DrLLPS - Data resource of LLPS

LLPS-Hos-0808
EWSR1

▼ OVERVIEW


Status:	Reviewed
Protein Name:	RNA-binding protein EWS; EWS oncogene; Ewing sarcoma breakpoint region 1 protein
Gene Name:	EWSR1, EWS
Ensembl Gene:	ENSG00000182944.17
Ensembl Protein:	ENSP00000385726.1
Organism:	Homo sapiens
Taxa ID:	9606
LLPS Type:	Scaffold

PDB: 2CPE (A) More

▼ PROPERTY

——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Minimum set of experiments:

Experiment	Description	PMIDs
In vitro
Assembly	"...At a concentration similar to the nuclear concentration (7.6 μM), FUS phase separated into droplets (Fig. 1, E and F). This behavior contrasted with that in living cells, where only 1% of the nuclear FUS protein was contained in condensates (Fig. 1F), which are paraspeckles (19). The remaining 99% of nuclear FUS protein was diffusely localized. Similar observations were made for TDP43, EWSR1, TAF15, and hnRNPA1."	29961577
In cells
Experiment	Description	PMIDs
Assembly	"...At a concentration similar to the nuclear concentration (7.6 μM), FUS phase separated into droplets (Fig. 1, E and F). This behavior contrasted with that in living cells, where only 1% of the nuclear FUS protein was contained in condensates (Fig. 1F), which are paraspeckles (19). The remaining 99% of nuclear FUS protein was diffusely localized. Similar observations were made for TDP43, EWSR1, TAF15, and hnRNPA1."	29961577

Partners:

Complex	Description	PMIDs
FUS + EWSR1	"...When ADMA FUS or HYPO FUS were mixed with TAF15 or EWS, their phase behavior was essentially indistinguishable from ADMA FUS or HYPO FUS alone. However, TNPO1 strongly suppressed phase separation of both ADMA FUS and HYPO FUS."	29677515
EWSR1 + RNA	"...Small amounts of RNA promoted liquid droplet formation. RNA-containing droplets contained a higher FUS concentration than RNA-free droplets, and they appeared slightly more viscous. However, upon further increase in the RNA/protein concentration ratio, the droplets became smaller and finally dissolved. The addition of RNase A resulted in droplet reappearance, indicating that droplet solubilization depends on intact RNA. Similar results were obtained for EWSR1, TAF15, hnRNPA1, and TDP43. Thus, we conclude that high RNA/protein ratios prevent phase separation and that low ratios promote phase separation."	29650702

Condensates:

Condensate	Description	Tissue/Cell	PMIDs
Droplet	"...To develop a predictor for the phase separation propensity of a given protein sequence, we started by defining a set of 11 proteins which have been shown, in the literature, to phase separate in vitro as single purified components due to interactions involving intrinsically disordered regions of the protein."	In vitro	29424691
Droplet	"...We were able to drive phase separation of most FUS family proteins (FUS, EWSR1, TAF15, hnRNPDL, hnRNPH3, hnRNPA3, hnRNPH1, hnRNPH2, CSTF2, hnRNPA2B1, CSTF2T, hnRNPA1b, hnRNPA1a, PSPC1, hnRNPD, hnRNPAB, hnRNPA0, DAZAP1, hnRNPA1L2, TIA1, TIAL1, TDP-43) either by increasing protein concentration or by adding dextran, which is a molecular crowding agent. However, only FUS, EWSR1, and TAF15, which constitute the FET family, showed robust phase separation in the absence of crowding agents at a protein concentration of 5 μM."	In vitro	29961577
Droplet	"...No trapping whatsoever was observed when the GFP:CTD test protein was exposed to either hnRNPA2 or CIRBP hydrogel droplets, and weak trapping was observed for FUS and EWS hydrogels."	In vitro	24267890
Nucleolus	"...The data set from all our nucleolar mass spectrometry analyses defines an updated group of 692 proteins that reproducibly copurify with human nucleoli."	HeLa cells	15635413
Centrosome/Spindle pole body	"...MiCroKiTS 4.0: a database of midbody, centrosome, kinetochore, telomere and spindle."	N/A	19133275
Stress granule	"...We found that the insoluble fraction of TAF15 was markedly reduced in PAD4-expressing cells and there was a corresponding increase in the TAF15 soluble fraction. In addition, the solubility of the ALS-linked mutant form of TAF15 (G391E) was modulated by citrullination. Similarly, TAF15, FUS, EWSR1, and hnRNPA1 proteins in insoluble fraction were remarkably decreased in PAD4-expressing HEK293T and Neuro-2A neural cells."	HEK293T cells	29425503
Stress granule	"...By adding known stress granule components not identified by mass spectrometry to this list, we created the first stress granule proteome for a mammalian cell."	U2OS cells	26777405
Stress granule	"...283 proteins identified as APEX hits in HEK293T cells or previously shown to associate with SGs."	N/A	29373831
Nuclear speckle, Neuronal granule, Chromatoid body	Predicted from orthologs	N/A	(View)

