DrLLPS - Data resource of LLPS

LLPS-Ran-1671
Aptx

▼ OVERVIEW


Status:	Unreviewed
Protein Name:	Aprataxin
Gene Name:	Aptx
Ensembl Gene:	ENSRNOG00000006582.7
Ensembl Protein:	ENSRNOP00000046400.4
Organism:	Rattus norvegicus
Taxa ID:	10116
LLPS Type:	LLPS regulator

▼ PROPERTY

——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:

Condensate	Evidence	Orthologs
Nucleolus, P-body	Predicted from orthologs	(View)

Organism	DrLLPS ID	UniProt ID	LLPS type	Condensate	Identity	E-value	Score
Saccharomyces cerevisiae	LLPS-Sac-0212	Q08702	Regulator	P-body	30.13	2e-12	68.9
Mus musculus	LLPS-Mum-0073	Q7TQC5	Client	Nucleolus	91.34	0.0	627

▼ FUNCTION

DNA-binding protein involved in single-strand DNA break repair, double-strand DNA break repair and base excision repair. Resolves abortive DNA ligation intermediates formed either at base excision sites, or when DNA ligases attempt to repair non-ligatable breaks induced by reactive oxygen species. Catalyzes the release of adenylate groups covalently linked to 5'-phosphate termini, resulting in the production of 5'-phosphate termini that can be efficiently rejoined. Also able to hydrolyze adenosine 5'-monophosphoramidate (AMP-NH(2)) and diadenosine tetraphosphate (AppppA), but with lower catalytic activity (By similarity). Likewise, catalyzes the release of 3'-linked guanosine (DNAppG) and inosine (DNAppI) from DNA, but has higher specific activity with 5'-linked adenosine (AppDNA) (By similarity).

▼ CROSS REFERENCE

Database	Nucleotide ID	Protein ID
Ensembl	ENSRNOT00000046463.4	ENSRNOP00000046400.4
Ensembl	ENSRNOT00000090891.1	ENSRNOP00000072443.1
UniProt		Q8K4H4, APTX_RAT
GeneBank	BC078716, AF398235	AAM90583.1, AAH78716.1
RefSeq	NM_148889.2, XM_006238027.3, XM_006238028.3	NP_683687.1, XP_006238089.1, XP_006238090.1
Entrez	259271

▼ SEQUENCE

Protein Sequence (FASTA)
1 MRVCWLVRQD CWHQRIKLPH LEAVVIGRSP ETKITDKKCS RQQVQLKAEC NKRYVNVKQM 60 61 GVNPTSIDEV VIGKDREMKL LPGQVLHMVN ELYPYMVEFE EVAESPNVTQ RKRKRPDCDS 120 121 QEMEAEAGAS PSQCSVSPKT GKHGAAKEES LGHWSQGLKI SMKDPKMQVY KDDQVVVIKD 180 181 KYPKARHHWL VLPWASISSL KVVTSEHLEL LKHMHAVGEK VIADFTGSSK LRFRLGYHAI 240 241 PSMSHVHLHV ISQDFDSPCL KNKKHWNSFN TEYFLESQAV IKMVQEAGRV TVKDGTCELL 300 301 KLPLRCHECQ QLLPSIPQLK EHLRKHWGG 329
Nucleotide CDS Sequence (FASTA)
1 ATGCGGGTGT GCTGGTTGGT GAGACAGGAC TGCTGGCACC AGCGAATCAA ACTTCCCCAT 60 61 TTAGAAGCTG TTGTGATTGG TCGAAGCCCG GAGACCAAGA TCACAGATAA GAAATGTTCC 120 121 CGACAGCAAG TACAGTTGAA AGCGGAGTGT AACAAGAGAT ATGTCAACGT TAAGCAGATG 180 181 GGGGTCAATC CCACCAGCAT TGACGAAGTC GTCATTGGGA AGGACCGGGA GATGAAGCTG 240 241 CTGCCTGGTC AGGTTCTCCA CATGGTGAAT GAACTTTATC CATACATGGT GGAGTTTGAG 300 301 GAGGTGGCAG AGAGCCCTAA CGTAACACAG AGGAAGAGAA AGAGGCCAGA CTGTGATAGT 360 361 CAGGAGATGG AAGCTGAGGC TGGGGCCAGC CCCAGCCAGT GCTCTGTGTC CCCTAAGACG 420 421 GGCAAGCATG GAGCCGCCAA GGAGGAATCA CTGGGCCACT GGAGTCAAGG CTTGAAGATA 480 481 TCTATGAAAG ACCCCAAAAT GCAGGTTTAT AAGGATGATC AGGTGGTGGT GATTAAGGAT 540 541 AAATACCCCA AGGCCCGGCA CCACTGGCTG GTCTTACCAT GGGCCTCCAT TTCCAGTCTG 600 601 AAGGTTGTGA CCAGTGAACA CCTCGAACTT CTCAAACACA TGCACGCAGT AGGGGAAAAG 660 661 GTGATAGCAG ATTTTACTGG ATCCAGCAAA CTGCGCTTCC GACTGGGTTA CCATGCCATT 720 721 CCCAGCATGA GCCATGTACA TCTTCATGTG ATCAGCCAGG ATTTTGATTC TCCTTGCCTT 780 781 AAAAACAAAA AGCATTGGAA TTCTTTCAAT ACAGAATATT TTCTGGAGTC ACAAGCTGTG 840 841 ATCAAGATGG TTCAGGAAGC TGGCAGAGTG ACTGTTAAAG ATGGGACTTG CGAACTCTTG 900 901 AAGCTGCCTC TCCGTTGCCA TGAGTGTCAG CAGCTGCTGC CTTCCATCCC ACAGCTGAAG 960 961 GAGCACCTCA GGAAGCACTG GGGCGGGTGA 990

