Pongo abelii      Histone locus body


※ Histone locus body introduction

    The histone locus body (HLB) contains factors required for processing histone pre-mRNAs, which is present throughout the interphase of the cell cycle, but disappear during mitosis. It is associated with the genes that code for histones, suggesting that it may function to concentrate processing factors at their site of action (1). Besides, as one of the coilin-containing bodies like Cajal bodies , HLB in nuclei of late two-cell embryos are heterogeneous in both morphology and molecular composition, but their heterogeneity is not related to the number of coilin-positive intranuclear HLB structures (2).

Reference
1. Nizami, Z., Deryusheva, S., & Gall, J. G. (2010) The Cajal body and histone locus body. Cold Spring Harb Perspect Biol, 2(7), a000653. PMID: 20504965
2. Bogolyubova, I. O. (2017) Heterogeneity of Coilin-Containing Nuclear Domains in Early Mouse Embryos. Tsitologiia, 59(4), 290-297. PMID: 30188094


There are 17 genes.  Reviewed (0 or Unreviewed (17

No.StatusDrLLPS IDEnsemble Gene IDUniProt AccessionGene Name
1
LLPS-Poa-1085
ENSPPYG00000029792.1
K7ETQ9
2
LLPS-Poa-1782
ENSPPYG00000008734.1
H2NV13
3
LLPS-Poa-2302
ENSPPYG00000029685.1
K7ETB0
4
LLPS-Poa-2807
ENSPPYG00000016847.2
H2PJT9
CASP8AP2
5
LLPS-Poa-0485
ENSPPYG00000018973.2
H2PRG8
CPSF1
6
LLPS-Poa-3522
ENSPPYG00000012666.2
H2P703
CPSF3
7
LLPS-Poa-2374
ENSPPYG00000017378.2
H2PLJ0
CPSF4
8
LLPS-Poa-0146
ENSPPYG00000007461.2
H2NR83
CTCF
9
LLPS-Poa-0441
ENSPPYG00000003486.2
H2NE37
CTR9
10
LLPS-Poa-1802
ENSPPYG00000001026.1
H2N6D3
DDX20
11
LLPS-Poa-3825
ENSPPYG00000014773.2
H2PDF0
FIP1L1
12
LLPS-Poa-3820
ENSPPYG00000000739.1
A0A2J8VGQ6
GON4L
13
LLPS-Poa-0928
ENSPPYG00000017585.2
H2PM72
H2AFV
14
LLPS-Poa-2305
ENSPPYG00000003957.2
A0A2J8X0P5
HINFP
15
LLPS-Poa-1501
ENSPPYG00000001539.1
H2N7Z2
LSM10
16
LLPS-Poa-0872
ENSPPYG00000003844.2
H2NF72
NPAT
17
LLPS-Poa-0730
ENSPPYG00000007934.2
H2NSL2
TP53