Ailuropoda melanoleuca      Gemini of cajal body


※ Gemini of cajal body introduction

    Eukaryotic cells are inhomogeneously crowded with biological macromolecules (proteins and nucleic acids) and often contain numerous cellular bodies, including proteinaceous membrane-less organelles (PMLOs), They are formed as a result of highly regulated and reversible liquid-liquid demixing phase separation and represent condensed liquid droplets, which are invariantly enriched in intrinsically disordered proteins (1). Gemini of Cajal bodies, also called as Gemini of coiled bodies or nuclear gems, is a kind of these bodies located in Nucleus of spherical shape, It do not contain snRNPs. The function of nuclear gems is still unknown, may be related to further maturation, storage or recycling of splicing factors (1).

Reference
1. Uversky, V. N. (2017) Intrinsically disordered proteins in overcrowded milieu: Membrane-less organelles, phase separation, and intrinsic disorder. Curr Opin Struct Biol, 44, 18-30. PMID: 27838525


There are 11 genes.  Reviewed (0 or Unreviewed (11

No.StatusDrLLPS IDEnsemble Gene IDUniProt AccessionGene Name
1
LLPS-Aim-0369
ENSAMEG00000003316.1
G1L9E2
2
LLPS-Aim-0709
ENSAMEG00000005344.1
G1LFI1
DDX20
3
LLPS-Aim-1792
ENSAMEG00000003856.1
G1LB15
GEMIN2
4
LLPS-Aim-2046
ENSAMEG00000018474.1
G1MJJ2
GEMIN4
5
LLPS-Aim-4220
ENSAMEG00000016618.1
G1ME02
GEMIN5
6
LLPS-Aim-0623
ENSAMEG00000016004.1
D2HNQ4
GEMIN6
7
LLPS-Aim-1214
ENSAMEG00000019697.1
D2HPB0
GEMIN7
8
LLPS-Aim-3373
ENSAMEG00000015945.1
G1MBU8
GEMIN8
9
LLPS-Aim-1925
ENSAMEG00000014468.1
G1M7E6
SNRNP70
10
LLPS-Aim-2908
ENSAMEG00000003583.1
G1LA86
STRAP
11
LLPS-Aim-3622
ENSAMEG00000009476.1
D2HKA5
TARDBP