• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Anp-0556
WDR12

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: Ribosome biogenesis protein WDR12; WD repeat-containing protein 12
Gene Name: WDR12
Ensembl Gene: ENSAPLG00000007646.1
Ensembl Protein: ENSAPLP00000007314.1
Organism: Anas platyrhynchos
Taxa ID: 8839
LLPS Type: Others


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
Nucleolus, Stress granulePredicted from orthologs(View)

▼ FUNCTION

Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.

▼ CROSS REFERENCE

▼ SEQUENCE

Protein Sequence (FASTA)
1     SADHKYVEFD  FLINGQFLRM  PLVTHMEMEN  ISTEEVVEIE  YVEKYMAPQP  EECIFHDDWI  60
61    SSVQATEEWI  LTGCYDQTAR  IWSLEGKSIM  TIAGHTEVVK  DVAWVKQDSL  SCLLLSASMD  120
121   QTILLWEWNA  EKNKVKALHC  CRGHAGSVDS  IAVDCTRTKF  CSGSWDKMLK  IWSTVPTDEE  180
181   DEMEEAANRP  RKKQKTEQLG  LTRTPLATLS  GHTEAISSVL  WSDAEEICSA  SWDHTIKLWD  240
241   AETGGLKSTL  TGNKVFNSVS  YSTLCRRLAS  GSTDRHIRLW  DPRSKDGSLV  LLSLTSHTGW  300
301   VTSVKWSPTH  EHQLISGSLD  NIVKLWDTRS  CKAPLYDLAA  HEDKVLCVDW  TETGLLLSGG  360
361   ADNKLYCYRY  PATASDVGA  379
Nucleotide CDS Sequence (FASTA)
1     TCAGCTGACC  ACAAGTATGT  GGAATTTGAC  TTCCTTATCA  ATGGCCAGTT  CTTGCGTATG  60
61    CCGCTGGTCA  CACACATGGA  GATGGAAAAT  ATCTCCACGG  AAGAAGTGGT  GGAAATAGAG  120
121   TATGTGGAGA  AATACATGGC  CCCTCAACCA  GAGGAGTGTA  TCTTCCATGA  TGACTGGATC  180
181   AGTTCTGTTC  AAGCCACTGA  AGAATGGATA  TTAACTGGCT  GCTATGATCA  GACTGCTCGA  240
241   ATCTGGTCTT  TGGAAGGAAA  ATCTATCATG  ACAATAGCTG  GTCATACAGA  AGTAGTGAAG  300
301   GATGTGGCAT  GGGTGAAGCA  AGATAGTCTA  TCCTGCCTGT  TACTCAGTGC  CTCTATGGAT  360
361   CAAACTATCC  TGCTCTGGGA  GTGGAATGCA  GAGAAGAACA  AAGTGAAAGC  CCTTCACTGC  420
421   TGCAGGGGGC  ATGCTGGGAG  TGTGGACTCT  ATAGCTGTTG  ATTGCACGCG  AACTAAATTC  480
481   TGCAGTGGGT  CTTGGGATAA  AATGTTAAAG  ATTTGGTCTA  CAGTCCCTAC  AGATGAAGAG  540
541   GATGAAATGG  AAGAAGCAGC  AAACAGACCA  CGGAAGAAGC  AGAAAACAGA  ACAGTTGGGA  600
601   CTAACAAGGA  CTCCCCTGGC  AACCCTCTCT  GGCCACACAG  AAGCCATCTC  CTCCGTGCTG  660
661   TGGTCAGATG  CTGAAGAAAT  TTGCAGTGCA  TCGTGGGACC  ATACCATTAA  GCTCTGGGAT  720
721   GCTGAGACAG  GAGGTCTCAA  ATCAACTTTG  ACGGGAAACA  AAGTGTTTAA  TTCTGTCTCC  780
781   TACTCAACAC  TTTGTCGACG  TCTTGCATCT  GGGAGCACTG  ACAGACATAT  TAGACTATGG  840
841   GATCCTCGCA  GCAAAGATGG  CTCCTTGGTT  CTCCTGTCTC  TGACTTCTCA  CACAGGCTGG  900
901   GTGACATCTG  TGAAGTGGTC  ACCCACCCAT  GAGCATCAGC  TAATCTCTGG  TTCTCTGGAC  960
961   AACATTGTGA  AGCTGTGGGA  CACAAGGAGT  TGCAAAGCTC  CTCTCTATGA  CTTGGCTGCT  1020
1021  CATGAAGATA  AGGTTTTGTG  TGTGGACTGG  ACAGAAACAG  GGTTACTATT  GAGTGGTGGT  1080
1081  GCAGACAACA  AACTATATTG  CTACAGATAC  CCAGCCACAG  CCTCTGACGT  CGGAGCATGA  1140

