LLPS-Mum-2574
Aplp2

▼ OVERVIEW

Status: Reviewed
Protein Name: Amyloid-like protein 2
Gene Name: Aplp2
Ensembl Gene: ENSMUSG00000031996.17
Ensembl Protein: ENSMUSP00000149023.1
Organism: Mus musculus
Taxa ID: 10090
LLPS Type: Others


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateDescriptionTissue/CellPMIDs

▼ FUNCTION

May play a role in the regulation of hemostasis. The soluble form may have inhibitory properties towards coagulation factors. May interact with cellular G-protein signaling pathways. May bind to the DNA 5'-GTCACATG-3'(CDEI box). Inhibits trypsin, chymotrypsin, plasmin, factor XIA and plasma and glandular kallikrein (By similarity). Modulates the Cu/Zn nitric oxide-catalyzed autodegradation of GPC1 heparan sulfate side chains in fibroblasts.

▼ SEQUENCE

Protein Sequence (FASTA)
1     MAATGTAAAA  ATGKLLVLLL  LGLTAPAAAL  AGYIEALAAN  AGTGFAVAEP  QIAMFCGKLN  60
61    MHVNIQTGKW  EPDPTGTKSC  LGTKEEVLQY  CQEIYPELQI  TNVMEANQPV  NIDSWCRRDK  120
121   RQCKSHIVIP  FKCLVGEFVS  DVLLVPDNCQ  FFHQERMEVC  EKHQRWHTLV  KEACLTEGLT  180
181   LYSYGMLLPC  GVDQFHGTEY  VCCPQTKTVD  SDSTMSKEEE  EEEEDEEDEE  EDYDLDKSEF  240
241   PTEADLEDFT  EAAADEEEED  EEEGEEVVED  RDYYYDPFKG  DDYNEENPTE  PSSEGTISDK  300
301   EIVHDVKAVC  SQEAMTGPCR  AVMPRWYFDL  SKGKCVRFIY  GGCGGNRNNF  ESEDYCMAVC  360
361   KAMIPPTPLP  TNDVDVYFET  SADDNEHARF  QKAKEQLEIR  HRNRMDRVKK  EWEEAELQAK  420
421   NLPKTERQTL  IQHFQAMVKA  LEKEAASEKQ  QLVETHLARV  EAMLNDRRRI  ALENYLAALQ  480
481   SDPPRPHRIL  QALRRYVRAE  NKDRLHTIRH  YQHVLAVDPE  KAAQMKSQVM  THLHVIEERR  540
541   NQSLSLLYKV  PYVAQEIQEE  IDELLQEQRA  DMDQFTSSIS  ENPVDVRVSS  EESEEIPPFH  600
601   PLHPFPSLSE  NEGSGMAEQD  GGLIGAEEKV  INSKNKMDEN  MVIDETLDVK  EMIFNAERVG  660
661   GLEEEPESVG  PLREDFSLSS  NALIGLLVIA  VAIATVIVIS  LVMLRKRQYG  TISHGIVEVD  720
721   PMLTPEERHL  NKMQNHGYEN  PTYKYLEQMQ  I  751
Nucleotide CDS Sequence (FASTA)
1     ATGGCGGCCA  CCGGGACCGC  GGCCGCTGCG  GCCACCGGCA  AGCTTCTTGT  CCTGCTGCTG  60
61    CTCGGGCTCA  CGGCGCCCGC  TGCGGCTCTG  GCTGGCTACA  TAGAGGCTCT  TGCAGCCAAT  120
121   GCTGGAACAG  GCTTCGCTGT  TGCTGAGCCT  CAGATTGCGA  TGTTCTGTGG  GAAGCTGAAT  180
181   ATGCATGTGA  ACATTCAGAC  TGGCAAATGG  GAGCCTGACC  CAACAGGCAC  CAAGAGCTGC  240
241   CTTGGAACAA  AGGAGGAGGT  TCTTCAGTAC  TGCCAGGAGA  TATATCCAGA  GCTGCAGATC  300
301   ACAAATGTGA  TGGAAGCAAA  CCAGCCAGTC  AATATTGATA  GTTGGTGCCG  AAGGGACAAA  360
361   AGGCAGTGCA  AGAGTCACAT  TGTTATACCA  TTCAAGTGTC  TTGTGGGTGA  ATTTGTAAGT  420
421   GATGTCCTGC  TAGTTCCAGA  TAACTGCCAG  TTTTTCCACC  AAGAGCGGAT  GGAGGTGTGT  480
481   GAGAAGCACC  AGCGCTGGCA  CACGTTAGTC  AAGGAGGCAT  GTCTGACTGA  GGGGCTGACC  540
