Schizosaccharomyces pombe      Spindle apparatus


※ Spindle apparatus introduction

    The spindle is an important structure when cells divide. Phase separation promotes the concentration of molecules into the droplets, thereby promoting biochemical reactions. Some protein mixtures undergo a phase change to form droplets that concentrate actin to promote F-actin assembly in vitro. In addition, studies have shown that the phase transition of spindle regulatory protein BuGZ concentrates tubulin and promotes MT polymerizationbinds to tubulin and promotes spindle assembly (1).

Reference
1. Jiang, H., Wang, S., Huang, Y., He, X., Cui, H., Zhu, X., & Zheng, Y. (2015) Phase transition of spindle-associated protein regulate spindle apparatus assembly. Cell, 163(1), 108-122. PMID: 26388440


There are 10 genes.  Reviewed (2 or Unreviewed (8

No.StatusDrLLPS IDEnsemble Gene IDUniProt AccessionGene Name
1
LLPS-Scp-0161
SPCC895.07
O94534
alp14
2
LLPS-Scp-0016
SPAC25G10.07c
P24339
cut7
3
LLPS-Scp-1315
SPAPB1A10.09
Q9HDY1
ase1
4
LLPS-Scp-0474
SPBC14C8.07c
P41411
cdc18
5
LLPS-Scp-1533
SPBC9B6.08
Q9USP6
clc1
6
LLPS-Scp-0066
SPBC20F10.06
O14417
mad2
7
LLPS-Scp-0582
SPAC10F6.09c
O42649
psm3
8
LLPS-Scp-0509
SPBC12D12.09
Q0E7J8
rev7
9
LLPS-Scp-1173
SPCC1259.12c
O94712
SPCC1259.12c
10
LLPS-Scp-0356
SPBC216.07c
Q9Y7K2
tor2