Sarcophilus harrisii      Histone locus body


※ Histone locus body introduction

    The histone locus body (HLB) contains factors required for processing histone pre-mRNAs, which is present throughout the interphase of the cell cycle, but disappear during mitosis. It is associated with the genes that code for histones, suggesting that it may function to concentrate processing factors at their site of action (1). Besides, as one of the coilin-containing bodies like Cajal bodies , HLB in nuclei of late two-cell embryos are heterogeneous in both morphology and molecular composition, but their heterogeneity is not related to the number of coilin-positive intranuclear HLB structures (2).

Reference
1. Nizami, Z., Deryusheva, S., & Gall, J. G. (2010) The Cajal body and histone locus body. Cold Spring Harb Perspect Biol, 2(7), a000653. PMID: 20504965
2. Bogolyubova, I. O. (2017) Heterogeneity of Coilin-Containing Nuclear Domains in Early Mouse Embryos. Tsitologiia, 59(4), 290-297. PMID: 30188094


There are 16 genes.  Reviewed (0 or Unreviewed (16

No.StatusDrLLPS IDEnsemble Gene IDUniProt AccessionGene Name
1
LLPS-Sah-0365
ENSSHAG00000011779.1
G3WEB8
2
LLPS-Sah-2731
ENSSHAG00000015789.1
G3WT43
3
LLPS-Sah-3896
ENSSHAG00000016958.1
G3WX34
4
LLPS-Sah-3155
ENSSHAG00000016180.1
G3WUF5
CASP8AP2
5
LLPS-Sah-3676
ENSSHAG00000006500.1
G3VWC5
CPSF1
6
LLPS-Sah-3726
ENSSHAG00000010458.1
G3W9U8
CPSF2
7
LLPS-Sah-1067
ENSSHAG00000007024.1
G3VY42
CPSF3
8
LLPS-Sah-2661
ENSSHAG00000011533.1
G3WDI8
CPSF4
9
LLPS-Sah-0973
ENSSHAG00000003783.1
G3VM90
CTCF
10
LLPS-Sah-1815
ENSSHAG00000000556.1
G3VBS1
CTR9
11
LLPS-Sah-2515
ENSSHAG00000017127.1
G3WXN6
H2AFV
12
LLPS-Sah-1698
ENSSHAG00000009681.1
G3W746
HINFP
13
LLPS-Sah-0980
ENSSHAG00000018056.1
G3X0U7
LSM10
14
LLPS-Sah-1852
ENSSHAG00000011566.1
G3WDM6
NPAT
15
LLPS-Sah-3784
ENSSHAG00000003139.1
G3VK69
SYMPK
16
LLPS-Sah-3463
ENSSHAG00000009526.1
G3W6K4
TNRC18