▼ KEYWORD

ID
Family
Complete proteome
Nucleus
Reference proteome
Repeat
Ribosome biogenesis
rRNA processing
WD repeat

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Nucleoplasm
Cellular Component
PeBoW complex
Cellular Component
Preribosome, large subunit precursor
Molecular Function
Ribonucleoprotein complex binding
Biological Process
Cell population proliferation
Biological Process
Maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Biological Process
Maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Biological Process
Notch signaling pathway

▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Gaga-0362Gallus gallus97.880.0 721
LLPS-Fia-0170Ficedula albicollis97.460.0 641
LLPS-Meg-2446Meleagris gallopavo96.580.0 711
LLPS-Tag-1384Taeniopygia guttata96.570.0 692
LLPS-Pes-1162Pelodiscus sinensis90.430.0 651
LLPS-Ora-1084Ornithorhynchus anatinus88.830.0 682
LLPS-Aim-0379Ailuropoda melanoleuca87.50.0 647
LLPS-Ict-0609Ictidomys tridecemlineatus87.50.0 650
LLPS-Hos-1652Homo sapiens87.230.0 645
LLPS-Urm-0135Ursus maritimus87.230.0 648
LLPS-Poa-2006Pongo abelii87.230.0 644
LLPS-Bot-0154Bos taurus86.970.0 646
LLPS-Mup-1717Mustela putorius furo86.970.0 646
LLPS-Loa-0761Loxodonta africana86.970.0 664
LLPS-Orc-1914Oryctolagus cuniculus86.970.0 647
LLPS-Mum-2280Mus musculus86.70.0 666
LLPS-Chs-2284Chlorocebus sabaeus86.70.0 644
LLPS-Aon-0682Aotus nancymaae86.70.0 642
LLPS-Caj-0937Callithrix jacchus86.70.0 642
LLPS-Mal-2207Mandrillus leucophaeus86.70.0 645
LLPS-Fec-1914Felis catus86.70.0 644
LLPS-Rhb-1579Rhinopithecus bieti86.70.0 644
LLPS-Eqc-2354Equus caballus86.70.0 644
LLPS-Anc-0498Anolis carolinensis86.510.0 630
LLPS-Sus-0793Sus scrofa86.440.0 640
LLPS-Gog-2033Gorilla gorilla86.440.0 639
LLPS-Cap-1242Cavia porcellus86.440.0 643
LLPS-Nol-1340Nomascus leucogenys86.440.0 620
LLPS-Fud-1652Fukomys damarensis86.170.0 640
LLPS-Ova-0076Ovis aries86.170.0 661
LLPS-Myl-1006Myotis lucifugus86.170.0 662
LLPS-Cas-1114Carlito syrichta86.170.0 661
LLPS-Caf-1633Canis familiaris85.90.0 642
LLPS-Otg-2054Otolemur garnettii85.370.0 640
LLPS-Ran-2801Rattus norvegicus85.110.0 658
LLPS-Paa-2015Papio anubis83.860.0 617
LLPS-Cea-0817Cercocebus atys83.60.0 614
LLPS-Leo-0047Lepisosteus oculatus82.760.0 626
LLPS-Sah-1556Sarcophilus harrisii82.40.0 628
LLPS-Man-0242Macaca nemestrina82.180.0 596
LLPS-Mod-0711Monodelphis domestica82.040.0 617
LLPS-Pat-0600Pan troglodytes80.050.0 610
LLPS-Pap-0450Pan paniscus79.790.0 607
LLPS-Dar-0860Danio rerio79.680.0 615
