LLPS-Aim-a456
DAD1
Integrated Annotations
▼ OVERVIEW
| Status: | Unreviewed |
| Protein Name: | Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1 |
| Gene Name: | DAD1, PANDA_015644 |
| Ensembl Gene: | ENSAMEG00000007157.1 |
| Ensembl Protein: | ENSAMEP00000007522.1 |
| Organism: | Ailuropoda melanoleuca |
| Taxa ID: | 9646 |
| LLPS Type: | Others |
▼ Classification
Condensates:
| Condensate | Evidence | Orthologs |
|---|---|---|
| Postsynaptic density | Predicted from orthologs | (View) |
▼ FUNCTION
| Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. |
▼ CROSS REFERENCE
| Database | Nucleotide ID | Protein ID |
|---|---|---|
| Ensembl | ENSAMET00000007838.1 | ENSAMEP00000007522.1 |
| UniProt | D2HTV2, D2HTV2_AILME | |
| GeneBank | GL193372, ACTA01035783, ACTA01027783 | , EFB18950.1 |
| RefSeq | XM_011233328.2 | XP_011231630.1 |
| Entrez | 100470635 |
▼ SEQUENCE
| Protein Sequence (FASTA) |
|---|
1 MSASVVSVIS RFLEEYLSST PQRLKLLDAY LLYILLTGAL QFGYCLLVGT FPFNSFLSGF 60 61 ISCVGSFILA VCLRIQINPQ NKADFQGISP ERAFADFLFA STILHLVVMN FVG 113 |
| Nucleotide CDS Sequence (FASTA) |
1 ATGTCGGCGT CGGTGGTGTC GGTCATCTCG CGGTTCTTAG AAGAGTACTT GAGCTCCACT 60 61 CCTCAGCGTC TGAAGTTGCT TGACGCGTAC CTCCTGTACA TACTGCTGAC CGGGGCGCTG 120 121 CAGTTCGGTT ATTGTCTCCT CGTGGGGACC TTCCCCTTCA ACTCTTTCCT CTCGGGCTTC 180 181 ATCTCTTGTG TGGGGAGCTT CATCCTAGCG GTTTGCCTCA GGATACAGAT CAACCCACAG 240 241 AACAAAGCGG ATTTCCAAGG CATCTCCCCA GAGCGAGCAT TTGCTGATTT TCTCTTTGCC 300 301 AGCACCATCC TACACCTTGT TGTAATGAAC TTCGTTGGC 339 |
▼ KEYWORD
▼ GENE ONTOLOGY
ID | Classification | Description |
Cellular Component | Integral component of membrane | |
Cellular Component | Oligosaccharyltransferase complex | |
Molecular Function | Dolichyl-diphosphooligosaccharide-protein glycotransferase activity | |
Biological Process | Blastocyst development | |
Biological Process | Negative regulation of apoptotic process | |
Biological Process | Protein glycosylation |
▼ ORTHOLOGY
| DrLLPS ID | Organism | Identity | E-value | Score |
|---|---|---|---|---|
| LLPS-Hos-a475 | Homo sapiens | 7e-75 | 226 | undefined |
| LLPS-Mum-a471 | Mus musculus | 7e-75 | 226 | undefined |