Monodelphis domestica      Gemini of cajal body


※ Gemini of cajal body introduction

    Eukaryotic cells are inhomogeneously crowded with biological macromolecules (proteins and nucleic acids) and often contain numerous cellular bodies, including proteinaceous membrane-less organelles (PMLOs), They are formed as a result of highly regulated and reversible liquid-liquid demixing phase separation and represent condensed liquid droplets, which are invariantly enriched in intrinsically disordered proteins (1). Gemini of Cajal bodies, also called as Gemini of coiled bodies or nuclear gems, is a kind of these bodies located in Nucleus of spherical shape, It do not contain snRNPs. The function of nuclear gems is still unknown, may be related to further maturation, storage or recycling of splicing factors (1).

Reference
1. Uversky, V. N. (2017) Intrinsically disordered proteins in overcrowded milieu: Membrane-less organelles, phase separation, and intrinsic disorder. Curr Opin Struct Biol, 44, 18-30. PMID: 27838525


There are 9 genes.  Reviewed (0 or Unreviewed (9

No.StatusDrLLPS IDEnsemble Gene IDUniProt AccessionGene Name
1
LLPS-Mod-0917
ENSMODG00000001436.2
F7BCE9
2
LLPS-Mod-0607
ENSMODG00000001311.3
F7BEL2
DDX20
3
LLPS-Mod-0316
ENSMODG00000001889.3
F6WGL5
FUS
4
LLPS-Mod-2546
ENSMODG00000011946.3
F7CV43
GEMIN2
5
LLPS-Mod-3220
ENSMODG00000023170.2
F7D829
GEMIN4
6
LLPS-Mod-3684
ENSMODG00000008598.3
F7BTY5
GEMIN5
7
LLPS-Mod-3632
ENSMODG00000008690.2
F6PXP0
GEMIN6
8
LLPS-Mod-2482
ENSMODG00000017297.3
F6S4R6
GEMIN8
9
LLPS-Mod-1351
ENSMODG00000017913.3
F7F2C8
STRAP