Drosophila melanogaster      Spindle apparatus


※ Spindle apparatus introduction

    The spindle is an important structure when cells divide. Phase separation promotes the concentration of molecules into the droplets, thereby promoting biochemical reactions. Some protein mixtures undergo a phase change to form droplets that concentrate actin to promote F-actin assembly in vitro. In addition, studies have shown that the phase transition of spindle regulatory protein BuGZ concentrates tubulin and promotes MT polymerizationbinds to tubulin and promotes spindle assembly (1).

Reference
1. Jiang, H., Wang, S., Huang, Y., He, X., Cui, H., Zhu, X., & Zheng, Y. (2015) Phase transition of spindle-associated protein regulate spindle apparatus assembly. Cell, 163(1), 108-122. PMID: 26388440


There are 23 genes.  Reviewed (9 or Unreviewed (14

No.StatusDrLLPS IDEnsemble Gene IDUniProt AccessionGene Name
1
LLPS-Drm-0224
FBgn0039638
Q9VAP2
dgt6
2
LLPS-Drm-0183
FBgn0040208
A0A0B4KFL3
Kat60
3
LLPS-Drm-0010
FBgn0033845
Q7K3L1
mars
4
LLPS-Drm-0082
FBgn0011661
P46150
Moe
5
LLPS-Drm-0198
FBgn0027948
Q9VEZ3
msps
6
LLPS-Drm-0151
FBgn0013756
A1Z8P9
Mtor
7
LLPS-Drm-0223
FBgn0036059
Q9VT70
nudE
8
LLPS-Drm-2447
FBgn0262717
Q9GPJ1
Skeletor
9
LLPS-Drm-0245
FBgn0015600
Q9VQM0
toc
10
LLPS-Drm-1620
FBgn0032691
Q9VJ73
Atac2
11
LLPS-Drm-0811
FBgn0000163
Q0KHR3
baz
12
LLPS-Drm-2015
FBgn0035918
Q9VSM9
Cdc6
13
LLPS-Drm-0375
FBgn0024814
Q9VWA1
Clc
14
LLPS-Drm-0829
FBgn0034447
A1ZBL2
DmelCG7744
15
LLPS-Drm-0027
FBgn0004378
P46863
Klp61F
16
LLPS-Drm-0291
FBgn0265003
A0A0B4KEE4
koi
17
LLPS-Drm-0083
FBgn0035640
Q9VRQ2
mad2
18
LLPS-Drm-1722
FBgn0040080
Q9VB22
pins
19
LLPS-Drm-0896
FBgn0003346
Q9VIW3
RanGAP
20
LLPS-Drm-1554
FBgn0037345
Q9VNE1
rev7
21
LLPS-Drm-1401
FBgn0011710
P42207
Sep1
22
LLPS-Drm-0322
FBgn0015615
Q9VXE9
SMC3
23
LLPS-Drm-2241
FBgn0021796
Q9VK45
Tor