• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Anc-0020
PTEN

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
Gene Name: PTEN
Ensembl Gene: ENSACAG00000015101.3
Ensembl Protein: ENSACAP00000014851.3
Organism: Anolis carolinensis
Taxa ID: 28377
LLPS Type: Others


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateEvidenceOrthologs
PML nuclear body, Centrosome/Spindle pole bodyPredicted from orthologs(View)

▼ FUNCTION

Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine-phosphorylated proteins. Also acts as a lipid phosphatase.

▼ CROSS REFERENCE

▼ SEQUENCE

Protein Sequence (FASTA)
1     MTAIIKEIVS  RNKRRYQEDG  FDLDLTYIYP  NIIAMGFPAE  RLEGVYRNNI  DDVVRFLDSK  60
61    HKNHYKIYNL  CAERHYDTAK  FNCRVAQYPF  EDHNPPQLEL  IKPFCEDLDR  WLSEDGNHVA  120
121   AIHCKAGKGR  TGVMICAYLL  HRGRFHKAQE  ALDFYGEVRT  RDKKGVTIPS  QRRYVYYYSY  180
181   LLKNHLDYRP  VALLFHKMMF  ETIPMFSGGT  CNPQFVVYQL  KVKIFTSTSG  PTRREDKYMY  240
241   FEFPQPLPVC  GDIKVEFFHK  QNKMLKKEKM  FHFWVNTFFI  PGLEENSDKV  ENGSLLGDPE  300
301   LDGIFSTERS  DNDKEYLILT  LTKNDLDKAN  KDKANRYFSP  NFKVKLFFTK  TVEEPSNPEA  360
361   SSSTSVTPDV  SDNEPDHYRY  SDTTDSDPEN  EPFDEDQHTQ  ITKV  404
Nucleotide CDS Sequence (FASTA)
1     ATGACCGCCA  TCATCAAAGA  GATCGTCAGC  AGGAACAAAA  GGCGATACCA  GGAGGATGGC  60
61    TTCGATCTAG  ACCTGACCTA  TATTTATCCA  AATATCATTG  CAATGGGTTT  TCCTGCAGAA  120
121   CGACTTGAAG  GAGTATACAG  AAACAATATT  GATGACGTTG  TAAGGTTTTT  GGATTCAAAG  180
181   CATAAAAACC  ATTACAAGAT  ATACAATCTA  TGTGCTGAAC  GACATTATGA  TACCGCCAAA  240
241   TTTAACTGCA  GAGTTGCACA  ATATCCCTTT  GAAGACCATA  ACCCTCCACA  GCTGGAGCTT  300
301   ATCAAACCTT  TTTGTGAAGA  TCTTGATCGA  TGGCTTAGTG  AAGATGGCAA  TCATGTTGCA  360
361   GCAATCCACT  GTAAAGCTGG  AAAGGGACGA  ACTGGTGTAA  TGATTTGTGC  ATATTTGTTA  420
421   CATCGAGGAA  GATTTCATAA  GGCACAAGAA  GCCCTAGATT  TCTATGGTGA  AGTAAGGACC  480
481   AGAGATAAAA  AGGGAGTAAC  TATTCCCAGT  CAGAGGCGCT  ATGTATATTA  CTATAGCTAC  540
541   CTGTTAAAGA  ATCATCTGGA  TTACCGACCA  GTGGCACTGC  TCTTTCACAA  AATGATGTTT  600
601   GAAACAATTC  CAATGTTCAG  TGGTGGCACC  TGCAATCCTC  AATTTGTGGT  CTACCAGCTC  660
661   AAGGTAAAGA  TATTCACCTC  TACTTCAGGG  CCCACAAGGC  GTGAAGACAA  ATACATGTAC  720
721   TTCGAATTCC  CTCAGCCATT  GCCAGTGTGT  GGTGACATCA  AAGTGGAATT  CTTCCATAAG  780
781   CAAAACAAGA  TGTTGAAAAA  GGAAAAAATG  TTTCATTTCT  GGGTAAATAC  ATTCTTCATA  840
841   CCAGGACTGG  AAGAAAATTC  TGACAAAGTA  GAAAATGGAA  GTCTTCTTGG  GGACCCGGAA  900
901   CTTGATGGGA  TTTTCAGTAC  AGAGCGTTCA  GATAATGACA  AGGAATATCT  AATACTTACA  960
961   CTAACAAAAA  ATGATTTGGA  CAAGGCAAAT  AAAGACAAAG  CAAATCGTTA  CTTTTCTCCA  1020
1021  AACTTTAAGG  TGAAGCTATT  TTTCACGAAA  ACAGTAGAGG  AGCCATCAAA  CCCAGAAGCA  1080
1081  AGCAGCTCAA  CTTCAGTAAC  ACCGGATGTT  AGTGATAATG  AACCTGATCA  TTATAGGTAT  1140
1141  TCTGACACCA  CTGACTCTGA  TCCAGAGAAT  GAACCTTTTG  ATGAAGATCA  GCATACACAG  1200
1201  ATTACAAAAG  TCTGA  1215

