Ictidomys tridecemlineatus      Gemini of cajal body


※ Gemini of cajal body introduction

    Eukaryotic cells are inhomogeneously crowded with biological macromolecules (proteins and nucleic acids) and often contain numerous cellular bodies, including proteinaceous membrane-less organelles (PMLOs), They are formed as a result of highly regulated and reversible liquid-liquid demixing phase separation and represent condensed liquid droplets, which are invariantly enriched in intrinsically disordered proteins (1). Gemini of Cajal bodies, also called as Gemini of coiled bodies or nuclear gems, is a kind of these bodies located in Nucleus of spherical shape, It do not contain snRNPs. The function of nuclear gems is still unknown, may be related to further maturation, storage or recycling of splicing factors (1).

Reference
1. Uversky, V. N. (2017) Intrinsically disordered proteins in overcrowded milieu: Membrane-less organelles, phase separation, and intrinsic disorder. Curr Opin Struct Biol, 44, 18-30. PMID: 27838525


There are 11 genes.  Reviewed (0 or Unreviewed (11

No.StatusDrLLPS IDEnsemble Gene IDUniProt AccessionGene Name
1
LLPS-Ict-2240
ENSSTOG00000013988.3
I3MM30
2
LLPS-Ict-0431
ENSSTOG00000029089.2
I3N9G4
DDX20
3
LLPS-Ict-1094
ENSSTOG00000006357.3
I3M7S3
GEMIN2
4
LLPS-Ict-0224
ENSSTOG00000027263.2
I3MY36
GEMIN4
5
LLPS-Ict-4470
ENSSTOG00000005759.3
A0A287DD21
GEMIN5
6
LLPS-Ict-3914
ENSSTOG00000032476.1
A0A287D4Y4
Gemin6
7
LLPS-Ict-0203
ENSSTOG00000033006.1
A0A287D8H0
GEMIN7
8
LLPS-Ict-1985
ENSSTOG00000003330.3
I3M230
GEMIN8
9
LLPS-Ict-1817
ENSSTOG00000012288.3
I3MIW3
LOC101965836
10
LLPS-Ict-0211
ENSSTOG00000000951.3
I3LXN5
STRAP
11
LLPS-Ict-1286
ENSSTOG00000008406.3
I3MBK5
Tardbp