LLPS-Anc-1475
CTU2
Integrated Annotations
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | Cytoplasmic tRNA 2-thiolation protein 2 |
| Gene Name: | CTU2, NCS2 |
| Ensembl Gene: | ENSACAG00000006759.3 |
| Ensembl Protein: | ENSACAP00000006628.3 |
| Organism: | Anolis carolinensis |
| Taxa ID: | 28377 |
| LLPS Type: | Others |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Stress granule | Predicted from orthologs | (View) |
▼ FUNCTION
| Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with CTU1/ATPBD3 that ligates sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENSACAT00000006774.3 | ENSACAP00000006628.3 |
| UniProt | H9GBW8, H9GBW8_ANOCA | |
| RefSeq | XM_008122266.2 | XP_008120473.1 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MCEAEEGDCG GGQLWRPLQR SRPLKCMKCK EGSPVLIIRV GDAFCKTCFK EYFIHKFRAT 60 61 LGKNRCIYPG EKVLLAFSGG PASSSMVRQV QEGLSQGAAK KLRFKPGIVY IDEGAVCGQS 120 121 LAAREDIRNE VETILEATGF PYHLVHLEEV FDLPSSVLHS VSREIPDQSN SYKEAVDDFI 180 181 KQQREKERDT AELSLRDQQG ELSLQDASRE EELIDPRKEM PAVSHTEKLI NLFQTVKTLT 240 241 AKEELLQTLR THLILHVART NGYGKVMMGD SCTRVAVKLL TNLSLGRGAF LAADTGFSDN 300 301 RHGDVLFLRP MREYPAKEIA FYNRLFGVPS VFIPALDTKA SERASIHRLI ESFLYKLQSE 360 361 FPSTVSTVYR TGEKLSGDAG GLSEPARCLF CLCLLDTNVV DGSSLQSTLL SEQLCKKGTP 420 421 LSPGVDGCCG GTGDRAGCCQ RPIVTRDSSP HTQLLPFLCY SCRLTAKDMN SLESLPPYIQ 480 481 SEAEHRQCRA AMKLEIQEFL LEDDPETS 508 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGTGCGAAG CGGAGGAAGG AGACTGCGGC GGCGGGCAGC TCTGGAGGCC TCTTCAGAGG 60 61 AGCCGCCCCT TGAAATGCAT GAAGTGCAAA GAAGGTTCCC CGGTGTTAAT CATTCGTGTT 120 121 GGAGATGCTT TTTGCAAGAC GTGTTTCAAG GAATATTTCA TCCACAAGTT TCGTGCCACT 180 181 CTTGGAAAAA ATCGATGCAT CTATCCTGGA GAAAAGGTTC TCCTCGCCTT TTCGGGTGGC 240 241 CCTGCCTCAA GTTCGATGGT GCGGCAAGTG CAAGAGGGCC TGAGTCAAGG AGCAGCCAAG 300 301 AAACTCCGCT TCAAACCAGG AATCGTCTAC ATTGATGAAG GAGCTGTGTG TGGACAGAGC 360 361 CTGGCTGCTC GGGAGGATAT CCGCAACGAA GTGGAGACGA TCTTGGAAGC CACTGGATTC 420 421 CCCTATCACT TGGTGCATTT GGAAGAGGTG TTTGACCTTC CCAGTTCTGT CCTCCACTCA 480 481 GTTTCCCGTG AAATCCCTGA CCAGAGCAAC AGCTATAAGG AAGCAGTGGA TGACTTCATA 540 541 AAACAGCAGC GTGAAAAGGA AAGAGACACA GCAGAACTCT CCTTGAGGGA CCAGCAGGGA 600 601 GAGTTAAGCC TACAAGATGC TTCAAGGGAA GAAGAGTTAA TAGACCCAAG AAAGGAGATG 660 661 CCTGCAGTTT CCCATACAGA GAAACTGATC AATCTCTTTC AGACTGTGAA AACCCTGACG 720 721 GCCAAAGAGG AATTATTGCA GACCCTCCGG ACCCACCTCA TCCTCCACGT GGCGCGGACA 780 781 AACGGCTACG GCAAGGTGAT GATGGGAGAC AGCTGCACCC GCGTGGCAGT CAAGCTCCTG 840 841 ACCAACCTCT CCTTGGGACG CGGAGCCTTT CTTGCTGCAG ATACAGGATT CTCAGACAAC 900 901 CGCCATGGTG ATGTGCTGTT CCTGCGCCCG ATGCGGGAGT ACCCTGCCAA AGAGATTGCC 960 961 TTCTACAATC GCCTCTTTGG TGTGCCCTCC GTCTTCATTC CTGCACTCGA TACCAAGGCA 1020 1021 TCAGAGAGAG CCAGCATTCA CCGGCTGATT GAGAGTTTCC TGTACAAGCT GCAGTCTGAG 1080 1081 TTCCCCTCCA