• Disorder▼
  • Domain▼
  • PTM▼
  • Variation▼
  • Mutation▼
  • Interaction▼
  • Disease▼
  • Drug▼
  • Physicochemical▼
  • Function▼
  • Proteomics▼
  • Structure▼
  • Localization▼
  • Expression▼
  • Element▼
  • Methylation▼

LLPS-Aim-0284
ATP2B4

Integrated Annotations

▼ OVERVIEW

Status: Unreviewed
Protein Name: Calcium-transporting ATPase
Gene Name: ATP2B4
Ensembl Gene: ENSAMEG00000000712.1
Ensembl Protein: ENSAMEP00000000856.1
Organism: Ailuropoda melanoleuca
Taxa ID: 9646
LLPS Type: Others


▼ Classification

Condensates:
CondensateEvidenceOrthologs
Nucleolus, Postsynaptic densityPredicted from orthologs(View)

▼ FUNCTION

This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.

▼ CROSS REFERENCE

DatabaseNucleotide IDProtein ID
EnsemblENSAMET00000000888.1ENSAMEP00000000856.1
UniProtG1L1V3, G1L1V3_AILME
GeneBankACTA01072426

▼ SEQUENCE

Protein Sequence (FASTA)
1     AGKMTNPTEH  ALPANSMVES  REGDFGCTVM  DLRKLMELRS  TDAIDQINAH  YGGVMSLCNR  60
61    LRTDPVEGLS  GNPADLEKRK  QVFGQNFIPP  KKPKTFLELV  WEALQDVTLI  ILEIAAIISL  120
121   VLSFYRPPGE  ENKQCGLPVS  SPEDEGEAEA  GWIEGAAILF  SVIIVVLVTA  FNDWSKEKQF  180
181   RGLQNRIEKE  QKFSVIRNGH  IIQLPVAEIV  VGDIAQIKYG  DLLPADGILI  QGNDLKIDES  240
241   SLTGESDHVR  KSLERDPMLL  SGTHVMEGSG  RMVVTAVGIN  SQTGIIFTLL  GANEGEEEEK  300
301   KKKGKEKQGK  KQGVPENRNK  AKTQDGVALE  IQPLNSQEGI  DNEEKEKKAA  KLPKKEKSVL  360
361   QGKLTRLAVQ  IGKAGLIMSA  ITVLILILYF  VIDNFVIHRR  PWLSECTPIY  IQYFVKFFII  420
421   GITVLVVAVP  EGLPLAVTIS  LAYSVKKMMK  DNNLVRHLDA  CETMGNATAI  CSDKTGTLTM  480
481   NRMTVVQAYI  GDTHYHQIPS  PDALVPKVLD  LIVNGISINS  AYTSKILPPE  KEGGLPRQVG  540
541   NKTECALLGF  VTDLKQDYHA  VRNEVPEEKL  YKVYTFNSVR  KSMSTVIEKP  SGGYRMYSKG  600
601   ASEIILRKCN  RILDKKGDVM  PFKNKDRDEM  VRTVIEPMAS  EGLRTICIAY  RDFSDGEPPW  660
661   DNENEILTEL  TCVAVVGIED  PVRPEVPEAI  AKCKRAGITV  RMVTGDNINT  ARAIATKCGI  720
721   VTPGDDFLCL  EGKEFNRLIR  NEKGEVEQEK  LDKIWPKLRV  LARSSPTDKH  TLVKGIIDST  780