Organism	DrLLPS ID	UniProt ID	LLPS type	Condensate	Identity	E-value	Score
Mus musculus	LLPS-Mum-2279	Q61545	Scaffold	Nuclear speckle, Neuronal granule, Stress granule, Chromatoid body	100.00	3e-16	86.7

▼ FUNCTION

Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

▼ CROSS REFERENCE

Database	Nucleotide ID	Protein ID
Ensembl	ENST00000406548.5	ENSP00000385726.1
Ensembl	ENST00000436425.5	ENSP00000406824.1
Ensembl	ENST00000333395.10	ENSP00000327456.6
Ensembl	ENST00000447973.5	ENSP00000405947.1
Ensembl	ENST00000397938.6	ENSP00000381031.2
Ensembl	ENST00000437155.6	ENSP00000412670.2
Ensembl	ENST00000415761.5	ENSP00000395200.1
Ensembl	ENST00000414183.6	ENSP00000400142.2
Ensembl	ENST00000455726.5	ENSP00000393637.1
Ensembl	ENST00000332035.10	ENSP00000331699.6
Ensembl	ENST00000332050.10	ENSP00000330896.7
Ensembl	ENST00000629659.2	ENSP00000486709.1
Ensembl	ENST00000444626.5	ENSP00000416171.1
Ensembl	ENST00000331029.11	ENSP00000330516.7
Ensembl	ENST00000360091.3	ENSP00000353204.3
UniProt		Q01844, EWS_HUMAN, B0QYK1, Q5THL0, Q92635, Q96FE8, Q96MN4, Q96MX4, Q9BWA2
GeneBank	X72991, AL031186, AB016435, X66899, AC000026, Y08806, X72999, X72997, BC072442, X72990, Y07848, CR456490, X72993, BC000527, X73002, AC002059, X73003, CH471095, X73004, AK056681, X72996, AK056309, X73001, X73000, X72995, X72994, BC004817, X72998, BC011048, X72992	EAW59781.1, AAH04817.1, EAW59780.1, CAA70044.1, BAB71252.1, CAQ10938.1, CAA47350.1, CAI18001.1, AAH11048.1, AAH00527.1, AAH72442.1, CAQ10940.1, BAA31990.1, CAA69177.1, CAG30376.1, BAB71145.1, EAW59786.1, EAW59785.1, EAW59787.1, CAA51489.1, CAQ10937.1
RefSeq	NM_001163285.1, NM_001163286.1, NM_001163287.1, NM_005243.3, NM_013986.3	NP_001156757.1, NP_001156758.1, NP_001156759.1, NP_005234.1, NP_053733.2
Entrez	2130

