Ursus maritimus      Gemini of cajal body


※ Gemini of cajal body introduction

    Eukaryotic cells are inhomogeneously crowded with biological macromolecules (proteins and nucleic acids) and often contain numerous cellular bodies, including proteinaceous membrane-less organelles (PMLOs), They are formed as a result of highly regulated and reversible liquid-liquid demixing phase separation and represent condensed liquid droplets, which are invariantly enriched in intrinsically disordered proteins (1). Gemini of Cajal bodies, also called as Gemini of coiled bodies or nuclear gems, is a kind of these bodies located in Nucleus of spherical shape, It do not contain snRNPs. The function of nuclear gems is still unknown, may be related to further maturation, storage or recycling of splicing factors (1).

Reference
1. Uversky, V. N. (2017) Intrinsically disordered proteins in overcrowded milieu: Membrane-less organelles, phase separation, and intrinsic disorder. Curr Opin Struct Biol, 44, 18-30. PMID: 27838525


There are 9 genes.  Reviewed (0 or Unreviewed (9

No.StatusDrLLPS IDEnsemble Gene IDUniProt AccessionGene Name
1
LLPS-Urm-3826
ENSUMAG00000013897.1
A0A384D6R9
DDX20
2
LLPS-Urm-1894
ENSUMAG00000008366.1
A0A384CB63
GEMIN2
3
LLPS-Urm-1552
ENSUMAG00000010047.1
A0A384CGI4
GEMIN4
4
LLPS-Urm-3449
ENSUMAG00000002730.1
A0A384C714
GEMIN5
5
LLPS-Urm-3256
ENSUMAG00000013522.1
A0A384CUI2
GEMIN6
6
LLPS-Urm-2262
ENSUMAG00000023443.1
A0A384BJA3
GEMIN7
7
LLPS-Urm-0727
ENSUMAG00000005467.1
A0A384CJH4
GEMIN8
8
LLPS-Urm-1746
ENSUMAG00000002820.1
A0A384DE37
STRAP
9
LLPS-Urm-1676
ENSUMAG00000023737.1
A0A384CER9
TARDBP