781   VGEQRQVVAV  TGDGTNDGPA  LKKADVGFAM  GIAGTDVAKE  ASDIILTDDN  FTSIVKAVMW  840
841   GRNVYDSISK  FLQFQLTVNV  VAVIVAFTGA  CITQDSPLKA  VQMLWVNLIM  DTFASLALAT  900
901   EPPTESLLKR  RPYGRNKPLI  SRTMMKNILG  HAVYQLSVIF  FLIFAGEKFF  DIDSGRKAPL  960
961   HSPPSQHYTI  IFNTFLMQLF  NEINSRKIHG  ERNVFAGIFR  NLIFCSVVLG  TFISQILIVE  1020
1021  FGGKPFSCTK  LTLSQWFWCL  FIGIGELLWG  QVISTIPTQS  LKFLKEAGHG  TTKEEITKDA  1080
1081  EGLDEIDHAE  MELRRGQILW  FRGLNRIQTQ  IDVINTFQTG  ASFKGVLKRQ  TMGQHLDVKH  1140
1141  VPSSSYIKVV  KAFHSSLHES  IQKPKNQNSI  HNFMTHPEFA  IDEEVPRTPL  LDEHEEEILN  1200
1201  NPKAGTRVLL  LDGEVPPYTN  KNNNAVDCSQ  VQIVASHSDS  PLHSLETSV  1249
Nucleotide CDS Sequence (FASTA)
1     GCGGGCAAAA  TGACGAACCC  AACAGAACAT  GCCTTGCCGG  CTAACTCGAT  GGTCGAGAGC  60
61    CGCGAAGGGG  ACTTCGGCTG  CACGGTAATG  GACCTAAGGA  AGCTCATGGA  GCTCCGTTCC  120
121   ACGGATGCAA  TCGACCAGAT  CAATGCCCAC  TATGGAGGTG  TGATGAGTCT  CTGCAACAGA  180
181   CTGAGAACCG  ACCCTGTGGA  AGGTCTGTCT  GGGAACCCTG  CGGACCTGGA  GAAACGTAAG  240
241   CAAGTGTTTG  GACAGAACTT  CATCCCCCCC  AAAAAGCCCA  AGACCTTCTT  AGAACTAGTG  300
301   TGGGAAGCCC  TTCAAGATGT  CACACTCATC  ATCCTGGAGA  TTGCAGCCAT  CATCTCCCTC  360
361   GTCCTGTCCT  TCTACCGCCC  GCCTGGGGAA  GAAAATAAAC  AGTGTGGTCT  ACCTGTAAGT  420
421   AGCCCAGAAG  ATGAAGGAGA  GGCAGAAGCC  GGCTGGATTG  AGGGGGCAGC  CATCCTGTTC  480
481   TCTGTGATCA  TCGTGGTGCT  GGTGACTGCC  TTCAATGATT  GGAGCAAGGA  GAAGCAATTC  540
541   CGGGGGCTGC  AGAACCGCAT  TGAAAAGGAA  CAGAAGTTCT  CCGTGATCCG  AAATGGCCAC  600
601   ATCATCCAGC  TGCCTGTGGC  TGAGATTGTG  GTGGGTGACA  TCGCCCAAAT  CAAATACGGT  660
661   GACCTGCTGC  CTGCAGATGG  GATCCTGATC  CAGGGGAATG  ATCTCAAGAT  TGATGAGAGC  720
721   TCTCTGACTG  GGGAATCAGA  CCATGTCAGG  AAGTCCTTGG  AAAGAGACCC  AATGCTGCTC  780
781   TCAGGGACCC  ATGTCATGGA  AGGTTCTGGC  CGGATGGTAG  TGACTGCCGT  GGGTATCAAC  840
841   TCCCAGACTG  GAATCATCTT  TACCCTTTTG  GGAGCCAATG  AGGGAGAAGA  GGAGGAGAAG  900
901   AAAAAAAAAG  GGAAGGAAAA  ACAAGGTAAA  AAACAAGGAG  TCCCCGAAAA  TCGCAACAAA  960