▼ SEQUENCE

Protein Sequence (FASTA)
1 MASTDYSTYS QAAAQQGYSA YTAQPTQGYA QTTQAYGQQS YGTYGQPTDV SYTQAQTTAT 60 61 YGQTAYATSY GQPPTVEGTS TGYTTPTAPQ AYSQPVQGYG TGAYDTTTAT VTTTQASYAA 120 121 QSAYGTQPAY PAYGQQPAAT APTRPQDGNK PTETSQPQSS TGGYNQPSLG YGQSNYSYPQ 180 181 VPGSYPMQPV TAPPSYPPTS YSSTQPTSYD QSSYSQQNTY GQPSSYGQQS SYGQQSSYGQ 240 241 QPPTSYPPQT GSYSQAPSQY SQQSSSYGQQ SSFRQDHPSS MGVYGQESGG FSGPGENRSM 300 301 SGPDNRGRGR GGFDRGGMSR GGRGGGRGGM GAGERGGFNK PGGPMDEGPD LDLGPPVDPD 360 361 EDSDNSAIYV QGLNDSVTLD DLADFFKQCG VVKMNKRTGQ PMIHIYLDKE TGKPKGDATV 420 421 SYEDPPTAKA AVEWFDGKDF QGSKLKVSLA RKKPPMNSMR GGLPPREGRG MPPPLRGGPG 480 481 GPGGPGGPMG RMGGRGGDRG GFPPRGPRGS RGNPSGGGNV QHRAGDWQCP NPGCGNQNFA 540 541 WRTECNQCKA PKPEGFLPPP FPPPGGDRGR GGPGGMRGGR GGLMDRGGPG GMFRGGRGGD 600 601 RGGFRGGRGM DRGGFGGGRR GGPGGPPGPL MEQMGGRRGG RGGPGKMDKG EHRQERRDRP 660 661 Y 661
Nucleotide CDS Sequence (FASTA)
1 ATGGCGTCCA CGGATTACAG TACCTATAGC CAAGCTGCAG CGCAGCAGGG CTACAGTGCT 60 61 TACACCGCCC AGCCCACTCA AGGATATGCA CAGACCACCC AGGCATATGG GCAACAAAGC 120 121 TATGGAACCT ATGGACAGCC CACTGATGTC AGCTATACCC AGGCTCAGAC CACTGCAACC 180 181 TATGGGCAGA CCGCCTATGC AACTTCTTAT GGACAGCCTC CCACTGGTTA TACTACTCCA 240 241 ACTGCCCCCC AGGCATACAG CCAGCCTGTC CAGGGGTATG GCACTGGTGC TTATGATACC 300 301 ACCACTGCTA CAGTCACCAC CACCCAGGCC TCCTATGCAG CTCAGTCTGC ATATGGCACT 360 361 CAGCCTGCTT ATCCAGCCTA TGGGCAGCAG CCAGCAGCCA CTGCACCTAC AAGACCGCAG 420 421 GATGGAAACA AGCCCACTGA GACTAGTCAA CCTCAATCTA GCACAGGGGG TTACAACCAG 480 481 CCCAGCCTAG GATATGGACA GAGTAACTAC AGTTATCCCC AGGTACCTGG GAGCTACCCC 540 541 ATGCAGCCAG TCACTGCACC TCCATCCTAC CCTCCTACCA GCTATTCCTC TACACAGCCG 600 601 ACTAGTTATG ATCAGAGCAG TTACTCTCAG CAGAACACCT ATGGGCAACC GAGCAGCTAT 660 661 GGACAGCAGA GTAGCTATGG TCAACAAAGC AGCTATGGGC AGCAGCCTCC CACTAGTTAC 720 721 CCACCCCAAA CTGGATCCTA CAGCCAAGCT CCAAGTCAAT ATAGCCAACA GAGCAGCAGC 780 781 TACGGGCAGC AGAGTTCATT CCGACAGGAC CACCCCAGTA GCATGGGTGT TTATGGGCAG 840 841 GAGTCTGGAG GATTTTCCGG ACCAGGAGAG AACCGGAGCA TGAGTGGCCC TGATAACCGG 900 901 GGCAGGGGAA GAGGGGGATT TGATCGTGGA GGCATGAGCA GAGATCCAGA TGAAGACTCT 960 961 GACAACAGTG CAATTTATGT ACAAGGATTA AATGACAGTG TGACTCTAGA TGATCTGGCA 1020 1021 GACTTCTTTA AGCAGTGTGG GGTTGTTAAG ATGAACAAGA GAACTGGGCA ACCCATGATC 1080 1081 CACATCTACC TGGACAAGGA AACAGGAAAG CCCAAAGGCG ATGCCACAGT GTCCTATGAA 1140 1141 GACCCACCCA CTGCCAAGGC TGCCGTGGAA TGGTTTGATG GGAAAGATTT TCAAGGGAGC 1200 1201 AAACTTAAAG TCTCCCTTGC TCGGAAGAAG CCTCCAATGA ACAGTATGCG GGGTGGTCTG 1260 1261 CCACCCCGTG AGGGCAGAGG CATGCCACCA CCACTCCGTG GAGGTCCAGG AGGCCCAGGA 1320 1321 GGTCCTGGGG GACCCATGGG TCGCATGGGA GGCCGTGGAG GAGATAGAGG AGGCTTCCCT 1380 1381 CCAAGAGGAC CCCGGGGTTC CCGAGGGAAC CCCTCTGGAG GAGGAAACGT CCAGCACCGA 1440 1441 GCTGGAGACT GGCAGTGTCC CAATCCGGGT TGTGGAAACC AGAACTTCGC CTGGAGAACA 1500 1501 GAGTGCAACC AGTGTAAGGC CCCAAAGCCT GAAGGCTTCC TCCCGCCACC CTTTCCGCCC 1560 1561 CCGGGTGGTG ATCGTGGCAG AGGTGGCCCT GGTGGCATGC GGGGAGGAAG AGGTGGCCTC 1620 1621 ATGGATCGTG GTGGTCCCGG TGGAATGTTC AGAGGTGGCC GTGGTGGAGA CAGAGGTGGC 1680 1681 TTCCGTGGTG GCCGGGGCAT GGACCGAGGT GGCTTTGGTG GAGGAAGACG AGGTGGCCCT 1740 1741 GGGGGGCCCC CTGGACCTTT GATGGAACAG ATGGGAGGAA GAAGAGGAGG ACGTGGAGGA 1800 1801 CCTGGAAAAA TGGATAAAGG CGAGCACCGT CAGGAGCGCA GAGATCGGCC CTACTAG 1857

