Sorghum bicolor      Nuclear speckle


※ Nuclear speckle introduction

    Nuclear speckles or splicing speckles, also known as interchromatin granule clusters, are membrane-less nuclear organelles enriched in pre-mRNA splicing and transcription factors and play important roles in RNA metabolism, such as transcription, pre-mRNA splicing, 3′-end mRNA processing, and execution of mRNA nuclear export (1; 2). They are dynamic subnuclear structures, and their size, shape, and number can vary accompanied with RNA regulation, nuclear speckles disperse in high activity of mRNA processing when transcription or pre-mRNA splicing is inhibited, GSK-3β can regulate assembly of nuclear speckles (2). Because many naturally intronless mRNAs, including eight exogenously expressed and four endogenous ones, are proved to be associate with NSs, So Nuclear speckles (NSs) are thought to serve as splicing factor storage sites (3).

Reference
1. Lee, K. H., Zhang, P., Kim, H. J., Mitrea, D. M., Sarkar, M., Freibaum, B. D., et al. (2016) C9orf72 Dipeptide Repeats Impair the Assembly, Dynamics, and Function of Membrane-Less Organelles. Cell, 167(3), 774-788 e717. PMID: 27768896
2. Wang, K., Wang, L., Wang, J., Chen, S., Shi, M., & Cheng, H. (2018) Intronless mRNAs transit through nuclear speckles to gain export competence. J Cell Biol, 217(11), 3912-3929. PMID: 30194269
3. An, Y., Zou, Y., Cao, Y., Yao, M., Ma, N., Wu, Y., et al. (2019) The nuclear GSK-3beta regulated post-transcriptional processing of mRNA through phosphorylation of SC35. Mol Cell Biochem, 451(1-2), 55-67. PMID: 30030778


