Mus musculus Pericentriolar matrix
※ Pericentriolar matrix introduction Pericentriolar matrix, also known as pericentriolar material. A centrosome consists of two barrel-shaped centrioles embedded in a matrix of proteins known as the pericentriolar material (PCM). The PCM serves as a platform for protein complexes that regulate organelle trafficking, protein degradation and spindle assembly. However, unlike other organelles, the PCM is not membrane bound, but rather a dynamic collection of protein complexes and nucleic acids that constitute the organelle's interior and determine its boundary (1). DYRK3 acts as a central dissolvase of several types of membraneless organelle during mitosis, through its ability to control the condensation of multiple compartments, DYRK3 may link structural and functional roles for RNA, transcription and splicing to the assembly of the mitotic spindle, and be involved in the maintenance of the pericentriolar matrix (2). Reference
1. Woodruff, J. B., Wueseke, O., & Hyman, A. A. (2014) Pericentriolar material structure and dynamics. Philos Trans R Soc Lond B Biol Sci, 369(1650). PMID: 25047613
2. Rai, A. K., Chen, J. X., Selbach, M., & Pelkmans, L. (2018) Kinase-controlled phase transition of membraneless organelles in mitosis. Nature, 559(7713), 211-216. PMID:29973724
There are 2 genes. Reviewed (1)
or Unreviewed (1) 
※ Pericentriolar matrix introduction Pericentriolar matrix, also known as pericentriolar material. A centrosome consists of two barrel-shaped centrioles embedded in a matrix of proteins known as the pericentriolar material (PCM). The PCM serves as a platform for protein complexes that regulate organelle trafficking, protein degradation and spindle assembly. However, unlike other organelles, the PCM is not membrane bound, but rather a dynamic collection of protein complexes and nucleic acids that constitute the organelle's interior and determine its boundary (1). DYRK3 acts as a central dissolvase of several types of membraneless organelle during mitosis, through its ability to control the condensation of multiple compartments, DYRK3 may link structural and functional roles for RNA, transcription and splicing to the assembly of the mitotic spindle, and be involved in the maintenance of the pericentriolar matrix (2). Reference
1. Woodruff, J. B., Wueseke, O., & Hyman, A. A. (2014) Pericentriolar material structure and dynamics. Philos Trans R Soc Lond B Biol Sci, 369(1650). PMID: 25047613
2. Rai, A. K., Chen, J. X., Selbach, M., & Pelkmans, L. (2018) Kinase-controlled phase transition of membraneless organelles in mitosis. Nature, 559(7713), 211-216. PMID:29973724
There are 2 genes. Reviewed (1)
or Unreviewed (1) | No. | Status | DrLLPS ID | Ensemble Gene ID | UniProt Accession | Gene Name |
|---|---|---|---|---|---|
| 1 | | ||||
| 2 | |