541   TTATATAGCT  ATGGCATGCT  GCTGCCCTGC  GGGGTAGACC  AGTTCCATGG  CACCGAGTAT  600
601   GTGTGCTGCC  CTCAGACAAA  GACTGTTGAC  TCGGACTCGA  CTATGTCCAA  AGAAGAGGAG  660
661   GAAGAGGAAG  AGGATGAAGA  GGACGAAGAG  GAAGACTATG  ATCTTGATAA  AAGTGAATTT  720
721   CCTACTGAAG  CAGATTTGGA  AGACTTCACA  GAAGCAGCAG  CAGATGAGGA  AGAAGAGGAT  780
781   GAGGAGGAAG  GGGAGGAAGT  GGTGGAAGAC  CGTGACTACT  ACTATGACCC  CTTTAAAGGA  840
841   GACGATTACA  ATGAGGAGAA  TCCAACCGAA  CCCAGCAGCG  AGGGCACCAT  TTCAGACAAG  900
901   GAGATTGTTC  ACGATGTTAA  AGCTGTCTGC  TCCCAGGAGG  CCATGACGGG  GCCCTGCCGG  960
961   GCTGTGATGC  CTCGTTGGTA  CTTCGACCTC  TCCAAGGGAA  AGTGCGTACG  CTTTATATAT  1020
1021  GGCGGCTGCG  GCGGCAACAG  GAACAATTTT  GAGTCTGAGG  ATTATTGTAT  GGCTGTGTGT  1080
1081  AAAGCGATGA  TTCCCCCGAC  TCCCCTGCCA  ACCAATGATG  TTGATGTGTA  TTTTGAGACC  1140
1141  TCAGCGGATG  ATAATGAGCA  CGCCCGCTTC  CAGAAGGCTA  AGGAACAGCT  GGAAATTCGA  1200
1201  CATCGAAACC  GAATGGACAG  GGTAAAGAAG  GAATGGGAAG  AGGCAGAACT  TCAAGCCAAG  1260
1261  AACCTCCCCA  AGACAGAAAG  ACAGACCCTC  ATCCAGCATT  TCCAAGCTAT  GGTTAAAGCT  1320
1321  TTAGAGAAAG  AAGCAGCCAG  TGAGAAGCAG  CAGCTTGTGG  AAACCCATCT  GGCCCGAGTA  1380
1381  GAAGCCATGC  TGAATGACCG  CCGACGCATA  GCTCTGGAAA  ATTACCTGGC  TGCCCTGCAG  1440
1441  TCTGACCCAC  CTCGGCCACA  TCGCATTCTT  CAAGCTCTTC  GTCGTTACGT  CCGTGCTGAG  1500
1501  AACAAAGATC  GCCTGCATAC  CATTCGTCAT  TACCAACACG  TGTTGGCTGT  TGACCCAGAA  1560
1561  AAGGCCGCCC  AGATGAAATC  CCAGGTGATG  ACACACCTCC  ATGTGATTGA  AGAAAGAAGG  1620
1621  AACCAAAGTC  TTTCTCTTCT  GTACAAAGTT  CCTTATGTTG  CTCAAGAAAT  TCAAGAGGAA  1680
1681  ATTGATGAGC  TCCTTCAGGA  ACAGCGAGCG  GATATGGACC  AATTTACCTC  CTCCATCTCA  1740
1741  GAGAACCCTG  TGGATGTCCG  GGTGAGCTCT  GAGGAGAGTG  AGGAGATCCC  GCCGTTCCAC  1800
1801  CCTCTCCATC  CCTTCCCATC  CTTGTCTGAG  AATGAAGGCT  CTGGAATGGC  AGAACAAGAC  1860
1861  GGGGGACTGA  TTGGTGCAGA  AGAAAAAGTG  ATTAACAGCA  AGAATAAAAT  GGATGAAAAT  1920
1921  ATGGTCATTG  ACGAGACTCT  GGATGTTAAG  GAAATGATTT  TCAATGCTGA  GAGAGTTGGA  1980
1981  GGCCTTGAGG  AAGAGCCGGA  ATCGGTGGGA  CCTTTAAGGG  AGGATTTCAG  TTTGAGCAGC  2040
2041  AATGCCCTTA  TTGGCTTGCT  GGTTATCGCA  GTGGCCATTG  CTACGGTCAT  CGTTATCAGC  2100
2101  CTGGTGATGC  TGAGGAAGAG  GCAGTACGGC  ACCATCAGCC  ACGGGATTGT  GGAGGTTGAC  2160
2161  CCAATGCTCA  CCCCAGAAGA  GCGTCACCTG  AACAAGATGC  AGAACCATGG  TTATGAAAAC  2220
2221  CCAACCTACA  AATACCTGGA  GCAGATGCAG  ATTTAA  2256

▼ KEYWORD

ID
Family
Alternative splicing
Cell membrane
Complete proteome
Copper
Disulfide bond
DNA-binding
Glycoprotein
Membrane
Metal-binding
Nucleus
Phosphoprotein
Reference proteome
Signal
Transmembrane
Transmembrane helix

