Mesocricetus auratus      Gemini of cajal body


※ Gemini of cajal body introduction

    Eukaryotic cells are inhomogeneously crowded with biological macromolecules (proteins and nucleic acids) and often contain numerous cellular bodies, including proteinaceous membrane-less organelles (PMLOs), They are formed as a result of highly regulated and reversible liquid-liquid demixing phase separation and represent condensed liquid droplets, which are invariantly enriched in intrinsically disordered proteins (1). Gemini of Cajal bodies, also called as Gemini of coiled bodies or nuclear gems, is a kind of these bodies located in Nucleus of spherical shape, It do not contain snRNPs. The function of nuclear gems is still unknown, may be related to further maturation, storage or recycling of splicing factors (1).

Reference
1. Uversky, V. N. (2017) Intrinsically disordered proteins in overcrowded milieu: Membrane-less organelles, phase separation, and intrinsic disorder. Curr Opin Struct Biol, 44, 18-30. PMID: 27838525


There are 11 genes.  Reviewed (0 or Unreviewed (11

No.StatusDrLLPS IDEnsemble Gene IDUniProt AccessionGene Name
1
LLPS-Mea-0268
ENSMAUG00000010659.1
A0A1U7QLR1
Ddx20
2
LLPS-Mea-0125
ENSMAUG00000009599.1
A0A1U7Q6P8
Fus
3
LLPS-Mea-1199
ENSMAUG00000017447.1
A0A1U7R3Z7
Gemin2
4
LLPS-Mea-2198
ENSMAUG00000018640.1
A0A1U7Q890
Gemin4
5
LLPS-Mea-1344
ENSMAUG00000005361.1
A0A1U7Q8S2
Gemin5
6
LLPS-Mea-0497
ENSMAUG00000018897.1
A0A1U7R5H4
Gemin7
7
LLPS-Mea-0785
ENSMAUG00000014430.1
A0A1U8C0I7
Gemin8
8
LLPS-Mea-1185
ENSMAUG00000010262.1
A0A1U7Q817
Smn1
9
LLPS-Mea-2206
ENSMAUG00000020970.1
A0A1U8CV31
Snrnp70
10
LLPS-Mea-2528
ENSMAUG00000016217.1
A0A1U7QIH6
Strap
11
LLPS-Mea-3565
ENSMAUG00000018057.1
A0A1U7R1X6
Tardbp