▼ KEYWORD

ID
Family
Complete proteome
Cytoplasm
Hydrolase
Lipid metabolism
Neurogenesis
Nucleus
Protein phosphatase
Reference proteome

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Apical plasma membrane
Cellular Component
Cytoplasmic side of plasma membrane
Cellular Component
Cytosol
Cellular Component
Myelin sheath adaxonal region
Cellular Component
Neuron projection
Cellular Component
PML body
Cellular Component
Schmidt-Lanterman incisure
Molecular Function
Anaphase-promoting complex binding
Molecular Function
Identical protein binding
Molecular Function
Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity
Molecular Function
PDZ domain binding
Molecular Function
Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity
Molecular Function
Phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity
Molecular Function
Phosphatidylinositol-3-phosphatase activity
Molecular Function
Protein kinase binding
Molecular Function
Protein serine/threonine phosphatase activity
Molecular Function
Protein tyrosine phosphatase activity
Molecular Function
Protein tyrosine/serine/threonine phosphatase activity
Molecular Function
Ubiquitin-specific protease binding
Biological Process
Adult behavior
Biological Process
Angiogenesis
Biological Process
Canonical Wnt signaling pathway
Biological Process
Cardiac muscle tissue development
Biological Process
Cellular response to electrical stimulus
Biological Process
Cellular response to hypoxia
Biological Process
Central nervous system myelin maintenance
Biological Process
Central nervous system neuron axonogenesis
Biological Process
Dendritic spine morphogenesis
Biological Process
Dentate gyrus development
Biological Process
Endothelial cell migration
Biological Process
Forebrain morphogenesis
Biological Process
Inositol phosphate dephosphorylation
Biological Process
Learning or memory
Biological Process
Locomotor rhythm
Biological Process
Long-term synaptic potentiation
Biological Process
Male mating behavior
Biological Process
Maternal behavior
Biological Process
Multicellular organismal response to stress
Biological Process
Negative regulation of apoptotic process
Biological Process
Negative regulation of axon regeneration
Biological Process
Negative regulation of axonogenesis
Biological Process
Negative regulation of cardiac muscle cell proliferation
Biological Process
Negative regulation of cell aging
Biological Process
Negative regulation of cell size
Biological Process
Negative regulation of cyclin-dependent protein serine/threonine kinase activity
Biological Process
Negative regulation of dendritic spine morphogenesis
Biological Process
Negative regulation of epithelial cell proliferation
Biological Process
Negative regulation of epithelial to mesenchymal transition
Biological Process
Negative regulation of ERK1 and ERK2 cascade
Biological Process
Negative regulation of excitatory postsynaptic potential
Biological Process
Negative regulation of focal adhesion assembly
Biological Process
Negative regulation of G1/S transition of mitotic cell cycle
Biological Process
Negative regulation of keratinocyte migration
Biological Process
Negative regulation of myelination
Biological Process
Negative regulation of protein kinase B signaling
Biological Process
Negative regulation of ribosome biogenesis
Biological Process
Negative regulation of synaptic vesicle clustering
Biological Process
Negative regulation of vascular smooth muscle cell proliferation
Biological Process
Negative regulation of wound healing, spreading of epidermal cells
Biological Process
Neuron-neuron synaptic transmission
Biological Process
Phosphatidylinositol dephosphorylation
Biological Process
Positive regulation of cell population proliferation
Biological Process
Positive regulation of DNA-binding transcription factor activity
Biological Process
Positive regulation of ERK1 and ERK2 cascade
Biological Process
Positive regulation of excitatory postsynaptic potential
Biological Process
Positive regulation of TRAIL-activated apoptotic signaling pathway
Biological Process
Positive regulation of ubiquitin protein ligase activity
Biological Process
Positive regulation of ubiquitin-dependent protein catabolic process
Biological Process
Postsynaptic density assembly
Biological Process
Prepulse inhibition
Biological Process
Presynaptic membrane assembly
Biological Process
Prostate gland growth
Biological Process
Protein kinase B signaling
Biological Process
Protein stabilization
Biological Process
Regulation of B cell apoptotic process
Biological Process
Regulation of myeloid cell apoptotic process
Biological Process
Regulation of synaptic transmission, GABAergic
Biological Process
Rhythmic synaptic transmission
Biological Process
Social behavior
Biological Process
Synapse maturation

