LLPS-Art-1177
HMGB1

▼ OVERVIEW

Status: Reviewed
Protein Name: High mobility group B protein 1; High mobility group protein A; AtHMGalpha; HMG alpha; Nucleosome/chromatin assembly factor group D 01; Nucleosome/chromatin assembly factor group D 1
Gene Name: HMGB1, HMGA, HMGALPHA, NFD01, NFD1, ORF13, At3g51880, ATEM1.13
Ensembl Gene: AT3G51880
Ensembl Protein: AT3G51880.3
Organism: Arabidopsis thaliana
Taxa ID: 3702
LLPS Type: Client


▼ PROPERTY


——— Disorder propensity (calculated by IUPred2A)

▼ Classification

Condensates:
CondensateDescriptionTissue/CellPMIDs
Nucleolus
"...We identified 1602 proteins in the nucleolar and 2544 proteins in the nuclear fraction with an overlap of 1429 proteins."
Arabidopsis thaliana cells26980300

▼ FUNCTION

Binds preferentially double-stranded DNA. Modulates general plant growth and stress tolerance. Confers sensitivity to salt and genotoxic (methyl methanesulfonate, MMS) stresses.

▼ SEQUENCE

Protein Sequence (FASTA)
1     MKTAKGKDKV  KTTKEALKPV  DDRKVGKRKA  PAEKPTKRET  RKEKKAKKDP  NKPKRAPSAF  60
61    FVFLEDFRVT  FKKENPNVKA  VSAVGKAGGQ  KWKSMSQAEK  APYEEKAAKR  KAEYEKQMDA  120
121   YNKNLEEGSD  ESEKSRSEIN  DEDEASGEVT  IPLSNEELLE  KEAAGDDEEE  EEEEDDDDDD  180
181   DEEED  185
Nucleotide CDS Sequence (FASTA)
1     ATGAAAACAG  CAAAGGGGAA  AGATAAAGTT  AAGACCACAA  AGGAAGCCTT  GAAGCCAGTT  60
61    GATGACAGAA  AGGTGGGAAA  GAGGAAGGCA  CCGGCTGAGA  AGCCTACTAA  ACGAGAGACT  120
121   CGTAAAGAGA  AGAAGGCTAA  AAAGGACCCA  AACAAACCAA  AAAGAGCTCC  TAGTGCCTTC  180
181   TTTGTCTTTC  TAGAAGATTT  TAGGGTCACG  TTCAAGAAAG  AAAATCCAAA  TGTGAAGGCC  240
241   GTCTCTGCTG  TTGGGAAAGC  TGGAGGGCAG  AAATGGAAGT  CAATGTCTCA  AGCTGAAAAA  300
301   GCTCCATATG  AAGAGAAAGC  TGCAAAAAGG  AAAGCTGAAT  ATGAGAAGCA  AATGGATGCA  360
361   TACAACAAAA  ACTTGGAGGA  AGGGAGTGAT  GAATCTGAAA  AGTCTAGATC  TGAGATAAAT  420
421   GATGAAGATG  AAGCCAGTGG  GGAGGTAACA  ATTCCACTAA  GCAATGAAGA  ACTATTAGAG  480
481   AAGGAAGCGG  CAGGTGATGA  TGAAGAAGAA  GAAGAGGAAG  AAGATGACGA  TGATGATGAC  540
541   GACGAGGAAG  AAGACTAA  558

▼ KEYWORD

ID
Family
Alternative splicing
Complete proteome
DNA-binding
Nucleus
Phosphoprotein
Reference proteome

▼ GENE ONTOLOGY

ID
Classification
Description
Cellular Component
Chromatin
Cellular Component
Nucleus
Molecular Function
Chromatin binding
Molecular Function
DNA binding
Molecular Function
DNA-binding transcription factor activity
Molecular Function
Structural constituent of chromatin
Biological Process
Chromatin assembly or disassembly

▼ KEGG


▼ ORTHOLOGY

DrLLPS IDOrganismIdentityE-valueScore
LLPS-Arl-2556Arabidopsis lyrata95.819e-70 216
LLPS-Bro-2882Brassica oleracea82.141e-48 162
LLPS-Brn-2128Brassica napus78.955e-50 166
LLPS-Hea-2563Helianthus annuus77.911e-2191.7
LLPS-Nia-1249Nicotiana attenuata77.241e-2397.4
LLPS-Sot-2091Solanum tuberosum74.84e-2395.9
LLPS-Met-1457Medicago truncatula74.655e-1573.6
LLPS-Sol-0362Solanum lycopersicum73.985e-2395.9
LLPS-Prp-1633Prunus persica72.961e-34 126
LLPS-Glm-0739Glycine max71.145e-33 122
LLPS-Amt-1514Amborella trichopoda70.772e-1265.9
LLPS-Phv-2289Phaseolus vulgaris70.396e-34 124
LLPS-Thc-1459Theobroma cacao69.743e-37 133
LLPS-Gor-2058Gossypium raimondii69.234e-25 101
LLPS-Vir-1335Vigna radiata68.492e-1368.6
LLPS-Mae-2259Manihot esculenta67.611e-1267.0
LLPS-Brr-2599Brassica rapa67.34e-44 150
LLPS-Pot-1205Populus trichocarpa66.28e-1367.4
LLPS-Coc-0244Corchorus capsularis65.262e-1985.5
LLPS-Mua-2476Musa acuminata62.226e-1779.0
LLPS-Orb-1408Oryza barthii62.123e-0957.8
LLPS-Viv-0401Vitis vinifera61.363e-1677.0
LLPS-Tra-2163Triticum aestivum60.922e-1676.6
LLPS-Zem-2012Zea mays60.617e-1058.5
LLPS-Tru-1959Triticum urartu60.613e-0957.0
LLPS-Via-2045Vigna angularis59.35e-1470.5
LLPS-Brd-2036Brachypodium distachyon59.092e-0957.4
LLPS-Sem-2154Selaginella moellendorffii56.068e-1057.4
LLPS-Orgl-1111Oryza glumaepatula50.03e-0751.2
LLPS-Orni-1360Oryza nivara50.05e-0750.4
LLPS-Php-0085Physcomitrella patens50.07e-1675.9