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Integral component of membrane
Cellular Component
Nucleus
Cellular Component
Plasma membrane
Molecular Function
DNA binding
Molecular Function
Heparin binding
Molecular Function
Identical protein binding
Molecular Function
Transition metal ion binding
Biological Process
Cellular copper ion homeostasis
Biological Process
Cholesterol metabolic process
Biological Process
Extracellular matrix organization
Biological Process
Forebrain development
Biological Process
Locomotory behavior
Biological Process
Mating behavior
Biological Process
Midbrain development
Biological Process
Neuromuscular process controlling balance
Biological Process
Regulation of epidermal growth factor-activated receptor activity
Biological Process
Regulation of protein binding
Biological Process
Suckling behavior

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Nol-0808Nomascus leucogenys96.430.0 770
LLPS-Dio-2637Dipodomys ordii95.564e-169 496
LLPS-Ran-4198Rattus norvegicus95.10.01221
LLPS-Ora-2245Ornithorhynchus anatinus94.885e-147 436
LLPS-Mup-0201Mustela putorius furo93.250.01179
LLPS-Man-2527Macaca nemestrina92.820.01164
LLPS-Maf-3432Macaca fascicularis92.820.01164
LLPS-Rhb-1402Rhinopithecus bieti92.70.01165
LLPS-Aon-2575Aotus nancymaae91.690.01164
LLPS-Eqc-2576Equus caballus91.590.0 946
LLPS-Hos-3047Homo sapiens91.410.01162
LLPS-Fec-0797Felis catus91.410.01176
LLPS-Cas-3389Carlito syrichta91.270.01172
LLPS-Mam-4029Macaca mulatta91.270.01155
LLPS-Poa-3748Pongo abelii91.270.01160
LLPS-Paa-0287Papio anubis91.270.01160
LLPS-Cea-3552Cercocebus atys91.150.01154
LLPS-Chs-2368Chlorocebus sabaeus91.150.01154
LLPS-Caj-4685Callithrix jacchus91.060.01159
LLPS-Mal-2877Mandrillus leucophaeus91.010.01149
LLPS-Gog-4283Gorilla gorilla90.910.01157
LLPS-Pat-4166Pan troglodytes90.720.01152
LLPS-Aim-2240Ailuropoda melanoleuca90.580.01159
LLPS-Ict-0640Ictidomys tridecemlineatus90.460.01172
LLPS-Pap-2706Pan paniscus90.440.01155
LLPS-Caf-2890Canis familiaris90.30.01160
LLPS-Urm-2294Ursus maritimus89.80.01154
LLPS-Myl-1728Myotis lucifugus88.930.01155
LLPS-Fud-3014Fukomys damarensis88.00.01138
LLPS-Loa-2434Loxodonta africana87.640.01131
LLPS-Ova-2849Ovis aries87.530.01132
LLPS-Bot-3937Bos taurus86.360.01128
LLPS-Sus-4493Sus scrofa85.910.01122
LLPS-Sah-0519Sarcophilus harrisii85.20.01095
LLPS-Cap-0916Cavia porcellus83.660.01076
LLPS-Fia-2883Ficedula albicollis79.890.01036
LLPS-Lac-0606Latimeria chalumnae79.531e-96 322
LLPS-Anc-2141Anolis carolinensis79.170.01009
LLPS-Mod-2320Monodelphis domestica79.060.01024
LLPS-Meg-3272Meleagris gallopavo78.990.01033
LLPS-Tag-0783Taeniopygia guttata78.110.0 863
LLPS-Gaga-2701Gallus gallus77.760.01008
LLPS-Leo-0499Lepisosteus oculatus76.940.0 616
LLPS-Dar-4173Danio rerio75.950.0 605
LLPS-Ten-0790Tetraodon nigroviridis75.60.0 593
LLPS-Orc-2236Oryctolagus cuniculus75.340.0 964
LLPS-Orl-4026Oryzias latipes75.320.0 604
LLPS-Gaa-0777Gasterosteus aculeatus75.270.0 594
LLPS-Scm-1877Scophthalmus maximus75.210.0 610
LLPS-Xet-0993Xenopus tropicalis74.390.0 977
LLPS-Asm-0352Astyanax mexicanus73.740.0 587
LLPS-Scf-3570Scleropages formosus72.839e-87 296
LLPS-Pof-2036Poecilia formosa70.834e-1480.5
LLPS-Mea-3987Mesocricetus auratus70.833e-1480.5
LLPS-Xim-1656Xiphophorus maculatus69.894e-179 539
LLPS-Icp-0734Ictalurus punctatus68.092e-1378.2
LLPS-Tar-2185Takifugu rubripes67.910.0 871
LLPS-Orn-4105Oreochromis niloticus67.427e-84 288
LLPS-Ere-0200Erinaceus europaeus55.562e-1371.2
LLPS-Cii-0997Ciona intestinalis46.677e-1165.9
LLPS-Drm-1324Drosophila melanogaster39.312e-27 123
LLPS-Cae-1115Caenorhabditis elegans36.025e-26 118