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Mod-0338Monodelphis domestica100.01e-26 114
LLPS-Gaga-1275Gallus gallus97.030.0 759
LLPS-Pes-2503Pelodiscus sinensis96.760.0 691
LLPS-Anp-1689Anas platyrhynchos96.340.0 706
LLPS-Tag-2591Taeniopygia guttata96.290.0 702
LLPS-Fia-0568Ficedula albicollis96.220.0 688
LLPS-Loa-0909Loxodonta africana94.550.0 741
LLPS-Gog-4130Gorilla gorilla94.310.0 739
LLPS-Caj-3492Callithrix jacchus94.310.0 739
LLPS-Maf-0981Macaca fascicularis94.310.0 739
LLPS-Chs-3267Chlorocebus sabaeus94.310.0 739
LLPS-Cea-2236Cercocebus atys94.310.0 739
LLPS-Sus-1150Sus scrofa94.310.0 743
LLPS-Paa-0888Papio anubis94.310.0 739
LLPS-Mal-3619Mandrillus leucophaeus94.310.0 739
LLPS-Aim-1597Ailuropoda melanoleuca94.310.0 739
LLPS-Orc-3838Oryctolagus cuniculus94.310.0 739
LLPS-Pat-3040Pan troglodytes94.310.0 739
LLPS-Hos-0538Homo sapiens94.310.0 739
LLPS-Fec-2397Felis catus94.310.0 739
LLPS-Man-0008Macaca nemestrina94.310.0 739
LLPS-Cas-3361Carlito syrichta94.310.0 739
LLPS-Nol-2905Nomascus leucogenys94.310.0 739
LLPS-Eqc-4581Equus caballus94.310.0 744
LLPS-Mam-3838Macaca mulatta94.310.0 744
LLPS-Fud-1517Fukomys damarensis94.060.0 737
LLPS-Mea-2023Mesocricetus auratus94.060.0 738
LLPS-Mum-0186Mus musculus94.060.0 738
LLPS-Ran-1719Rattus norvegicus94.060.0 736
LLPS-Ova-0277Ovis aries94.060.0 736
LLPS-Bot-2586Bos taurus94.060.0 741
LLPS-Ict-1711Ictidomys tridecemlineatus94.060.0 738
LLPS-Poa-3742Pongo abelii94.060.0 736
LLPS-Otg-2730Otolemur garnettii94.050.0 672
LLPS-Ere-0805Erinaceus europaeus93.90.0 687
LLPS-Caf-1388Canis familiaris92.930.0 685
LLPS-Aon-3263Aotus nancymaae92.820.0 721
LLPS-Myl-3410Myotis lucifugus92.370.0 619
LLPS-Meg-1075Meleagris gallopavo92.330.0 717
LLPS-Lac-1039Latimeria chalumnae92.330.0 716
LLPS-Pap-4299Pan paniscus92.310.0 717
LLPS-Sah-1474Sarcophilus harrisii91.670.0 697
LLPS-Scf-1717Scleropages formosus90.840.0 713
LLPS-Urm-3621Ursus maritimus90.840.0 709
LLPS-Xet-2599Xenopus tropicalis90.590.0 682
LLPS-Icp-3152Ictalurus punctatus89.110.0 701
LLPS-Rhb-0965Rhinopithecus bieti88.860.0 682
LLPS-Dio-3045Dipodomys ordii88.610.0 669
LLPS-Asm-3204Astyanax mexicanus86.170.0 667
LLPS-Gaa-1147Gasterosteus aculeatus85.510.0 682
LLPS-Ten-2087Tetraodon nigroviridis85.440.0 682
LLPS-Leo-3439Lepisosteus oculatus84.940.0 656
LLPS-Cap-4402Cavia porcellus82.430.0 614
LLPS-Dar-3252Danio rerio82.20.0 671
LLPS-Orl-3164Oryzias latipes80.910.0 664
LLPS-Xim-1575Xiphophorus maculatus78.910.0 657
LLPS-Scm-0192Scophthalmus maximus78.880.0 659
LLPS-Orn-2607Oreochromis niloticus76.770.0 652
LLPS-Tar-1658Takifugu rubripes76.030.0 652
LLPS-Ora-2421Ornithorhynchus anatinus75.922e-176 505
LLPS-Pof-1212Poecilia formosa74.630.0 649
LLPS-Cis-0123Ciona savignyi63.041e-123 366
LLPS-Cii-0767Ciona intestinalis55.682e-125 375
LLPS-Vir-0970Vigna radiata51.111e-56 198
LLPS-Sem-1643Selaginella moellendorffii50.567e-55 192
LLPS-Via-0707Vigna angularis50.563e-56 197
