Anolis carolinensis      DNA damage foci


※ DNA damage foci introduction

    DNA damage response proteins such as γH2AX, ATM, 53BP1, RAD51, and the MRE11/RAD50/NBS1 complex, that accumulate and/or are modified in the vicinity of a chromosomal DNA double-strand break to form microscopically visible, subnuclear foci called DNA damage foci, also called (ionizing) radiation‐induced foci (IRIF or RIF) or DNA repair foci. The discovery of DNA damage foci has opened a new dimension to the field of DNA damage signaling. Analysis of the spatiotemporal dynamics of DSB induction and repair in situ or even in live cells has now become a standard method in many different fields (1).

Reference
1. Rothkamm, K., Barnard, S., Moquet, J., Ellender, M., Rana, Z., & Burdak-Rothkamm, S. (2015) DNA damage foci: Meaning and significance. Environ Mol Mutagen, 56(6), 491-504. PMID: 25773265


There are 8 genes.  Reviewed (0 or Unreviewed (8

No.StatusDrLLPS IDEnsemble Gene IDUniProt AccessionGene Name
1
LLPS-Anc-1423
ENSACAG00000002967.2
H9G6X0
ATM
2
LLPS-Anc-3494
ENSACAG00000008885.2
H9GEH3
ATMIN
3
LLPS-Anc-1177
ENSACAG00000004915.3
G1KDD8
ATR
4
LLPS-Anc-0018
ENSACAG00000006776.3
H9GC18
FUS
5
LLPS-Anc-1107
ENSACAG00000029672.1
R4GBB6
LOC100559548
6
LLPS-Anc-3187
ENSACAG00000005169.3
H9G9Y7
LOC103282074
7
LLPS-Anc-2820
ENSACAG00000012723.3
G1KMS1
rad50
8
LLPS-Anc-1588
ENSACAG00000013786.3
H9GKC7
rad51