CGGTCAGCAC TGTCTATCGG ACAGGGGAGA AGCTCTCTGG TGACGCCGGG 1140 1141 GGACTTTCAG AACCGGCCCG GTGCCTCTTC TGCCTCTGTT TGCTGGACAC GAATGTTGTG 1200 1201 GATGGCTCTT CCTTGCAGTC GACGCTGTTG TCCGAACAGC TCTGCAAGAA GGGGACCCCT 1260 1261 CTGTCCCCTG GTGTGGATGG CTGCTGCGGA GGGACTGGGG ACCGAGCAGG GTGCTGCCAA 1320 1321 AGGCCTATTG TCACCAGGGA CTCTTCCCCT CATACCCAGC TCCTCCCATT TCTCTGCTAC 1380 1381 AGCTGCCGCC TGACCGCCAA AGATATGAAC AGTTTGGAGT CCCTCCCACC GTACATCCAG 1440 1441 TCTGAAGCTG AGCATCGGCA ATGCAGGGCT GCAATGAAGC TGGAAATCCA GGAGTTTTTG 1500 1501 CTTGAAGACG ATCCGGAGAC ATCCTAA 1527 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Cytosol | |
Molecular Function | Nucleotidyltransferase activity | |
Molecular Function | Sulfurtransferase activity | |
Molecular Function | TRNA binding | |
Biological Process | Protein urmylation | |
Biological Process | TRNA wobble position uridine thiolation |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Ora-1110 | Ornithorhynchus anatinus | 56.77 | 0.0 | 538 |
| LLPS-Icp-3456 | Ictalurus punctatus | 56.25 | 1e-156 | 462 |
| LLPS-Asm-3187 | Astyanax mexicanus | 55.77 | 3e-176 | 513 |
| LLPS-Scm-3880 | Scophthalmus maximus | 55.61 | 9e-136 | 405 |
| LLPS-Dar-2867 | Danio rerio | 54.12 | 4e-163 | 479 |
| LLPS-Xim-2456 | Xiphophorus maculatus | 50.76 | 6e-152 | 451 |
| LLPS-Gaa-2950 | Gasterosteus aculeatus | 50.48 | 4e-161 | 474 |
| LLPS-Orn-4116 | Oreochromis niloticus | 49.62 | 1e-154 | 458 |
| LLPS-Fia-1153 | Ficedula albicollis | 48.81 | 4e-146 | 436 |
| LLPS-Tar-3717 | Takifugu rubripes | 48.02 | 1e-137 | 414 |
| LLPS-Scj-1141 | Schizosaccharomyces japonicus | 31.11 | 5e-13 | 74.7 |
| LLPS-Scp-1628 | Schizosaccharomyces pombe | 29.37 | 2e-09 | 63.2 |
| LLPS-Pyt-1000 | Pyrenophora teres | 29.07 | 8e-13 | 73.9 |
| LLPS-Scc-0397 | Schizosaccharomyces cryophilus | 28.77 | 1e-08 | 61.2 |
| LLPS-Blg-0422 | Blumeria graminis | 27.59 | 6e-06 | 52.4 |
| LLPS-Nef-1586 | Neosartorya fischeri | 27.17 | 8e-07 | 55.5 |
| LLPS-Yal-1371 | Yarrowia lipolytica | 26.86 | 8e-10 | 65.1 |
| LLPS-Asn-1530 | Aspergillus nidulans | 26.63 | 7e-07 | 55.1 |
| LLPS-Phn-1462 | Phaeosphaeria nodorum | 26.55 | 2e-18 | 90.9 |
| LLPS-Pytr-1288 | Pyrenophora triticirepentis | 26.19 | 2e-15 | 82.4 |
| LLPS-Asni-0195 | Aspergillus niger | 26.09 | 6e-07 | 55.8 |
| LLPS-Tum-1515 | Tuber melanosporum | 26.01 | 3e-17 | 87.8 |
| LLPS-Asf-0774 | Aspergillus flavus | 25.93 | 5e-06 | 52.8 |
| LLPS-Aso-0437 | Aspergillus oryzae | 25.93 | 5e-06 | 52.8 |
| LLPS-Zyt-1362 | Zymoseptoria tritici | 25.86 | 1e-10 | 65.9 |
| LLPS-Dos-1484 | Dothistroma septosporum | 24.65 | 7e-12 | 70.9 |
| LLPS-Lem-1028 | Leptosphaeria maculans | 23.77 | 5e-11 | 68.9 |
| LLPS-Sac-0470 | Saccharomyces cerevisiae | 21.16 | 8e-13 | 74.7 |
| LLPS-Beb-0158 | Beauveria bassiana | 21.04 | 2e-08 | 60.5 |