Meleagris gallopavo      Gemini of cajal body


※ Gemini of cajal body introduction

    Eukaryotic cells are inhomogeneously crowded with biological macromolecules (proteins and nucleic acids) and often contain numerous cellular bodies, including proteinaceous membrane-less organelles (PMLOs), They are formed as a result of highly regulated and reversible liquid-liquid demixing phase separation and represent condensed liquid droplets, which are invariantly enriched in intrinsically disordered proteins (1). Gemini of Cajal bodies, also called as Gemini of coiled bodies or nuclear gems, is a kind of these bodies located in Nucleus of spherical shape, It do not contain snRNPs. The function of nuclear gems is still unknown, may be related to further maturation, storage or recycling of splicing factors (1).

Reference
1. Uversky, V. N. (2017) Intrinsically disordered proteins in overcrowded milieu: Membrane-less organelles, phase separation, and intrinsic disorder. Curr Opin Struct Biol, 44, 18-30. PMID: 27838525


There are 6 genes.  Reviewed (0 or Unreviewed (6

No.StatusDrLLPS IDEnsemble Gene IDUniProt AccessionGene Name
1
LLPS-Meg-1258
ENSMGAG00000004624.1
G1MZL9
DDX20
2
LLPS-Meg-1262
ENSMGAG00000012566.1
G1NIW8
GEMIN2
3
LLPS-Meg-1045
ENSMGAG00000015487.2
G1NR70
GEMIN4
4
LLPS-Meg-1502
ENSMGAG00000007412.1
G1N663
GEMIN6
5
LLPS-Meg-2297
ENSMGAG00000013559.1
G1NLE2
STRAP
6
LLPS-Meg-1481
ENSMGAG00000004637.2
G1MZJ1
TARDBP