▼ KEYWORD

ID	Family
KW-0002	3D-structure
KW-0007	Acetylation
KW-0025	Alternative splicing
KW-0112	Calmodulin-binding
KW-1003	Cell membrane
KW-0160	Chromosomal rearrangement
KW-0181	Complete proteome
KW-0963	Cytoplasm
KW-0903	Direct protein sequencing
KW-0472	Membrane
KW-0479	Metal-binding
KW-0488	Methylation
KW-0539	Nucleus
KW-0597	Phosphoprotein
KW-0656	Proto-oncogene
KW-1185	Reference proteome
KW-0677	Repeat
KW-0678	Repressor
KW-0694	RNA-binding
KW-0804	Transcription
KW-0805	Transcription regulation
KW-0862	Zinc
KW-0863	Zinc-finger

▼ GENE ONTOLOGY

ID	Classification	Description
GO:0005737	Cellular Component	Cytoplasm
GO:0005730	Cellular Component	Nucleolus
GO:0005634	Cellular Component	Nucleus
GO:0005886	Cellular Component	Plasma membrane
GO:0005516	Molecular Function	Calmodulin binding
GO:0042802	Molecular Function	Identical protein binding
GO:0046872	Molecular Function	Metal ion binding
GO:0003723	Molecular Function	RNA binding
GO:0006355	Biological Process	Regulation of transcription, DNA-templated

▼ KEGG

hsa:2130

▼ ANNOTATION

Disorder
D²P²	IUPred2A	MobiDB	DisProt

Domain
PLAAC	SMART	Pfam	InterPro	LCR-eXXXplorer
CDD	PROSITE	Gene3D

PTM
EPSD	PLMD	PhosphoSitePlus	dbPTM	HPRD
BioGRID	mUbiSiDa	PTMcode

Variation
dbSNP

Mutation
TCGA	ICGC	COSMIC	CGAP	IntOGen
BioMuta

Interaction
HINT	InWeb_IM	RISE	TRRUST	RAIN
Mentha	PINA	IID	iRefIndex	MIST
DifferentialNET	RNAct

Disease
PancanQTL	TumorFusions	OMIM	DisGeNET	ActiveDriverDB

Drug
CTD

Physicochemical
Compute pI/Mw	AAindex

Function
PIRSF	ENPD	CORUM	CellMarker	RaftProt

Proteomics
THPA	HPM

Structure
PDB	MMDB

Localization
COMPARTMENTS	NLSdb

Expression
TCGA	ICGC	COSMIC	GEO	ArrayExpress
TISSUES	BioXpress	THPA

Element
UTRdb	circBase	circRNADb	CircNet	miRTarBase
miRWalk	miRcode	RAID	microRNA.org	m6AVar