▼ KEYWORD

ID	Family
KW-0181	Complete proteome
KW-0227	DNA damage
KW-0234	DNA repair
KW-0238	DNA-binding
KW-0378	Hydrolase
KW-0479	Metal-binding
KW-0539	Nucleus
KW-0597	Phosphoprotein
KW-1185	Reference proteome
KW-0862	Zinc
KW-0863	Zinc-finger

▼ GENE ONTOLOGY

ID	Classification	Description
GO:0000790	Cellular Component	Nuclear chromatin
GO:0005730	Cellular Component	Nucleolus
GO:0005654	Cellular Component	Nucleoplasm
GO:0005634	Cellular Component	Nucleus
GO:0003682	Molecular Function	Chromatin binding
GO:0033699	Molecular Function	DNA 5'-adenosine monophosphate hydrolase activity
GO:0120108	Molecular Function	DNA-3'-diphospho-5'-guanosine diphosphatase
GO:0003725	Molecular Function	Double-stranded RNA binding
GO:0046872	Molecular Function	Metal ion binding
GO:0030983	Molecular Function	Mismatched DNA binding
GO:0008967	Molecular Function	Phosphoglycolate phosphatase activity
GO:0051219	Molecular Function	Phosphoprotein binding
GO:0047485	Molecular Function	Protein N-terminus binding
GO:1990165	Molecular Function	Single-strand break-containing DNA binding
GO:0003697	Molecular Function	Single-stranded DNA binding
GO:0006266	Biological Process	DNA ligation
GO:0006302	Biological Process	Double-strand break repair
GO:0031647	Biological Process	Regulation of protein stability
GO:0042542	Biological Process	Response to hydrogen peroxide
GO:0000012	Biological Process	Single strand break repair

