGAAGA  TATAGCCGAG  AAGATTGAGG  GCTATTCTGG  TGCTGACATC  1260
1261  ACTAATGTTT  GCAGGGATGC  CTCTTTAATG  GCAATGAGAC  GGCGTATCAA  TGGCTTAAGT  1320
1321  CCAGAAGAGA  TCCGTGCACT  TTCTAAAGAA  GAGCTTCAGA  TGCCTGTTAC  CAAAGGAGAC  1380
1381  TTTGAATTGG  CCCTTAAGAA  AATTGCTAAG  TCTGTCTCTG  CTGCAGACTT  GGAGAAGTAT  1440
1441  GAAAAATGGA  TGGTTGAATT  TGGATCTGCT  TGA  1473

▼ KEYWORD

ID
Family
ATP-binding
Cell cycle
Cell division
Complete proteome
Cytoplasm
Cytoskeleton
Isomerase
Microtubule
Mitosis
Nucleotide-binding
Phosphoprotein
Reference proteome
Ubl conjugation

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Centrosome
Cellular Component
Cytoplasm
Cellular Component
Microtubule
Cellular Component
Midbody
Cellular Component
Spindle pole
Molecular Function
ATP binding
Molecular Function
Identical protein binding
Molecular Function
Isomerase activity
Molecular Function
Microtubule binding
Molecular Function
Microtubule-severing ATPase activity
Biological Process
Cell cycle
Biological Process
Cell division
Biological Process
Spermatogenesis

▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Ict-2642Ictidomys tridecemlineatus98.980.0 918
LLPS-Rhb-3010Rhinopithecus bieti98.980.0 924
LLPS-Chs-0665Chlorocebus sabaeus98.980.0 924
LLPS-Cea-0110Cercocebus atys98.980.0 924
LLPS-Mam-0756Macaca mulatta98.780.0 923
LLPS-Hos-3187Homo sapiens98.780.0 921
LLPS-Maf-0860Macaca fascicularis98.780.0 923
LLPS-Man-4498Macaca nemestrina98.750.0 901
LLPS-Poa-0868Pongo abelii98.570.0 920
LLPS-Pat-0938Pan troglodytes98.570.0 919
LLPS-Pap-2204Pan paniscus98.570.0 919
LLPS-Gog-4410Gorilla gorilla98.570.0 919
LLPS-Nol-0889Nomascus leucogenys98.370.0 931
LLPS-Aim-0039Ailuropoda melanoleuca98.370.0 918
LLPS-Urm-1450Ursus maritimus97.960.0 914
LLPS-Mup-2988Mustela putorius furo97.960.0 916
LLPS-Caf-0395Canis familiaris97.760.0 914
LLPS-Orc-3009Oryctolagus cuniculus97.760.0 917
LLPS-Dio-0651Dipodomys ordii97.760.0 909
LLPS-Fec-3667Felis catus97.550.0 912
LLPS-Myl-3710Myotis lucifugus97.550.0 914
LLPS-Otg-4542Otolemur garnettii97.160.0 908
LLPS-Bot-2822Bos taurus97.140.0 917
LLPS-Ova-0340Ovis aries96.940.0 914
LLPS-Fud-4266Fukomys damarensis96.940.0 908
LLPS-Paa-4111Papio anubis96.730.0 898
LLPS-Loa-2601Loxodonta africana96.330.0 902
LLPS-Mod-2148Monodelphis domestica95.920.0 901
LLPS-Eqc-1136Equus caballus95.730.0 886
LLPS-Cap-3139Cavia porcellus95.510.0 894
LLPS-Mea-0942Mesocricetus auratus93.270.0 890
LLPS-Tag-1231Taeniopygia guttata90.820.0 855
LLPS-Caj-1143Callithrix jacchus90.610.0 813
LLPS-Anc-0540Anolis carolinensis90.20.0 829
LLPS-Tar-2027Takifugu rubripes86.390.0 562
LLPS-Xet-1838Xenopus tropicalis86.120.0 819
LLPS-Mal-0092Mandrillus leucophaeus85.650.0 707
LLPS-Icp-2537Ictalurus punctatus82.570.0 585
LLPS-Dar-3289Danio rerio80.820.0 759
LLPS-Leo-0781Lepisosteus oculatus79.80.0 790
LLPS-Pof-0947Poecilia formosa79.750.0 742
LLPS-Scf-1518Scleropages formosus78.570.0 753
LLPS-Asm-0538Astyanax mexicanus78.430.0 768
LLPS-Xim-0867Xiphophorus maculatus78.160.0 744
LLPS-Orn-2488Oreochromis niloticus76.690.0 721
LLPS-Orl-1444Oryzias latipes76.580.0 723
LLPS-Scm-2119Scophthalmus maximus76.520.0 717
LLPS-Gaa-0422Gasterosteus aculeatus75.870.0 723
LLPS-Lac-1765Latimeria chalumnae73.892e-168 488
LLPS-Meg-0849Meleagris gallopavo69.230.0 655
LLPS-Gaga-0388Gallus gallus68.20.0 653
LLPS-Pes-1548Pelodiscus sinensis68.20.0 660
LLPS-Anp-1815Anas platyrhynchos68.140.0 655
LLPS-Fia-0078Ficedula albicollis68.060.0 653
LLPS-Ora-0665Ornithorhynchus anatinus67.810.0 651
LLPS-Bro-1156Brassica oleracea66.896e-144 422
LLPS-Sus-2208Sus scrofa65.870.0 643
LLPS-Sah-1142Sarcophilus harrisii65.740.0 641
LLPS-Cas-0964Carlito syrichta65.670.0 642
LLPS-Ran-0321Rattus norvegicus65.610.0 645
LLPS-Mum-3049Mus musculus65.610.0 644
LLPS-Sem-0225Selaginella moellendorffii65.194e-148 441
LLPS-Orgl-0734Oryza glumaepatula64.383e-146 429
LLPS-Cis-0514Ciona savignyi64.20.0 597
LLPS-Vir-1151Vigna radiata63.192e-141 425
LLPS-Ten-1297Tetraodon nigroviridis62.70.0 605
LLPS-Chr-0962Chlamydomonas reinhardtii61.474e-132 401
LLPS-Drm-0183Drosophila melanogaster52.543e-178 521
LLPS-Met-0966Medicago truncatula51.275e-165 484
LLPS-Gor-0230Gossypium raimondii50.861e-164 483
LLPS-Nia-0561Nicotiana attenuata50.497e-165 484
LLPS-Dac-1529Daucus carota50.423e-145 432
LLPS-Brn-3223Brassica napus50.387e-163 478
LLPS-Glm-0109Glycine max50.22e-159 468
LLPS-Coc-0729Corchorus capsularis50.195e-162 477
LLPS-Cus-0563Cucumis sativus50.192e-167 491
LLPS-Zem-1424Zea mays49.92e-163 480
LLPS-Sot-1309Solanum tuberosum49.92e-160 473
LLPS-Thc-1932Theobroma cacao49.92e-160 475
LLPS-Brr-0621Brassica rapa49.815e-163 479
LLPS-Mae-0944Manihot esculenta49.812e-166 488
LLPS-Viv-0434Vitis vinifera49.623e-162 477
LLPS-Sob-0126Sorghum bicolor49.623e-161 475
LLPS-Ori-0739Oryza indica49.622e-163 480
LLPS-Orni-1227Oryza nivara49.622e-163 480
LLPS-Orbr-0771Oryza brachyantha49.523e-163 479
LLPS-Amt-0631Amborella trichopoda49.522e-161 475
LLPS-Sei-0290Setaria italica49.521e-160 473
LLPS-Tru-1688Triticum urartu49.437e-163 479
LLPS-Hov-0723Hordeum vulgare49.432e-161 475
LLPS-Tra-0574Triticum aestivum49.438e-163 479
LLPS-Hea-0639Helianthus annuus49.431e-163 481
LLPS-Brd-0394Brachypodium distachyon49.331e-160 473
LLPS-Sol-0030Solanum lycopersicum49.323e-162 477
LLPS-Pot-2019Populus trichocarpa49.245e-160 472
LLPS-Org-0429Oryza glaberrima49.235e-161 474
LLPS-Ors-0171Oryza sativa49.235e-161 474
LLPS-Orp-0513Oryza punctata49.237e-161 474
LLPS-Lep-0248Leersia perrieri49.233e-162 477
LLPS-Art-0049Arabidopsis thaliana49.131e-165 486
LLPS-Arl-1358Arabidopsis lyrata49.137e-164 481
LLPS-Orm-0783Oryza meridionalis49.045e-152 468
LLPS-Orr-0073Oryza rufipogon48.72e-148 441
LLPS-Orb-0026Oryza barthii48.71e-145 442
LLPS-Prp-0397Prunus persica48.552e-161 475
LLPS-Via-1963Vigna angularis48.51e-159 471
LLPS-Phv-0638Phaseolus vulgaris48.338e-161 474
LLPS-Mua-0147Musa acuminata48.036e-141 426
LLPS-Php-1576Physcomitrella patens46.346e-82 268
LLPS-Cog-0741Colletotrichum gloeosporioides46.063e-82 268
LLPS-Cae-0147Caenorhabditis elegans46.037e-84 274
LLPS-Chc-0605Chondrus crispus45.782e-82 270
LLPS-Cogr-1560Colletotrichum graminicola45.763e-80 263
LLPS-Beb-1235Beauveria bassiana45.762e-82 268
LLPS-Trr-0807Trichoderma reesei45.591e-81 266
LLPS-Ved-0260Verticillium dahliae45.532e-86 279
LLPS-Fus-0219Fusarium solani45.292e-80 263
LLPS-Coo-1010Colletotrichum orbiculare45.096e-84 273
LLPS-Fuo-0279Fusarium oxysporum44.676e-81 265
LLPS-Fuv-1141Fusarium verticillioides44.677e-81 264
LLPS-Cii-1541Ciona intestinalis43.893e-82 271
LLPS-Mao-0131Magnaporthe oryzae41.65e-82 267