Methylation
TCGA	ICGC	MethyCancer

▼ ORTHOLOGY

DrLLPS ID	Organism	Identity	E-value	Score
LLPS-Dio-1039	Dipodomys ordii	100.0	3e-16	84.3
LLPS-Bot-0548	Bos taurus	100.0	6e-16	85.9
LLPS-Ran-0538	Rattus norvegicus	100.0	3e-16	86.7
LLPS-Paa-2937	Papio anubis	100.0	3e-16	86.7
LLPS-Mal-3101	Mandrillus leucophaeus	100.0	3e-41	163
LLPS-Myl-1316	Myotis lucifugus	100.0	1e-11	71.6
LLPS-Ova-2888	Ovis aries	100.0	1e-11	71.6
LLPS-Aim-3827	Ailuropoda melanoleuca	100.0	4e-16	86.3
LLPS-Mup-1311	Mustela putorius furo	100.0	3e-16	86.7
LLPS-Mum-2279	Mus musculus	100.0	3e-16	86.7
LLPS-Maf-1508	Macaca fascicularis	100.0	3e-41	163
LLPS-Chs-2848	Chlorocebus sabaeus	100.0	4e-16	84.7
LLPS-Ora-2576	Ornithorhynchus anatinus	100.0	2e-16	87.0
LLPS-Sus-3401	Sus scrofa	100.0	5e-16	86.3
LLPS-Aon-3978	Aotus nancymaae	100.0	3e-16	86.7
LLPS-Sah-2286	Sarcophilus harrisii	100.0	9e-12	72.4
LLPS-Cea-0156	Cercocebus atys	100.0	3e-41	163
LLPS-Gog-1454	Gorilla gorilla	100.0	6e-73	254
LLPS-Fud-1072	Fukomys damarensis	100.0	3e-16	86.7
LLPS-Caj-3101	Callithrix jacchus	100.0	3e-41	163
LLPS-Caf-1578	Canis familiaris	100.0	3e-16	86.7
LLPS-Poa-2607	Pongo abelii	100.0	3e-16	86.7
LLPS-Eqc-1131	Equus caballus	100.0	3e-16	86.7
LLPS-Mam-2464	Macaca mulatta	100.0	3e-16	86.7
LLPS-Cas-0933	Carlito syrichta	100.0	3e-16	86.7
LLPS-Xet-2303	Xenopus tropicalis	100.0	4e-15	83.2
LLPS-Nol-3433	Nomascus leucogenys	100.0	3e-16	86.3
LLPS-Anc-2346	Anolis carolinensis	100.0	1e-17	90.9
LLPS-Ict-2955	Ictidomys tridecemlineatus	100.0	5e-16	85.9
LLPS-Pap-2087	Pan paniscus	100.0	3e-16	86.7
LLPS-Urm-0139	Ursus maritimus	100.0	4e-16	86.7
LLPS-Pat-1353	Pan troglodytes	100.0	6e-73	254
LLPS-Mod-2572	Monodelphis domestica	100.0	2e-16	87.0
LLPS-Fec-1353	Felis catus	100.0	3e-16	86.7
LLPS-Man-2674	Macaca nemestrina	100.0	3e-16	86.7
LLPS-Loa-0495	Loxodonta africana	100.0	3e-16	86.7
LLPS-Otg-2864	Otolemur garnettii	100.0	3e-16	86.7
LLPS-Pes-2226	Pelodiscus sinensis	100.0	2e-16	87.4
LLPS-Orc-1376	Oryctolagus cuniculus	100.0	2e-11	71.6
LLPS-Rhb-3350	Rhinopithecus bieti	100.0	3e-16	86.7
LLPS-Cap-4025	Cavia porcellus	98.4	2e-40	160
LLPS-Gaga-0945	Gallus gallus	97.06	2e-15	84.3
LLPS-Lac-1061	Latimeria chalumnae	97.06	9e-16	85.1
LLPS-Fia-2970	Ficedula albicollis	97.06	2e-15	84.0
LLPS-Tag-1079	Taeniopygia guttata	92.0	1e-07	59.3
LLPS-Mea-1617	Mesocricetus auratus	91.67	1e-15	85.1
LLPS-Asm-0085	Astyanax mexicanus	91.67	5e-16	85.9
LLPS-Leo-0508	Lepisosteus oculatus	91.18	4e-14	80.1
LLPS-Scf-1222	Scleropages formosus	88.89	8e-15	82.4
LLPS-Gaa-1242	Gasterosteus aculeatus	87.5	2e-12	74.7
LLPS-Orl-2252	Oryzias latipes	87.5	1e-12	75.1
LLPS-Scm-3083	Scophthalmus maximus	87.5	1e-12	75.5
LLPS-Meg-0473	Meleagris gallopavo	87.17	1e-63	229
LLPS-Icp-1108	Ictalurus punctatus	86.11	4e-14	79.7
LLPS-Dar-2944	Danio rerio	86.11	2e-14	80.5