There are 55 genes.  Reviewed (0 or Unreviewed (55

No.StatusDrLLPS IDEnsemble Gene IDUniProt AccessionGene Name
1
LLPS-Sob-1235
SORBI_3002G380500
M1H9A6
SC30
2
LLPS-Sob-2431
SORBI_3001G362300
M1H9B4
SCL28
3
LLPS-Sob-1222
SORBI_3001G010600
C5WSV0
SORBI_3001G010600
4
LLPS-Sob-2190
SORBI_3001G029400
C5WU44
SORBI_3001G029400
5
LLPS-Sob-1730
SORBI_3001G124000
C5WNT6
SORBI_3001G124000
6
LLPS-Sob-1415
SORBI_3001G226000
A0A1B6QKE9
SORBI_3001G226000
7
LLPS-Sob-2262
SORBI_3001G358500
C5WYN7
SORBI_3001G358500
8
LLPS-Sob-1560
SORBI_3001G377700
C5X0Q4
SORBI_3001G377700
9
LLPS-Sob-0232
SORBI_3001G402300
C5WNF2
SORBI_3001G402300
10
LLPS-Sob-0199
SORBI_3001G415500
C5WPB0
SORBI_3001G415500
11
LLPS-Sob-1327
SORBI_3001G417900
C5WPD6
SORBI_3001G417900
12
LLPS-Sob-1747
SORBI_3001G420200
C5WPG0
SORBI_3001G420200
13
LLPS-Sob-2172
SORBI_3001G423700
A0A1B6QP73
SORBI_3001G423700
14
LLPS-Sob-0286
SORBI_3001G428400
C5WQ64
SORBI_3001G428400
15
LLPS-Sob-0202
SORBI_3001G512900
Q1KSA9
SORBI_3001G512900
16
LLPS-Sob-2134
SORBI_3002G037700
C5X9M1
SORBI_3002G037700
17
LLPS-Sob-1968
SORBI_3002G058700
C5XB79
SORBI_3002G058700
18
LLPS-Sob-0885
SORBI_3002G114900
C5X4C5
SORBI_3002G114900
19
LLPS-Sob-1772
SORBI_3002G224700
A0A1B6QCW3
SORBI_3002G224700
20
LLPS-Sob-0711
SORBI_3002G262700
C5X5D1
SORBI_3002G262700
21
LLPS-Sob-0872
SORBI_3002G394600
C5X3Y6
SORBI_3002G394600
22
LLPS-Sob-0896
SORBI_3002G412700
C5X4W2
SORBI_3002G412700
23
LLPS-Sob-1417
SORBI_3003G122000
C5XGI1
SORBI_3003G122000
24
LLPS-Sob-0020
SORBI_3003G123000
C5XGI9
SORBI_3003G123000
25
LLPS-Sob-0422
SORBI_3003G258900
C5XGS1
SORBI_3003G258900
26
LLPS-Sob-1123
SORBI_3004G005400
C5XRK9
SORBI_3004G005400
27
LLPS-Sob-1370
SORBI_3004G039200
C5XUM0
SORBI_3004G039200
28
LLPS-Sob-2274
SORBI_3004G065100
C5XWU9
SORBI_3004G065100
29
LLPS-Sob-1879
SORBI_3004G175300
C5XU78
SORBI_3004G175300
30
LLPS-Sob-0296
SORBI_3004G202500
A0A194YQT0
SORBI_3004G202500
31
LLPS-Sob-1513
SORBI_3004G208900
C5XX85
SORBI_3004G208900
32
LLPS-Sob-0866
SORBI_3004G212200
C5XXB6
SORBI_3004G212200
33
LLPS-Sob-0775
SORBI_3004G229000
A0A194YR92
SORBI_3004G229000
34
LLPS-Sob-1297
SORBI_3004G312600
A0A194YSG7
SORBI_3004G312600
35
LLPS-Sob-1194
SORBI_3004G357400
A0A1Z5RQL4
SORBI_3004G357400
36
LLPS-Sob-1986
SORBI_3005G190000
C5Y6G4
SORBI_3005G190000
37
LLPS-Sob-0269
SORBI_3005G195800
A0A1B6PTJ4
SORBI_3005G195800
38
LLPS-Sob-0911
SORBI_3006G017000
A0A1B6PJI0
SORBI_3006G017000
39
LLPS-Sob-2098
SORBI_3006G088100
C5Y8T2
SORBI_3006G088100
40
LLPS-Sob-2184
SORBI_3006G183800
C5YE34
SORBI_3006G183800
41
LLPS-Sob-1130
SORBI_3006G204900
A0A1B6PMY5
SORBI_3006G204900
42
LLPS-Sob-2009
SORBI_3007G029100
C5YMX3
SORBI_3007G029100
43
LLPS-Sob-0107
SORBI_3007G050400
C5YHD5
SORBI_3007G050400
44
LLPS-Sob-2494
SORBI_3008G100100
C5YNT7
SORBI_3008G100100
45
LLPS-Sob-1471
SORBI_3008G137600
C5YPZ8
SORBI_3008G137600
46
LLPS-Sob-1703
SORBI_3009G032300
C5YZI1
SORBI_3009G032300
47
LLPS-Sob-0282
SORBI_3009G050100
C5Z0J1
SORBI_3009G050100
48
LLPS-Sob-1547
SORBI_3009G126600
C5YXJ4
SORBI_3009G126600
49
LLPS-Sob-0925
SORBI_3009G257600
A0A1B6PAQ6
SORBI_3009G257600
50
LLPS-Sob-1770
SORBI_3010G017400
C5Z374
SORBI_3010G017400
51
LLPS-Sob-0546
SORBI_3010G045600
C5Z4F1
SORBI_3010G045600
52
LLPS-Sob-0294
SORBI_3010G052400
C5Z4W5
SORBI_3010G052400
53
LLPS-Sob-0040
SORBI_3010G053600
A0A1W0VRL2
SORBI_3010G053600
54
LLPS-Sob-1936
SORBI_3010G269600
A0A1W0VV56
SORBI_3010G269600
55
LLPS-Sob-0441
SORBI_3010G269800
A0A1W0VV41
SORBI_3010G269800