Caenorhabditis elegans Client
※ Client introduction A large number of proteins were identified to be co-complexed with known MLO scaffolds by conventional biochemical assays or mass spectrometry, or co-localized with MLOs by immunofluorescence. For example, C14ORF166, FAM98A/B, and RTCB were identified as candidate stress granule proteins, which form an RNA transport complex with the DEAD-box helicase DDX1, a known scaffold of multiple MLOs including stress granules (1). It was not known whether C14ORF166, FAM98A, FAM98B and RTCB are indispensable for stress granule assembly, and the four proteins were annotated as potential clients. References
1. Markmiller, S., Soltanieh, S., Server, K.L., Mak, R., Jin, W., Fang, M.Y., Luo, E.C., Krach, F., Yang, D., Sen, A. et al. (2018) Context-dependent and disease-specific diversity in protein Interactions within stress granules. Cell, 172, 590-604.e13. PMID: 29373831
There are 1321 genes. Reviewed (48)
or Unreviewed (1273) 
※ Client introduction A large number of proteins were identified to be co-complexed with known MLO scaffolds by conventional biochemical assays or mass spectrometry, or co-localized with MLOs by immunofluorescence. For example, C14ORF166, FAM98A/B, and RTCB were identified as candidate stress granule proteins, which form an RNA transport complex with the DEAD-box helicase DDX1, a known scaffold of multiple MLOs including stress granules (1). It was not known whether C14ORF166, FAM98A, FAM98B and RTCB are indispensable for stress granule assembly, and the four proteins were annotated as potential clients. References
1. Markmiller, S., Soltanieh, S., Server, K.L., Mak, R., Jin, W., Fang, M.Y., Luo, E.C., Krach, F., Yang, D., Sen, A. et al. (2018) Context-dependent and disease-specific diversity in protein Interactions within stress granules. Cell, 172, 590-604.e13. PMID: 29373831
There are 1321 genes. Reviewed (48)
or Unreviewed (1273)