Oreochromis niloticus      Neuronal granule


※ Neuronal granule introduction

    Neuronal granules are also referred to as neuronal transport granules, RNA-transporting granules, neuronal RNA granules, dendritic P-body like structures (dlP-bodies), FMRP granules and Staufen granules(1,2). They are broadly identified by the presence of two highly conserved proteins: Staufen, a double-stranded RNA-binding protein and FMRP. As a kind of cytoplasmic RNP bodies located in Cytoplasm of neurons, neuronal transport RNPs have highly specialized functions and have been shown to interact or co-localize with components of GW/P bodies (1), it's microtubule-dependent and contain Silenced mRNAs and ribosomes components. Neuronal RNA bodies is of spherical shape with fluid characteristics, proved to be associated with rotein synthesis in response to exogenous stimuli (2).

Reference
1. Moser, J. J., & Fritzler, M. J. (2013) Relationship of other cytoplasmic ribonucleoprotein bodies (cRNPB) to GW/P bodies. Adv Exp Med Biol, 768, 213-242. PMID: 23224973
2. Hirano, M., Muto, M., Sakai, M., Kondo, H., Kobayashi, S., Kariwa, H., Yoshii, K.(2017) Dendritic transport of tick-borne flavivirus RNA by neuronal granules affects development of neurological disease. Proc Natl Acad Sci U S A, 114, 9960–9965. PMID: 28847946
3. Darling, A. L., Liu, Y., Oldfield, C. J., & Uversky, V. N. (2018) Intrinsically Disordered Proteome of Human Membrane-Less Organelles. Proteomics, 18(5-6), e1700193. PMID: 27838525


There are 38 genes.  Reviewed (0 or Unreviewed (38

No.StatusDrLLPS IDEnsemble Gene IDUniProt AccessionGene Name
1
LLPS-Orn-0141
ENSONIG00000017737.1
I3KML8
2
LLPS-Orn-0187
ENSONIG00000004263.1
I3J927
3
LLPS-Orn-0349
ENSONIG00000009439.1
I3JSL5
4
LLPS-Orn-0502
ENSONIG00000003626.1
I3J6S2
5
LLPS-Orn-1004
ENSONIG00000004152.1
I3J8P0
6
LLPS-Orn-1284
ENSONIG00000011937.1
I3K1N5
7
LLPS-Orn-1495
ENSONIG00000007705.1
I3JLG7
8
LLPS-Orn-1993
ENSONIG00000000513.1
I3IVL5
9
LLPS-Orn-2357
ENSONIG00000001260.1
I3IY99
10
LLPS-Orn-3218
ENSONIG00000014300.1
I3KA32
11
LLPS-Orn-a055
ENSONIG00000018143.1
I3KP15
12
LLPS-Orn-1457
ENSONIG00000008449.1
I3JP30
caprin1
13
LLPS-Orn-3194
ENSONIG00000008518.1
I3JPB6
CPEB4 (1 of many)
14
LLPS-Orn-1033
ENSONIG00000016252.1
I3KH65
ddx3x
15
LLPS-Orn-0208
ENSONIG00000018269.1
I3KPF9
DDX5
16
LLPS-Orn-0031
ENSONIG00000017284.1
I3KL04
eif2a
17
LLPS-Orn-0466
ENSONIG00000005931.1
I3JF24
eif2s1
18
LLPS-Orn-0492
ENSONIG00000001927.1
I3J0M5
eif2s2
19
LLPS-Orn-0455
ENSONIG00000015823.1
I3KFM3
fmr1
20
LLPS-Orn-1752
ENSONIG00000003740.1
I3J762
fxr1
21
LLPS-Orn-1347
ENSONIG00000015390.1
I3KE15
hnrnpd
22
LLPS-Orn-1000
ENSONIG00000008977.1
I3JQZ4
LOC100691481
23
LLPS-Orn-3427
ENSONIG00000018373.1
I3KPT7
LOC100694078
24
LLPS-Orn-2197
ENSONIG00000001077.1
I3IXM7
LOC100695556
25
LLPS-Orn-0886
ENSONIG00000004653.1
I3JAG9
LOC100700101
26
LLPS-Orn-0825
ENSONIG00000019097.1
I3KSE4
LOC100702076
27
LLPS-Orn-0526
ENSONIG00000021362.1
I3KZW7
LOC100706653
28
LLPS-Orn-2348
ENSONIG00000012982.1
I3K5D2
LOC100707314
29
LLPS-Orn-1525
ENSONIG00000002360.1
I3J261
LOC100710029
30
LLPS-Orn-0123
ENSONIG00000009730.1
I3JTM5
LOC100711099
31
LLPS-Orn-1366
ENSONIG00000012508.1
I3K3Q2
ncl
32
LLPS-Orn-2914
ENSONIG00000020497.1
I3KXF6
nono
33
LLPS-Orn-3101
ENSONIG00000012010.1
I3K1X3
pspc1
34
LLPS-Orn-2820
ENSONIG00000007546.1
I3JKX2
RBPMS
35
LLPS-Orn-3772
ENSONIG00000013876.1
I3K8K0
ripk4
36
LLPS-Orn-0433
ENSONIG00000007474.1
I3JKM8
rtcb
37
LLPS-Orn-2402
ENSONIG00000016315.1
I3KHE6
SRSF10
38
LLPS-Orn-1425
ENSONIG00000010212.1
I3JVE3
trim2