961   GCAAAGACCC  AGGATGGAGT  GGCCCTGGAA  ATCCAGCCAC  TCAACAGCCA  GGAGGGGATC  1020
1021  GACAATGAGG  AAAAGGAGAA  AAAGGCGGCC  AAGCTGCCCA  AAAAGGAGAA  GTCGGTGCTG  1080
1081  CAGGGCAAGC  TGACGCGCTT  GGCGGTTCAG  ATCGGGAAAG  CCGGTCTCAT  CATGTCGGCC  1140
1141  ATCACGGTTC  TCATCCTGAT  CCTGTACTTT  GTGATCGACA  ACTTCGTGAT  CCACCGCAGG  1200
1201  CCGTGGCTGT  CCGAGTGCAC  GCCCATCTAC  ATCCAGTACT  TCGTCAAGTT  CTTCATTATC  1260
1261  GGCATCACCG  TGCTGGTGGT  GGCCGTGCCG  GAGGGGCTGC  CGCTGGCTGT  CACCATCTCA  1320
1321  CTGGCCTACT  CTGTGAAGAA  AATGATGAAA  GACAATAACT  TGGTGCGACA  CCTGGATGCT  1380
1381  TGTGAGACGA  TGGGCAACGC  CACAGCCATC  TGCTCTGATA  AGACCGGCAC  GTTGACCATG  1440
1441  AACCGCATGA  CTGTGGTCCA  GGCGTATATT  GGAGACACCC  ATTACCATCA  GATCCCAAGC  1500
1501  CCCGATGCCC  TTGTGCCCAA  GGTCCTGGAC  CTTATCGTCA  ATGGCATTTC  TATCAACAGT  1560
1561  GCCTATACCT  CCAAGATTCT  GCCTCCGGAG  AAGGAGGGAG  GTCTCCCGCG  GCAAGTGGGC  1620
1621  AACAAGACCG  AGTGTGCTCT  GCTGGGCTTT  GTCACGGACC  TGAAGCAGGA  TTACCACGCC  1680
1681  GTGCGCAACG  AGGTGCCGGA  GGAGAAGCTC  TACAAGGTGT  ACACGTTCAA  CTCCGTGCGC  1740
1741  AAGTCCATGA  GCACGGTCAT  CGAGAAGCCC  AGTGGTGGCT  ACCGCATGTA  CAGCAAGGGC  1800
1801  GCGTCTGAGA  TCATCTTGCG  CAAGTGTAAC  CGAATCCTGG  ACAAGAAAGG  GGATGTGATG  1860
1861  CCATTCAAGA  ATAAGGACCG  AGATGAGATG  GTGCGCACCG  TCATCGAGCC  CATGGCCTCG  1920
1921  GAGGGCCTCC  GAACCATCTG  CATAGCTTAC  CGGGATTTCA  GCGACGGGGA  GCCCCCGTGG  1980
1981  GACAATGAGA  ACGAAATCCT  CACTGAGCTC  ACGTGTGTCG  CAGTGGTGGG  CATTGAGGAC  2040
2041  CCTGTGCGCC  CAGAGGTACC  CGAAGCTATT  GCCAAATGCA  AACGAGCTGG  CATTACTGTC  2100
2101  AGAATGGTGA  CAGGTGACAA  CATCAACACA  GCCCGAGCCA  TTGCCACCAA  ATGTGGCATT  2160
2161  GTGACACCTG  GGGATGACTT  CTTGTGCTTA  GAAGGCAAAG  AATTCAACCG  ACTTATCCGC  2220
2221  AACGAGAAGG  GAGAGGTGGA  GCAAGAGAAG  CTGGACAAGA  TCTGGCCGAA  GCTTCGAGTC  2280
2281  CTGGCGCGAT  CATCCCCCAC  GGACAAGCAC  ACACTGGTAA  AAGGCATCAT  CGACAGCACT  2340
