Ailuropoda melanoleuca      DNA damage foci


※ DNA damage foci introduction

    DNA damage response proteins such as γH2AX, ATM, 53BP1, RAD51, and the MRE11/RAD50/NBS1 complex, that accumulate and/or are modified in the vicinity of a chromosomal DNA double-strand break to form microscopically visible, subnuclear foci called DNA damage foci, also called (ionizing) radiation‐induced foci (IRIF or RIF) or DNA repair foci. The discovery of DNA damage foci has opened a new dimension to the field of DNA damage signaling. Analysis of the spatiotemporal dynamics of DSB induction and repair in situ or even in live cells has now become a standard method in many different fields (1).

Reference
1. Rothkamm, K., Barnard, S., Moquet, J., Ellender, M., Rana, Z., & Burdak-Rothkamm, S. (2015) DNA damage foci: Meaning and significance. Environ Mol Mutagen, 56(6), 491-504. PMID: 25773265


There are 9 genes.  Reviewed (0 or Unreviewed (9

No.StatusDrLLPS IDEnsemble Gene IDUniProt AccessionGene Name
1
LLPS-Aim-1407
ENSAMEG00000016965.1
G1MF01
2
LLPS-Aim-3254
ENSAMEG00000016741.1
G1MEC3
ATM
3
LLPS-Aim-4012
ENSAMEG00000013952.1
D2H7J1
ATMIN
4
LLPS-Aim-3522
ENSAMEG00000012578.1
G1M1R0
ATR
5
LLPS-Aim-3628
ENSAMEG00000007608.1
G1LM86
HDAC1
6
LLPS-Aim-2810
ENSAMEG00000000249.1
G1L084
PRKDC
7
LLPS-Aim-2311
ENSAMEG00000017712.1
G1MH82
RAD50
8
LLPS-Aim-2453
ENSAMEG00000000896.1
G1L223
RBM45
9
LLPS-Aim-1900
ENSAMEG00000015350.1
G1MA50
TP53BP1