Equus caballus      Gemini of cajal body


※ Gemini of cajal body introduction

    Eukaryotic cells are inhomogeneously crowded with biological macromolecules (proteins and nucleic acids) and often contain numerous cellular bodies, including proteinaceous membrane-less organelles (PMLOs), They are formed as a result of highly regulated and reversible liquid-liquid demixing phase separation and represent condensed liquid droplets, which are invariantly enriched in intrinsically disordered proteins (1). Gemini of Cajal bodies, also called as Gemini of coiled bodies or nuclear gems, is a kind of these bodies located in Nucleus of spherical shape, It do not contain snRNPs. The function of nuclear gems is still unknown, may be related to further maturation, storage or recycling of splicing factors (1).

Reference
1. Uversky, V. N. (2017) Intrinsically disordered proteins in overcrowded milieu: Membrane-less organelles, phase separation, and intrinsic disorder. Curr Opin Struct Biol, 44, 18-30. PMID: 27838525


There are 12 genes.  Reviewed (0 or Unreviewed (12

No.StatusDrLLPS IDEnsemble Gene IDUniProt AccessionGene Name
1
LLPS-Eqc-1167
ENSECAG00000013936.2
F7BMY5
2
LLPS-Eqc-1372
ENSECAG00000031050.1
3
LLPS-Eqc-0203
ENSECAG00000013565.2
F7ALE3
DDX20
4
LLPS-Eqc-2819
ENSECAG00000007554.2
F7DBX5
GEMIN2
5
LLPS-Eqc-3305
ENSECAG00000006339.2
F7A9K8
GEMIN4
6
LLPS-Eqc-3923
ENSECAG00000020479.2
F6WDM0
GEMIN5
7
LLPS-Eqc-4353
ENSECAG00000007191.2
F7CS99
GEMIN6
8
LLPS-Eqc-1859
ENSECAG00000005915.2
F7ABS8
GEMIN7
9
LLPS-Eqc-2671
ENSECAG00000010665.2
F6R8U8
GEMIN8
10
LLPS-Eqc-2070
ENSECAG00000015215.2
F6TME2
LOC100065744
11
LLPS-Eqc-2338
ENSECAG00000022958.2
F6T5Q6
STRAP
12
LLPS-Eqc-0335
ENSECAG00000008338.2
F6WAU6
TARDBP