LLPS-Xet-0412Xenopus tropicalis79.680.0 588
LLPS-Asm-0231Astyanax mexicanus79.630.0 595
LLPS-Icp-0489Ictalurus punctatus79.160.0 596
LLPS-Orn-1207Oreochromis niloticus77.390.0 593
LLPS-Tar-0177Takifugu rubripes77.310.0 594
LLPS-Scm-0474Scophthalmus maximus77.310.0 590
LLPS-Orl-0026Oryzias latipes76.980.0 598
LLPS-Gaa-1257Gasterosteus aculeatus76.520.0 590
LLPS-Pof-1095Poecilia formosa76.460.0 595
LLPS-Scf-1978Scleropages formosus76.290.0 575
LLPS-Xim-0049Xiphophorus maculatus75.930.0 591
LLPS-Lac-0289Latimeria chalumnae75.932e-152 441
LLPS-Ten-1230Tetraodon nigroviridis75.730.0 587
LLPS-Maf-1925Macaca fascicularis74.740.0 538
LLPS-Mam-1221Macaca mulatta73.460.0 514
LLPS-Mea-0043Mesocricetus auratus70.138e-177 506
LLPS-Dio-1531Dipodomys ordii62.962e-160 464
LLPS-Cii-0990Ciona intestinalis45.455e-106 325
LLPS-Drm-0805Drosophila melanogaster43.378e-103 317
LLPS-Pyt-1336Pyrenophora teres40.242e-22 102
LLPS-Abg-0627Absidia glauca40.054e-81 261
LLPS-Pytr-0308Pyrenophora triticirepentis39.762e-22 100
LLPS-Prp-1315Prunus persica38.256e-67 224
LLPS-Mae-0048Manihot esculenta38.073e-69 230
LLPS-Cus-0431Cucumis sativus37.71e-63 216
LLPS-Chc-0561Chondrus crispus37.53e-1888.2
LLPS-Hea-0538Helianthus annuus37.351e-58 202
LLPS-Brd-2494Brachypodium distachyon37.271e-2095.1
LLPS-Met-0611Medicago truncatula36.931e-65 222
LLPS-Sot-0700Solanum tuberosum36.683e-66 223
LLPS-Via-0010Vigna angularis36.631e-64 220
LLPS-Glm-0530Glycine max36.561e-66 224
LLPS-Dos-0652Dothistroma septosporum36.512e-23 104
LLPS-Thc-0288Theobroma cacao36.312e-64 218
LLPS-Phv-1125Phaseolus vulgaris36.291e-65 221
LLPS-Pot-1912Populus trichocarpa36.163e-66 223
LLPS-Nia-0337Nicotiana attenuata36.144e-64 217
LLPS-Viv-0221Vitis vinifera36.077e-64 216
LLPS-Gor-0900Gossypium raimondii36.049e-63 213
LLPS-Coc-1123Corchorus capsularis36.041e-63 216
LLPS-Scs-0860Sclerotinia sclerotiorum35.931e-1891.7
LLPS-Lep-0291Leersia perrieri35.96e-62 214
LLPS-Brr-2123Brassica rapa35.791e-61 210
LLPS-Bro-2747Brassica oleracea35.795e-62 211
LLPS-Vir-0455Vigna radiata35.758e-66 221
LLPS-Dac-0237Daucus carota35.543e-63 215
LLPS-Sei-1201Setaria italica35.453e-63 215
LLPS-Tra-2832Triticum aestivum35.48e-1989.7
LLPS-Orgl-0951Oryza glumaepatula35.373e-1684.0
LLPS-Ors-0294Oryza sativa35.374e-1683.6
LLPS-Org-0137Oryza glaberrima35.376e-1785.9
LLPS-Orbr-0168Oryza brachyantha35.368e-63 214
LLPS-Sol-0672Solanum lycopersicum35.332e-59 214
LLPS-Phn-0587Phaeosphaeria nodorum35.331e-1891.3
LLPS-Arl-0458Arabidopsis lyrata35.073e-60 207