▼ KEGG

rno:259271

▼ ANNOTATION

Disorder
D²P²	IUPred2A

Domain
SMART	Pfam	InterPro	CDD	PROSITE
Gene3D

PTM
EPSD

Interaction
RAIN	IID	MIST

Physicochemical
Compute pI/Mw	AAindex

Function
iEKPD

Localization
COMPARTMENTS

Expression
ArrayExpress	TISSUES

Element
miRWalk	RAID	microRNA.org

▼ ORTHOLOGY

DrLLPS ID	Organism	Identity	E-value	Score
LLPS-Mum-0073	Mus musculus	91.34	0.0	627
LLPS-Mea-2283	Mesocricetus auratus	84.96	0.0	583
LLPS-Loa-2748	Loxodonta africana	82.3	0.0	553
LLPS-Dio-1951	Dipodomys ordii	82.23	0.0	553
LLPS-Poa-3135	Pongo abelii	82.01	0.0	557
LLPS-Mam-1821	Macaca mulatta	82.01	0.0	559
LLPS-Nol-1193	Nomascus leucogenys	82.01	0.0	560
LLPS-Pap-0769	Pan paniscus	82.01	0.0	556
LLPS-Pat-2438	Pan troglodytes	82.01	0.0	556
LLPS-Hos-4783	Homo sapiens	82.01	0.0	553
LLPS-Chs-0007	Chlorocebus sabaeus	82.01	0.0	558
LLPS-Maf-1782	Macaca fascicularis	82.01	0.0	560
LLPS-Sus-1074	Sus scrofa	81.95	0.0	560
LLPS-Cas-1371	Carlito syrichta	81.71	0.0	554
LLPS-Man-1238	Macaca nemestrina	81.71	0.0	557
LLPS-Paa-1553	Papio anubis	81.71	0.0	557
LLPS-Cea-3657	Cercocebus atys	81.71	0.0	555
LLPS-Eqc-2202	Equus caballus	81.42	0.0	559
LLPS-Otg-1812	Otolemur garnettii	81.42	0.0	550
LLPS-Myl-3941	Myotis lucifugus	81.42	0.0	553
LLPS-Mal-0460	Mandrillus leucophaeus	81.42	0.0	555
LLPS-Aon-1119	Aotus nancymaae	81.42	0.0	557
LLPS-Rhb-3225	Rhinopithecus bieti	81.12	0.0	555
LLPS-Gog-2865	Gorilla gorilla	81.1	2e-163	466
LLPS-Fud-1608	Fukomys damarensis	81.1	0.0	547
LLPS-Ict-1845	Ictidomys tridecemlineatus	81.02	0.0	555
LLPS-Ova-1581	Ovis aries	80.83	0.0	551
LLPS-Caf-1482	Canis familiaris	80.53	0.0	551
LLPS-Fec-3819	Felis catus	80.53	0.0	549
LLPS-Mup-3125	Mustela putorius furo	80.53	0.0	553
LLPS-Aim-3866	Ailuropoda melanoleuca	80.53	0.0	552
LLPS-Cap-3132	Cavia porcellus	79.94	0.0	547
LLPS-Urm-1472	Ursus maritimus	79.94	0.0	550
LLPS-Caj-2859	Callithrix jacchus	79.94	0.0	549
LLPS-Ere-0683	Erinaceus europaeus	78.35	1e-159	456
LLPS-Bot-0391	Bos taurus	76.47	2e-179	508
LLPS-Orc-3092	Oryctolagus cuniculus	76.32	1e-116	345
LLPS-Meg-1625	Meleagris gallopavo	72.63	5e-90	274
LLPS-Pes-2839	Pelodiscus sinensis	67.94	5e-157	451
LLPS-Sah-2337	Sarcophilus harrisii	66.87	6e-159	456
LLPS-Tag-2222	Taeniopygia guttata	63.24	1e-143	417
LLPS-Fia-0257	Ficedula albicollis	63.16	7e-149	430
LLPS-Ora-2359	Ornithorhynchus anatinus	62.83	8e-131	383
LLPS-Scf-3621	Scleropages formosus	61.71	2e-149	432
LLPS-Mod-2674	Monodelphis domestica	61.56	2e-148	429
LLPS-Anc-0172	Anolis carolinensis	60.58	1e-140	410
