Homo sapiens      Cleavage body


※ Cleavage body introduction

    Cleavage bodies is a kind of nuclear PMLO (proteinaceous membrane-less organelles) located in Nucleus, It contains no DNA or RNA and it is fluid shaped as a spherical, it is associated with RNA metabolism, potentially serves as storage/assembly sites for proteins involved in transcription, splicing 3’-end processing of pre-mRNAs, and RNA degradation (1). They are formed as a result of highly regulated and reversible liquid-liquid demixing phase separation and represent condensed liquid droplets, which are invariantly enriched in intrinsically disordered proteins (1).

Reference
1. Uversky, V. N. (2017) Intrinsically disordered proteins in overcrowded milieu: Membrane-less organelles, phase separation, and intrinsic disorder. Curr Opin Struct Biol, 44, 18-30. PMID: 27838525


There are 3 genes.  Reviewed (3 or Unreviewed (0

No.StatusDrLLPS IDEnsemble Gene IDUniProt AccessionGene Name
1
LLPS-Hos-0182
ENSG00000165934.12
Q9P2I0
CPSF2
2
LLPS-Hos-1657
ENSG00000101811.13
P33240
CSTF2
3
LLPS-Hos-2503
ENSG00000079785.14
Q92499
DDX1