2341  GTTGGGGAGC  AGCGACAGGT  GGTGGCTGTC  ACTGGTGATG  GCACAAATGA  TGGGCCGGCT  2400
2401  CTGAAGAAAG  CAGACGTTGG  TTTTGCCATG  GGCATTGCAG  GCACGGACGT  GGCAAAGGAG  2460
2461  GCATCAGACA  TCATCCTAAC  CGATGACAAC  TTCACCAGCA  TTGTGAAGGC  AGTGATGTGG  2520
2521  GGGCGAAACG  TCTATGACAG  CATCTCCAAG  TTTCTGCAGT  TCCAACTCAC  TGTCAACGTG  2580
2581  GTAGCCGTGA  TCGTGGCCTT  CACCGGAGCC  TGTATCACTC  AGGATTCCCC  GCTGAAAGCC  2640
2641  GTGCAGATGT  TGTGGGTTAA  CCTGATCATG  GACACTTTCG  CCTCGTTGGC  CCTGGCCACA  2700
2701  GAGCCTCCCA  CAGAGTCCCT  GCTGAAGCGC  CGCCCCTATG  GCCGAAACAA  GCCCCTGATC  2760
2761  TCACGCACTA  TGATGAAGAA  CATCCTGGGC  CACGCCGTCT  ACCAGCTCAG  TGTTATCTTC  2820
2821  TTCCTCATCT  TTGCCGGTGA  GAAATTCTTT  GACATCGATA  GCGGGAGGAA  GGCGCCCCTG  2880
2881  CACTCGCCGC  CCAGCCAGCA  TTACACCATC  ATCTTCAACA  CCTTCCTGAT  GCAGCTCTTC  2940
2941  AACGAGATCA  ACTCCCGCAA  GATCCACGGG  GAGAGGAACG  TCTTCGCGGG  CATCTTCCGC  3000
3001  AACCTCATCT  TCTGCTCCGT  GGTCCTGGGC  ACCTTCATCA  GCCAGATTCT  CATTGTGGAA  3060
3061  TTTGGGGGTA  AACCCTTCAG  TTGTACGAAG  CTCACCCTGT  CTCAGTGGTT  TTGGTGTCTC  3120
3121  TTCATCGGCA  TCGGAGAACT  GCTGTGGGGC  CAGGTAATCT  CCACGATACC  TACCCAATCC  3180
3181  CTGAAGTTCC  TGAAGGAGGC  TGGGCACGGC  ACCACCAAAG  AGGAGATCAC  CAAGGACGCA  3240
3241  GAGGGGCTGG  ACGAGATCGA  CCACGCGGAG  ATGGAGCTGC  GCCGCGGCCA  GATCCTCTGG  3300
3301  TTCCGGGGCC  TGAACCGTAT  CCAGACTCAG  ATCGACGTAA  TTAACACATT  CCAGACGGGA  3360
3361  GCCTCTTTTA  AGGGAGTCCT  AAAGCGACAG  ACCATGGGGC  AGCACCTTGA  TGTTAAACAT  3420
3421  GTTCCTAGCT  CATCCTATAT  CAAAGTGGTC  AAAGCATTCC  ATAGTTCCCT  CCACGAAAGC  3480
3481  ATTCAGAAAC  CCAAGAACCA  AAACTCCATC  CACAACTTCA  TGACCCACCC  TGAATTCGCC  3540
3541  ATAGACGAGG  AGGTGCCACG  GACACCACTC  CTGGATGAGC  ACGAGGAGGA  AATTCTTAAC  3600
3601  AATCCTAAGG  CCGGGACTAG  GGTGCTCCTG  TTGGATGGTG  AGGTCCCTCC  ATATACCAAC  3660
3661  AAAAACAACA  ATGCGGTGGA  CTGCAGCCAA  GTGCAAATTG  TGGCCTCCCA  CTCAGACAGC  3720
3721  CCTCTACACA  GCCTGGAGAC  ATCCGTTTGA  3750

