Zea mays      Nuclear pore complex


※ Nuclear pore complex introduction

    The nuclear pore is proposed to be a LLPS stress granules initially condense to form stable cores, possibly with a nascent shell layer, and these cores merge into larger structures through interactions between the shell structures (1). A stable core assemblies could provide a structural platform for the formation of stress granules, due to the high concentration of IDRs on stress granule components to then rapidly phase-separate a dynamic shell that grows as a result of fusion with other small granules and surface exchange with an increasing pool of untranslating mRNPs. This general principle is also seen in the formation of the nuclear pore, wherein the creation of a high local concentration of FG repeat proteins by the structure of the nuclear pore, allows for a phase transition within the nuclear pore itself, even if the interactions between the FG repeats are relatively weak and non-specific (1).

Reference
1. Wheeler, J. R., Matheny, T., Jain, S., Abrisch, R., & Parker, R. (2016) Distinct stages in stress granule assembly and disassembly. Elife, 5. PMID: 27602576


There are 2 genes.  Reviewed (0 or Unreviewed (2

No.StatusDrLLPS IDEnsemble Gene IDUniProt AccessionGene Name
1
LLPS-Zem-0807
Zm00001d012314
A0A1D6G850
100382780
2
LLPS-Zem-1810
Zm00001d048308
A0A1D6PJ52
103639534