LLPS-Phv-0009Phaseolus vulgaris50.554e-57 199
LLPS-Amt-0184Amborella trichopoda50.282e-54 193
LLPS-Dac-0848Daucus carota50.07e-58 199
LLPS-Mae-1794Manihot esculenta50.01e-55 199
LLPS-Chr-1414Chlamydomonas reinhardtii49.729e-43 163
LLPS-Sot-0900Solanum tuberosum48.913e-54 191
LLPS-Arl-2124Arabidopsis lyrata48.733e-57 204
LLPS-Art-2666Arabidopsis thaliana48.734e-57 203
LLPS-Spr-1333Sporisorium reilianum47.228e-31 129
LLPS-Drm-1997Drosophila melanogaster46.742e-85 276
LLPS-Viv-2221Vitis vinifera45.652e-53 183
LLPS-Orgl-2400Oryza glumaepatula43.722e-40 148
LLPS-Mel-1254Melampsora laricipopulina42.586e-32 132
LLPS-Tut-0665Tursiops truncatus42.117e-0957.0
LLPS-Usm-1156Ustilago maydis40.944e-30 127
LLPS-Scc-0592Schizosaccharomyces cryophilus40.681e-29 122
LLPS-Abg-1991Absidia glauca39.742e-63 213
LLPS-Orni-2252Oryza nivara39.664e-59 206
LLPS-Orb-1775Oryza barthii39.664e-59 206
LLPS-Orp-0212Oryza punctata39.664e-59 206
LLPS-Ors-1429Oryza sativa39.01e-58 208
LLPS-Org-1044Oryza glaberrima39.02e-58 207
LLPS-Orr-1419Oryza rufipogon39.03e-58 207
LLPS-Bro-1460Brassica oleracea38.76e-62 216
LLPS-Sei-2350Setaria italica38.671e-57 205
LLPS-Orbr-0905Oryza brachyantha38.673e-58 207
LLPS-Sob-2409Sorghum bicolor38.671e-57 205
LLPS-Thc-2151Theobroma cacao38.395e-61 214
LLPS-Brn-0654Brassica napus38.398e-61 213
LLPS-Brr-1950Brassica rapa38.398e-61 213
LLPS-Coc-1234Corchorus capsularis38.392e-58 207
LLPS-Met-0894Medicago truncatula38.369e-57 202
LLPS-Hov-1706Hordeum vulgare38.335e-58 206
LLPS-Brd-1464Brachypodium distachyon38.333e-58 207
LLPS-Tra-2770Triticum aestivum38.335e-58 206
LLPS-Lep-1918Leersia perrieri38.337e-58 206
LLPS-Mua-1916Musa acuminata38.012e-58 206
LLPS-Cus-1298Cucumis sativus38.015e-57 203
LLPS-Put-0747Puccinia triticina37.933e-0860.1
LLPS-Blg-1172Blumeria graminis37.861e-29 124
LLPS-Hea-1760Helianthus annuus37.654e-58 205
LLPS-Crn-0390Cryptococcus neoformans37.214e-0653.1
LLPS-Glm-0125Glycine max37.155e-58 205
LLPS-Nia-0879Nicotiana attenuata37.156e-57 202
LLPS-Gor-1014Gossypium raimondii37.152e-57 204
LLPS-Scp-0654Schizosaccharomyces pombe36.961e-31 127
LLPS-Prp-2181Prunus persica36.845e-59 207
LLPS-Asc-0664Aspergillus clavatus36.745e-28 119
LLPS-Zyt-0675Zymoseptoria tritici36.734e-29 119
LLPS-Asni-1309Aspergillus niger36.456e-29 122
LLPS-Php-1376Physcomitrella patens36.031e-54 197
LLPS-Pot-2157Populus trichocarpa35.981e-59 209
LLPS-Cae-2003Caenorhabditis elegans35.143e-48 181
LLPS-Asfu-0134Aspergillus fumigatus34.883e-26 114
LLPS-Tru-1081Triticum urartu34.357e-33 130
LLPS-Ori-1981Oryza indica34.336e-42 160
LLPS-Cog-0360Colletotrichum gloeosporioides34.271e-26 115
LLPS-Coo-1088Colletotrichum orbiculare34.081e-27 119
LLPS-Cogr-0160Colletotrichum graminicola33.652e-25 112
LLPS-Zem-0710Zea mays33.335e-44 167
LLPS-Scj-1338Schizosaccharomyces japonicus32.093e-30 124
LLPS-Pug-0439Puccinia graminis30.571e-1067.4
LLPS-Kop-0211Komagataella pastoris27.575e-0755.8
LLPS-Miv-0297Microbotryum violaceum26.97e-0962.0