LLPS-Scm-2577	Scophthalmus maximus	60.48	1e-141	411
LLPS-Orn-0835	Oreochromis niloticus	60.24	1e-141	413
LLPS-Leo-2146	Lepisosteus oculatus	60.0	8e-142	412
LLPS-Pof-1216	Poecilia formosa	59.94	6e-140	407
LLPS-Gaa-2065	Gasterosteus aculeatus	59.82	3e-140	408
LLPS-Gaga-3561	Gallus gallus	59.66	1e-141	412
LLPS-Xim-3362	Xiphophorus maculatus	59.34	4e-140	408
LLPS-Icp-0165	Ictalurus punctatus	59.23	4e-137	400
LLPS-Xet-2302	Xenopus tropicalis	58.84	4e-141	410
LLPS-Asm-1250	Astyanax mexicanus	58.81	7e-140	407
LLPS-Lac-3020	Latimeria chalumnae	58.76	9e-136	398
LLPS-Dar-0034	Danio rerio	58.48	5e-132	386
LLPS-Orl-1478	Oryzias latipes	57.53	3e-133	390
LLPS-Tar-1030	Takifugu rubripes	57.31	2e-133	390
LLPS-Ten-1638	Tetraodon nigroviridis	56.89	2e-132	388
LLPS-Tru-0404	Triticum urartu	53.57	9e-23	97.8
LLPS-Tum-0638	Tuber melanosporum	52.38	6e-07	52.8
LLPS-Lem-0602	Leptosphaeria maculans	51.22	4e-06	52.0
LLPS-Art-2151	Arabidopsis thaliana	50.65	5e-39	150
LLPS-Arl-0161	Arabidopsis lyrata	50.32	1e-38	151
LLPS-Sem-1880	Selaginella moellendorffii	49.69	1e-36	144
LLPS-Met-0784	Medicago truncatula	49.44	5e-42	159
LLPS-Pot-1308	Populus trichocarpa	49.18	3e-40	154
LLPS-Gor-0378	Gossypium raimondii	48.37	1e-37	147
LLPS-Glm-1640	Glycine max	48.33	1e-39	153
LLPS-Mua-0356	Musa acuminata	48.31	1e-38	145
LLPS-Thc-1547	Theobroma cacao	48.04	6e-39	152
LLPS-Hea-2278	Helianthus annuus	47.75	5e-38	147
LLPS-Viv-0168	Vitis vinifera	47.22	3e-38	149
LLPS-Coc-0835	Corchorus capsularis	47.16	1e-38	151
LLPS-Via-1101	Vigna angularis	47.03	4e-40	153
LLPS-Nia-0502	Nicotiana attenuata	46.88	2e-42	160
LLPS-Vir-1142	Vigna radiata	46.2	8e-39	150
LLPS-Cus-1378	Cucumis sativus	46.11	2e-38	149
LLPS-Sol-1636	Solanum lycopersicum	46.07	2e-41	157
LLPS-Phv-1520	Phaseolus vulgaris	45.65	2e-39	152
LLPS-Sot-1144	Solanum tuberosum	44.85	9e-41	155
LLPS-Dac-0946	Daucus carota	44.79	5e-36	142
LLPS-Prp-1025	Prunus persica	44.33	2e-40	155
LLPS-Tra-2607	Triticum aestivum	44.21	2e-39	152
LLPS-Php-0192	Physcomitrella patens	43.89	8e-36	142
LLPS-Hov-1663	Hordeum vulgare	43.16	8e-39	150
LLPS-Amt-0347	Amborella trichopoda	42.86	5e-38	149
LLPS-Chr-0790	Chlamydomonas reinhardtii	42.54	6e-35	140
LLPS-Brd-1615	Brachypodium distachyon	42.21	5e-38	149
LLPS-Zem-0099	Zea mays	40.86	2e-30	127
LLPS-Drm-1723	Drosophila melanogaster	40.57	5e-27	116
LLPS-Yal-0736	Yarrowia lipolytica	40.52	5e-15	76.6
LLPS-Sei-1193	Setaria italica	40.45	3e-40	154
LLPS-Orbr-2195	Oryza brachyantha	40.3	1e-37	147
LLPS-Cis-0260	Ciona savignyi	40.11	2e-83	264
LLPS-Mae-0197	Manihot esculenta	39.91	2e-38	149
