Homo sapiens      Spindle apparatus


※ Spindle apparatus introduction

    The spindle is an important structure when cells divide. Phase separation promotes the concentration of molecules into the droplets, thereby promoting biochemical reactions. Some protein mixtures undergo a phase change to form droplets that concentrate actin to promote F-actin assembly in vitro. In addition, studies have shown that the phase transition of spindle regulatory protein BuGZ concentrates tubulin and promotes MT polymerizationbinds to tubulin and promotes spindle assembly (1).

Reference
1. Jiang, H., Wang, S., Huang, Y., He, X., Cui, H., Zhu, X., & Zheng, Y. (2015) Phase transition of spindle-associated protein regulate spindle apparatus assembly. Cell, 163(1), 108-122. PMID: 26388440


There are 43 genes.  Reviewed (32 or Unreviewed (11

No.StatusDrLLPS IDEnsemble Gene IDUniProt AccessionGene Name
1
LLPS-Hos-0651
ENSG00000087586.17
O14965
AURKA
2
LLPS-Hos-2866
ENSG00000178999.12
Q96GD4
AURKB
3
LLPS-Hos-0998
ENSG00000198824.6
Q96JM3
CHAMP1
4
LLPS-Hos-0371
ENSG00000136108.14
Q8WWK9
CKAP2
5
LLPS-Hos-0306
ENSG00000175216.14
Q14008
CKAP5
6
LLPS-Hos-2140
ENSG00000175416.12
P09497
CLTB
7
LLPS-Hos-0220
ENSG00000137100.15
O75935
DCTN3
8
LLPS-Hos-1645
ENSG00000092964.17
Q16555
DPYSL2
9
LLPS-Hos-2002
ENSG00000143479.16
O43781
DYRK3
10
LLPS-Hos-1351
ENSG00000121957.13
P81274
GPSM2
11
LLPS-Hos-0917
ENSG00000138160.5
P52732
KIF11
12
LLPS-Hos-0041
ENSG00000164109.13
Q13257
MAD2L1
13
LLPS-Hos-1671
ENSG00000116670.14
Q9UI95
MAD2L2
14
LLPS-Hos-1986
ENSG00000101367.8
Q15691
MAPRE1
15
LLPS-Hos-1875
ENSG00000079277.20
Q9BUB5
MKNK1
16
LLPS-Hos-4386
ENSG00000147065.16
P26038
MSN
17
LLPS-Hos-0901
ENSG00000198793.12
P42345
MTOR
18
LLPS-Hos-2736
ENSG00000129422.14
Q9ULD2
MTUS1
19
LLPS-Hos-0819
ENSG00000266412.5
Q13772
NCOA4
20
LLPS-Hos-0213
ENSG00000198901.13
O43663
PRC1
21
LLPS-Hos-2904
ENSG00000153201.15
P49792
RANBP2
22
LLPS-Hos-0792
ENSG00000157110.15
Q93062
RBPMS
23
LLPS-Hos-2614
ENSG00000168385.17
Q15019
SEPT2
24
LLPS-Hos-0116
ENSG00000108055.9
Q9UQE7
SMC3
25
LLPS-Hos-2118
ENSG00000164828.17
O94901
SUN1
26
LLPS-Hos-2355
ENSG00000100242.15
Q9UH99
SUN2
27
LLPS-Hos-2704
ENSG00000171148.13
O75528
TADA3
28
LLPS-Hos-2449
ENSG00000188807.12
Q5SNT2
TMEM201
29
LLPS-Hos-0954
ENSG00000047410.13
P12270
TPR
30
LLPS-Hos-2655
ENSG00000258947.6
Q13509
TUBB3
31
LLPS-Hos-1412
ENSG00000174282.11
Q9P1Z0
ZBTB4
32
LLPS-Hos-0100
ENSG00000010244.18
O43670
ZNF207
33
LLPS-Hos-4426
ENSG00000094804.10
Q99741
CDC6
34
LLPS-Hos-0587
ENSG00000126787.12
Q15398
DLGAP5
35
LLPS-Hos-2208
ENSG00000182511.11
P07332
FES
36
LLPS-Hos-4790
ENSG00000214367.7
Q68CZ6
HAUS3
37
LLPS-Hos-3737
ENSG00000147874.10
Q7Z4H7
HAUS6
38
LLPS-Hos-4815
ENSG00000149474.13
Q9H8E8
KAT14
39
LLPS-Hos-3187
ENSG00000102781.13
Q9BW62
KATNAL1
40
LLPS-Hos-3977
ENSG00000069956.11
Q16659
MAPK6
41
LLPS-Hos-4510
ENSG00000155254.12
Q9BSK0
MARVELD1
42
LLPS-Hos-3844
ENSG00000148498.15
Q8TEW0
PARD3
43
LLPS-Hos-3540
ENSG00000141084.10
Q6VN20
RANBP10