LLPS-Art-0297Arabidopsis thaliana35.074e-60 206
LLPS-Orm-0216Oryza meridionalis34.936e-64 219
LLPS-Sob-0651Sorghum bicolor34.834e-62 213
LLPS-Orb-1199Oryza barthii34.762e-1684.7
LLPS-Orni-1374Oryza nivara34.762e-1684.7
LLPS-Hov-0688Hordeum vulgare34.762e-1684.7
LLPS-Orp-0479Oryza punctata34.762e-1684.7
LLPS-Orr-1044Oryza rufipogon34.762e-1684.7
LLPS-Asn-0684Aspergillus nidulans34.732e-1787.8
LLPS-Php-1261Physcomitrella patens34.571e-65 221
LLPS-Coo-1002Colletotrichum orbiculare34.521e-1891.7
LLPS-Ori-0322Oryza indica34.45e-63 214
LLPS-Zem-0375Zea mays34.44e-61 209
LLPS-Tru-1109Triticum urartu34.313e-63 214
LLPS-Mua-0138Musa acuminata33.331e-55 195
LLPS-Amt-1023Amborella trichopoda33.331e-56 197
LLPS-Cae-1471Caenorhabditis elegans33.063e-48 175
LLPS-Sem-0471Selaginella moellendorffii32.974e-53 187
LLPS-Nef-0511Neosartorya fischeri32.932e-1581.6
LLPS-Trv-1582Trichoderma virens32.443e-1991.7
LLPS-Chr-0195Chlamydomonas reinhardtii32.171e-47 173
LLPS-Asf-0883Aspergillus flavus31.965e-44 164
LLPS-Scc-0261Schizosaccharomyces cryophilus31.937e-44 164
LLPS-Kop-0216Komagataella pastoris31.755e-47 172
LLPS-Ast-0232Aspergillus terreus31.56e-30 122
LLPS-Sac-1202Saccharomyces cerevisiae31.433e-1787.0
LLPS-Aso-0655Aspergillus oryzae31.423e-43 162
LLPS-Tum-0423Tuber melanosporum31.46e-46 169
LLPS-Scj-0253Schizosaccharomyces japonicus31.127e-43 160
LLPS-Asg-0250Ashbya gossypii31.062e-40 153
LLPS-Miv-0440Microbotryum violaceum30.92e-36 143
LLPS-Scp-0911Schizosaccharomyces pombe30.682e-1272.8
LLPS-Asfu-0322Aspergillus fumigatus30.684e-41 156
LLPS-Asc-0069Aspergillus clavatus30.61e-40 155
LLPS-Osl-0068Ostreococcus lucimarinus30.591e-44 165
LLPS-Asni-0124Aspergillus niger30.414e-38 147
LLPS-Pug-0197Puccinia graminis30.332e-35 140
LLPS-Put-0653Puccinia triticina29.591e-35 140
LLPS-Blg-0748Blumeria graminis28.372e-37 145
LLPS-Mel-0230Melampsora laricipopulina28.221e-31 128
LLPS-Lem-0782Leptosphaeria maculans28.063e-32 134
LLPS-Zyt-0169Zymoseptoria tritici27.674e-32 130
LLPS-Nec-0543Neurospora crassa27.615e-37 144
LLPS-Yal-0082Yarrowia lipolytica27.444e-30 124
LLPS-Trr-0222Trichoderma reesei27.342e-35 139
LLPS-Fuv-0092Fusarium verticillioides26.389e-35 138
LLPS-Fus-1246Fusarium solani26.382e-35 139
LLPS-Fuo-1004Fusarium oxysporum26.388e-35 138
LLPS-Mao-0222Magnaporthe oryzae25.951e-30 126
LLPS-Beb-0837Beauveria bassiana25.658e-29 120
LLPS-Cogr-0695Colletotrichum graminicola25.352e-30 125
LLPS-Crn-0226Cryptococcus neoformans24.824e-22 101
LLPS-Gag-0168Gaeumannomyces graminis24.075e-24 107