LLPS-Sob-1625	Sorghum bicolor	38.89	7e-38	148
LLPS-Cii-0045	Ciona intestinalis	38.89	2e-10	66.2
LLPS-Org-0434	Oryza glaberrima	38.68	9e-40	153
LLPS-Ors-0810	Oryza sativa	38.27	1e-40	152
LLPS-Ori-0364	Oryza indica	38.27	1e-39	153
LLPS-Orp-1998	Oryza punctata	38.17	1e-39	153
LLPS-Bro-2919	Brassica oleracea	36.95	2e-35	140
LLPS-Orm-1838	Oryza meridionalis	36.36	3e-31	129
LLPS-Lep-0934	Leersia perrieri	36.24	4e-31	129
LLPS-Brn-0541	Brassica napus	36.14	1e-36	143
LLPS-Brr-1220	Brassica rapa	35.74	2e-35	140
LLPS-Orb-0083	Oryza barthii	35.54	2e-32	132
LLPS-Orr-0169	Oryza rufipogon	35.12	3e-32	132
LLPS-Orgl-1692	Oryza glumaepatula	35.12	2e-32	132
LLPS-Orni-1309	Oryza nivara	35.12	3e-32	132
LLPS-Gag-0514	Gaeumannomyces graminis	34.78	9e-08	56.2
LLPS-Tut-0590	Tursiops truncatus	34.44	4e-07	52.8
LLPS-Trv-1293	Trichoderma virens	34.41	5e-10	63.9
LLPS-Asg-0333	Ashbya gossypii	34.33	1e-15	79.7
LLPS-Crn-0216	Cryptococcus neoformans	33.0	9e-22	97.4
LLPS-Trr-1460	Trichoderma reesei	30.96	2e-14	75.5
LLPS-Asn-0044	Aspergillus nidulans	29.88	4e-10	63.5
LLPS-Cogr-0644	Colletotrichum graminicola	29.7	1e-15	79.0
LLPS-Blg-0674	Blumeria graminis	29.55	3e-12	69.3
LLPS-Sac-0212	Saccharomyces cerevisiae	29.49	1e-12	69.7
LLPS-Coo-0052	Colletotrichum orbiculare	29.29	1e-12	71.2
LLPS-Usm-0477	Ustilago maydis	28.94	8e-17	83.2
LLPS-Pytr-1298	Pyrenophora triticirepentis	28.82	6e-08	57.4
LLPS-Pyt-0228	Pyrenophora teres	28.49	9e-08	57.0
LLPS-Ved-0268	Verticillium dahliae	28.12	1e-11	68.2
LLPS-Cog-1069	Colletotrichum gloeosporioides	27.96	6e-14	74.7
LLPS-Ast-0175	Aspergillus terreus	27.73	6e-09	60.5
LLPS-Spr-0871	Sporisorium reilianum	27.71	4e-13	72.8
LLPS-Aso-0224	Aspergillus oryzae	27.12	2e-08	58.9
LLPS-Asf-1007	Aspergillus flavus	27.12	1e-08	59.7
LLPS-Asni-0941	Aspergillus niger	27.12	2e-11	67.8
LLPS-Asc-0370	Aspergillus clavatus	27.04	6e-08	57.4
LLPS-Nec-0157	Neurospora crassa	27.03	6e-12	69.3
LLPS-Scp-0829	Schizosaccharomyces pombe	26.5	3e-12	68.9
LLPS-Beb-0692	Beauveria bassiana	26.35	8e-13	71.6
LLPS-Scc-1312	Schizosaccharomyces cryophilus	26.23	7e-12	68.2
LLPS-Asfu-1050	Aspergillus fumigatus	26.02	5e-09	60.5
LLPS-Nef-0477	Neosartorya fischeri	26.02	9e-09	59.7
LLPS-Fus-0059	Fusarium solani	25.51	1e-11	68.2
LLPS-Zyt-0171	Zymoseptoria tritici	24.71	3e-11	66.6
LLPS-Fuo-0426	Fusarium oxysporum	24.65	5e-10	63.2
LLPS-Scj-0505	Schizosaccharomyces japonicus	23.86	7e-09	60.1
LLPS-Phn-0776	Phaeosphaeria nodorum	23.14	2e-08	58.9

LLPS-Ran-1671Aptx

Protein Sequence

Nucleotide Sequence

LLPS-Ran-1671
Aptx