▼ KEYWORD

ID
Family
ATP-binding
Calcium
Calcium transport
Complete proteome
Ion transport
Membrane
Nucleotide-binding
Reference proteome
Transmembrane
Transmembrane helix
Transport

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Integral component of membrane
Cellular Component
Sperm flagellum
Cellular Component
T-tubule
Cellular Component
Z disc
Molecular Function
ATP binding
Molecular Function
Calcium-transporting ATPase activity
Molecular Function
Calmodulin binding
Molecular Function
Nitric-oxide synthase binding
Molecular Function
Nitric-oxide synthase inhibitor activity
Molecular Function
Protein phosphatase 2B binding
Biological Process
Cellular calcium ion homeostasis
Biological Process
Cellular response to epinephrine stimulus
Biological Process
Flagellated sperm motility
Biological Process
Negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process
Biological Process
Negative regulation of arginine catabolic process
Biological Process
Negative regulation of calcineurin-NFAT signaling cascade
Biological Process
Negative regulation of cardiac muscle hypertrophy in response to stress
Biological Process
Negative regulation of citrulline biosynthetic process
Biological Process
Negative regulation of nitric oxide biosynthetic process
Biological Process
Negative regulation of nitric oxide mediated signal transduction
Biological Process
Negative regulation of nitric-oxide synthase activity
Biological Process
Negative regulation of the force of heart contraction
Biological Process
Positive regulation of cAMP-dependent protein kinase activity
Biological Process
Positive regulation of peptidyl-serine phosphorylation
Biological Process
Regulation of cell cycle G1/S phase transition
Biological Process
Regulation of transcription by RNA polymerase II
Biological Process
Response to hydrostatic pressure

▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Urm-3246Ursus maritimus95.270.02291
LLPS-Caf-3782Canis familiaris93.910.02270
LLPS-Mup-2733Mustela putorius furo93.340.02263
LLPS-Fec-2008Felis catus92.790.02212
LLPS-Sus-0980Sus scrofa91.740.02208
LLPS-Bot-3543Bos taurus91.510.02209
LLPS-Myl-1013Myotis lucifugus91.350.02240
LLPS-Chs-3196Chlorocebus sabaeus90.410.02043
LLPS-Eqc-3131Equus caballus90.380.02180
LLPS-Mal-4006Mandrillus leucophaeus89.530.02198
LLPS-Nol-3456Nomascus leucogenys89.530.02191
LLPS-Cas-3032Carlito syrichta89.420.02049
LLPS-Paa-3722Papio anubis89.370.02193
LLPS-Loa-4576Loxodonta africana88.390.02123
LLPS-Fud-1034Fukomys damarensis87.250.02095
LLPS-Man-0351Macaca nemestrina86.890.02112
LLPS-Hos-2168Homo sapiens86.890.02105
LLPS-Pap-2874Pan paniscus86.890.02105
LLPS-Maf-2515Macaca fascicularis86.810.02110
LLPS-Rhb-1344Rhinopithecus bieti86.810.02111
LLPS-Pat-0363Pan troglodytes86.810.02103
LLPS-Gog-2165Gorilla gorilla86.790.02110
LLPS-Mam-1639Macaca mulatta86.730.02109
LLPS-Cea-4467Cercocebus atys86.650.02107
LLPS-Otg-4419Otolemur garnettii86.290.02098
LLPS-Orc-3484Oryctolagus cuniculus86.090.02118
LLPS-Cap-3465Cavia porcellus85.820.02071
LLPS-Ict-2390Ictidomys tridecemlineatus85.60.02077
LLPS-Poa-2318Pongo abelii85.180.01871
LLPS-Dio-3063Dipodomys ordii84.210.02073
LLPS-Anc-3813Anolis carolinensis83.360.01871
LLPS-Caj-0166Callithrix jacchus83.280.01971
LLPS-Meg-0867Meleagris gallopavo82.760.01845
LLPS-Ran-4504Rattus norvegicus81.150.01961
LLPS-Mum-3529Mus musculus80.770.01959
LLPS-Anp-1294Anas platyrhynchos79.630.01840
LLPS-Gaga-3741Gallus gallus79.540.01914
LLPS-Ora-0552Ornithorhynchus anatinus79.320.01915
LLPS-Scf-3680Scleropages formosus79.070.01783
LLPS-Pof-1037Poecilia formosa78.990.01758
LLPS-Pes-3451Pelodiscus sinensis78.710.01914
LLPS-Xet-2534Xenopus tropicalis78.570.01878
LLPS-Xim-1285Xiphophorus maculatus78.370.01743
LLPS-Lac-3573Latimeria chalumnae76.540.01724
LLPS-Mea-3633Mesocricetus auratus76.380.01724
LLPS-Leo-1290Lepisosteus oculatus76.220.01852
LLPS-Icp-0982Ictalurus punctatus76.080.01739
LLPS-Sah-3559Sarcophilus harrisii75.640.01805
LLPS-Ova-3677Ovis aries74.840.01761
LLPS-Scm-1150Scophthalmus maximus74.020.01659
LLPS-Dar-1799Danio rerio73.270.01650
LLPS-Asm-2279Astyanax mexicanus72.670.01691
LLPS-Aon-0404Aotus nancymaae71.850.01704
LLPS-Mod-0110Monodelphis domestica71.730.01725
LLPS-Orn-0471Oreochromis niloticus71.270.01721
LLPS-Tar-2285Takifugu rubripes70.010.01652
LLPS-Orl-0652Oryzias latipes69.240.01582
LLPS-Ten-2887Tetraodon nigroviridis67.570.01411
LLPS-Cae-1362Caenorhabditis elegans58.630.01203
LLPS-Glm-1831Glycine max48.070.0 572
LLPS-Prp-2328Prunus persica46.854e-176 555
LLPS-Orb-1712Oryza barthii46.722e-172 545
LLPS-Ors-0474Oryza sativa46.723e-173 547
LLPS-Brd-2332Brachypodium distachyon46.625e-179 564
LLPS-Nia-0923Nicotiana attenuata46.566e-174 549
LLPS-Via-0301Vigna angularis46.441e-175 554
LLPS-Thc-0051Theobroma cacao46.437e-178 560
LLPS-Hov-2082Hordeum vulgare46.143e-175 553
LLPS-Zem-2525Zea mays46.146e-173 548
LLPS-Vir-1376Vigna radiata46.068e-176 555
LLPS-Brn-0676Brassica napus45.837e-175 552
LLPS-Orni-2411Oryza nivara45.733e-173 547
LLPS-Ori-2085Oryza indica45.732e-173 548
LLPS-Orr-0922Oryza rufipogon45.734e-173 547
LLPS-Arl-1793Arabidopsis lyrata45.652e-178 561
LLPS-Orgl-0954Oryza glumaepatula45.591e-172 546
LLPS-Art-2143Arabidopsis thaliana45.542e-175 553
LLPS-Tra-2133Triticum aestivum45.445e-172 544
LLPS-Orp-0799Oryza punctata45.389e-172 543
LLPS-Bro-0717Brassica oleracea45.262e-175 552
LLPS-Orbr-2081Oryza brachyantha45.139e-174 549
LLPS-Met-0822Medicago truncatula45.081e-173 548
LLPS-Sot-1750Solanum tuberosum45.061e-171 544
LLPS-Abg-0122Absidia glauca45.07e-164 527
LLPS-Lep-0194Leersia perrieri44.962e-171 543
LLPS-Sol-2464Solanum lycopersicum44.846e-172 545
LLPS-Cus-0835Cucumis sativus44.84e-171 542
LLPS-Brr-2183Brassica rapa44.767e-173 546
LLPS-Amt-1678Amborella trichopoda44.753e-177 558
LLPS-Phv-1661Phaseolus vulgaris44.654e-174 550
LLPS-Mae-1730Manihot esculenta44.541e-166 530
LLPS-Pot-1751Populus trichocarpa44.526e-172 544
LLPS-Hea-0299Helianthus annuus44.29e-173 546
LLPS-Sob-1596Sorghum bicolor44.192e-176 556
LLPS-Sei-2397Setaria italica44.027e-171 542
LLPS-Dac-1456Daucus carota43.791e-169 538
LLPS-Org-0542Oryza glaberrima43.743e-170 540
LLPS-Tru-0081Triticum urartu43.464e-173 546
LLPS-Gor-2334Gossypium raimondii43.186e-164 523
LLPS-Viv-1569Vitis vinifera43.172e-172 546
LLPS-Sem-2021Selaginella moellendorffii41.198e-168 534
LLPS-Phn-1208Phaeosphaeria nodorum40.190.0 604