LLPS-Tar-2016	Takifugu rubripes	84.38	4e-12	73.6
LLPS-Ten-0292	Tetraodon nigroviridis	76.47	6e-11	69.7
LLPS-Orn-0349	Oreochromis niloticus	76.47	1e-10	68.9
LLPS-Sot-2048	Solanum tuberosum	71.43	6e-06	53.5
LLPS-Bro-0016	Brassica oleracea	71.43	7e-06	53.1
LLPS-Anp-2499	Anas platyrhynchos	68.75	6e-08	60.1
LLPS-Glm-1372	Glycine max	67.44	2e-10	64.3
LLPS-Tut-0706	Tursiops truncatus	65.62	3e-07	57.8
LLPS-Xim-3708	Xiphophorus maculatus	63.89	1e-07	58.5
LLPS-Pof-3703	Poecilia formosa	63.89	2e-07	58.5
LLPS-Ors-1718	Oryza sativa	52.81	5e-21	95.9
LLPS-Orgl-1067	Oryza glumaepatula	51.69	4e-19	94.7
LLPS-Cus-0334	Cucumis sativus	51.69	1e-19	95.9
LLPS-Ori-2100	Oryza indica	51.69	4e-19	94.7
LLPS-Orni-1289	Oryza nivara	51.69	4e-19	94.7
LLPS-Orr-1411	Oryza rufipogon	51.69	4e-19	94.4
LLPS-Org-1835	Oryza glaberrima	51.69	6e-20	94.4
LLPS-Gor-0149	Gossypium raimondii	51.69	5e-19	93.6
LLPS-Orb-1582	Oryza barthii	51.19	3e-18	90.9
LLPS-Sei-1264	Setaria italica	50.56	7e-19	93.2
LLPS-Brn-0759	Brassica napus	49.44	1e-18	92.4
LLPS-Brr-2803	Brassica rapa	49.44	1e-18	92.4
LLPS-Pot-0882	Populus trichocarpa	49.44	6e-18	90.1
LLPS-Dac-0882	Daucus carota	47.87	2e-17	89.0
LLPS-Chr-1691	Chlamydomonas reinhardtii	46.67	2e-17	90.1
LLPS-Drm-1254	Drosophila melanogaster	46.15	1e-19	95.9
LLPS-Abg-1156	Absidia glauca	46.15	5e-20	95.9
LLPS-Tra-0674	Triticum aestivum	44.76	2e-16	86.3
LLPS-Amt-1962	Amborella trichopoda	44.44	7e-14	78.6
LLPS-Arl-0102	Arabidopsis lyrata	43.33	3e-13	77.0
LLPS-Art-0955	Arabidopsis thaliana	43.33	2e-13	77.4
LLPS-Cii-0483	Ciona intestinalis	43.21	1e-19	92.4
LLPS-Hea-0597	Helianthus annuus	41.86	1e-14	81.3
LLPS-Sob-1373	Sorghum bicolor	41.38	8e-14	78.6
LLPS-Thc-1265	Theobroma cacao	41.11	2e-14	80.5
LLPS-Zem-0482	Zea mays	40.23	3e-13	76.6
LLPS-Met-2481	Medicago truncatula	40.0	2e-12	73.9
LLPS-Phv-1267	Phaseolus vulgaris	40.0	3e-14	79.7
LLPS-Php-0563	Physcomitrella patens	39.73	2e-10	67.8
LLPS-Scp-1198	Schizosaccharomyces pombe	39.33	3e-10	66.6
LLPS-Orm-0390	Oryza meridionalis	39.08	5e-13	76.3
LLPS-Nia-1420	Nicotiana attenuata	39.0	1e-10	68.6
LLPS-Via-0173	Vigna angularis	38.89	4e-14	79.7
LLPS-Vir-0473	Vigna radiata	38.89	6e-14	79.0
LLPS-Mua-1310	Musa acuminata	38.89	1e-12	74.7
LLPS-Orbr-1470	Oryza brachyantha	38.89	2e-13	77.0
LLPS-Coc-0027	Corchorus capsularis	38.64	6e-14	76.3
LLPS-Hov-0877	Hordeum vulgare	37.78	1e-12	75.1
LLPS-Brd-1092	Brachypodium distachyon	37.78	4e-13	76.3
LLPS-Tru-1275	Triticum urartu	37.78	1e-12	75.1
LLPS-Orp-0977	Oryza punctata	37.78	4e-13	76.3
LLPS-Mae-0158	Manihot esculenta	37.78	1e-12	74.7
LLPS-Osl-0087	Ostreococcus lucimarinus	37.23	5e-10	63.9
LLPS-Lep-0463	Leersia perrieri	36.67	6e-13	75.5
LLPS-Sem-1352	Selaginella moellendorffii	36.67	8e-11	68.9

LLPS-Hos-0808EWSR1

Protein Sequence

Nucleotide Sequence

LLPS-Hos-0808
EWSR1