Drosophila melanogaster      Chromatoid body


※ Chromatoid body introduction

    A single large granule of nuage, presents in post-meiotic spermatids is called the chromatoid body (1). Multiple proteins and some mRNAs have been found to localized to the chromatoid body including mouse VASA homolog , tudor-domain containing 1 (TDRD1), tudor-domain containing 6 (TDRD6), and tudor-domain containing 7 (TDRD7) , transition protein 2 (Tnp2), RANBP9, as a known MVH interactor also localizes to it. Its formation is related to the coalescence of intermitochondrial cement granules. In fact, the formation of the chromatoid body is not required for microRNA biogenesis, but might be important for its action on target mRNAs (1). In mice, the chromatoid body is a structure resembles Gp, TDRD6 plays a role in establishing the body and the localization of piRNA pathway components to this body (2).

Reference
1. Woodruff, J. B., Hyman, A. A., & Boke, E. (2018) Organization and Function of Non-dynamic Biomolecular Condensates. Trends Biochem Sci, 43(2), 81-94. PMID: 30086300
2. Ma, L., Buchold, G. M., Greenbaum, M. P., Roy, A., Burns, K. H., Zhu, H., et al. (2009) GASZ is essential for male meiosis and suppression of retrotransposon expression in the male germline. PLoS Genet, 5(9), e1000635. PMID: 19730684


There are 40 genes.  Reviewed (4 or Unreviewed (36

No.StatusDrLLPS IDEnsemble Gene IDUniProt AccessionGene Name
1
LLPS-Drm-0088
FBgn0015218
P48598
eIF4E1
2
LLPS-Drm-0150
FBgn0283682
Q9VKK1
Ge-1
3
LLPS-Drm-0096
FBgn0001233
P02828
Hsp83
4
LLPS-Drm-0120
FBgn0003483
Q9VF26
spn-E
5
LLPS-Drm-1273
FBgn0250816
Q7PLK0
AGO3
6
LLPS-Drm-0758
FBgn0003884
P06603
alphaTub84B
7
LLPS-Drm-1129
FBgn0034816
Q9W1V2
anon-WO0140519.123
8
LLPS-Drm-0235
FBgn0004581
Q9W1I2
bgcn
9
LLPS-Drm-1254
FBgn0285954
Q27294
caz
10
LLPS-Drm-0763
FBgn0034802
Q8T8R1
CG3800
11
LLPS-Drm-1927
FBgn0264712
Q9VNB2
CR43473
12
LLPS-Drm-1810
FBgn0030521
Q9VY87
CtsB1
13
LLPS-Drm-0308
FBgn0284248
P84029
Cyt-c-p
14
LLPS-Drm-0533
FBgn0039016
Q9VCU9
Dcr-1
15
LLPS-Drm-0118
FBgn0015075
Q9VNV3
Ddx1
16
LLPS-Drm-0111
FBgn0033507
Q7K0D3
DmelCG12909
17
LLPS-Drm-0656
FBgn0000557
P05303
eEF1alpha2
18
LLPS-Drm-1261
FBgn0005632
P55824
faf
19
LLPS-Drm-0331
FBgn0013981
P84040
His4:CG33909
20
LLPS-Drm-1347
FBgn0032949
Q9V9S0
Lamp1
21
LLPS-Drm-0149
FBgn0002774
P24785
mle
22
LLPS-Drm-1685
FBgn0013674
P00399
mt:CoI
23
LLPS-Drm-1566
FBgn0035720
Q8MZI3
p90
24
LLPS-Drm-0571
FBgn0035438
Q8IRD3
PHGPx
25
LLPS-Drm-0589
FBgn0013325
P46222
RpL11
26
LLPS-Drm-0677
FBgn0026372
Q9W0A8
RpL23A
27
LLPS-Drm-0972
FBgn0032518
Q9VJY6
RpL24
28
LLPS-Drm-1353
FBgn0004403
C0HKA1
RpS14b
29
LLPS-Drm-0295
FBgn0039713
Q8MLY8
RpS8
30
LLPS-Drm-0643
FBgn0283477
Q9V3W7
SF2
31
LLPS-Drm-1035
FBgn0039260
Q9VBZ6
Smg6
32
LLPS-Drm-1865
FBgn0027529
Q0E910
tapas
33
LLPS-Drm-1627
FBgn0036450
Q9VUH8
Tdrd3
34
LLPS-Drm-2271
FBgn0033921
A1Z9P1
tej
35
LLPS-Drm-0638
FBgn0024921
Q9VRV8
Tnpo
36
LLPS-Drm-1240
FBgn0026015
O96651
Top3beta
37
LLPS-Drm-0164
FBgn0003742
P19018
tra2
38
LLPS-Drm-0908
FBgn0038271
Q9VFF0
UQCR-C1
39
LLPS-Drm-0064
FBgn0283442
P09052
vas
40
LLPS-Drm-1929
FBgn0034708
Q9W277
Vps35