Arabidopsis thaliana      Nuclear speckle


※ Nuclear speckle introduction

    Nuclear speckles or splicing speckles, also known as interchromatin granule clusters, are membrane-less nuclear organelles enriched in pre-mRNA splicing and transcription factors and play important roles in RNA metabolism, such as transcription, pre-mRNA splicing, 3′-end mRNA processing, and execution of mRNA nuclear export (1; 2). They are dynamic subnuclear structures, and their size, shape, and number can vary accompanied with RNA regulation, nuclear speckles disperse in high activity of mRNA processing when transcription or pre-mRNA splicing is inhibited, GSK-3β can regulate assembly of nuclear speckles (2). Because many naturally intronless mRNAs, including eight exogenously expressed and four endogenous ones, are proved to be associate with NSs, So Nuclear speckles (NSs) are thought to serve as splicing factor storage sites (3).

Reference
1. Lee, K. H., Zhang, P., Kim, H. J., Mitrea, D. M., Sarkar, M., Freibaum, B. D., et al. (2016) C9orf72 Dipeptide Repeats Impair the Assembly, Dynamics, and Function of Membrane-Less Organelles. Cell, 167(3), 774-788 e717. PMID: 27768896
2. Wang, K., Wang, L., Wang, J., Chen, S., Shi, M., & Cheng, H. (2018) Intronless mRNAs transit through nuclear speckles to gain export competence. J Cell Biol, 217(11), 3912-3929. PMID: 30194269
3. An, Y., Zou, Y., Cao, Y., Yao, M., Ma, N., Wu, Y., et al. (2019) The nuclear GSK-3beta regulated post-transcriptional processing of mRNA through phosphorylation of SC35. Mol Cell Biochem, 451(1-2), 55-67. PMID: 30030778


There are 61 genes.  Reviewed (38 or Unreviewed (23

No.StatusDrLLPS IDEnsemble Gene IDUniProt AccessionGene Name
1
LLPS-Art-0780
AT1G09760
P43333
At1g09760
2
LLPS-Art-0065
AT1G14650
Q8RXF1
At1g14650
3
LLPS-Art-0364
AT2G29210
Q8L7W3
At2g29210
4
LLPS-Art-0375
AT2G32600
O80897
At2g32600
5
LLPS-Art-0100
AT3G47120
Q9SD61
At3g47120
6
LLPS-Art-0696
AT3G49601
B3H6J5
At3g49601
7
LLPS-Art-0965
AT5G10810
Q96319
At5g10810
8
LLPS-Art-0037
AT5G06160
Q9FG01
ATO
9
LLPS-Art-1360
AT1G20960
Q9SYP1
BRR2A
10
LLPS-Art-0910
AT1G09770
P92948
CDC5
11
LLPS-Art-0757
AT2G23380
P93831
CLF
12
LLPS-Art-1090
AT2G32950
P43254
COP1
13
LLPS-Art-0253
AT1G61620
Q9SY88
CSU1
14
LLPS-Art-0419
AT1G02330
F4HVZ5
CSU2
15
LLPS-Art-1322
AT3G63400
Q9LY75
CYP63
16
LLPS-Art-0829
AT5G59950
F4JXE3
MMN10.26
17
LLPS-Art-0393
AT3G18165
Q949S9
MOS4
18
LLPS-Art-0578
AT5G23590
Q8L7M3
MQM1.14
19
LLPS-Art-0931
AT5G64270
Q9FMF9
MSJ1.11
20
LLPS-Art-0162
AT4G15900
Q42384
PRL1
21
LLPS-Art-1158
AT2G33340
O22785
PRP19B
22
LLPS-Art-0102
AT1G80070
Q9SSD2
PRP8A
23
LLPS-Art-0985
AT1G20920
Q8H0U8
RH42
24
LLPS-Art-1079
AT3G50670
Q42404
RNU1
25
LLPS-Art-1705
AT2G37340
Q8VYA5
RS2Z33
26
LLPS-Art-1704
AT1G60650
O22703
RZ1B
27
LLPS-Art-1307
AT5G04280
Q8RWN5
RZ1C
28
LLPS-Art-1390
AT5G64200
Q9FMG4
SC35
29
LLPS-Art-0191
AT5G18810
Q1PDV2
SCL28
30
LLPS-Art-1269
AT1G63100
Q9CAN3
SCL28
31
LLPS-Art-1235
AT3G55460
Q8L3X8
SCL30
32
LLPS-Art-1750
AT3G46600
Q9SNB8
SCL30
33
LLPS-Art-0759
AT2G43370
Q8VY74
SNRNP35
34
LLPS-Art-0553
AT1G09140
Q9XFR5
SR30
35
LLPS-Art-0722
AT1G02840
O22315
SR34
36
LLPS-Art-1282
AT1G16610
Q9SEE9
SR45
37
LLPS-Art-1420
AT1G27650
Q9S709
U2AF35A
38
LLPS-Art-0339
AT1G60900
Q8L716
U2AF65B
39
LLPS-Art-3021
AT3G53570
P51566
AFC1
40
LLPS-Art-2623
AT5G14640
Q8VZD5
ASK5
41
LLPS-Art-2884
AT1G06960
Q8H1S6
At1g06960
42
LLPS-Art-3020
AT1G30540
Q8LGE0
At1g30540
43
LLPS-Art-2080
AT2G27285
Q9XIN5
At2g27280
44
LLPS-Art-2265
AT3G02710
A3KPF3
At3g02710
45
LLPS-Art-2174
AT4G14970
F4JIJ1
At4g14970
46
LLPS-Art-3085
AT5G49110
F4K4R1
At5g49110
47
LLPS-Art-2992
AT5G40820
Q9FKS4
ATR
48
LLPS-Art-1982
AT2G39760
O22286
BPM3
49
LLPS-Art-1962
AT1G20930
Q8LG64
CDKB2-2
50
LLPS-Art-2083
AT1G18040
Q9LMT0
CDKD-3
51
LLPS-Art-2054
AT1G30480
P42698
DRT111
52
LLPS-Art-1937
AT1G21710
Q9FNY7
OGG1
53
LLPS-Art-2617
AT5G10350
Q9LX90
PABN3
54
LLPS-Art-2127
AT2G27020
O23715
PAG1
55
LLPS-Art-2480
AT3G06930
Q84W92
PRMT13
56
LLPS-Art-2405
AT5G11200
Q56XG6
RH15
57
LLPS-Art-2030
AT5G25060
Q9C5J3
RRC1
58
LLPS-Art-2436
AT3G13570
Q9LHP2
SCL30A
59
LLPS-Art-2023
AT5G51300
Q9LU44
SF1
60
LLPS-Art-3002
AT5G55856
B3H5R8
SUMO8
61
LLPS-Art-2014
AT3G03110
F4IZR5
XPO1B