Rhinopithecus bieti      Gemini of cajal body


※ Gemini of cajal body introduction

    Eukaryotic cells are inhomogeneously crowded with biological macromolecules (proteins and nucleic acids) and often contain numerous cellular bodies, including proteinaceous membrane-less organelles (PMLOs), They are formed as a result of highly regulated and reversible liquid-liquid demixing phase separation and represent condensed liquid droplets, which are invariantly enriched in intrinsically disordered proteins (1). Gemini of Cajal bodies, also called as Gemini of coiled bodies or nuclear gems, is a kind of these bodies located in Nucleus of spherical shape, It do not contain snRNPs. The function of nuclear gems is still unknown, may be related to further maturation, storage or recycling of splicing factors (1).

Reference
1. Uversky, V. N. (2017) Intrinsically disordered proteins in overcrowded milieu: Membrane-less organelles, phase separation, and intrinsic disorder. Curr Opin Struct Biol, 44, 18-30. PMID: 27838525


There are 11 genes.  Reviewed (0 or Unreviewed (11

No.StatusDrLLPS IDEnsemble Gene IDUniProt AccessionGene Name
1
LLPS-Rhb-1342
ENSRBIG00000037052.1
A0A2K6LS95
2
LLPS-Rhb-0383
ENSRBIG00000030629.1
A0A2K6KPP1
DDX20
3
LLPS-Rhb-1468
ENSRBIG00000042196.1
A0A2K6MN44
FUS
4
LLPS-Rhb-3461
ENSRBIG00000034601.1
A0A2K6LCK9
GEMIN2
5
LLPS-Rhb-2940
ENSRBIG00000042493.1
A0A2K6MQ27
GEMIN4
6
LLPS-Rhb-1550
ENSRBIG00000040382.1
A0A2K6MBW8
GEMIN5
7
LLPS-Rhb-1312
ENSRBIG00000041939.1
A0A2K6MLT2
GEMIN6
8
LLPS-Rhb-4764
ENSRBIG00000009966.1
A0A2K6JSH1
GEMIN8
9
LLPS-Rhb-1742
ENSRBIG00000042387.1
A0A2K6MPI5
SNRNP70
10
LLPS-Rhb-0223
ENSRBIG00000034652.1
A0A2K6LCV7
STRAP
11
LLPS-Rhb-0817
ENSRBIG00000034783.1
A0A2K6LE20
TARDBP